Dr Doowon Lee

Senior Lecturer - Finance

Newcastle Business School (Accounting and Finance)

Career Summary

Biography

Doowon Lee joined the Newcastle Business School in 2009. He has been teaching postgraduate courses such as Corporate Finance and Derivatives and Risk Management. Doowon has taught at Sogang Business School and the Korea Banking Institute prior to his appointment at the Newcastle Business School. His research interest is in market micro-structure and dividend policy. He has strong skills in quantitative methods in finance using programs such as Matlab, SAS, and Visual Basic using Excel, C++, STATA, and E-views. Research Expertise
Market micro-structure, Derivatives & Dividend policy









Qualifications

  • PhD, Korea Advanced Institute of Science and Technology
  • Bachelor of Science, Korea Advanced Institute of Science and Technology
  • Master of Science, Korea Advanced Institute of Science and Technology

Keywords

  • Banking
  • Finance
  • Investment
  • Risk Management

Fields of Research

Code Description Percentage
150199 Accounting, Auditing and Accountability not elsewhere classified 25
150202 Financial Econometrics 75

Professional Experience

UON Appointment

Title Organisation / Department
Senior Lecturer - Finance University of Newcastle
Newcastle Business School
Australia
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2014 Hoong KI, Kang J, Lee Doowon, 'Decomposition of Volatility in Asian Equity Markets', Asian Capital Market Development and Integration: Challenges and Opportunities, Oxford University Press, New Delhi 363-396 (2014) [B1]

Journal article (45 outputs)

Year Citation Altmetrics Link
2017 Rahman MD, Lee D, Shamsuddin A, 'Time-varying return predictability in South Asian equity markets', International Review of Economics & Finance, 48 179-200 (2017)
DOI 10.1016/j.iref.2016.12.004
Co-authors Abul Shamsuddin
2017 Anthony J, Docherty P, Lee D, Shamsuddin A, 'Liquidity shocks in the secondary corporate loan market', Journal of Fixed Income, 26 53-72 (2017)

© 2015 Institutional Investor LLC. All Rights Reserved.This article examines the influence of liquidity risk on the U.S. secondary corporate loan market (herein loan market). The... [more]

© 2015 Institutional Investor LLC. All Rights Reserved.This article examines the influence of liquidity risk on the U.S. secondary corporate loan market (herein loan market). The authors empirically disentangle the impact of both loan-level liquidity shocks and systematic liquidity risk from default risk. Loans that experience shocks to either liquidity or default risk experience ongoing price declines, complementing evidence presented elsewhere of price momentum in loan markets. The prices of loans with high liquidity risk are significantly discounted when market liquidity is low, consistent with the time-varying funding liquidity constraints of financial intermediaries. In keeping with a close link between high risk debt markets and equity markets, there is evidence that equity market risk is priced in the loan market.

DOI 10.3905/jfi.2017.26.4.053
Co-authors Paul Docherty, Abul Shamsuddin
2016 Docherty PA, Easton S, Elliot B, Lee D, 'Profitability and investment-based factor pricing models', Accounting and Finance, (2016)
DOI 10.1111/acfi.12217
Co-authors Paul Docherty, Steve Easton
2015 Lee D, HASSAN MK, RAHMAN MA, 'FIRM SPECIFIC VARIATION IN RETURNS AND FUNDAMENTALS IN KOREA STOCK MARKET', Singapore Economic Review, 60 (2015)
DOI 10.1142/S0217590815500927
2015 Lee DW, Bhopal MF, Ur Rehman A, Lee SH, 'Characteristics of ITO film dependence upon substrate temperature using electron beam evaporator', Journal of Korean Institute of Metals and Materials, 53 729-734 (2015)

© The Korean Institute of Metals and Materials.The optical and electrical characteristics of an ITO film were analyzed by depositing it on a glass substrate using an electron bea... [more]

© The Korean Institute of Metals and Materials.The optical and electrical characteristics of an ITO film were analyzed by depositing it on a glass substrate using an electron beam evaporator (EBE) for application in thin-film solar cells. The temperature of the substrate during the deposition was adjusted from room temperature to 400 °C. The optical properties of the ITO film were analyzed with a UV-Vis-NIR spectrometer. A four point probe system was used to measure the electrical characteristics. The surface morphology was studied by field emission scanning electron microscopy (FE-SEM) and atomic force microscopy (AFM). A high-resolution x-ray diffractometer (HR-XRD) was used to analyze the phases of the ITO film at various substrate temperatures. From the results, ITO whiskers grew at 200 °C. However, ITO whisker growth changed to ITO nanowire growth above 300 °C for the substrate temperature. When the growth changed from whiskers to wires, the morphology of the film and the electrical and optical properties also changed. The ITO nanowires have good transmittance for application in thin-film solar cells above a 300 °C substrate temperature.

DOI 10.3365/KJMM.2015.53.10.729
2015 Choi BB, Jung K, Lee D, 'Trading Behavior Prior to Public Release of Analyst Reports: Evidence from Korea', Contemporary Accounting Research, 32 105-138 (2015) [C1]
DOI 10.1111/1911-3846.12090
Citations Scopus - 2Web of Science - 2
Co-authors Bobae Choi
2014 Choi Bobae, Kang J, Lee D, 'Determinants and market implications of differentiated dividends in Korea', International Journal of Managerial Finance, 10 453-469 (2014) [C1]
DOI 10.1108/IJMF-11-2012-0116
Co-authors Bobae Choi
2013 Choi BB, Lee D, Psaros J, 'An analysis of Australian company carbon emission disclosures', Pacific Accounting Review, 25 58-79 (2013) [C1]
DOI 10.1108/01140581311318968
Co-authors Jim Psaros, Bobae Choi
2013 Choi BB, Lee D, Park Y, 'Corporate Social Responsibility, Corporate Governance and Earnings Quality: Evidence from Korea', CORPORATE GOVERNANCE-AN INTERNATIONAL REVIEW, 21 447-467 (2013) [C1]
DOI 10.1111/corg.12033
Citations Scopus - 15Web of Science - 9
Co-authors Bobae Choi
2011 Kang J, Lee C, Lee D, 'Equity fund performance persistence with investment style: Evidence from Korea', Emerging Markets Finance and Trade, 47 111-135 (2011) [C1]
DOI 10.2753/REE1540-496X470306
Citations Scopus - 7Web of Science - 5
2011 Lee DW, Gil GT, Kim DH, 'A handover decision strategy with a novel modified load-based adaptive hysteresis adjustment in 3GPP LTE system', IEICE Transactions on Information and Systems, E94-D 1130-1136 (2011)

This paper introduces a hard handover strategy with a novel adaptive hysteresis adjustment that is needed to reduce handover drop rate in 3GPP long term evolution (LTE). First of ... [more]

This paper introduces a hard handover strategy with a novel adaptive hysteresis adjustment that is needed to reduce handover drop rate in 3GPP long term evolution (LTE). First of all, we adopt a Hybrid handover scheme considering both the received signal strength (RSS) and the load information of the adjacent evolved Node Bs (eNBs) as a factor for deciding the target eNB. The Hybrid scheme causes the load status between the adjacent eNBs to be largely similar. Then, we propose a modified load-based adaptive hysteresis scheme to find a suitable handover hysteresis value utilizing the feature of the small load difference between the target and serving eNBs obtained from the result of the Hybrid scheme. As a result, through the proposed modified load-based adaptive hysteresis scheme, the best target cell is very well selected according to the dynamically changing communication environments. The simulation results show that the proposed scheme provides good performance in terms of handover drop rate. Copyright © 2011 The Institute of Electronics, Information and Communication Engineers.

DOI 10.1587/transinf.E94.D.1130
2010 Lee D, Kim DH, 'The probability distribution selection for self-configuration and target cell selection for self-optimization in 3gpp lte system', International Journal of Innovative Computing, Information and Control, 6 5685-5695 (2010)

This paper aims to minimize the handover drop rrite and distribute the cell load evenly in the self organizing network (SON,) of SGPP long term evolution (LTEJ) system with a vari... [more]

This paper aims to minimize the handover drop rrite and distribute the cell load evenly in the self organizing network (SON,) of SGPP long term evolution (LTEJ) system with a variable loading and dynamic mobility environment. To accomplish the object, we propose two schemes. Firstly, at self-configuration phase, we propose a probability distribution selection scheme for estimating the load change value which means the difference of load value changed during the time interval between the handover decision stage and the admission control stage. Secondly, at self-optimization phase, we propose a target cell selection (TOS) scheme reflecting the estimated load change value obtained from the above-mentioned scheme. The simulation results reveal that the proposed schemes provide better performance than the ensting schemes in terms of handover drop rate and load balancing. © 2010 ISSN.

Citations Scopus - 3
2010 Kim DH, Lee DW, Gil GT, 'A cost-based adaptive handover hysteresis scheme to minimize the handover failure rate in 3GPP LTE system', Eurasip Journal on Wireless Communications and Networking, 2010 (2010)

We deal with a cost-based adaptive handover hysteresis scheme for the horizontal handover decision strategies, as one of the self-optimization techniques that can minimize the han... [more]

We deal with a cost-based adaptive handover hysteresis scheme for the horizontal handover decision strategies, as one of the self-optimization techniques that can minimize the handover failure rate (HFR) in the 3rd generation partnership project (3GPP) long-term evolution (LTE) system based on the network-controlled hard handover. Especially, for real-time operation, we propose an adaptive hysteresis scheme with a simplified cost function considering some dominant factors closely related to HFR performance such as the load difference between the target and serving cells, the velocity of user equipment (UE), and the service type. With the proposed scheme, a proper hysteresis value based on the dominant factors is easily obtained, so that the handover parameter optimization for minimizing the HFR can be effectively achieved. Simulation results show that the proposed scheme can support better HFR performance than the conventional schemes. Copyright © 2010 Doo-Won Lee et al.

DOI 10.1155/2010/750173
Citations Scopus - 5
2008 Lee DW, Park SY, Ryu JS, Kim SH, Im CU, Choi SH, et al., 'Relaxation effect of synthetic ceramide analogues in cat esophageal smooth muscle cells', Korean Journal of Physiology and Pharmacology, 12 137-142 (2008)

Ceramide has emerged as a novel second messenger for intracellular signalling. It is produced from sphingomyelin and is involved in the control of cell differntiation, proliferati... [more]

Ceramide has emerged as a novel second messenger for intracellular signalling. It is produced from sphingomyelin and is involved in the control of cell differntiation, proliferation, and apoptosis. C2-ceramide, short chain ceramide, plays a role in mediating contraction of cat esophageal smooth muscle cells. We examined the effect of synthesized ceramide analogues on the C2-ceramide and ACh-induced contraction in esophageal smooth muscle cells isolated with collagenase. CY3523, CY3525, or CY3723 inhibited C2-ceramide induced contraction, in a time dependent manne. Each analogue also inhibited the contraction in concentration dependent manners. CY 3523, CY 3525, and CY 3723 had no effect to the contraction induced by PMA. The inhibition with CY3523, CY3525 and CY3723 on the C2-ceramide induced contraction was recovered by PMA. These analogues decreased the density of MAPK bands (p44/42 or p38) in the western blot. These results suggest that ceramide analogues can inhibit C2-ceramide induced contraction via PKC and MAPK dependent pathway.

Citations Scopus - 3
2007 Das A, Fu ZQ, Tempel W, Liu ZJ, Chang J, Chen L, et al., 'Characterization of a corrinoid protein involved in the C1 metabolism of strict anaerobic bacterium Moorella thermoacetica', Proteins: Structure, Function and Genetics, 67 167-176 (2007)

The strict anaerobic, thermophilic bacterium Moorella thermoacetica metabolizes C1 compounds for example CO2/H2, CO, formate, and methanol into acetate via the Wood/Ljungdahl path... [more]

The strict anaerobic, thermophilic bacterium Moorella thermoacetica metabolizes C1 compounds for example CO2/H2, CO, formate, and methanol into acetate via the Wood/Ljungdahl pathway. Some of the key steps in this pathway include the metabolism of the C1 compounds into the methyl group of methylenetetrahydrofolate (MTHF) and the transfer of the methyl group from MTHF to the methyl group of acetyl-CoA catalyzed by methyltransferase, corrinoid protein and CO dehydrogenase/acetyl CoA synthase. Recently, we reported the crystallization of a 25 kDa methanol-induced corrinoid protein from M. thermoacetica (Zhou et al., Acta Crystallogr F 2005;61:537-540). In this study we analyzed the crystal structure of the 25 kDa protein and provide genetic and biochemical evidences supporting its role in the methanol metabolism of M. thermoacetia. The 25 kDa protein was encoded by orf1948 of contig 303 in the M. thermoacetica genome. It resembles similarity to MtaC the corrinoid protein of the methanol:CoM methyltransferase system of methane producing archaea. The latter enzyme system also contains two additional enzymes MtaA and MtaB. Homologs of MtaA and MtaB were found to be encoded by orf2632 of contig 303 and orf1949 of contig 309, respectively, in the M. thermoacetica genome. The orf1948 and orf1949 were co-transcribed from a single polycistronic operon. Metal analysis and spectroscopic data confirmed the presence of cobalt and the corrinoid in the purified 25 kDa protein. High resolution X-ray crystal structure of the purified 25 kDa protein revealed corrinoid as methylcobalamin with the imidazole of histidine as the a-axial ligand replacing benziimidazole, suggesting base-off configuration for the corrinoid. Methanol significantly activated the expression of the 25 kDa protein. Cyanide and nitrate inhibited methanol metabolism and suppressed the level of the 25 kDa protein. The results suggest a role of the 25 kDa protein in the methanol metabolism of M. thermoacetica. © 2007 Wiley-Liss, Inc.

DOI 10.1002/prot.21094
Citations Scopus - 16
2007 Gerwe B, Kelley LLC, Dillard BD, Lai T, Liu ZJ, Tempel W, et al., 'Structural and transcriptional analyses of a purine nucleotide-binding protein from Pyrococcus furiosus: A component of a novel, membrane-bound multiprotein complex unique to this hyperthermophilic archaeon', Journal of Structural and Functional Genomics, 8 1-10 (2007)

The open-reading frame PF0895 in the genome of the hyperthermophilic archaeon, Pyrococcus furiosus, encodes a 206-residue protein (MR 23,152). The structure of the recombinant pro... [more]

The open-reading frame PF0895 in the genome of the hyperthermophilic archaeon, Pyrococcus furiosus, encodes a 206-residue protein (MR 23,152). The structure of the recombinant protein was solved by single isomorphous replacement with anomalous scattering (SIRAS) using a mercury derivative. It has been refined to 1.70 Å with a crystallographic R and Rfree values of 19.7% and 22.3%, respectively. The PF0895 structure is similar to those of the ATP binding cassettes observed in the ABC transporter family. However, bioinformatics and molecular analyses indicate that PF0895 is not part of the expected five-gene operon that encodes a typical prokaryotic solute-binding ABC transporter. Rather, transcriptional profiling data show that PF0895 is part of a novel four-gene operon (PF0895-PF0896-PF0897-PF0897.1) where only PF0895 has homologs in other organisms. Interestingly, from genome analysis, P. furiosus itself contains a second version of this complex, encoded by PF1090-PF1093. From the structural studies we can only conclude that one of the subunits of this novel membrane complex, PF0895, and its homolog PF1090, likely bind a purine nucleotide. PF0895 is therefore predicted to be part of a membrane-bound multiprotein complex unrelated to ABC transporters that is so far unique to P. furiosus. It appears to play a role in the stress response, as its expression is down regulated when the organism is subjected to cold-shock, where cells are transferred from 95°C, near the optimal growth temperature, to 72°C, near the minimal growth temperature. The related PF1090-containing operon is unaffected by cold-shock and is independently regulated. © 2007 Springer Science+Business Media B.V.

DOI 10.1007/s10969-007-9026-3
2007 Clancy Kelley LL, Dillard BD, Tempel W, Chen L, Shaw N, Lee D, et al., 'Structure of the hypothetical protein PF0899 from Pyrococcus furiosus at 1.85 Å resolution', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 63 549-552 (2007)

The hypothetical protein PF0899 is a 95-residue peptide from the hyperthermophilic archaeon Pyrococcus furiosus that represents a gene family with six members. P. furiosus ORF PF0... [more]

The hypothetical protein PF0899 is a 95-residue peptide from the hyperthermophilic archaeon Pyrococcus furiosus that represents a gene family with six members. P. furiosus ORF PF0899 has been cloned, expressed and crystallized and its structure has been determined by the Southeast Collaboratory for Structural Genomics (http://www.secsg.org). The structure was solved using the SCA2Structure pipeline from multiple data sets and has been refined to 1.85 Å against the highest resolution data set collected (a presumed gold derivative), with a crystallographic R factor of 21.0% and Rfree of 24.0%. The refined structure shows some structural similarity to a wedge-shaped domain observed in the structure of the major capsid protein from bacteriophage HK97, suggesting that PF0899 may be a structural protein. © International Union of Crystallography 2007.

DOI 10.1107/S1744309107024049
2006 Lee D, 'The Korean economy in transition: In search for a new model', Global Economic Review, 35 207-230 (2006)

Prior to the 1997 financial crisis, the Korean economy had based its growth policies on East Asia's economic catch-up model which was based mainly on the Japanese development expe... [more]

Prior to the 1997 financial crisis, the Korean economy had based its growth policies on East Asia's economic catch-up model which was based mainly on the Japanese development experience. However, the events that lead to the 1997 crisis and the changes instituted in the Korean economy after the crisis have put to question whether the traditional East Asian growth model will continue to be viable. This paper examines two alternative models of development, namely the "Anglo-Saxon" and the "Continental European" models, and evaluates their relevance for Korea's future development challenges. Despite many common features these models share, they are also quite distinctive with regard to their treatment of the labor market system and the role of government. By focusing on the model's capacity to expand employment and to provide sustainable growth as the most important criteria, it is suggested that Korea should follow the "Anglo-Saxon model", at least in the short- to medium-term. In comparing Korea's economy with other advanced economies when they were at the similar stage of development, it is found that Korea's growth potential lags behind that of countries such as Japan, Germany, Finland, and Ireland. The efficiency of Korea's investment is found to be only slightly better than Japan while it is inferior to all other advanced economies. Despite these challenges, Korea is apparently moving toward the "Continental European model", with the Korean government increasing its own size and plans for further expenditures on social security and welfare. However, in order to ensure sustainable development with significant job creation, this paper argues that Korea should switch its direction and adopt the "Anglo-Saxon model" as soon as possible. © 2006 Institute of East and West Studies, Yonsei University, Seoul.

DOI 10.1080/12265080600715475
Citations Scopus - 2
2005 Newton MG, Campana CF, Chi GC, Lee D, Liu ZJ, Nair V, et al., 'A non-natural dinucleotide containing an isomeric L-related deoxynucleoside: Dinucleotide inhibitors of anti-HIV integrase activity', Acta Crystallographica Section C: Crystal Structure Communications, 61 (2005)

The first X-ray crystal structure of a non-natural dinucleotide, 5'-O-phosphoryl-1'-deoxy-2'-isoadenylyl-(3' ¿ 5')-cytidine 6.5-hydrate (pIsodApC), C19H26N 8O13P2·6.5H2O, belong... [more]

The first X-ray crystal structure of a non-natural dinucleotide, 5'-O-phosphoryl-1'-deoxy-2'-isoadenylyl-(3' ¿ 5')-cytidine 6.5-hydrate (pIsodApC), C19H26N 8O13P2·6.5H2O, belonging to a family of dinucleotides that contain an isomeric nucleoside component, is described. A complex system of hydrogen bonds between water molecules and various sites on the dinucleotide was found. All H atoms were located from electron-density difference maps, which allowed identification of protonation sites. Compounds of this family have been found to bind at the active site of HIV integrase and to be inhibitors of this key viral enzyme. These dinucleotides are completely resistant to cleavage by exonucleases; an abnormal dihedral angle twist in an internucleotide phosphate bond revealed in the X-ray crystal structure may be contributing to this unusual stability towards nucleases. © 2005 International Union of Crystallography.

DOI 10.1107/S0108270105019037
Citations Scopus - 5
2005 Tempel W, Liu ZJ, Horanyi PS, Deng L, Lee D, Newton MG, et al., 'Three-dimensional structure of GlcNAca1-4Gal releasing endo-ß-galactosidase from Clostridium perfringens', Proteins: Structure, Function and Genetics, 59 141-144 (2005)
DOI 10.1002/prot.20363
Citations Scopus - 4
2005 Xu H, Yang C, Chen L, Kataeva IA, Tempel W, Lee D, et al., 'Away from the edge II: In-house Se-SAS phasing with chromium radiation', Acta Crystallographica Section D: Biological Crystallography, 61 960-966 (2005)

Recently, the demands of high-throughput macromolecular crystallography have driven continuous improvements in phasing methods, data-collection protocols and many other technologi... [more]

Recently, the demands of high-throughput macromolecular crystallography have driven continuous improvements in phasing methods, data-collection protocols and many other technologies. Single-wavelength anomalous scattering (SAS) phasing with chromium X-ray radiation opens a new possibility for phasing a protein with data collected in-house and has led to several successful examples of de novo structure solution using only weak anomalous scatterers such as sulfur. To further reduce data-collection time and make SAS phasing more robust, it is natural to combine selenomethionine-derivatized protein (SeMet protein) with Cr Ka radiation to take advantage of the larger anomalous scattering signal from selenium (f¿ = 2.28 e-) compared with sulfur (f¿ = 1.14 e-). As reported herein, the crystal structure of a putative chorismate mutase from Clostridium thermocellum was determined using Se-SAS with Cr Ka radiation. Each protein molecule contains eight selenomethionine residues in 148 amino-acid residues, providing a calculated Bijvoet ratio of about 3.5% at the Cr Ka wavelength. A single data set to 2.2 Å resolution with approximately ninefold redundancy was collected using an imaging-plate detector coupled with a Cr source. Structure solution, refinement and deposition to the Protein Data Bank were performed within 9 h of the availability of the scaled diffraction data. The procedure used here is applicable to many other proteins and promises to become a routine pathway for in-house high-throughput crystallography. © 2005 International Union of Crystallography - all rights reserved.

DOI 10.1107/S0907444905010644
Citations Scopus - 12
2005 Liu ZJ, Shah AK, Habel JE, Ng JD, Kataeva I, Xu H, et al., 'Salvaging Pyrococcus furiosus protein targets at SECSG', Journal of Structural and Functional Genomics, 6 121-127 (2005)

Proteins derived from the coding regions of Pyrococcus furiosus are targets for three-dimensional X-ray and NMR structure determination by the Southeast Collaboratory for Structur... [more]

Proteins derived from the coding regions of Pyrococcus furiosus are targets for three-dimensional X-ray and NMR structure determination by the Southeast Collaboratory for Structural Genomics (SECSG). Of the 2200 open reading frames (ORFs) in this organism, 220 protein targets were cloned and expressed in a high-throughput (HT) recombinant system for crystallographic studies. However, only 96 of the expressed proteins could be crystallized and, of these, only 15 have led to structures. To address this issue, SECSG has recently developed a two-tier approach to protein production and crystallization. In this approach, tier-1 efforts are focused on producing protein for new Pfu(italics?) targets using a high-throughput approach. Tier-2 protein production efforts support tier-1 activities by (1) producing additional protein for further crystallization trials, (2) producing modified protein (further purification, methylation, tag removal, selenium labeling, etc) as required and (3) serving as a salvaging pathway for failed tier-1 proteins. In a recent study using this two-tiered approach, nine structures were determined from a set of 50 Pfu proteins, which failed to produce crystals suitable for X-ray diffraction analysis. These results validate this approach and suggest that it has application to other HT crystal structure determination applications. © Springer 2005.

DOI 10.1007/s10969-005-5242-x
Citations Scopus - 3
2005 Zhou W, Das A, Liu ZJ, Chen L, Chang J, Lee D, et al., 'Isolation, crystallization and preliminary X-ray analysis of a methanol-induced corrinoid protein from Moorella thermoacetica', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 61 537-540 (2005)

A corrinoid protein was induced and overexpressed in methanol-grown cells of the thermophilic anaerobic bacterium Moorella thermoacetica. The protein was purified from cytosolic e... [more]

A corrinoid protein was induced and overexpressed in methanol-grown cells of the thermophilic anaerobic bacterium Moorella thermoacetica. The protein was purified from cytosolic extracts. After screening for crystallization conditions and optimization, crystals were obtained that diffracted strongly on a rotating-anode X-ray source. A diffraction data set was collected and processed including reflections to 1.9 Å resolution. Reflections were indexed in a primitive orthorhombic cell with unit-cell parameters a = 55.69, b = 62.74, c = 34.54 Å. N-terminal amino-acid sequencing indicates that the crystals contain a C-terminal fragment of the protein. © 2005 International Union of Crystallography All rights reserved.

DOI 10.1107/S1744309105010511
Citations Scopus - 5
2004 Shin CY, La HO, Lee YP, Lee DW, Kim DS, Huh IH, Sohn UD, 'The alteration of intracellular signaling on the smooth muscle cells contraction in cat esophagitis', Life Sciences, 74 2199-2211 (2004)

We investigated the alteration of signal transduction after acute esophagitis in cat lower esophageal sphincter (LES). Acute esophagitis (AE) was induced by perfusion with 0.1N HC... [more]

We investigated the alteration of signal transduction after acute esophagitis in cat lower esophageal sphincter (LES). Acute esophagitis (AE) was induced by perfusion with 0.1N HCl at a rate of 1 ml/min for 45 min over three consecutive days. Acetylcholine (ACh)-induced contraction was inhibited by M3» M1 or M2 antagonists in normal LES. In AE, inhibition by M2 antagonists increased significantly, so that contraction was inhibited by M3> M2> M1 antagonists and the expression of M2 and M3 receptors were increased when compared to normal LES. In normal cells, ACh-induced contractions were antagonized by antibody against Gq/11 and the phosphatidylinositol- specific phospholipase C (PI-PLC) antagonist, U73122. The phosphatidylcholine- specific phospholipase C (PC-PLC) inhibitor, D609, or the phospholipase D inhibitor, propranolol had no effects on contraction in normal LES. However, in AE, Gq/11, and Gi3 antibodies reduced ACh-induced contraction and U73122, propranolol and D609 also reduced the contraction. In AE, we found that the expressions of G protein subtypes were increased but the expression of PLCß1, and PLC¿1 were decreased when compared to normal LES. In conclusion, experimental esophagitis may alter the signal transduction by ACh in LES. ACh-induced contraction is mediated by M3 receptor, Gq/11 and PI-PLC in normal LES. However, in AE, the contractions are mediated by M2, M3 receptor, Gq/11 and Gi3. PC-PLC and PLD as PI-PLC are also involved in ACh-induced cell contraction in AE. © 2004 Elsevier Inc. All rights reserved.

DOI 10.1016/j.lfs.2003.09.057
Citations Scopus - 1
2002 Lee D, Shamsi SA, 'Chiral separation of anionic and neutral compounds using a hepta-substituted cationic ß-cyclodextrin as a chiral selector in capillary electrophoresis', Electrophoresis, 23 1314-1319 (2002)

Enantiomeric separations of six anionic and two neutral racemates were achieved using a fully substituted heptakis(6-hydroxyethylamino-6-deoxy)-ß-cyclodextrin (ß-CD-EA) as a chi... [more]

Enantiomeric separations of six anionic and two neutral racemates were achieved using a fully substituted heptakis(6-hydroxyethylamino-6-deoxy)-ß-cyclodextrin (ß-CD-EA) as a chiral selector. As ß-CD-EA provides a dynamic coating on the capillary wall, reverse-polarity capillary electrophoresis (CE) configuration is applied for separations of anionic and neutral chiral compounds. Chiral separations of various classes of anionic and neutral enantiomers were found to be highly dependent on pH because the degree of protonation of ß-CD-EA can alter the shape of the CD cavity by charge repulsion, altering complexation, aiding selectivity, and leading to better enantiomeric separation. In general, the chiral resolution of anionic enantiomers was enhanced at higher pH. This suggests that carboxylate or phosphate groups on the analyte may interact with the protonated amine groups of cationic CD. The successful enantioseparation was achieved in a pH range of 6.6-7.8 for all six anionic analytes, in the presence of 10 mM ß-CD-EA.

DOI 10.1002/1522-2683(200205)23:9<1314::AID-ELPS1314>3.0.CO;2-O
Citations Scopus - 20
2001 Lee D, 'South Korea's economic reform and its Aftermath', Global Economic Review, 30 23-50 (2001)

This paper analyzes the process of Korea's recovery from the 1997 financial crisis with several policy implications. The driving force behind the better-than-expected economic rec... [more]

This paper analyzes the process of Korea's recovery from the 1997 financial crisis with several policy implications. The driving force behind the better-than-expected economic recovery was the reform measures introduced by the Korean government in four major areas such as the financial, corporate, labor and public sectors. Also, Korea's strong export performance helped by the booming U.S. economy provided a favorable external condition for recoveiy. Internally, surging investment in the IT and venture industries, which was deliberately fostered by the government, along with the revived consumption level, enabled the rapid recovery. However, as the U.S. economy slowed and the technology bubble burst in 2000, the Korean economy went through a mild recession in 2001. Based on the experiences of crisis and recovery, the implication of macroeconomic fundamentals is re-examined. Even though the strong macroeconomic fundamentals were misleading in preventing the crisis, they later facilitated the Korean economy's recoveiy. As a result of various reform measures, the Korean economy as of today is in a different environment First, the low investment rate along with the decreased saving rate will marie the end of the high growth era. Second, the substantial deterioration of income distribution will be the major task to be tackled with in the future. Third, the Korean economy is now fully liberalized both in the commodity and capital markets with some side effects and merits. Fourth, the loan and deposit structure of the financial sector is significantly altered. Lastly, more fiscal burden is placed on the shoulders of the government due to the heavy debt service burden of public funds and the generous expansion of social welfare programs.

DOI 10.1080/12265080108449832
2001 Lee DW, Ko HS, 'Natural hairstyle modeling and animation', Graphical Models, 63 67-85 (2001)

In this paper, we develop a hairstyle modeling and animation technique specifically designed for human hairs, and we report several experimental results. Using simplified cantilev... [more]

In this paper, we develop a hairstyle modeling and animation technique specifically designed for human hairs, and we report several experimental results. Using simplified cantilever beam model and one-dimensional projective differential equations of angular momenta, we give a practical solution to the problem of enormous complexity. Even though our hair animation algorithm is an approximate solution, it includes all the relevant dynamic elements such as gravity, wind, inertia, air-resistance, hair-to-head, and hair-to-hair friction forces. Collision is an important element that makes a collection of hair strands look like hair. We develop an accurate but efficient hair-to-head and hair-to-hair collision detection and treatment algorithm. The algorithm produces quite realistic results; still it runs at an interactive speed. An interesting contribution of our algorithm is that it unifies hairstyle modeling and animation into a single equation, so that (1) hairstyling can be done under the effects of gravity and other internal or external forces, and (2) original hairstyle is more or less restored even after the initial hair is tangled by the application of external forces or head movements.

DOI 10.1006/gmod.2001.0547
Citations Scopus - 32
2000 Lee D, Shamsi SA, 'Development of a capillary zone electrophoresis method for the separation of a furan combinatorial library', Electrophoresis, 21 2405-2411 (2000)

Nine component mixtures of a furan library were simultaneously separated by capillary zone electrophoresis (CZE) using a phosphate buffer as a background electrolyte at low pH. Th... [more]

Nine component mixtures of a furan library were simultaneously separated by capillary zone electrophoresis (CZE) using a phosphate buffer as a background electrolyte at low pH. The effects of buffer concentration, buffer pH, type and concentration of organic solvents on the electrophoretic mobility, resolution, and analysis time were systematically investigated. Resolution and efficiency of furan library components were further improved using cyclodextrin (CD)-modified CZE. Under optimum conditions, eight of the nine furans were baseline-resolved in less than 10 min at 30 kV using 50 mM phosphate buffer, 10% v/v acetonitrile (ACN), pH 2.0, with 5 mM ¿-CD.

DOI 10.1002/1522-2683(20000701)21:12<2405::AID-ELPS2405>3.0.CO;2-2
Citations Scopus - 3
1999 Joshi BS, Rho T, Lee D, Coetzee A, Ratner GA, Newton MG, Pelletier SW, 'Crystal and molecular structure of ethyl-(1,4-dibenzyloxy-2,3-naphthalene)-diacetate', Journal of the Indian Chemical Society, 76 589-593 (1999)

In an attempted synthesis of radermachol (1), we had the occasion to prepare ethyl-(1,4-dibenzyloxy-2,3-naphthalene)-diacetate (2) for further structural modification. This paper ... [more]

In an attempted synthesis of radermachol (1), we had the occasion to prepare ethyl-(1,4-dibenzyloxy-2,3-naphthalene)-diacetate (2) for further structural modification. This paper describes the synthesis and the X-ray structure determination of compound 2.

1999 Lee D, Cheong Y, 'Comparison of FDI into China between Korean firms and ethnic Chinese firms', Global Economic Review, 28 28-53 (1999)

Foreign direct investment (FDI) into China contributed greatly to the current rapid economic development of China. Many efforts have been given to more thorough analysis of entry ... [more]

Foreign direct investment (FDI) into China contributed greatly to the current rapid economic development of China. Many efforts have been given to more thorough analysis of entry mode of FDI in China. Due to the lack of available relevant data, however, micro level analysis has rarely included firm level analysis or research, which includes variables such as detailed industrial sector especially in manufacturing sector, investment size, equity share, and regional distribution of FDI. In this respect, this paper focuses on analyzing both entry mode and cross country comparison of Korean and overseas ethnic Chinese firms' FDI into China. The cooperative analysis would provide a variety of information for further analysis of identifying success and failure factors. Two different kinds of data sources are used in this analysis: one is highly aggregated lump sum data, and the other is more detailed survey level data. This paper will also contrast differences in business behaviors of Korean firms and overseas ethnic Chinese firms investing in China.

DOI 10.1080/12265089908449750
Citations Scopus - 4
1997 Joshi BS, Rho T, Rinaldi PL, Liu W, Wagler TA, Newton MG, et al., 'The structure of the p-molecular complex between 1,4-dihydro-9,10-anthrahydroquinone and 1,4-dihydro-9,10-anthraquinone', Journal of Chemical Crystallography, 27 553-559 (1997)

The structure of the p-molecular complex (10) was assigned on the basis of the solid state 13C-nmr spectrum. The solid state 13C-nmr spectrum of quinhydrone (12) has also been det... [more]

The structure of the p-molecular complex (10) was assigned on the basis of the solid state 13C-nmr spectrum. The solid state 13C-nmr spectrum of quinhydrone (12) has also been determined. Accurate 1H and 13C chemical shift assignments have been made for the compounds 3, 5, 6, 7, 8, and 10 on the basis of HMQC and HMBC spectral data. The p-molecular complex 10 crystallizes in the space group P21/n with cell parameters: a = 4.052 (1) Å, b = 6.477 (1) Å, c = 19.093 (2) Å, ß = 90.17 (1)°, z = 1, Dc = 1.400 g cm-3. Crystal and molecular structure of the title compound, C28H22O4, has been determined by an X-ray analysis of 10 by direct methods from diffractometer data and refined by full-matrix least-squares.

Citations Scopus - 8
1996 Kumar V, Lee DW, Newton MG, King RB, 'Dialkylaminophosphorus metal carbonyls. 14. Stereochemistry of some HX additions to the (iPr2NP) 2Fe2(CO)6 unit from (iPr2NP) 2COFe2(CO)6', Journal of Organometallic Chemistry, 512 1-9 (1996)

Reaction of (iPr2NP)2COFe2(CO)6 with aniline in boiling hexane results in addition of aniline to the (iPr2NP)2Fe2(CO)6 unit to give yellow (iPr2NPNHPh)(iPr2NPH)Fe2(CO)6, shown by ... [more]

Reaction of (iPr2NP)2COFe2(CO)6 with aniline in boiling hexane results in addition of aniline to the (iPr2NP)2Fe2(CO)6 unit to give yellow (iPr2NPNHPh)(iPr2NPH)Fe2(CO)6, shown by X-ray diffraction to have a syn orientation of the two iPr2N groups. However, the (XPNiPr2)(iPr2NPH)Fe2(CO)6, adducts (X = Cl, OEt, OCH2SiMe3) of (iPr2NP)2Fe2(CO)6 with HCl and ROH (R = Et, CH2SiMe3) respectively, are shown by X-ray diffraction to have an anti orientation of the two iPr2N groups.

Citations Scopus - 8
1996 Joshi BS, Pelletier SW, Newton MG, Lee D, McGaughey GB, Puar MS, 'Extensive 1D, 2D NMR spectra of some [7.0]Metacyclophanes and X-ray analysis of (±)-myricanol', Journal of Natural Products, 59 759-764 (1996)

From the hexane extract of the bark of Myrica cerifera, the pentacyclic triterpenes taraxerol and myricadiol were isolated. The EtOH extract afforded the [7.0]metacyclophanes, (±... [more]

From the hexane extract of the bark of Myrica cerifera, the pentacyclic triterpenes taraxerol and myricadiol were isolated. The EtOH extract afforded the [7.0]metacyclophanes, (±)myricanol (4), and myricanone (7). Accurate 1H- and 13C-NMR spectral assignments have been made for (±)-myricanol (4), 5,11,17-tri-O-acetyl-(±)-myricanol (5), 11-O-methyl-(±)-myricanol (6), and myricanone (7) by a study of the 1H-1H-COSY, 1H-13C-COSY (HETCOR), selective INEPT, and 1D NOE experiments. The structure of (±)-myricanol was established by a single crystal X-ray analysis. Molecular mechanics MM-3(94) calculations have been made for (R,Sa)- and (S,Sa)-myricanol, and the bond lengths, bond angles, and the torsion angles have been calculated for the energy-minimized conformation.

DOI 10.1021/np960230k
Citations Scopus - 21
1996 Joshi BS, Newton MG, Lee DW, Barber AD, Pelletier SW, 'Reversal of absolute stereochemistry of the pyrrolo[2,1-b]quinazoline alkaloids vasicine, vasicinone, vasicinol and vasicinolone', Tetrahedron Asymmetry, 7 25-28 (1996)

The previously assigned 3R configuration of (-)-vasicinone has been reverse and this pyrrolo[2,1-b]quinazoline-9-one has been shown to have the 3S-configuration (3) on the basis o... [more]

The previously assigned 3R configuration of (-)-vasicinone has been reverse and this pyrrolo[2,1-b]quinazoline-9-one has been shown to have the 3S-configuration (3) on the basis of an X-ray diffraction study of (+)-vasicinone hydrobromide. Likewise, the 3R stereochemistry assigned earlier to (-)-vasicine (peganine) (1) on the basis of an X-ray analysis of its hydrochloride has also been reversed by reinvestigation of the X-ray diffraction analysis of the hydrobromide. The absolute stereochemistry of the alkaloids (+)-vasicinol (2) and vasicinolone (5) which have been interrelated, should also have the 3S-configuration. A study of the 1H nmr spectroscopy of (-)-vasicine by the use of Mosher's method using MTPA [a-methoxy-a-(trifluoromethyl)phenylacetic acid] esters indicated an exception to this model for establishing the absolute configuration.

DOI 10.1016/0957-4166(95)00412-2
Citations Scopus - 48
1995 Liang C, Lee DW, Newton MG, Chu CK, 'Synthesis of L-dioxolane nucleosides and related chemistry', Journal of Organic Chemistry, 60 1546-1553 (1995)

(+)-L- or (+)-(2R,4S)-1-[4-(hydroxymethyl)-1,3-dioxolan-2-yl]-5-fluorouracil (25) and other novel classes of 1,3-dioxolane nucleosides have been synthesized. Coupling of 2-methoxy... [more]

(+)-L- or (+)-(2R,4S)-1-[4-(hydroxymethyl)-1,3-dioxolan-2-yl]-5-fluorouracil (25) and other novel classes of 1,3-dioxolane nucleosides have been synthesized. Coupling of 2-methoxy-4-[[(tert-butyldiphenylsilyl)oxy]methyl]-1,3-dioxolane (23) or 2-methyl-1,3-dioxolane (9) with silylated 5-fluorouracil, thymine, cytosine, and 5-chlorocytosine in the presence of TMSOTf gave the corresponding 1,3-dioxolane nucleosides. These nucleosides were decomposed and rearranged to the ring-opened products in certain reaction conditions. It was found that 5-fluorouricil nucleosides (12 and 25) were relatively more stable than the thymine or cytosine derivatives (10, 13, and 16). Bulky protecting group (TBDPS) at the 1,3-dioxolane moiety in compound 24 may also contribute the stability to the 1,3-dioxolane nucleosides. The structures of these novel 1,3-dioxolane nucleosides and ring-opened products have been assigned by NMR spectra, and the mechanisms of decomposition and rearrangement to the ring opened products were discussed. © 1995 American Chemical Society.

Citations Scopus - 18
1995 Zhao Y, Yang T, Lee M, Lee D, Newton MG, Chu CK, 'Asymmetric synthesis of (1'S,2'R)-cyclopropyl carbocyclic nucleosides', The Journal of Organic Chemistry, 60 5236-5242 (1995)

Enantiomeric synthesis of cyclopropyl carbocyclic nucleosides has been accomplished. The key intermediates 7 and 9 were synthesized from D-glyceraldehyde acetonide 1, which was co... [more]

Enantiomeric synthesis of cyclopropyl carbocyclic nucleosides has been accomplished. The key intermediates 7 and 9 were synthesized from D-glyceraldehyde acetonide 1, which was converted to the a,ß-unsaturated ester 2 and then reduced to give allylic alcohol 3a. Stereoselective construction of the cyclopropyl ring of 3a and 3b followed by oxidation gave acid 5, which was treated under Curtius rearrangement conditions to obtain the urea intermediate 7. The urea intermediate was utilized to prepare uracil 14, thymine 15, and cytosine 18 nucleosides. The purine derivatives were prepared from cyclopropylamine 9 by condensation with 4,6-dichloro-5-formamidopyrimidine or 4,6-dichloro-2-aminopyrimidine. © 1995 American Chemical Society.

Citations Scopus - 53
1995 Kumar V, Lee DW, Newton MG, King RB, 'Dialkylaminophosphorus metal carbonyls XIII. Structure of a tertiary alcohol [(iPr2NP)2C(OH)R]Fe2(CO)6 and the effect of carbon hybridization on the geometry of the CP2Fe2 cage', Journal of Organometallic Chemistry, 502 61-65 (1995)

Reaction of (iPr2NP)2COFE2(CO)6 with benzyllithium (from PhCH2SnPh3 +n-Buli) gives the corresponding tertiary alcohol (iPr2NP)2C(CH2Ph)(OH)Fe2(CO)6, which has been characterized s... [more]

Reaction of (iPr2NP)2COFE2(CO)6 with benzyllithium (from PhCH2SnPh3 +n-Buli) gives the corresponding tertiary alcohol (iPr2NP)2C(CH2Ph)(OH)Fe2(CO)6, which has been characterized structurally by X-ray diffraction (monoclinic; space group, P1/a; a = 9.797(1), b = 16.593(1) and c = 19.671(2) A °; ß = 101.564(9)°; Z = 4). A comparison of the geometries of the CP2Fe2 cages in the series (iPr2NP)2C(CH2Ph)(OH)Fe2(CO)6 and [iPr2NP)2CHSiMe3]Fe2(CO)6 with P-C(sp3)-P bridges and (iPr2NP)2COFE2(CO)6, (iPr2NP)(tBu2PP)COFe2(CO)6, and (tBuP)2(COFe2(CO)6 with PC(sp2)P bridges indicates that changing the P bridging (i.e. cage) carbon atom from sp3 hybridization to sp2 hybridization increases the PCP bond angle from 78-80 to 84-86dg, the PFeP bond angles from 64-67 to 69-70°, and the non-bonding P...P distance from 2.44 to 2.53-2.55 Å while having relatively little effect on the PC, FeP and FeFe distances. © 1995.

DOI 10.1016/0022-328X(95)05679-J
Citations Scopus - 2
1995 Du J, Qu F, Lee DW, Newton MG, Chu CK, '1,3-Dioxolane C-Nucleosides: Asymmetric Synthesis of Four Stereoisomers of 2-[2-(Hydroxymethyl)-1,3-Dioxolan-S-yl)-1,3-Thiazole-4-Carboxamide', Tetrahedron Letters, 36 8167-8170 (1995)

Asymmetric synthesis of four novel C-nucleosides, (2'R,5'R)-, (2'S,5'R)-, (2'S,5'S)- and (2'R,5'S)-2-[2-hydroxymelhy])-1,3-dioxolan-5-yl]-1,3-thiazole-4-carboxamide has been accom... [more]

Asymmetric synthesis of four novel C-nucleosides, (2'R,5'R)-, (2'S,5'R)-, (2'S,5'S)- and (2'R,5'S)-2-[2-hydroxymelhy])-1,3-dioxolan-5-yl]-1,3-thiazole-4-carboxamide has been accomplished by the condensation of key intermediates, 2-(1R- and 1S-glycol-1-yl)-4-ethoxycarbonyl-1,3-thiazole with 2-benzoyloxy acetaldehyde dimethyl acetal. © 1995.

DOI 10.1016/0040-4039(95)01763-8
Citations Scopus - 10
1995 Srivastava SK, Joshi BS, Newton MG, Lee D, Pelletier SW, 'Heterolytic fragmentation of deltaline, a norditerpenoid alkaloid', Tetrahedron Letters, 36 519-522 (1995)

The rearrangement product obtained by treatment of the norditerpenoid alkaloid deltaline (1) with SOCl2 in moist benzene has been assigned structure 5. This compound was also obta... [more]

The rearrangement product obtained by treatment of the norditerpenoid alkaloid deltaline (1) with SOCl2 in moist benzene has been assigned structure 5. This compound was also obtained by treatment of 10-chloro-10-deoxydeltaline (4) with aqueous MeOH. However, when (4) was treated with methanolic KOH, a novel rearranged pyrrolidine (8) was obtained. Structures 5 and 8 for these heterolytic fragmentation products were established by nmr spectroscopic data and an X-ray crystal structure determination of 8. © 1995.

DOI 10.1016/0040-4039(94)02300-Z
Citations Scopus - 10
1995 Lee M, Lee D, Zhao Y, Gary Newton M, Chun MW, Chu CK, 'Enantioselective synthesis of cyclopropyl carbocyclic L-nucleosides', Tetrahedron Letters, 36 3499-3502 (1995)
DOI 10.1016/0040-4039(95)00575-W
Citations Scopus - 16
1995 Lee DW, Lee TH, 'Human capital and economic growth Tests based on the international evaluation of educational achievement', Economics Letters, 47 219-225 (1995)

Using the secondary school science achievement scores obtained by the International Association for the Evaluation of Educational Achievement, this paper provides more direct test... [more]

Using the secondary school science achievement scores obtained by the International Association for the Evaluation of Educational Achievement, this paper provides more direct tests than others on the effect of human capital on economic growth, bearing important implications for theory and olicy. © 1995.

DOI 10.1016/0165-1765(94)00539-E
Citations Scopus - 18
1995 Taj SS, Shah AC, Lee D, Newton G, Soman R, 'Asymmetric methylene transfer reactions II: Asymmetric synthesis of oxiranes from carbonyl compounds by methylene transfer reaction using chiral S-neomenthyl and S-exo-2-bornyl sulfoximines', Tetrahedron: Asymmetry, 6 1731-1740 (1995)

Three chiral sulfoximines, viz., (1R,Ss)-(-)-S-methyl-S-exo-2-bornyl-N-tosyl sulfoximine, 9a, its epimer at sulfur, (1R,Rs)-(+)-9b, and (1R,3S,4S,1'S,Rs)-(+)-S-methyl-S-neomenthyl... [more]

Three chiral sulfoximines, viz., (1R,Ss)-(-)-S-methyl-S-exo-2-bornyl-N-tosyl sulfoximine, 9a, its epimer at sulfur, (1R,Rs)-(+)-9b, and (1R,3S,4S,1'S,Rs)-(+)-S-methyl-S-neomenthyl-N-(camphor-10-sulfonyl ) sulfoximine, 19, were used as methylene transfer reagents in the preparation of nonracemic oxiranes (enantiomeric excess, 19-86%) from prochiral carbonyl compounds. Sulfoximines 9a and 9b were found to be less effective (ee, 19-68%) than the corresponding S-neomenthyl sulfoximines 2a and 2b (ee, 56-86%), and, sulfoximine 19, despite having a chiral auxiliary on nitrogen in place of the tosyl group, was found to be only as effective as the corresponding N-tosyl sulfoximine 2b in influencing the steric course of these reactions. The absolute configuration at sulfur of all the synthesised sulfoxides and sulfoximines has been established by X-ray studies. © 1995.

DOI 10.1016/0957-4166(95)00219-F
Citations Scopus - 9
1994 Zhao Y, Yang TF, Lee M, Chun BK, Du J, Schinazi RF, et al., 'Synthesis of enantiomerically pure cyclopropyl carbocyclic nucleosides', Tetrahedron Letters, 35 5405-5408 (1994)

The enantiomeric synthesis of cyclopropyl carbocyclic nucleosides has been achieved and the key intermediate was characterized by X-ray crystallography. © 1994.... [more]

The enantiomeric synthesis of cyclopropyl carbocyclic nucleosides has been achieved and the key intermediate was characterized by X-ray crystallography. © 1994.

DOI 10.1016/S0040-4039(00)73511-8
Citations Scopus - 44
1979 Lee D, Castro CE, Jagodzinski LL, Sevall JS, 'Functional significance of rat liver nonhistone protein-DNA interactions: RNA hybridization of protein-bound DNA', Biochemistry, 18 3160-3165 (1979)

The complexity of polysomal messenger RNA (mRNA) has been measured by saturation hybridization analysis of purified whole single-copy DNA and single-copy sequences enriched from l... [more]

The complexity of polysomal messenger RNA (mRNA) has been measured by saturation hybridization analysis of purified whole single-copy DNA and single-copy sequences enriched from liver nonhistone-bound sequences of the rat genome. Nine and two-tenths percent (2.5 × 108 nucleotide pairs) of the whole single-copy component of the rat genome is complementary to liver mRNA, while 4.3% (1.2 × 108 nucleotide pairs) is complementary with kidney mRNA. Liver nonhistone proteins have been fractionated by selective solubilization (0.35-1.0 M sodium chloride) from purified liver nuclei and have been shown to interact with sheared rat DNA in vitro. It has also been demonstrated in these studies that nonhistone-bound DNA can be fractionated into repetitive and single-copy components. The bound single-copy component (2.9 × 108 nucleotide pairs) is 43% complementary with liver mRNA and 31% complementary with kidney mRNA. The rate of hybridization of the nonhistone-bound single-copy DNA component with liver mRNA is threefold faster than that with kidney mRNA, suggesting that the nonhistone-DNA interactions enrich transcribed sequences that are transcribed with greater efficiency in rat liver than kidney tissue. © 1979 American Chemical Society.

Citations Scopus - 1
1979 Jagodzinski LL, Castro CE, Sherrod P, Lee D, Sevall JS, 'Reassociation kinetics of non-histone-bound DNA sites.', Journal of Biological Chemistry, 254 3038-3044 (1979)
Citations Scopus - 2
Show 42 more journal articles

Conference (6 outputs)

Year Citation Altmetrics Link
2015 Seamer MJ, Choi B, Lee D, 'The Relationship Between Corporate Governance and Firm Enterprise Risk Management Practice' (2015) [E3]
Co-authors Bobae Choi, Michael Seamer
2009 Choi BB, Lee D, Jung K, 'Trading behavior before the public release of analysts' reports', Asian Finance Association 2009 International Conference: Conference Program (2009) [E1]
Co-authors Bobae Choi
2009 Kang J, Lee C, Lee D, 'Equity fund style and performance persistence in an emerging market: Evidence from Korea', Asian Finance Association 2009 International Conference: Conference Program (2009) [E1]
2009 Choi BB, Kang J, Lee D, 'Catering incentives and differentiated dividend in Korea', Journal of Corporate Finance Special Conference on Emerging Markets (2009) [E1]
Co-authors Bobae Choi
2007 Kim DH, Kim HS, Lee DW, 'Packet scheduling algorithm for NRT service in wireless system supporting integrated services of RT and NRT applications', ISCIT 2007 - 2007 International Symposium on Communications and Information Technologies Proceedings (2007)

This paper considers a packet scheduling algorithm using two different priority metrics specified for each service to support integrated services of real-time (RT) and non-real-ti... [more]

This paper considers a packet scheduling algorithm using two different priority metrics specified for each service to support integrated services of real-time (RT) and non-real-time (NRT) applications. In particular, as a packet scheduling algorithm for NRT service, this paper proposes a new minimum guaranteed throughput scheduling (MGBRS) algorithm with two priority metrics based on average throughput and the minimum guaranteed throughput requirement and its design objective is to increase the number of NRT service users satisfying the required minimum guaranteed throughput. For the performance evaluation of the proposed MGBRS scheme in a wireless communication system, this paper adopts a transmission structure of an orthogonal frequency division multiple access (OFDMA) system. The simulation results show that the proposed algorithm can provide a significant improvement in terms of increase of the number of NRT service users satisfying the target outage probability and the per-cell total throughput performance by the number of NRT service users meeting the target outage probability is improved. © 2007 IEEE.

DOI 10.1109/ISCIT.2007.4392070
Citations Scopus - 2
2005 Liu ZJ, Tempel W, Ng JD, Lin D, Shah AK, Chen L, et al., 'The high-throughput protein-to-structure pipeline at SECSG', Acta Crystallographica Section D: Biological Crystallography (2005)

Using a high degree of automation, the crystallography core at the Southeast Collaboratory for Structural Genomics (SECSG) has developed a high-throughput protein-to-structure pip... [more]

Using a high degree of automation, the crystallography core at the Southeast Collaboratory for Structural Genomics (SECSG) has developed a high-throughput protein-to-structure pipeline. Various robots and automation procedures have been adopted and integrated into a pipeline that is capable of screening 40 proteins for crystallization and solving four protein structures per week. This pipeline is composed of three major units: crystallization, structure determination/validation and crystallomics. Coupled with the protein-production cores at SECSG, the protein-to-structure pipeline provides a two-tiered approach for protein production at SECSG In tier 1, all protein samples supplied by the protein-production cores pass through the pipeline using standard crystallization screening and optimization procedures. The protein targets that failed to yield diffraction-quality crystals (resolution better than 3.0 Å) become tier 2 or salvaging targets. The goal of tier 2 target salvaging, carried out by the crystallomics core, is to produce the target proteins with increased purity and homogeneity, which would render them more likely to yield well diffracting crystals. This is performed by alternative purification procedures and/or the introduction of chemical modifications to the proteins (such as tag removal, methylation, surface mutagenesis, selenomethionine labelling etc.). Details of the various procedures in the pipeline for protein crystallization, target salvaging, data collection/processing and high-throughput structure determination/validation, as well as some examples, are described. © 2005 International Union of Crystallography - all rights reserved.

DOI 10.1107/S0907444905013132
Citations Scopus - 21
Show 3 more conferences
Edit

Grants and Funding

Summary

Number of grants 3
Total funding $13,793

Click on a grant title below to expand the full details for that specific grant.


20161 grants / $4,000

The impact of institutional ownership on executive compensation: Australian evidence$4,000

Funding body: Accounting & Finance Association of Australia and New Zealand Ltd

Funding body Accounting & Finance Association of Australia and New Zealand Ltd
Project Team Doctor Bobae Choi, Doctor Doowon Lee
Scheme Research Grant
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo G1601093
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20102 grants / $9,793

Investor trading activity within the index futures and options market$5,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Doowon Lee
Scheme New Staff Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000621
Type Of Funding Internal
Category INTE
UON Y

An Assessment of the Quality and Market Implications of Carbon Emission Disclosure by Australian Listed Public Companies$4,793

Funding body: Accounting & Finance Association of Australia and New Zealand Ltd

Funding body Accounting & Finance Association of Australia and New Zealand Ltd
Project Team Doctor Bobae Choi, Doctor Doowon Lee, Emeritus Professor Jim Psaros
Scheme Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000971
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y
Edit

Research Supervision

Number of supervisions

Completed3
Current4

Total current UON EFTSL

Masters0.34
PhD1.16

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2017 Masters Firm's Life Cycle and the Shareholders' Expectation: An Accounting and Economic Profit Perspective. M Philosophy (Accnt & Finance), Faculty of Business and Law, The University of Newcastle Principal Supervisor
2017 PhD The Value Relevance of R&D Expenditure Before and After IFRS: Evidence From Australia PhD (Accounting & Finance), Faculty of Business and Law, The University of Newcastle Co-Supervisor
2016 PhD Jumps, Information Shocks, Liquidity Shocks and Foreign Exchange Dealers PhD (Accounting & Finance), Faculty of Business and Law, The University of Newcastle Principal Supervisor
2013 PhD An Empirical Analysis of the Investment and Profitability Effects PhD (Accounting & Finance), Faculty of Business and Law, The University of Newcastle Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2017 PhD Liquidity in the Secondary Corporate Loan Market PhD (Accounting & Finance), Faculty of Business and Law, The University of Newcastle Co-Supervisor
2016 PhD Return Predictability in South Asian Stock Markets PhD (Accounting & Finance), Faculty of Business and Law, The University of Newcastle Co-Supervisor
2015 PhD Determinants of Dividend Policy - International Evidence: 1990 to 2010 PhD (Accounting & Finance), Faculty of Business and Law, The University of Newcastle Co-Supervisor
Edit

Dr Doowon Lee

Position

Senior Lecturer - Finance
Newcastle Business School
Faculty of Business and Law

Focus area

Accounting and Finance

Contact Details

Email doowon.lee@newcastle.edu.au
Phone (02) 4921 8620

Office

Room SR273
Building SRS
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
Edit