Staff Profile

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Career Summary

Biography

Investigations are being made on cellular rhythms including those in lymphatics, blood vessels, gastrointestinal tract, heart and specific mood-associated brain nuclei. We have discovered a new mechanism that it is driven by intracellular Ca2+ stores that allow groups of cells to self pace and hence become rhythmic. We are now exploring the relevance of this mechanism in a range of tissues. We are also interested in specific proteins involved in the pacemaker mechanism including inositol 1,4,5-trisphosphate receptors, ryanodine receptors, store operated calcium channels and TRP family proteins. These studies may influence future therapies to control lymphedema, digestive disorders, heart arrhythmias and brain mood states. We also have a recent patent relating to use of a topical ointment as a first aid treatment against snakebite. This was a surprising outcome that arose from studies investigating whether snake venoms enhance lymphatic pumping and hence accelerate their own delivery. Our preliminary trials indicate topical application of the ointment slows lymphatic transport by some 350% with no obvious adverse effects. The cream will be of particular use for bites to the torso where pressure bandaging is ineffective. It may also be useful as a first aid treatment against bites from other venomous creatures.

Qualifications

  • PhD, University of New South Wales
  • Bachelor of Engineering, University of New South Wales

Research

Research keywords

  • Cellular physiologist
  • gastrointestinal physiology
  • heart pacemaking
  • neuroscience
  • smooth muscle

Research expertise

Lymphatic and gastric pacemaking: Pacemaking in the lymphatic and gastric systems are the basis for our discovery of store pacemaking and calcium phase waves. We are now unravelling the finer details of these mechanisms. Importantly, as for all good research, there can often be unexpected yet important serendipitous outcomes. One in case is that this work has led to development of a first aid treatment against bites from venomous animals whose venoms transit the lymphatic system and we have a patent application on this finding under review.

Heart pacemaking: Traditionally, this has been considered to operate through a clock in the cell surface membrane of pacemaker cells. However, recent evidence from our pilot and modelling studies and from the work of others indicates a significant role of calcium stores. This introduces the possibility that the heart pacemaker model is only part of the story and that pacemaking involves an intracellular clock (i.e. store pacemaking). We are investigating this hypothesis, which if upheld will change the text book model for heart pacemaking and help change present understanding of specific heart disorders and their treatment.

(National Health and Medical Research Program Grant -NHMRC PG Cardiac Pacemaking, 2007-2009).

Brain rhythms: Brain rhythms function in most areas of the brain and while fundamental to life and our psyche remain poorly understood. We are testing the hypothesis that specific rhythms in the Locus Coeruleus, a brain stem nucleus known to be associated with mood states, are generated by store pacemaking. Evidence that the rhythms are generated by store pacemaking could provide a new framework for interpreting drug action in the treatment of mood disorders such as Bipolar Disorder.

(Australian Research Council Discovery Program Grant Investigation of a Brain Rhythm 2005-2007).

Uterine pacemaking: Astonishingly, there is still no clear understanding of the pacemaker mechanism that initiates and times uterine contractions. Pilot studies we have undertaken suggest this to be mediated by store pacemaking. Proof for this hypothesis would herald a mechanistic description for uterine contractions and may provide new insight into associated dysfunctions such as premature birth.

(NHMRC PG Rhythmicity and synchronicity in uterine smooth muscle, 2007-2009).

Fields of Research

CodeDescriptionPercentage
111699Medical Physiology Not Elsewhere Classified60
110399Clinical Sciences Not Elsewhere Classified30
020599Optical Physics Not Elsewhere Classified10

Memberships

Body relevant to professional practice.

  • Faculty member - Cardiovascular Physiology/Circulation of 'Faculty of 1000 Biology'
  • member of council - Australian Physiological society

Other

  • Chair, Research Committee - HMRI Cardiovascular Group
  • Member of Editorial Board 2001-2005 - the British Journal of Pharmacology
  • Member - The British Journal of Pharmacology
  • member - Australian Physiological Society

Appointments

Fellowship
NHMRC (Australia)
01/01/2001 - 01/12/2011
NHMRC Senior Research Fellow
University of Newcastle (Australia)
01/01/1990 - 01/12/2000
Senior Brawn Fellowship
University of Newcastle (Australia)
01/01/1997

Awards

Honours.

2012Honorary Member
Hungarian Pharmacological Society (Australia)
Honorary Member of the Hungarian Society for Clinical and Experimantl Pharmacology This was awarded because of my laboratories contributions to understanding cellular pacemaking in smooth muscle.
2007Sparke Helmore
Hunter Medical Research Institute (Australia)
2004 Hunter Medical Research Institute Sparke Helmore/ NBN Award for Research Excellence from a field of ~350 scientists in the University and Area Health Sectors

Recognition.

2013Adjunct Professor
Deaprtment of Health Innovation; Shinshu University (Japan)
Invited Appontment

Invitations

calcium signaling
Gordon conference, United Kingdom (Conference Presentation - non published.)
2005
Department of physiology
University of Western Australia, Australia (External Reviewer - Departments.)
2005

Collaboration

Research Collaborations are being undertaken into:

1) Mechanisms underlying heart pacemaking with A/Prof Derek Laver, Prof Mark Boyett (Manchester University) and Prof Derek Terrar (Oxford University);

2) Gastrointestinal function Prof Hikaru Hashitani (Nagoya City University, Japan), Dr Bridget Southwell (Murdoch Children's Hospital) & Dr Costa Karihaloo (Lake Macquarrie Private Hospital);

3) Lymphatic function in health and disease ( Dr Mohammad Imtiaz and A/Prof Pierre Yves von der Weid (Calgary, Canada);

4) Spontaneous activity of the Locus coeruleus, a brain cell nucleus involved in establishement of attention and mood states (Dr Ramatis de Oliveira (Brazil), A/Prof Alan Brichta, Prof Robert Callister, Dr Rebecca Lim, Prof Janusz Lipski (Auckland), Mr Andrew Yee (Auckland).

Administrative

Administrative expertise

Research policy (e.g. Archetect of the Brawn Fellowship Scheme at the University of Newcastle)

Teaching

Teaching expertise

Honours and Postgraduate students

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2002Zhao J, Van Helden DF, 'ATP-induced endothelium-independent enhancement of lymphatic vasomotion in guinea-pig mesentery involves P2x and P2y receptors', British Journal of Pharmacology, 137 477-487 (2002) [C1]
2003Van Helden DF, Imtiaz MS, 'Ca2+ phase waves: a basis for cellular pacemaking and long-range synchronicity in the guinea-pig gastric pylorus', The Journal of Physiology, 548.1 271-296 (2003) [C1]
2006Imtiaz MS, Katnik CP, Smith DW, Van Helden DF, 'Role of voltage-dependent modulation of store Ca2+ release in synchronization of Ca2+ oscillations', Biophysical Journal, 90 1-23 (2006) [C1]
2005Odell AF, Scott JL, Van Helden DF, 'Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4', Journal of Biological Chemistry, 280 37974-37987 (2005) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (92 outputs)

YearCitationAltmetricsLink
2014van Helden DF, Thomas PA, Dosen PJ, Imtiaz MS, Laver DR, Isbister GK, 'Pharmacological approaches that slow lymphatic flow as a snakebite first aid.', PLoS Negl Trop Dis, 8 e2722 (2014) [C1]
2014Mehra D, Imtiaz MS, vanHelden DF, Knollmann BC, Laver DR, 'Multiple Modes of RyR2 Inhibition by Flecainide.', Mol Pharmacol, (2014)
2014Walweel K, Li J, Molenaar P, Imtiaz MS, Quail A, dos Remedios CG, et al., 'Differences in the regulation of RyR2 from human, sheep, and rat by Ca²¿ and Mg²¿ in the cytoplasm and in the lumen of the sarcoplasmic reticulum.', J Gen Physiol, 144 263-271 (2014)
2013Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne R, vanHelden DF, Laver DR, 'ß-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation.', PLoS One, 8 e58334 (2013) [C1]
2012De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Heterogeneous responses to antioxidants in noradrenergic neurons of the Locus coeruleus indicate differing susceptibility to free radical content', Oxidative Medicine and Cellular Longevity, 2012 820285 (2012) [C1]
2011Gravina FS, Jobling P, Kerr KP, De Oliveira R, Parkington HC, Van Helden DF, 'Oxytocin depolarizes mitochondria in isolated myometrial cells', Experimental Physiology, 96 949-956 (2011) [C1]
2011Laver DR, Van Helden DF, 'Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels', Journal of Molecular and Cellular Cardiology, 51 357-369 (2011) [C1]
2011De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Developmental changes in pacemaker currents in mouse locus coeruleus neurons', Brain Research, 1425 27-36 (2011) [C1]
2011Saul ME, Thomas PA, Dosen PJ, Isbister GK, O'Leary MA, Whyte IM, et al., 'A pharmacological approach to first aid treatment for snakebite', Nature Medicine, 17 809-811 (2011) [C1]
2010De Oliveira R, Graham BA, Howlett MC, Gravina FS, Oliveira MW, Imtiaz MS, et al., 'Ketamine anesthesia helps preserve neuronal viability', Journal of Neuroscience Methods, 189 230-232 (2010) [C1]
2010Imtiaz MS, Von Der Weid P-Y, Van Helden DF, 'Synchronization of Ca2+oscillations: A coupled oscillator-based mechanism in smooth muscle', FEBS Journal, 277 278-285 (2010) [C1]
2010Imtiaz MS, Von Der Weid P-Y, Laver DR, Van Helden DF, 'SR Ca2+ store refill-a key factor in cardiac pacemaking', Journal of Molecular and Cellular Cardiology, 49 412-426 (2010) [C1]
2010Van Helden DF, Laver DR, Holdsworth JL, Imtiaz MS, 'Generation and propagation of gastric slow waves', Clinical and Experimental Pharmacology and Physiology, 37 516-524 (2010) [C1]
2010Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Improved field scanner incorporating parabolic optics. Part 2: experimental verification and potential for volume scanning', Applied Optics, 49 5517-5527 (2010) [C1]
2010Gravina FS, Parkington HC, Kerr KP, De Oliveira R, Jobling P, Coleman HA, et al., 'Role of mitochondria in contraction and pacemaking in the mouse uterus', British Journal of Pharmacology, 161 1375-1390 (2010) [C1]
2010Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Calculated two-photon fluorescence correction factors for reflective scan engines', Applied Optics, 49 1472-1479 (2010) [C1]
2010De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Pacemaker currents in mouse locus coeruleus neurons', Neuroscience, 170 166-177 (2010) [C1]
2009Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Improved field scanner incorporating parabolic optics: Part 1: Simulation', Applied Optics, 48 4389-4396 (2009) [C1]
2009Imtiaz MS, von der Weid P-Y, Crowe M, van Helden D, 'Lymphatic pacemaking', FASEB JOURNAL, 23 (2009) [E3]
2008Von Der Weid P-Y, Rahman M, Imtiaz MS, Van Helden DF, 'Spontaneous transient depolarizations in lymphatic vessels of the guinea pig mesentery: Pharmacology and implication for spontaneous contractility', American Journal of Physiology: Heart and Circulatory Physiology, 295 H1989-H2000 (2008) [C1]
2008Odell AF, Van Helden DF, Scott JL, 'The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels', Journal of Biological Chemistry, 283 4395-4407 (2008) [C1]
2007Smith R, Van Helden DF, Hirst JJ, Zakar T, Read MA, Chan EC, et al., 'Pathological interactions with the timing of birth and uterine activation', Australian & New Zealand Journal of Obstetrics & Gynaecology, 47 430-437 (2007) [C1]
2007Imtiaz MS, Zhao J, Hosaka K, Von Der Weid PY, Crowe M, Van Helden DF, 'Pacemaking through Ca2+ stores interacting as coupled oscillators via membrane depolarization', Biophysical Journal, 92 3843-3861 (2007) [C1]
2006Hosaka K, Rayner SE, Von Der Weid PY, Zhao J, Imtiaz MS, Van Helden DF, 'Calcitonin gene-related peptide activates different signaling pathways in mesenteric lymphatics of guinea pigs', American Journal of Physiology-Heart and Circulatory Physiology, 290 H813-H822 (2006) [C1]
2006Dielenberg R, Halasz P, Hosaka K, Van Helden DF, 'Vessel motion measurement in real-time using movement detection at multiple regions of interest', Journal of Neuroscience Methods, 152 40-47 (2006) [C1]
2006Imtiaz MS, Katnik CP, Smith DW, Van Helden DF, 'Role of voltage-dependent modulation of store Ca2+ release in synchronization of Ca2+ oscillations', Biophysical Journal, 90 1-23 (2006) [C1]
2006Van Helden DF, Hosaka K, Imtiaz MS, 'Rhythmicity in the microcirculation', Clinical Hemorheology and Microcirculation, 34 59-66 (2006) [C1]
2005Odell AF, Scott JL, Van Helden DF, 'Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4', Journal of Biological Chemistry, 280 37974-37987 (2005) [C1]
2004Ferrusi I, Zhao J, Van Helden DF, Von Der Weid P-Y, 'Cyclopiazonic acid decreases spontaneous transient depolarizations in guinea pig mesenteric lymphatic vessels in endothelium-dependent and -independent manners', Am J Physiol Heart Circ Physiol, 286 H2287-H2295 (2004) [C1]
2003Zhao J, Van Helden DF, 'ET-1-associated vasomotion and vasospasm in lymphatic vessels of the guinea-pig mesentery', British Journal of Pharmacology, 140 1399-1413 (2003) [C1]
2003Van Helden DF, Imtiaz MS, 'Ca2+ phase waves: a basis for cellular pacemaking and long-range synchronicity in the guinea-pig gastric pylorus', The Journal of Physiology, 548.1 271-296 (2003) [C1]
2002Imtiaz MS, Smith DW, Van Helden DF, 'A Theoretical Model Of Slow Wave Regulation Using Voltage-Dependent Synthesis Of Inositol 1,4,5-Trisphosphate', Biophyhsical Journal, Vol. 83 1877-1890 (2002) [C1]
2002Zhao J, Van Helden DF, 'ATP-induced endothelium-independent enhancement of lymphatic vasomotion in guinea-pig mesentery involves P2x and P2y receptors', British Journal of Pharmacology, 137 477-487 (2002) [C1]
2001Von Der Weid P-Y, Zhao J, Van Helden DF, 'Nitric oxide decreases pacemaker activity in lymphatic vessels of guinea pig mesentery', Am J Physiol Heart Circ Physiol, 280 H2707-H2716 (2001) [C1]
2000Van Helden DF, Imtiaz MS, Nurgaliyeva K, Von Der Weid P-Y, Dosen PJ, 'Role of calcium stores and membrane voltage in the generation of slow wave action potentials in guinea-pig gastric pylorus', Journal of Physiology, 524.1 245-265 (2000) [C1]
2000Van Helden D, Zhao J, 'Lymphatic Vasomotion', Clinical and Experimental Pharmacology and Physiology, 27 1014-1018 (2000) [C1]
1999Gao JN, Zhao J, Rayner SE, Van Helden DF, 'Evidence that the ATP-induced increase in vasomotion of guinea-pig mesenteric lymphatics involves an endothelium-dependent release of thromboxane A(2)', BRITISH JOURNAL OF PHARMACOLOGY, 127 1597-1602 (1999)
1997Rayner SE, VanHelden DF, 'Evidence that the substance P-induced enhancement of pacemaking in lymphatics of the guinea-pig mesentery occurs through endothelial release of thromboxane A(2)', BRITISH JOURNAL OF PHARMACOLOGY, 121 1589-1596 (1997)
1997vonderWeid PY, VanHelden DF, 'Functional electrical properties of the endothelium in lymphatic vessels of the guinea-pig mesentery', JOURNAL OF PHYSIOLOGY-LONDON, 504 439-451 (1997)
1997Crowe MJ, vonderWeid PY, Brock JA, VanHelden DF, 'Co-ordination of contractile activity in guinea-pig mesenteric lymphatics', JOURNAL OF PHYSIOLOGY-LONDON, 500 235-244 (1997)
1996Stiles JR, VanHelden D, Bartol TM, Salpeter EE, Salpeter MM, 'Miniature endplate current rise times <100 mu s from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 93 5747-5752 (1996)
1996Oba T, Koshita M, VanHelden DF, 'Modulation of frog skeletal muscle Ca2+ release channel gating by anion channel blockers', AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 271 C819-C824 (1996)
1996Oba T, Koshita M, Van Helden DF, 'Modulation of frog skeletal muscle Ca release channel gating by anion channel blockers', American Journal of Physiology - Cell Physiology, 271 (1996)
1996Oba T, Koshita M, Van Helden DF, 'Modulation of frog skeletal muscle Ca2+ release channel gating by anion channel blockers.', The American journal of physiology, 271 C819-C824 (1996)
1996vonderWeid PY, VanHelden DF, 'beta-Adrenoceptor-mediated hyperpolarization in lymphatic smooth muscle of guinea pig mesentery', AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 270 H1687-H1695 (1996)
1996Hashitani H, VanHelden DF, Suzuki H, 'Properties of spontaneous depolarizations in circular smooth muscle cells of rabbit urethra', BRITISH JOURNAL OF PHARMACOLOGY, 118 1627-1632 (1996)
1996Von der Weid PY, Van Helden DF, 'Beta-adrenoceptor-mediated hyperpolarization in lymphatic smooth muscle of guinea pig mesentery.', The American journal of physiology, 270 H1687-H1695 (1996)
1996Brent PJ, Pang G, Little G, Dosen PJ, VanHelden DF, 'The sigma receptor ligand, reduced haloperidol, induces apoptosis and increases intracellular-free calcium levels [Ca2+](i) in colon and mammary adenocarcinoma cells', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 219 219-226 (1996)
1996Zipfel WR, OMalley JP, VanHelden D, Williams RM, Guild JB, Salpeter MM, Webb WW, 'Characterization of spontaneous calcium waves and sparks in primary cultures of fetal rat myotubes using two photon excitation point and line scanning microscopy.', BIOPHYSICAL JOURNAL, 70 WP283-WP283 (1996)
1996Von Der Weid P-Y, Van Helden DF, 'ß-Adrenoceptor-mediated hyperpolarization in lymphatic smooth muscle of guinea pig mesentery', American Journal of Physiology - Heart and Circulatory Physiology, 270 (1996)
1996Brock JA, VanHelden DF, Dosen P, Rush RA, 'Prevention of high blood pressure by reducing sympathetic innervation in the spontaneously hypertensive rat', JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 61 97-102 (1996)
1996vonderWeid PY, Crowe MJ, VanHelden DF, 'Endothelium-dependent modulation of pacemaking in lymphatic vessels of the guinea-pig mesentery', JOURNAL OF PHYSIOLOGY-LONDON, 493 563-575 (1996)
1995BRENT PJ, DOSEN PJ, PANG G, VANHELDEN DF, 'THE SIGMA-BINDING SITE LIGAND, REDUCED HALOPERIDOL (RHAL), INCREASES INTRACELLULAR FREE CALCIUM LEVELS [CA2+]I IN COLON-CANCER CELLS', JOURNAL OF NEUROCHEMISTRY, 65 S13-S13 (1995)
1995BROCK JA, VANHELDEN DF, 'ENHANCED EXCITATORY JUNCTION POTENTIALS IN MESENTERIC-ARTERIES FROM SPONTANEOUSLY HYPERTENSIVE RATS', PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 430 901-908 (1995)
1994BATES RC, BURET A, VANHELDEN DF, HORTON MA, BURNS GF, 'APOPTOSIS INDUCED BY INHIBITION OF INTERCELLULAR CONTACT', JOURNAL OF CELL BIOLOGY, 125 403-415 (1994)
1993BERESFORDSMITH B, NESBITT KV, VANHELDEN DF, 'EDGE-DETECTION AT MULTIPLE LOCATIONS USING A RADAR TRACKING ALGORITHM AS EXEMPLIFIED IN ISOLATED GUINEA-PIG LYMPHATIC VESSELS', JOURNAL OF NEUROSCIENCE METHODS, 49 69-79 (1993)
1993KLEMM MF, VANHELDEN DF, LUFF SE, 'ULTRASTRUCTURAL ANALYSIS OF SYMPATHETIC NEUROMUSCULAR-JUNCTIONS ON MESENTERIC VEINS OF THE GUINEA-PIG', JOURNAL OF COMPARATIVE NEUROLOGY, 334 159-167 (1993)
1993VANHELDEN DF, 'PACEMAKER POTENTIALS IN LYMPHATIC SMOOTH-MUSCLE OF THE GUINEA-PIG MESENTERY', JOURNAL OF PHYSIOLOGY-LONDON, 471 465-479 (1993)
1991VANHELDEN DF, 'SPONTANEOUS AND NORADRENALINE-INDUCED TRANSIENT DEPOLARIZATIONS IN THE SMOOTH-MUSCLE OF GUINEA-PIG MESENTERIC VEIN', JOURNAL OF PHYSIOLOGY-LONDON, 437 511-541 (1991)
1990VANHELDEN DF, WOOLRIDGE S, 'ROLE OF NERVES IN HYPERTENSION', NATURE, 348 118-119 (1990)
1989VANHELDEN DF, 'NORADRENALINE-INDUCED TRANSIENT DEPOLARIZATIONS IN THE SMOOTH-MUSCLE OF ISOLATED GUINEA-PIG MESENTERIC LYMPHATICS', JOURNAL OF PHYSIOLOGY-LONDON, 418 P173-P173 (1989)
1988VANHELDEN DF, 'ELECTROPHYSIOLOGY OF NEUROMUSCULAR-TRANSMISSION IN GUINEA-PIG MESENTERIC VEINS', JOURNAL OF PHYSIOLOGY-LONDON, 401 469-488 (1988)
1988VANHELDEN DF, 'AN ALPHA-ADRENOCEPTOR-MEDIATED CHLORIDE CONDUCTANCE IN MESENTERIC VEINS OF THE GUINEA-PIG', JOURNAL OF PHYSIOLOGY-LONDON, 401 489-501 (1988)
1988Van Helden DF, 'An a-adrenoceptor-mediated chloride conductance in mesenteric veins of the guinea-pig', Journal of Physiology, 401 489-501 (1988)
1986HIRST GDS, SILVERBERG GD, VANHELDEN DF, 'THE ACTION-POTENTIAL AND UNDERLYING IONIC CURRENTS IN PROXIMAL RAT MIDDLE CEREBRAL ARTERIOLES', JOURNAL OF PHYSIOLOGY-LONDON, 371 289-304 (1986)
1986HILL CE, HIRST GDS, SILVERBERG GD, VANHELDEN DF, 'SYMPATHETIC INNERVATION AND EXCITABILITY OF ARTERIOLES ORIGINATING FROM THE RAT MIDDLE CEREBRAL-ARTERY', JOURNAL OF PHYSIOLOGY-LONDON, 371 305-& (1986)
1985HILL CE, HENDRY IA, NGU MC, VANHELDEN DF, 'SUBPOPULATIONS OF SYMPATHETIC NEURONS DIFFER IN THEIR SENSITIVITY TO NERVE GROWTH-FACTOR ANTISERUM', DEVELOPMENTAL BRAIN RESEARCH, 23 121-130 (1985)
1985HILL CE, HIRST GDS, NGU MC, VANHELDEN DF, 'SYMPATHETIC POSTGANGLIONIC REINNERVATION OF MESENTERIC-ARTERIES AND ENTERIC NEURONS OF THE ILEUM OF THE RAT', JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 14 317-334 (1985)
1985TAYLOR WM, VANDEPOL E, VANHELDEN DF, REINHART PH, BYGRAVE FL, 'EFFECT OF DEPOLARIZING CONCENTRATIONS OF POTASSIUM ON CALCIUM-UPTAKE AND METABOLISM IN RAT-LIVER', FEBS LETTERS, 183 70-74 (1985)
1985Hill CE, Hendry IA, Ngu MC, van Helden DF, 'Subpopulations of sympathetic neurones differ in their sensitivity to nerve growth factor antiserum.', Brain Research, 355 121-130 (1985)
1985HIRST GDS, JOHNSON SM, VANHELDEN DF, 'THE CALCIUM CURRENT IN A MYENTERIC NEURON OF THE GUINEA-PIG ILEUM', JOURNAL OF PHYSIOLOGY-LONDON, 361 297-314 (1985)
1985HIRST GDS, JOHNSON SM, VANHELDEN DF, 'THE SLOW CALCIUM-DEPENDENT POTASSIUM CURRENT IN A MYENTERIC NEURON OF THE GUINEA-PIG ILEUM', JOURNAL OF PHYSIOLOGY-LONDON, 361 315-337 (1985)
1985HIRST GDS, DEGLERIA S, VANHELDEN DF, 'NEUROMUSCULAR-TRANSMISSION IN ARTERIOLES', EXPERIENTIA, 41 874-879 (1985)
1984FINKEL AS, HIRST GDS, VANHELDEN DF, 'SOME PROPERTIES OF EXCITATORY JUNCTION CURRENTS RECORDED FROM SUBMUCOSAL ARTERIOLES OF GUINEA-PIG ILEUM', JOURNAL OF PHYSIOLOGY-LONDON, 351 87-98 (1984)
1983ARHEM P, VANHELDEN D, 'EFFECTS OF ALIPHATIC-ALCOHOLS ON MYELINATED NERVE MEMBRANE', ACTA PHYSIOLOGICA SCANDINAVICA, 119 105-107 (1983)
1983HILL CE, HIRST GDS, VANHELDEN DF, 'DEVELOPMENT OF SYMPATHETIC INNERVATION TO PROXIMAL AND DISTAL ARTERIES OF THE RAT MESENTERY', JOURNAL OF PHYSIOLOGY-LONDON, 338 129-147 (1983)
1982GREEFF NG, KEYNES RD, VANHELDEN DF, 'FRACTIONATION OF THE ASYMMETRY CURRENT IN THE SQUID GIANT-AXON INTO INACTIVATING AND NON-INACTIVATING COMPONENTS', PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 215 375-389 (1982)
1982HIRST GDS, VANHELDEN DF, 'IONIC BASIS OF THE RESTING POTENTIAL OF SUBMUCOSAL ARTERIOLES IN THE ILEUM OF THE GUINEA-PIG', JOURNAL OF PHYSIOLOGY-LONDON, 333 53-67 (1982)
1982KEYNES RD, GREEFF NG, VANHELDEN DF, 'THE RELATIONSHIP BETWEEN THE INACTIVATING FRACTION OF THE ASYMMETRY CURRENT AND GATING OF THE SODIUM-CHANNEL IN THE SQUID GIANT-AXON', PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 215 391-404 (1982)
1981HARVEY AL, VANHELDEN D, 'ACETYLCHOLINE-RECEPTORS IN SINGLY AND MULTIPLY INNERVATED SKELETAL-MUSCLE FIBERS OF THE CHICKEN DURING DEVELOPMENT', JOURNAL OF PHYSIOLOGY-LONDON, 317 397-411 (1981)
1981HARVEY AL, VANHELDEN DF, 'AGE-RELATED-CHANGES IN PROPERTIES OF ACETYLCHOLINE-RECEPTORS IN SINGLY AND MULTIPLY INNERVATED SKELETAL-MUSCLES OF THE CHICKEN', BRITISH JOURNAL OF PHARMACOLOGY, 74 P297-P298 (1981)
1979BARRY PH, GAGE PW, VANHELDEN DF, 'ENDPLATE CHANNELS BEHAVE AS NEUTRAL SITE CHANNELS', NEUROSCIENCE LETTERS, 11 233-237 (1979)
1979VANHELDEN DF, GAGE PW, HAMILL OP, 'CONDUCTANCE OF ENDPLATE CHANNELS IS VOLTAGE DEPENDENT', NEUROSCIENCE LETTERS, 11 227-232 (1979)
1979BARRY PH, GAGE PW, VANHELDEN DF, 'CATION PERMEATION THROUGH SINGLE MOTOR ENDPLATE CHANNELS', MUSCLE & NERVE, 2 314-314 (1979)
1979GAGE PW, VANHELDEN D, 'EFFECTS OF PERMEANT MONO-VALENT CATIONS ON ENDPLATE CHANNELS', JOURNAL OF PHYSIOLOGY-LONDON, 288 509-528 (1979)
1979BARRY PH, GAGE PW, VANHELDEN DF, 'CATION PERMEATION AT THE AMPHIBIAN MOTOR ENDPLATE', JOURNAL OF MEMBRANE BIOLOGY, 45 245-276 (1979)
1979GAGE PW, HAMILL OP, VANHELDEN D, 'DUAL EFFECTS OF ETHER ON ENDPLATE CURRENTS', JOURNAL OF PHYSIOLOGY-LONDON, 287 353-369 (1979)
1979KEYNES RD, MALACHOWSKI GC, VANHELDEN DF, 'EFFECT OF CALCIUM ON THE SODIUM GATING CURRENT IN THE SQUID GIANT-AXON', JOURNAL OF PHYSIOLOGY-LONDON, 295 P54-P55 (1979)
1979GAGE PW, HAMILL OP, VANHELDEN DF, BARRY PH, 'ACETYLCHOLINE RECEPTORS', MUSCLE & NERVE, 2 314-314 (1979)
1978GAGE PW, MCBURNEY RN, VANHELDEN D, 'OCTANOL REDUCES ENDPLATE CHANNEL LIFETIME', JOURNAL OF PHYSIOLOGY-LONDON, 274 279-298 (1978)
1977VANHELDEN D, HAMILL OP, GAGE PW, 'PERMEANT CATIONS ALTER ENDPLATE CHANNEL CHARACTERISTICS', NATURE, 269 711-713 (1977)
1974GAGE PW, MCBURNEY RN, VANHELDE D, 'ENDPLATE CURRENTS ARE SHORTENED BY OCTANOL - POSSIBLE ROLE OF MEMBRANE LIPID', LIFE SCIENCES, 14 2277-2283 (1974)
Show 89 more

Conference (52 outputs)

YearCitationAltmetricsLink
2014Holdsworth JL, Sharafutdinova G, Hosseini A, Vafa E, van Helden D, 'Investigating a New Volume Scanner', Proceedings of 2013 Australian and New Zealand Conference on Optics and Photonics, Fremantle, W.A. (2014)
2014Walweel KD, vanHelden DF, Imtiaz MS, Dos Remedios C, Molenaar P, Laver DR, 'Inhibition of RyR2 from Failing and Non-Failing Human Hearts by Calmodulin', BIOPHYSICAL JOURNAL, San Francisco, CA (2014)
2013Van Heiden DF, Laver DR, Imtiaz MS, Hashitani H, 'Cellular Interactions Controlling Tonic and Peristaltic Contractions of Gastric Smooth Muscle', JOURNAL OF PHYSIOLOGICAL SCIENCES (2013) [E3]
2013Sharafutdinova G, Hosseini A, Holdsworth JL, van Helden D, 'Investigating A New Volume Scanner', ANZCOP 2013, Fremantle, WA (2013) [E3]
2012Walweel K, Beard NA, Li J, Van Helden DF, Imtiaz MS, Molenaar P, Laver DR, 'Regulation of human RYR2 by intracellular Ca2+ and Mg2+', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]

Co-authors: Derek Laver

2012Mehra DR, Van Helden DF, Laver DR, 'Role of cardiac Na+ channel blockers and Mg2+ in inhibiting the cardiac calcium release channel', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]

Co-authors: Derek Laver

2012Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne RF, Van Helden DF, Laver DR, 'Adrenergic stimulation increases RYR2 activity via intracellular Ca2+ and Mg2+ regulation', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
2012Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne RF, Van Helden DF, Laver DR, 'Adrenergic stimulation alters RyR2 regulation by Ca2+ and Mg2+', Heart, Lung and Circulation: Abstracts of ISHR Auckland Workshop, Auckland, NZ (2012) [E3]
2012Imtiaz MS, Allen DG, Van Helden DF, Laver DR, 'Role of intracellular Ca2+ in sinoatrial node pacemaking', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]

Co-authors: Derek Laver

2012Imtiaz MS, Van Helden DF, Laver DR, 'Three-dimensional modeling of Ca2+ dynamics in single cardiac cells', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]

Co-authors: Derek Laver

2011Holdsworth JL, Sharafutdinova G, Sanderson MJ, Van Helden DF, 'Off-axis parabolic optical relays: almost perfect imaging', Proceedings of SPIE: 22nd Congress of the International Commission for Optics: Light for the Development of the World, Puebla, Mexico (2011) [E1]
2011Li J, Beard NA, Dulhunty AF, vanHelden DF, Laver DR, 'The Effect of Adrenergic Stimulation on the Calcium Release Channel', BIOPHYSICAL JOURNAL, Baltimore, MD (2011) [E3]
2011Laver DR, vanHelden DF, 'Tetracaine Inhibits RyRs by Three Mechanisms', BIOPHYSICAL JOURNAL, Baltimore, MD (2011) [E3]
2011Mehra DR, vanHelden DF, Knollmann BC, Laver DR, 'Inhibition of Cardiac Ca2+ Release Channels by Class I Anti Arrhythmic Drugs as Therapy for Arrhythmia', BIOPHYSICAL JOURNAL, Baltimore, MD (2011) [E3]
2011Mehra DR, Van Helden DF, Hwang HS, Knollmann B, Laver DR, 'Role of cardiac Na+ channel blockers in inhibiting the cardiac calcium release channel', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]

Co-authors: Derek Laver

2011Walweel K, Li J, Van Helden DF, Imtiaz MS, Molenaar P, Laver DR, 'Regulation of RyRs by intracellular Ca2+ and Mg2+ compared in sheep, rat and human heart', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]

Co-authors: Derek Laver

2010Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Comparative scan engine field flatness', 19th Australian Institute of Physics Congress. Extended Abstracts and Refereed Full Papers, Melbourne, Vic (2010) [E1]
2010Zhang H, Van Helden DF, Offler CE, McCurdy DW, Patrick JW, 'Signalling related to solute and hormone transport I', Plant Membrane Biology 15th International Workshop, Adelaide 2010: Programme & Abstracts, Adelaide, S.A. (2010) [E3]
2010Zhang H, Van Helden DF, Offler CE, McCurdy DW, Patrick JW, 'Calcium is a component of the signalling cascade leading to wall ingrowth formation in transfer cells', International Conference on Plant Vascular Biology 2010: PVB2010, Columbus, OH (2010) [E3]
2010Zhang H, Van Helden DF, Offler CE, McCurdy DW, Patrick JW, 'A two-pore calcium channel is a component of the signalling cascade leading to wall ingrowth formation in transfer cells', Plant Membrane Biology 15th International Workshop, Adelaide 2010: Programme & Abstracts, Adelaide, S.A. (2010) [E3]
2010Gravina FS, Van Helden DF, De Oliveira R, Kerr KP, Jobling P, 'Relaxant effects of methanandamide unmasked by indomethacin in the mouse uterus', Australasian Society of Clinical and Experimental Pharmacology and Toxicology (ASCEPT) Annual Scientific Meeting, Melbourne, 2010, Melbourne, Vic (2010) [E3]
2009Sharafutdinova G, Holdsworth JL, Legge SR, Van Helden DF, 'Comparative performance of four-mirror parabolic and spherical afocal relays', ACOLS ACOFT 09 Conference: Proceedings of the Australasian Conference on Optics, Lasers and Spectroscopy and Australian Conference on Optical Fibre Technology in Association, Adelaide, SA (2009) [E1]
2009Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Scan engine induced pulse broadening in two-photon microscopy', Nanophotonics Down Under 2009: Devices and Applications: Program, Melbourne, VIC (2009) [E2]
2009De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Ion channel modulation by reactive species in mice locus coeruleus neurons', Journal of Physiological Sciences, Kyoto, Japan (2009) [E3]
2009Laver DR, Quail AW, Sitsapesan H, Van Helden DF, 'The effect of volatile anaesthetics on the cardiac ryanodine receptor', Biophysical Journal, Boston, MA (2009) [E3]

Co-authors: Derek Laver, Tony Quail

2009Gravina FS, Jobling P, Kerr KP, De Oliveira R, Van Helden DF, 'Identification of cannabinoid receptor 1 and the effect of methanandamide on uterine contractions of the mouse uterus', 1st National Symposium on Advances in Urogenital and Gut Research, Melbourne, VIC (2009) [E3]
2009Hollins SL, Johnstone DM, Van Helden DF, Kerr KP, Laver DR, Metelerkamp KM, et al., 'Cardiac gene expression in mouse models of iron loading', ASMR XVII NSW Scientific Meeting: Programme and Abstracts, Sydney, NSW (2009) [E3]
2009Kerr KP, Jobling P, Gravina FS, Van Helden DF, 'Contractility of the lower uterus and upper vagina in the mouse', 43rd ASCEPT Annual Scientific Meeting: Proceedings, Sydney, NSW (2009) [E3]
2009Van Helden DF, Imtiaz MS, Von Der Weid PY, ''Lymphatic hearts' - Are they really that primitive?', Journal of Vascular Research, Queenstown, NZ (2009) [E3]
2009Zhang H, Van Helden DF, McCurdy DW, Offler CE, Patrick JW, 'Calcium functions in the signalling cascade leading to wall ingrowth formation in transfer cells', ComBio 2009, Christchurch, NZ (2009) [E3]
2009Sharafutdinova G, Holdsworth JL, Van Helden DF, 'A new scanner design for two-photon fluorescence fast imaging microscopy', Light in Life Sciences Conference 2009: Program, Melbourne, VIC (2009) [E3]
2009De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Effect of antioxidants in pacemaking of mice locus coeruleus neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
2009Hollins SL, Johnstone DM, Graham R, Van Helden DF, Kerr KP, Laver DR, et al., 'Cardiac gene expression in mouse models of iron loading disorders', 2009 International Biolron Society Meeting: Program Book, Porto, Portugal (2009) [E3]
2009Mehra DR, Van Helden DF, Knollmann B, Laver DR, 'Flecainide inhibits CPVT induced cardiac arrhythmias by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass', 33rd Annual Meeting of the Australian Society for Biophysics: Program, Ballarat, VIC (2009) [E3]

Co-authors: Derek Laver

2009Gravina FS, Kerr KP, Sandow S, De Oliveira R, Parkington H, Imtiaz MS, Van Helden DF, 'Intracellular calcium stores in mouse uterus: SR and Mitochondria', Journal of Physiological Sciences, Kyoto, Japan (2009) [E3]

Co-authors: Karen Kerr

2008Gravina FS, Kerr KP, De Oliveira R, Parkington H, Imtiaz MS, Van Helden DF, 'Effects of the mitochondrial inhibitors CCCP, rotenone and CGP37157 on spontaneous contractions in the mouse uterus', Proceedings of the Australian Health and Medical Research Congress 2008, Brisbane, QLD (2008) [E3]

Co-authors: Karen Kerr

2008De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Influence of mitochondria in the interspike interval pacemaking currents of mice Locus Coeruleus neurons', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
2008Laver DR, Quail AW, Sitsapesan H, Van Helden DF, 'Effect of volatile anaesthetics on the calcium release channel in the heart', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]

Co-authors: Derek Laver, Tony Quail

2008Imtiaz MS, Van Helden DF, 'Pacemaking in lymphatic smooth muscle', Journal of Vascular Research, Hamilton Island, QLD (2008) [E3]
2008Gravina FS, Kerr KP, Sandow S, De Oliveira R, Parkington HC, Imtiaz MS, Van Helden DF, 'Uterine spontaneous contractions in the estrous cycle and the effect of mitochondrial inhibitors', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]

Co-authors: Karen Kerr

2008Van Helden DF, Laver DR, Imtiaz MS, 'Ca2+ phase waves: A fundamental mechanism underlying propagation of gastric slow waves', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]

Co-authors: Derek Laver

2006Hosaka K, Rayner SE, Von Der Weid PY, Zhao J, Imtiaz MS, Van Helden DF, 'Calcitonin gene-related peptide activates different signalling pathways in mesenteric lymphatics of the guinea pig', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
2005Honen BN, Dalton RL, Van Helden DF, Laver DR, 'Acute application of n-3 polyunsaturated fatty acids modify calcium sparks in permeabilised rat cardiac myocytes', Proceedings of the Australian Physiological Society, Canberra (2005) [E3]

Co-authors: Derek Laver

2005van Helden DF, Hosaka K, Imtiaz MS, 'Lymphatic 'hearts' and their modulation by the endothelium', DRUG DEVELOPMENT RESEARCH, Shanghai, PEOPLES R CHINA (2005)
2004Krajniak SG, Callister RJ, Imtiaz MS, Brichta AM, Van Helden DF, 'Investigation of a brain rhythm', Proceedings of the Australian Neuroscience Society, Australia (2004) [E3]
2004Honen BN, Saint DA, Van Helden DF, Laver DR, 'The effects of fatty acids on SR calcium release channels from cardiac muscle', Biophysical Journal, Maryland, USA (2004) [E3]

Co-authors: Derek Laver

1999Van Helden DF, Imtiaz MS, Nurgaliyeva K, Von Der Weid P-Y, Dosen PJ, 'Evidence that Slow Waves in the Guinea-Pig Gastric Pylorus are Mediated by Inositol 1,4,5-Trisphosphate-Sensitive Ca2+ Release', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2]
1999Imtiaz MS, Van Helden DF, 'A Mathematical Model of Depolarization-induced Slow Wave Action Potentials Arising by Intracellular Ca2+ Release from Inositol 1,4,5-Trisphosphate Sensitive Ca2+ Stores', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2]
1999Van Helden DF, Zhao J, 'Lymphatic Vasomotion', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2]
1999Zhao J, Gao J, Van Helden DF, 'The Effect of Neuropeptide Y on Vasomotion of Guinea-Pig Mesenteric Lymphatics', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2]
1995VANHELDEN DF, VONDERWEID PY, CROWE MJ, 'Electrophysiology of lymphatic smooth muscle', INTERSTITIUM, CONNECTIVE TISSUE AND LYMPHATICS, GLASGOW, SCOTLAND (1995)
1994BERESFORDSMITH B, VANHELDEN DF, 'APPLICATIONS OF RADAR TRACKING ALGORITHMS TO MOTION ANALYSIS IN BIOMEDICAL IMAGES', ICIP-94 - PROCEEDINGS, VOL I, AUSTIN, TX (1994)
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Grants and Funding

Summary

Number of grants84
Total funding$8,958,383

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Click on a grant title below to expand the full details for that specific grant.

2014 (1 grants)

Vascular adaptation of the newborn: Hydrogen sulphide as a fundamental signalling molecule and novel target for therapy$10,000
Funding Body: University of Newcastle

Project Team
Conjoint Professor Ian Wright, Doctor Phil Jobling, Professor Dirk Van Helden
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020142014
GNo:G1301409

2013 (8 grants)

HMRI MRSP Infrastructure (12-16) – CARDIOVASCULAR$255,777
Funding Body: Hunter Medical Research Institute

Project Team
Professor Dirk Van Helden, Professor Ronald Plotnikoff
SchemeRole
NSW MRSP Infrastructure GrantChief Investigator
Total AmountFunding StartFunding Finish
$255,77720132016
GNo:G1300589

Nano-Optical Microscopy, Characterization and Fabrication Facility$155,000
Funding Body: University of Newcastle

Project Team
Doctor Andrew Fleming, Doctor John Holdsworth, Doctor Grant Webber, Professor Erich Kisi, Professor Dirk Van Helden
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$155,00020132013
GNo:G1200167

Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Jude Weidenhofer, Doctor Rick Thorne, Doctor Kathryn Skelding, Doctor Nikki Verrills, Doctor Pradeep Tanwar, Associate Professor Phillip Dickson, Conjoint Associate Professor Murray Cairns, Professor Hubert Hondermarck, Professor Xu Dong Zhang, Associate Professor Estelle Sontag, Doctor Chen Chen Jiang, Associate Professor Liz Milward, Doctor Jean-Marie Sontag, Associate Professor Paul Tooney, Doctor Severine Roselli, Doctor Matt Dun, Doctor Chris Dayas, Doctor Lin Kooi Ong, Professor Dirk Van Helden, Mr Ben Copeland, Doctor Gabrielle Briggs, Emeritus Professor Leonie Ashman, Emeritus Professor John Rostas
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$24,59620132013
GNo:G1201189

Towards a Mammography Scanner$13,287
Funding Body: University of Newcastle - Faculty of Science & IT

Project Team
Doctor John Holdsworth, Doctor Galiya Sharafutdinova, Professor Dirk Van Helden
SchemeRole
Strategic Initiative Research Fund (SIRF)Investigator
Total AmountFunding StartFunding Finish
$13,28720132013
GNo:G1401036

Investigating the basis for diabetes-associated gastric motility disorders$10,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Dirk Van Helden
SchemeRole
Near MissChief Investigator
Total AmountFunding StartFunding Finish
$10,00020132013
GNo:G1300701

Investigating the basis for diabetes-associated gastric motility disorders$10,000
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden, Associate Professor Derek Laver
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020132013
GNo:G1300485

The 90th Annual Meeting of the Physiological Society of Japan, Tokyo 27-29 March 2013$1,569
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Professor Dirk Van Helden
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,56920132013
GNo:G1300979

2012 (5 grants)

A novel approach to snakebite first aid$195,721
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden, Doctor Geoff Isbister
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$195,72120122014
GNo:G1100333

HMRI MRSP Infrastructure (11-12)- CARDIOVASCULAR$118,434
Funding Body: Hunter Medical Research Institute

Project Team
Professor Dirk Van Helden, Professor Ronald Plotnikoff
SchemeRole
NSW MRSP Infrastructure GrantChief Investigator
Total AmountFunding StartFunding Finish
$118,43420122013
GNo:G1101118

First Aid for Cytotoxic Snakebite$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Dirk Van Helden, Doctor Geoff Isbister
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020122012
GNo:G1200154

Gastric Slow Waves and Motility Disorders$20,000
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden, Associate Professor Derek Laver
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020122012
GNo:G1200674

International Conference to Celebrate the 50th Anniversary of Hungarian Society for Experimental and Clinical Pharmacology, Budpest, Hungary, 19 - 21 September 2012$2,000
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Professor Dirk Van Helden
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,00020122012
GNo:G1200935

2011 (1 grants)

Ryanodine receptor inhibitors as therapy for Ca2+ store overload induced arrhythmias$536,706
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$536,70620112013
GNo:G1000274

2010 (3 grants)

HMRI MRSP Infrastructure Grant (10-11) - Cardiovascular$76,117
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Eugene Nalivaiko, Associate Professor Liz Milward, Professor Robert Callister, Professor Manohar Garg, Conjoint Professor Tony Quail
SchemeRole
NSW MRSP Infrastructure GrantInvestigator
Total AmountFunding StartFunding Finish
$76,11720102010
GNo:G1100525

Effective anti-arrhythmic drugs: How do they work?$30,000
Funding Body: BellBerry Limited

Project Team
Associate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
SchemeRole
Near MissInvestigator
Total AmountFunding StartFunding Finish
$30,00020102012
GNo:G0900218

Electron Multiplier Charge-Coupled Device Camera. Hamamatsu EM-CCD Camera C9100-13$29,079
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Keith Jones, Professor Eileen McLaughlin, Professor Dirk Van Helden, Doctor Rick Thorne
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$29,07920102010
GNo:G1000052

2009 (4 grants)

Electron Microscopes for Nanometer-scale Imaging/Microanalysis in the Materials, Biological, Physical, Engineering and Chemical Sciences$650,000
Funding Body: ARC (Australian Research Council)

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000
Funding Body: ARC (Australian Research Council)

Electron Microscopes for Nanometer-scale Imaging/Microanalysis in the Materials, Biological, Physical, Engineering and Chemical Sciences$70,000
Funding Body: ARC (Australian Research Council)

Propagation and directionality of gastric slow waves$20,000
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden, Associate Professor Derek Laver
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020092009
GNo:G0189817

2008 (4 grants)

The effects of iron status on calcium handling systems in heart and brain$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Derek Laver, Associate Professor Liz Milward, Professor Dirk Van Helden, Professor Rodney Scott
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$25,00020082008
GNo:G0188463

Colibri high-performance LED illumination system for fluorescence live cell microscopy$23,225
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Rick Thorne, Dr Charles De Bock, Professor Xu Dong Zhang, Doctor Lisa Lincz, Professor Gordon Burns, Conjoint Professor Peter Hersey, Professor Dirk Van Helden, Conjoint Professor Keith Jones, Professor Roger Smith
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$23,22520082008
GNo:G0188545

Leica VT2100S Vibrating Microtome$20,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Alan Brichta, Professor Robert Callister, Professor Dirk Van Helden, Associate Professor Philip Bolton, Doctor Rebecca Lim, Doctor Brett Graham, Dr Marcus Howlett, Doctor Angela McPherson, Doctor Mohammad Imtiaz, Doctor Ramatis De Oliveira, Mr Wayne Anderson, Mr Matthew Walsh
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020082008
GNo:G0188540

HMRI - Equipment Grant - High Speed Sensitivity CCD camera, centrifuge ELISA plate washer. etc$18,919
Funding Body: Hunter Medical Research Institute

Project Team
Professor Dirk Van Helden, Professor Manohar Garg
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$18,91920082008
GNo:G0189386

2007 (5 grants)

HMRI - Cardiovascular Research Program$518,556
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Derek Laver, Conjoint Professor Tony Quail, Professor Dirk Van Helden, Professor Manohar Garg, Professor Robin Callister
SchemeRole
NSW MRSP Infrastructure GrantInvestigator
Total AmountFunding StartFunding Finish
$518,55620072009
GNo:G0187946

Cardiac Pacemaking$327,750
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$327,75020072009
GNo:G0186436

Rhythmicity and Synchronicity in Uterine Smooth Muscle$281,250
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden, Associate Professor Helena Parkington
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$281,25020072009
GNo:G0186431

High speed/sensitivity CCD camera$30,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Associate Professor Alan Brichta, Professor Robert Callister, Doctor Brett Graham, Associate Professor Derek Laver, Associate Professor Liz Milward, Doctor John Holdsworth
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$30,00020072007
GNo:G0188196

5th International Symposium of Interstitial Cells of Cajal, Numore, Ireland, 20/8/2007 - 23/8/2007$1,700
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,70020072007
GNo:G0188167

2006 (2 grants)

2006 Research Fellowship$776,824
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Research FellowshipsChief Investigator
Total AmountFunding StartFunding Finish
$776,82420062011
GNo:G0185119

Mechanisms of action of w-3 fatty acids in control of atrial arrhythmias $16,000
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Derek Laver, Professor Dirk Van Helden, Doctor Bonny Honen
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$16,00020062006
GNo:G0186102

2005 (4 grants)

INVESTIGATION OF A BRAIN RHYTHM$220,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Dirk Van Helden, Professor Robert Callister, Associate Professor Alan Brichta
SchemeRole
Discovery ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$220,00020052007
GNo:G0184333

2005 RIBG allocation$20,000
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Research Infrastructure Block Grant (RIBG)Chief Investigator
Total AmountFunding StartFunding Finish
$20,00020052005
GNo:G0185808

Uterine Pacemaking$12,000
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$12,00020052005
GNo:G0184693

British Physiological Society Meeting: 4th International Mammalian Myocardium Symposium, 18-20 July 2005$2,500
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,50020052005
GNo:G0185646

2004 (5 grants)

Cardiac Pacemaking$409,950
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$409,95020042006
GNo:G0182936

High-Speed Confocal Microscope Live Cell Recording System$274,692
Funding Body: ARC (Australian Research Council)

Project Team
Professor Dirk Van Helden, Laureate Professor John Aitken, Professor Eileen McLaughlin, Associate Professor Alan Brichta, Associate Professor J Keast, Dr J Brock, Dr S Head
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF)Chief Investigator
Total AmountFunding StartFunding Finish
$274,69220042004
GNo:G0183031

High-speed Confocal Microscope Live Cell Recording System$30,000
Funding Body: University of New South Wales

Project Team
Professor Dirk Van Helden, Associate Professor J Keast, Laureate Professor John Aitken, Dr J Brock, Professor Eileen McLaughlin, Dr S Head, Associate Professor Alan Brichta
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF) Partner fundingChief Investigator
Total AmountFunding StartFunding Finish
$30,00020042004
GNo:G0183841

Investigation a brain rythym$14,500
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden, Professor Robert Callister, Associate Professor Alan Brichta
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$14,50020042004
GNo:G0184506

HMRI Award for Research Excellence$10,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Dirk Van Helden
SchemeRole
Sparke Helmore/NBN Television Corporate Triathlon Award for Research ExcellenceChief Investigator
Total AmountFunding StartFunding Finish
$10,00020042004
GNo:G0184891

2003 (6 grants)

CCD Camera: a Sub-Component for the High-Speed Confocal Microscope$30,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$30,00020032003
GNo:G0183064

Ratiometric Ion Imaging System.$30,000
Funding Body: Ramaciotti Foundations

Project Team
Professor Dirk Van Helden
SchemeRole
Major Equipment AwardChief Investigator
Total AmountFunding StartFunding Finish
$30,00020032003
GNo:G0182194

Mechanisms of action of omega-3 fatty acids in reduction of hypertension.$17,000
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Derek Laver, Professor Dirk Van Helden
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$17,00020032003
GNo:G0182641

Investigation of a Brain Rhythm$11,000
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden, Professor Robert Callister
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$11,00020032003
GNo:G0182443

Visit by Dr Kayoko Hosaka 1/07/03 to 30/06/04$5,600
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Visitor GrantChief Investigator
Total AmountFunding StartFunding Finish
$5,60020032003
GNo:G0183266

British Physiological and Pharmacological Society Meeting. Manchester 9-12 Sept 2003$2,400
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40020032003
GNo:G0183578

2002 (2 grants)

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Emeritus Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$21,31520022002
GNo:G0181919

Role of inositol 1,4,5-trisphosphate in cellular pacemaking$13,000
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden, Professor Judith Scott
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$13,00020022002
GNo:G0181329

2001 (10 grants)

Rhythmicity, synchronicity and spasm in smooth muscle.$600,285
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$600,28520012005
GNo:G0179698

Rhythmicity, Synchronicity and Spasm in Smooth Muscle.$543,008
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Research FellowshipsChief Investigator
Total AmountFunding StartFunding Finish
$543,00820012005
GNo:G0180718

Till Photonics Polychrome II Monochromator$16,896
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$16,89620012001
GNo:G0181171

Cardiac Pacemaking.$15,000
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$15,00020012001
GNo:G0180003

Mechanisms underlying cerebral vasospasm.$12,000
Funding Body: Ramaciotti Foundations

Project Team
Professor Dirk Van Helden
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$12,00020012001
GNo:G0179768

The effect of Defocus on the Vascular and Lymphatic System of the Avian Choroid$12,000
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden, Doctor Sally McFadden, Dr Claudia Diaz
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$12,00020012001
GNo:G0180055

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Emeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$11,77020012001
GNo:G0181178

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770
Funding Body: University of Newcastle

Project Team
Emeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
SchemeRole
University/NHMRC Equipment Grant FundsInvestigator
Total AmountFunding StartFunding Finish
$11,77020012001
GNo:G0181179

Till Photonics Polychrome II Monochromator$4,896
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
University/NHMRC Equipment Grant FundsChief Investigator
Total AmountFunding StartFunding Finish
$4,89620012001
GNo:G0181172

International Union of Physiological Sciences Congress 2001, New Zealand 26 August - 2 September 2001$1,629
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,62920012001
GNo:G0181433

2000 (2 grants)

The Physiological Basis for Spasm in Blood and Lymphatic Vessels.$19,500
Funding Body: ARC (Australian Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Small GrantChief Investigator
Total AmountFunding StartFunding Finish
$19,50020002000
GNo:G0178967

Festschrift in honour of Professor Miriam Salpeter, USA 11-12 November 2000$2,500
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,50020002000
GNo:G0180568

1999 (1 grants)

ISSMETCS Symposium of Rhythmic activity in smooth muscle, Japan$1,896
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,89619991999
GNo:G0180521

1998 (6 grants)

The role of Calcium sparks in early muscle development$193,471
Funding Body: ARC (Australian Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Large GrantChief Investigator
Total AmountFunding StartFunding Finish
$193,47119982000
GNo:G0177119

Senior Brawn Research Support Fellowship.$80,000
Funding Body: Gladys M Brawn Memorial Fellowships

Project Team
Professor Dirk Van Helden
SchemeRole
Postdoctoral Research FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$80,00019982001
GNo:G0178626

Vasomotion and Nerve-Induced Tone in the Smooth Muscle of Blood Vessels.$59,492
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Multi-Year Project Grant ScholarshipChief Investigator
Total AmountFunding StartFunding Finish
$59,49219982001
GNo:G0177264

THE ACTION OF SNAKE VENOMS ON LYMPHATIC PUMPING$15,000
Funding Body: Ramaciotti Foundations

Project Team
Professor Dirk Van Helden
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$15,00019981998
GNo:G0177450

Van Helden - Visit by Dr Kulmira B Nurgaliyeva$8,048
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden, Dulat Nurgaliyev
SchemeRole
Visitor GrantChief Investigator
Total AmountFunding StartFunding Finish
$8,04819981998
GNo:G0177540

18th World Congress of the International Union of Angiology, Tokyo, Japan$2,400
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40019981998
GNo:G0180618

1997 (2 grants)

Pacemaking in Smooth Muscle.$700,949
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$700,94919972001
GNo:G0176261

XXXIII International Congress of Physiological Sciences, Russia, 30 June - 5 July 1997$2,500
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,50019971997
GNo:G0179593

1996 (2 grants)

Electrical pacemaking in smooth muscle.$49,092
Funding Body: ARC (Australian Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Multi-Year Small Grant ScholarshipChief Investigator
Total AmountFunding StartFunding Finish
$49,09219961998
GNo:G0175832

Microscope and infra-red camera$42,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Dr Pankaj Sah, Dr B Walmsley, Emeritus Professor Peter Dunkley, Professor Dirk Van Helden
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$42,00019961996
GNo:G0175473

1995 (1 grants)

The development of sensory innervation to blood vessels.$2
Funding Body: Ramaciotti Foundations

Project Team
Professor Dirk Van Helden
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$219951996
GNo:G0174698

1994 (2 grants)

Role of Mast Cells in Smooth Muscle Spasm$44,983
Funding Body: ARC (Australian Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Multi-Year Small Grant ScholarshipChief Investigator
Total AmountFunding StartFunding Finish
$44,98319941996
GNo:G0174826

Neurotransmitter release mechanism at the sympathetic neurovascular junction.$21,523
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Dr James Brock, Professor Dirk Van Helden
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$21,52319941996
GNo:G0173006

1993 (4 grants)

Spontaneous Excitation in Lymphatic Smooth Muscle.$560,834
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$560,83419931997
GNo:G0173196

Control of Calcium in Neurones on the Dorsal Motor Nucleus of the Vagus.Refer A/c 43.200.948 no File opened refer s.rye 29/5/95$22,406
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Dr Pankaj Sah, Professor Dirk Van Helden
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$22,40619931995
GNo:G0173188

Receptor Mechanisms Of Vascular Sensory Neurones$10,000
Funding Body: Ramaciotti Foundations

Project Team
Professor Dirk Van Helden, Dr James Brock
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00019931993
GNo:G0173272

'XXXII Intern. Union of Physiological Sciences', Glasgow, U.K. 1-6 Aug 1993, (b) 'Symposia on Autonomic Nervous System', Oxford Univ, UK,10-14 Aug 1993$2,500
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,50019931993
GNo:G0174390

1992 (2 grants)

Role Of Sympathetic Nerves In The Development Of Hypertension$72,675
Funding Body: National Heart Foundation of Australia

Project Team
Professor Dirk Van Helden
SchemeRole
Grant-In-AidChief Investigator
Total AmountFunding StartFunding Finish
$72,67519921993
GNo:G0173714

Mechanisms Of Activation Of Afferent Nerves On Blood Vessels$18,500
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$18,50019921992
GNo:G0174237

1991 (2 grants)

Receptor Mechanisms In Vascular Smooth Muscle$60,745
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$60,74519911991
GNo:G0173960

The Physiological Basis For Lymphatic Pumping$11,646
Funding Body: Ramaciotti Foundations

Project Team
Professor Dirk Van Helden
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$11,64619911991
GNo:G0173988
Edit

Research Supervision

Number of current supervisions3
Total current UoN Masters EFTSL0.25
Total current UoN PhD EFTSL0.55

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20132015M Philosophy (Human Physiolog)Co-SupervisorElectrophysiological and Computational Investigation of Voltage-gated Potassium and Sodium Ion Channel Modulation by Large Polypetide Toxins
20122016PhD (Human Physiology)Co-SupervisorEffects of Calmodulin on Function of Cardiac Ryanodine Receptor
20112015PhD (Human Physiology)Co-SupervisorThe Lymphatic Function in Diabetes

Past Supervision

YearProgramSupervisor TypeResearch Title
2014PhD (Human Physiology)Co-SupervisorMechanisms of Cardiac Ryanodine Receptor Inhibition by Anti Arrhythmic Drugs
2014PhD (Human Physiology)Co-SupervisorRegulation of Calcium Release Channels (RyR2) in Healthy and Failing Human Hearts
2013PhD (Human Physiology)Co-SupervisorRegulation of Cardiac Calcium Release Channels During Acute Beta-Adrenergic Stimulation
2011PhD (Human Physiology)Principal SupervisorContractile Properties of the Female Reproductive Tract
2010PhD (Human Physiology)Principal SupervisorPacemaking in Mouse Locus Coeruleus Neurons: Electrophysiological Properties, Role of Mitochondria and Development
2010PhD (Physics)Co-SupervisorDesign and Investigation of a Four Mirror Scan Engine Incorporating Parabolic Reflectors
2006PhD (Human Physiology)Principal SupervisorBiochemical Characterisation of the Human Transient Receptor Potential Channel, TRPC4
2003PhD (Human Physiology)Sole SupervisorDistribution pacemaking through coupled oscillator-based mechanisms: A basis for long-range signalling in smooth muscle
2003PhD (Human Physiology)Sole SupervisorLymphatic Vasomotion
2003PhD (Human Physiology)Sole SupervisorThe Effects of Specific Neurotransmitters on Vasomotion in Guinea-Pig Mesenteric Lymphatics
Edit

Professor Dirk Van Helden

Work Phone(02) 4921 5623
Fax(02) 4921 7406
Email
PositionProfessor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaHuman Physiology
Office
MS405,
Medical Sciences,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/dirk-vanhelden