Profile Image

Staff Profile

Edit

Career Summary

Biography

Professor Darryl Knight joins the University of Newcastle as the Head of the School of Biomedical Sciences and Pharmacy.

Having received his BSc Honours degree in Pharmacology and his PhD from the University of Western Australia, Prof Knight undertook post-doctoral training at the University of British Columbia from 1995-1997. From 1997 to 2001 he was a Senior Research Officer in the Asthma & Allergy Research Institute (now the Lung Institute of Western Australia) at the University of Western Australia and was Head of the Experimental Biology division of the Institute from 2002-2004.

In 2004, Prof Knight was recruited back to the University of British Columbia as the Canada Research Chair in Airway Disease and Associate Professor of Pharmacology. In 2007, Prof Knight was awarded a Michael Smith Foundation for Health Research Senior Scholar Career Investigator award and was named the William Thurlbeck Distinguished Lecturer by the Churg Foundation. He was also chosen as the recipient of funds from an endowment fund made to the University from a prominent local businessman, Peter Dhillon, in memory of his father who died of pulmonary fibrosis. In 2008, and assumed the role of Associate Director of the UBC James Hogg Research Centre and in 2009 was promoted to Full Professor.

Prof Knight has had an outstanding research career with over 100 published papers and 2500+ citations (H-index = 27), and is focused on his research interests of pulmonary pharmacology and pathology and how they impact on airway and lung function.

Qualifications

  • PhD, University of Western Australia, 24/08/1993
  • Bachelor of Science (Honours), University of Western Australia, 14/04/1987

Research

Research keywords

  • Asthma and Interstitial lung diseases

Research expertise

Prof Knight’s primary fields of teaching and research interest are centered on pulmonary pharmacology and pathology and how they impact on airway and lung function. Asthma and Interstitial lung diseases are his primary research interests.

Prof Knight’s research program is focused on two independent but interrelated themes designed to increase our understanding of how the abnormal repair responses within the lung i) develop ii) contribute to the severity and chronicity of disease and iii) impact on treatment. These themes are focused the respiratory epithelium and adjacent fibroblasts. This microenvironment is the critical site for the initiation and perpetuation of the pathologic processes which contribute to fibrotic pulmonary diseases. His research program involves the investigation of two diseases, Asthma and idiopathic pulmonary fibrosis, both of which are intimately associated with remodelling and fibrosis. The research is performed at molecular, cellular levels as well as intact animal models in the belief that no single disease perspective or methodology will yield complete insights into the nature of the interaction between these two cell types. He also links to clinical investigators who bring his work directly into the context of patients suffering from these diseases.

Fields of Research

CodeDescriptionPercentage
110203Respiratory Diseases100

Memberships

Committee/Associations (relevant to research).

  • Member - Thoracic Society of Australia and New Zealand
  • Member - Australian Lung Foundation
  • Member - American Society for Cell Biology
  • Member - American Society for Biochemistry and Molecular Biology
  • Member - American Thoracic Society
  • Member - Canadian Thoracic Society
  • Member - Institute for Heart+Lung Health Executive Committee
  • Member - Canadian Institutes of Health Research Respiratory System (RS) Grants Committee
  • Member - Program Advisory and Scientific committee 16th International Colloquium on Lung and airway fibrosis
  • Member - Program Advisory Committee and Chair of the HQP committee, Allergen NCE 6th Annual Research Conference
  • Member - Program Advisory and local organizing committee – CIHR/ICRH Young Investigators Forum

Editorial Board.

  • Member - Faculty of 1000
  • Editor - Experimental Lung Research
  • Editor - International Journal Biochemistry and Cell Biology
  • Editor - American Journal of Respiratory Cell and Molecular Biology
  • Editor - Journal of Epithelial Biology and Pharmacology
  • Editor - Respirology
  • Editor - Pulmonary Pharmacology and Therapeutics

National & International Standards Committees.

  • Member - National Advisory Committee, Australian Lung Foundation

Appointments

Canada Research Chair in Airway Disease
Government of Canada (Canada)
01/01/2004 - 01/01/2013
Chair (Basic Science Grant Review Committee)
Canadian Lung Association (Canada)
01/01/2011 - 01/12/2012
Research Steering Committee
Canadian Lung Association (Canada)
01/01/2009 - 01/12/2012
Chair (Department of Anesthesiology, Pharmacology and Therapeutics) Graduate Program Committee
University of British Columbia (Canada)
01/01/2008 - 01/12/2011

Awards

Research Award.

2010Career Investigator Award (Senior Scholar)
Michael Smith Foundation for Health Research (Canada)
"Mechanisms and consequences of aberrant repair in the lung"
2007The William Thurlbeck Distinguished Researcher Award
The Wolfe and Gita Churg Foundation (United States)
This is a three-year award with an annual value of $40,000 given in memory of Dr. William Thurlbeck to an individual in mid-career who has made significant contributions to understanding basic mechanisms of pulmonary disease.
2007Rashpal Dhillon Fund for Idiopathic Pulmonary Fibrosis (IPF) Research
Dhillon Family (Canada)
Two funds totalling $2 million that will advance medical and food nutrition research at the University of British Columbia were established in memory of Rashpal Dhillon.
2001New Investigator Infrastructure support award
Medical & Health Research Infrastructure Council (Australia)
The New Independent Researcher Infrastructure Support (NIRIS) Awards recognise outstanding new independent medical and health researchers in Western Australia (WA).
2001Senior Scientist travel award
Asthma & Allergy Research Institute (Australia)
Inaugural Recipient.
1998Career Development Award
Australian Lung Foundation/Astra (Australia)
1994Young Investigator of the Year
Thoracic Society of Australia and New Zealand (WA Branch) (Australia)
1994Encouragement award for Clinical Research
Sandoz (Australia)

Invitations

The epithelial innate and adaptive immune profile
AbCam Symposium on Allergy and Asthma, Belgium (Invited Presenter)
2013
Severe Asthma – Is it also an epithelial disease?
Thoracic Society of Australia and New Zealand Annual Scientific Conference, Australia (Conference Presentation - non published.)
2013
Stem Cells for repair of the human airway epithelium.
Keystone Symposium on Pathogenic processes in asthma and COPD, United States (Invited Presenter)
2013
The epithelium in asthma: How not to be an effective barrier.
Federation of Clinical Immunology Societies (FOCIS) Annual Scientific Conference, Canada (Invited Presenter)
2012
Thematic Poster Session on pathways regulating airway cell differentiation
American Thoracic Society Annual Scientific Conference, United States (Session Facilitator)
2012
Symposium session on the Regulation of the ECM in lung disease.
American Thoracic Society Annual Scientific Conference, United States (Session Co-Chair)
2012
Breakout session on future of IPF research
17th International Colloquium on Lung and airway fibrosis. , Italy (Session moderator)
2012
Exogenous control of the ECM, is this an unrealistic goal?
American Thoracic Society Annual Scientific Conference, United States (Invited Presenter)
2012
The epithelium in asthma – how did it get to be so bad?
Simon Fraser University Invited Lecture Series, Australia (Invited Presenter)
2012
Whats in a STAT?
Northwestern University Invited Lecture Series, United States (Invited Presenter)
2012
Fibroblast heterogeneity in lung fibrosis
Canadian Respiratory Conference, Canada (Invited Presenter)
2012
Regenerative Medicine for the treatment of Asthma
UBC Celebrate Research Week, Canada (Invited Presenter)
2012
Disturbing Double Entendres: Disrupting the fine control of epithelial differentiation in Asthma
Meakins-Christie Laboratory 15th Annual International workshop on recent advances in Asthma and COPD, Australia (Invited Presenter)
2012
Role of gp130/STAT3 in extracellular matrix
Transatlantic Airway Conference, Lung Injury and Repair, Switzerland (Invited Presenter)
2012
Epithelial repair and Airway remodeling.
Pulmonary Research Group Symposium on the Role of the Epithelium in Chronic Inflammatory Lung Disease , United States (Invited Presenter)
2011
The epithelium in asthma – should it just grow up or is it OK as it is?
University of Calgary, Asthma and Allergy Research Group, Canada (Invited Presenter)
2011
Thematic Poster Session on pathways Regulating fibroblast gene expression
American Thoracic Society Annual Scientific Conference, United States (Session Facilitator)
2011
The role of the Epithelium in Chronic Inflammatory Lung Disease
Spring 2011 Pulmonary Research Group Symposium, United States (Session Chair)
2011
Insights into the pathogenesis of lung fibrosis and granulomas
American Thoracic Society Annual Scientific Conference, United States (Symposium co-chair)
2011
Epithelial differentiation as a novel target for asthma therapy.
National Heart and Lung Institute, United Kingdom (Invited Presenter)
2011
The role of the epithelium in airway remodeling.
Injury and Repair Mechanisms in Chronic Airway Disease, United Kingdom (Invited Presenter)
2011
New strategies applied to old cells in IPF.
Medimmune, Cambridge, United Kingdom (Invited Presenter)
2011
When is a myofibroblast not a myofibroblast?
University of Nottingham, United Kingdom (Invited Presenter)
2011
Journey to the Centre of the lung in search of a myofibroblasts.
Meakins-Christie Laboratory 14th Annual International workshop on recent advances in Asthma and COPD, Jordan (Invited Presenter)
2011
When is a myofibroblast not a myofibroblast?
16th International Colloquium on Lung and airway fibrosis, Australia (Invited Presenter)
2010
Molecular Aspects of the origins of IPF
BC Lung Health Forum, Canada (Invited Presenter)
2010
Epigenetic influences on epithelial function in asthma.
Meakins-Christie Laboratory 13th Annual International workshop on recent advances in Asthma and COPD, Canada (Invited Presenter)
2010
Journey to the Centre of the lung in search of a cause for IPF
Woolcock Institute for Respiratory Medicine, Australia (Invited Presenter)
2010

Collaboration

Prof Knight has several ongoing collaborations with investigators locally as well as both nationally and internationally, including laboratories in the United Kingdom, Australia, USA and Mexico. These collaborations are all productive, yielding several manuscripts in high impact factor journals and competitively funded grant applications.

Administrative

Administrative expertise

Prof Knight has extensive administrative experience, most recently as Associate Director of the James Hogg Research Centre (JHRC) at the University of British Columbia. This role required him to work closely with the Centre Director and executive research leaders team to enhance the quality, quantity and recognition of research at Providence Health Care and the University. Prof Knight was also responsible for human, capital, financial and information resources to ensure that research objectives are achieved, while seeking partnership opportunities and developing strong relationships within the health community. From September-December 2012, Prof Knight filled the role of Interim Director of the JHRC.

From 2008-2011, Prof Knight held the position of Chair of the Graduate Program Committee (Department of Anaesthesiology, Pharmacology and Therapeutics). As chair, he was the Graduate Advisor for the department and designed a modular course for graduate students in the department that was implemented in September 2010.

Teaching

Teaching keywords

  • pulmonary pathology
  • pulmonary pharmacology

Teaching expertise

Prof Knight’s teaching experience spans Honours, Masters, and PhD and Post Doctorial students. He supervised students across all of these levels, with many receiving awards and over 90% were self-funded while under his tutelage. He also examined theses and lectured in Pharmacology and Therapeutics at the University of British Columbia from 2004-2012. While at the University of British Columbia, Prof Knight also served on many Graduate Student Advisory Committees and Graduate Student Comprehensive Exam Committees.

Edit

Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2012Pechkovsky DV, Prele CM, Wong J, Hogaboam CM, McAnulty RJ, Laurent GJ, et al., 'STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF', American Journal of Pathology, 180 1398-1412 (2012) [C1]
2010Henderson Jr WR, Chi EY, Ye X, Nguyen C, Tien Y-T, Zhou B, et al., 'Inhibition of Wnt/ß-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis', Proceedings of the National Academy of Sciences of USA, 107 4309-4314 (2010) [C1]
2006Kicic A, Sutanto EN, Stevens PT, Knight D, Stick SM, 'Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma', American Journal of Respiratory and Critical Care Medicine, 174 1110-1118 (2006) [C1]
2008Hackett T-L, Shaheen F, Johnson A, Wadsworth S, Pechkovsky DV, Jacoby DB, et al., 'Characterization of side population cells from human airway epithelium', Stem Cells, 26 2576-2585 (2008) [C1]
2010Kicic A, Hallstrand TS, Sutanto EN, Stevens PT, Kobor MS, Taplin C, et al., 'Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium', American Journal of Respiratory and Critical Care Medicine, 181 889-898 (2010) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (4 outputs)

YearCitationAltmetricsLink
2011Hackett T-L, Warner S, Stefanowicz D, Knight D, 'Epithelial cells', Inflammation and Allergy Drug Design, Wiley-Blackwell, Oxford, United Kingdom 139-148 (2011) [B1]
2009Murray LA, Knight D, Laurent GJ, 'Fibroblasts', Asthma and COPD : Basic Mechanisms and Clinical Management, Academic, London, United Kingdom 193-200 (2009) [B1]
2006Knight DA, 'ONCOSTATIN M', Encyclopedia of Respiratory Medicine, Academic Press, London, United Kingdom 254-258 (2006) [B1]
2001Bai TR, Knight DA, 'Role of the Airway Nervous System in Airway Remodeling', Airway Remodeling, Marcel Dekker, New York, United States 147-167 (2001) [B1]
Show 1 more

Journal article (98 outputs)

YearCitationAltmetricsLink
2014Hallstrand TS, Altemeier WA, Matute-Bello G, Hackett TL, Hansbro PM, Knight DA, 'Airway epithelial regulation of pulmonary immune homeostasis and inflammation', Clinical Immunology, 151 1-15 (2014) [C1]
2014Hirota JA, Sin DD, Pui M, Wong S, Fung E, Carlsten C, et al., 'PM10-stimulated airway epithelial cells activate primary human dendritic cells independent of uric acid: Application of an in vitro model system exposing dendritic cells to airway epithelial cell-conditioned media', Respirology, 19 881-890 (2014)
2014Hirota JA, Gold MJ, Hiebert PR, Parkinson LG, Wee T, Smith D, et al., 'The NLRP3 Inflammasome/IL-1RI Axis Mediates Innate Immune but Not Adaptive Immune Responses Following PM10 Exposure.', Am J Respir Cell Mol Biol, (2014)
2014Hirota JA, Sin DD, Pui M, Wong S, Fung E, Carlsten C, et al., 'PM10-stimulated airway epithelial cells activate primary human dendritic cells independent of uric acid: Application of an in vitro model system exposing dendritic cells to airway epithelial cell-conditioned media', Respirology, (2014)
2014Murray LA, Zhang H, Oak SR, Coelho AL, Herath A, Flaherty KR, et al., 'Targeting Interleukin-13 with Tralokinumab Attenuates Lung Fibrosis and Epithelial Damage in a Humanized SCID Idiopathic Pulmonary Fibrosis Model', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 50 985-994 (2014)
2013Hirota JA, Hiebert PR, Gold M, Wu D, Graydon C, Smith JA, et al., 'Granzyme B Deficiency Exacerbates Lung Inflammation in Mice after Acute Lung Injury', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 49 453-462 (2013) [C1]
2013Warner SMB, Hackett T-L, Shaheen F, Hallstrand TS, Kicic A, Stick SM, Knight DA, 'Transcription Factor p63 Regulates Key Genes and Wound Repair in Human Airway Epithelial Basal Cells', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 49 978-988 (2013) [C1]
2013Wei W, Hou J, Alder O, Ye X, Lee S, Cullum R, et al., 'Genome-wide microRNA and messenger RNA profiling in rodent liver development implicates mir302b and mir20a in repressing transforming growth factor-beta signaling', HEPATOLOGY, 57 2491-2501 (2013) [C1]
2013Christenson SA, Campbell JD, Lenburg M, Spira A, Brandsma C-A, Timens W, et al., 'MiR-638 regulates gene expression networks associated with emphysematous lung destruction', Genome Medicine, 5 (2013) [C1]
2013Murray LA, Knight DA, 'Advances in industry for chronic respiratory diseases', Inflammation and Allergy - Drug Targets, 12 79-80 (2013) [C3]
2013Hansbro PM, Knight DA, 'Are Lymphoid Follicles Important in the Pathogenesis of Chronic Obstructive Pulmonary Disease?', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 188 267-269 (2013) [C3]
2012Hirota JA, Hirota SA, Warner SM, Stefanowicz D, Shaheen F, Beck PL, et al., 'The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter', Journal of Allergy and Clinical Immunology, 129 1116-1125 (2012) [C1]
2012Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma C-A, et al., 'A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK', Genome Medicine: medicine in the post-genomic era, 4 67-67 (2012) [C1]
2012Dudas PL, De Garavilla L, Lundblad LKA, Knight DA, 'The role of the epithelium in chronic inflammatory airway disease', Pulmonary Pharmacology and Therapeutics, 25 413-414 (2012) [C1]
2012O'Donoghue RJ, Knight D, Richards CD, Prele CM, Lau HL, Jarnicki AG, et al., 'Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis', EMBO Molecular Medicine, 4 939-951 (2012) [C1]
2012Banerjee B, Musk M, Sutanto EN, Yerkovich ST, Hopkins P, Knight DA, et al., 'Regional Differences in Susceptibiity of Bronchial Epithelium to Mesenchymal Transition and Inhibition by the Macrolide Antibiotic Azithromycin', PLoS One, 7 (2012) [C1]
2012Asdaghi N, Kilani RT, Hosseini-Tabatabaei A, Odemuyiwa SO, Hackett T-L, Knight D, et al., 'Extracellular 14-3-3 from human lung epithelial cells enhances MMP-1 expression', Molecular and Cellular Biochemistry: an international journal for chemical biology in health and disease, 360 261-270 (2012) [C1]
2012Stefanowicz D, Hackett T-L, Garmaroudi FS, Gunther OP, Neumann S, Sutanto EN, et al., 'DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children', PLoS One, 7 (2012) [C1]
2012Hirota JA, Knight DA, 'Human airway epithelial cell innate immunity: relevance to asthma', Current Opinion in Immunology, 24 740-746 (2012) [C1]
2012Prele MC, Yao E, O'Donoghue RJJ, Mutsaers SE, Knight D, 'STAT3 A Central Mediator of Pulmonary Fibrosis?', Proceedings of the Ameican Thoracic Society, 9 177-182 (2012) [C1]
2012Pechkovsky DV, Prele CM, Wong J, Hogaboam CM, McAnulty RJ, Laurent GJ, et al., 'STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF', American Journal of Pathology, 180 1398-1412 (2012) [C1]
2012Cruz-Sanchez TM, Haddrell AE, Hackett TL, Singhera GK, Marchant D, Lekivetz R, et al., 'Formation of a Stable Mimic of Ambient Particulate Matter Containing Viable Infectious Respiratory Syncytial Virus and Its Dry-Deposition Directly onto Cell Cultures', Analytical Chemistry, 85 898-906 (2012) [C1]
2012Boivin WA, Shackleford M, Vanden Hoek A, Zhao H, Hackett TL, Knight D, Granville DJ, 'Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-ß1', PLoS One, 7 (2012) [C1]
2012Hallstrand TS, Woodruff PG, Holgate ST, Knight DA, 'Function of the Airway Epithelium in Asthma', Journal of Allergy, 2012 1-89 (2012) [C6]
2011Oosthuizen JL, Gomez P, Ruan J, Hackett T-L, Moore MM, Knight D, Tebbutt SJ, 'Dual organism transcriptomics of airway epithelial cells interacting with conidia of Aspergillus fumigatus', PLoS One, 6 (2011) [C1]
2011Hackett T-L, Singhera GK, Shaheen F, Hayden P, Jackson GR, Hegele RG, et al., 'Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution', American Journal of Respiratory Cell and Molecular Biology, 45 1090-1100 (2011) [C1]
2011Murgia C, Grosser D, Truong-Tran AQ, Roscioli E, Michalczyk A, Ackland ML, et al., 'Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation', Nutrients, 3 910-928 (2011) [C1]
2011Cooper DM, Petchkovsky DV, Hackett TL, Knight D, Granville DJ, 'Granzyme K activates protease-activated receptor-1', PLoS One, 6 (2011) [C1]
2011Oak SR, Murray L, Herath A, Sleeman M, Anderson I, Joshi AD, et al., 'A micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosis', PLoS One, 6 (2011) [C1]
2011Abraham T, Hirota JA, Wadsworth S, Knight D, 'Minimally invasive multiphoton and harmonic generation imaging of extracellular matrix structures in lung airway and related diseases', Pulmonary Pharmacology and Therapeutics, 24 487-496 (2011) [C1]
2011Sutanto EN, Kicic A, Foo CJ, Stevens PT, Mullane D, Knight D, Stick SM, 'Innate inflammatory responses of pediatric cystic fibrosis airway epithelial cells: Effects of nonviral and viral stimulation', American Journal of Respiratory Cell and Molecular Biology, 44 761-767 (2011) [C1]
2011Moreira AP, Cavassani KA, Ismailoglu UB, Hullinger R, Dunleavy MP, Knight D, et al., 'The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A', Journal of Clinical Investigation, 121 4420-4432 (2011) [C1]
2011Knight D, Mutsaers SE, Prele CM, 'STAT3 in tissue fibrosis: Is there a role in the lung?', Pulmonary Pharmacology and Therapeutics, 24 193-198 (2011) [C1]
2011Knight D, Stick SM, Hackett T-L, 'Defective function at the epithelial junction: A novel therapeutic frontier in asthma?', Journal of Allergy and Clinical Immunology, 128 557-558 (2011) [C3]
2010Henderson Jr WR, Chi EY, Ye X, Nguyen C, Tien Y-T, Zhou B, et al., 'Inhibition of Wnt/ß-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis', Proceedings of the National Academy of Sciences of USA, 107 4309-4314 (2010) [C1]
2010Kicic A, Hallstrand TS, Sutanto EN, Stevens PT, Kobor MS, Taplin C, et al., 'Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium', American Journal of Respiratory and Critical Care Medicine, 181 889-898 (2010) [C1]
2010Pechkovsky DV, Hackett TL, An SS, Shaheen F, Murray LA, Knight D, 'Human lung parenchyma but not proximal bronchi produces fibroblasts with enhanced TGF-ß signaling and a-SMA expression', American Journal of Respiratory Cell and Molecular Biology, 43 641-651 (2010) [C1]
2010Murray LA, Kramer MS, Hesson DP, Watkins BA, Fey EG, Argentieri RL, et al., 'Serum amyloid P ameliorates radiation-induced oral mucositis and fibrosis', Fibrogenesis and Tissue Repair, 3 11 (2010) [C1]
2010Gomez P, Hackett TL, Moore MM, Knight D, Tebbutt SJ, 'Functional genomics of human bronchial epithelial cells directly interacting with conidia of Aspergillus fumigatus', BMC Genomics, 11 358 (2010) [C1]
2010Stefanowicz D, Hackett T, Pare P, Knight DA, 'Alterations In Histone Acetylation In Asthmatic Airway Epithelial Cells', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 181 (2010) [E3]
2009Hackett T-L, Warner SM, Stefanowicz D, Shaheen F, Pechkovsky DV, Murray LA, et al., 'Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-ß1', American Journal of Respiratory and Critical Care Medicine, 180 122-133 (2009) [C1]
2009He J-Q, Hallstrand TS, Knight D, Chan-Yeung M, Sandford A, Tripp B, et al., 'A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness', Journal of Allergy and Clinical Immunology, 124 222-229 (2009) [C1]
2008Hackett T-L, Shaheen F, Johnson A, Wadsworth S, Pechkovsky DV, Jacoby DB, et al., 'Characterization of side population cells from human airway epithelium', Stem Cells, 26 2576-2585 (2008) [C1]
2008Murray LA, Knight D, McAlonan L, Argentieri R, Joshi A, Shaheen F, et al., 'Deleterious role of TLR3 during hyperoxia-induced acute lung injury', American Journal of Respiratory and Critical Care Medicine, 178 1227-1237 (2008) [C1]
2008He J-Q, Sandford AJ, Wang I-M, Stepaniants S, Knight D, Kicic A, et al., 'Selection of housekeeping genes for real-time PCR in atopic human bronchial epithelial cells', European Respiratory Journal, 32 755-762 (2008) [C1]
2008Stevens PT, Kicic A, Sutanto EN, Knight D, Stick SM, 'Dysregulated repair in asthmatic paediatric airway epithelial cells: The role of plasminogen activator inhibitor-1', Clinical and Experimental Allergy, 38 1901-1910 (2008) [C1]
2008Pechkovsky DV, Scaffidi AK, Hackett TL, Ballard J, Shaheen F, Thompson PJ, et al., 'Transforming growth factor ß1 induces avß3 integrin expression in human lung fibroblasts via a ß3 integrin-, c-Src-, and p38 MAPK-dependent pathway', Journal of Biological Chemistry, 283 2898-2908 (2008) [C1]
2008Allahverdian S, Harada N, Singhera GK, Knight D, Dorscheid DR, 'Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF', American Journal of Respiratory Cell and Molecular Biology, 38 153-160 (2008) [C1]
2008Murray LA, Hackett TL, Warner SM, Shaheen F, Argentieri RL, Dudas P, et al., 'BMP-7 does not protect against bleomycin-induced lung or skin fibrosis', PLoS One, 3 4039 (2008) [C1]
2007McWhinnie R, Pechkovsky DV, Zhou D, Lane D, Halayko AJ, Knight D, Bai TR, 'Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells', American Journal of Physiology: Lung Cellular and Molecular Physiology, 292 L278-L286 (2007) [C1]
2007Bateman RM, Hodgson KC, Kohli K, Knight D, Walley KR, 'Endotoxemia increases the clearance of mPEGylated 5000-MW quantum dots as revealed by multiphoton microvascular imaging', Journal of Biomedical Optics, 12 (2007) [C1]
2007Lang C, Murgia C, Leong M, Tan L-W, Perozzi G, Knight D, et al., 'Anti-inflammatory effects of zinc and alterations in zinc transporter mRNA in mouse models of allergic inflammation', American Journal of Physiology: Lung Cellular and Molecular Physiology, 292 L577-L584 (2007) [C1]
2006Petrovic N, Knight D, Bomalaski JS, Thompson PJ, Misso NLA, 'Concomitant activation of extracellular signal-regulated kinase and induction of COX-2 stimulates maximum prostaglandin E2 synthesis in human airway epithelial cells', Prostaglandins and Other Lipid Mediators, 81 126-135 (2006) [C1]
2006Knight DA, 'New Drug Targets for the Treatment of Asthma', Current Drug Targets, 7 523-523 (2006) [C1]
2006Kicic A, Sutanto EN, Stevens PT, Knight D, Stick SM, 'Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma', American Journal of Respiratory and Critical Care Medicine, 174 1110-1118 (2006) [C1]
2006Knight D, 'Editorial: New drug targets for the treatment of asthma', Current Drug Targets, 7 523-523 (2006) [C1]
2006Moeller A, Horak Jr F, Lane C, Knight D, Kicic A, Brennan S, et al., 'Inducible NO synthase expression is low in airway epithelium from young children with cystic fibrosis', Thorax, 61 514-520 (2006) [C1]
2005Lee YCG, Knight DA, Lane KB, Cheng DS, Koay MA, Teixeira LR, et al., 'Activation of proteinase-activated receptor-2 in mesothelial cells induces pleural inflammation', American Journal of Physiology: Lung Cellular and Molecular Physiology, 288 L734-L740 (2005) [C1]
2005Weichselbaum M, Sparrow MP, Hamilton EJ, Thompson PJ, Knight DA, 'A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium', Respiratory Research, 6 1-30 (2005) [C1]
2005Lane C, Burgess S, Kicic A, Knight DA, Stick S, 'The use of non-bronchoscopic brushings to study the paediatric airway', Respiratory Research, 6 1-10 (2005) [C1]
2005O'Hara KA, Kedda M-A, Fogel-Petrovic M, Thompson PJ, Abraham LJ, Knight DA, 'Characterization of the Human Oncostatin M (OSM) Receptort Sub-Unit, OSMBR', INFLAMMATION RESEARCH, 54 S157-S157 (2005)
2005Fonceca AM, Sutanto EN, Kicic A, Knight DA, Stick SM, 'Cellular microenvironment: A defining role for TLR4 location and expression in vivo', INFLAMMATION RESEARCH, 54 S187-S187 (2005)
2004Lane C, Burgess S, Franklin P, Horak F, Legg J, Moeller A, et al., 'Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath', Thorax, 59 757-760 (2004) [C1]
2004Knight DA, Lane CL, Stick SM, 'Does aberrant activation of the epithelial-mesenchymal trophic unit play a key role in asthma or is it an unimportant sideshow?', Current Opinion in Pharmacology, 4 251-256 (2004) [C1]
2004Fogel-Petrovic M, Long JA, Knight DA, Thompson PJ, Upham JW, 'Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2', Immunology and Cell Biology, 82 47-54 (2004) [C1]
2004Scaffidi AK, Petrovic N, Moodley YP, Fogel-Petrovic M, Kroeger KM, Seeber RM, et al., 'avß3 integrin interacts with the transforming growth factor ß (TGFß) type II receptor to potentiate the proliferative effects of TGFß1 in living human lung fibroblasts', Journal of Biological Chemistry, 279 7726-7733 (2004) [C1]
2004Long JA, Fogel-Petrovic M, Knight DA, Thompson PJ, Upham JW, 'Higher prostaglandin E2 production by dendritic cells from subjects with asthma compared with normal subjects', American Journal of Respiratory and Critical Care Medicine, 170 485-491 (2004) [C1]
2004Moodley YP, Caterina P, Scaffidi AK, Misso NL, Papadimitrou JM, McAnulty RJ, et al., 'Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL-induced apoptosis', Journal of Pathology, 202 486-495 (2004) [C1]
2003Laurent GJ, Mutsaers SE, Thompson PJ, Knight DA, Moodley YP, Scaffidi AK, et al., 'Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation', American Journal of Pathology, 163 345-354 (2003) [C1]
2003Moodley Y, Rigby P, Bundell C, Bunt S, Hayashi H, Misso N, et al., 'Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36', American Journal of Pathology, 162 771-779 (2003) [C1]
2003Moodley YP, Misso NLA, Scaffidi AK, Fogel-Petrovic M, McAnulty RJ, Laurent GJ, et al., 'Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs', American Journal of Respiratory Cell and Molecular Biology, 29 490-498 (2003) [C1]
2002Knight DA, 'Increased permeability of asthmatic epithelial cells to pollutants. Does this mean that they are intrinsically abnormal?', Clinical and Experimental Allergy, 32 1263-1265 (2002) [C1]
2002Asokananthan N, Graham PT, Fink J, Knight DA, Bakker AJ, McWilliam AS, et al., 'Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E 2 release from human respiratory epithelial cells', Journal of Immunology, 168 3577-3585 (2002) [C1]
2002Scaffidi AK, Mutsaers SE, Moodley YP, McAnulty RJ, Laurent GJ, Thompson PJ, Knight DA, 'Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts', British Journal of Pharmacology, 136 793-801 (2002) [C1]
2001Lan RS, Knight DA, Stewart GA, Henry PJ, 'Role of PGE 2 in protease-activated receptor-1, -2 and -4 mediated relaxation in the mouse isolated trachea', British Journal of Pharmacology, 132 93-100 (2001) [C1]
2001Scaffidi AK, Moodley YP, Weichselbaum M, Thompson PJ, Knight DA, 'Regulation of human lung fibroblast phenotype and function by vitronectin and vitronectin integrins', Journal of Cell Science, 114 3507-3516 (2001) [C1]
2001Knight DA, 'Leukaemia Inhibitory Factor (LIF): A cytokine of emerging importance in chronic airway inflammation', Pulmonary Pharmacology and Therapeutics, 14 169-176 (2001) [C1]
2001Tulic MK, Knight DA, Holt PG, Sly PD, 'Lipopolysaccharide inhibits the late-phase response to allergen by altering nitric oxide synthase activity and interleukin-10', American Journal of Respiratory Cell and Molecular Biology, 24 640-646 (2001) [C1]
2001Knight DA, 'Epithelium-fibroblast interactions in response to airway inflammation', Immunology and Cell Biology, 79 160-164 (2001) [C1]
2001Knight DA, Lim S, Scaffidi AK, Roche N, Chung KF, Stewart GA, Thompson PJ, 'Protease-activated receptors in human airways: Upregulation of PAR-2 in respiratory epithelium from patients with asthma', Journal of Allergy and Clinical Immunology, 108 797-803 (2001) [C1]
2001Thompson PJ, Asokananthan N, Knight DA, Stewart GA, 'Protease-activated receptors and the airway epithelium', Clinical and Experimental Allergy Reviews, 1 107-110 (2001) [C1]
2000Knight DA, Asokananthan N, Watkins DN, Misso NLA, Thompson PJ, Stewart GA, 'Oncostatin M synergises with house dust mite proteases to induce the production of PGE 2 from cultured lung epithelial cells', British Journal of Pharmacology, 131 465-472 (2000) [C1]
2000Knight DA, D'Aprile AC, Spalding LJ, Goldie RG, Thompson PJ, 'Leukaemia inhibitory factor (LIF) upregulates excitatory non-adrenergic non-cholinergic and maintains cholinergic neural function in tracheal explants', British Journal of Pharmacology, 130 975-979 (2000) [C1]
1999Knight DA, Lydell CP, Zhou DY, Weir TD, Schellenberg RR, Bai TR, 'Leukemia inhibitory factor (LIF) and LIF receptor in human lung distribution and regulation of LIF release', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 20 834-841 (1999)
1999Knight DA, Nithinanthan A, Watkins DN, Thompson PJ, Stewart GA, 'Synergy between oncostatin M (OSM) and house dust mite (HDM) allergens in stimulating PGE(2) release from epithelial cells.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A334-A334 (1999)
1999Thompson PJ, Knight DA, Nithinanthan A, Stewart GA, 'The presence of proteinase activated receptors (PAR) in cultured human airway epithelial cells: Differential effects on PGE(2) release.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A98-A98 (1999)
1999Watkins DN, Peroni DJ, Lenzo JC, Knight DA, Garlepp MJ, Thompson PJ, 'Expression and localization of COX-2 in human airways and cultured airway epithelial cells', EUROPEAN RESPIRATORY JOURNAL, 13 999-1007 (1999)
1999Zheng XY, Knight DA, Zhou DY, Weir TD, Peacock C, Schellenberg RR, Bai TR, 'Leukemia inhibitory factor is synthesized and released by human eosinophils and modulates activation state and chemotaxis', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 104 136-144 (1999)
1999Knight DA, D'Aprile AC, Thompson PJ, Goldie RG, 'Leukemia inhibitory factor (LIF) but not oncostatin M (OSM) upregulates eNANC and maintains cholinergic neural activity in tracheal explants.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A334-A334 (1999)
1997Walker BAM, Jacobson MA, Knight DA, Salvatore CA, Weir T, Zhou DY, Bai TR, 'Adenosine A(3) receptor expression and function in eosinophils', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 16 531-537 (1997)
1997Knight DA, Stewart GA, Thompson PJ, 'Histamine-induced contraction of human isolated bronchus is enhanced by endogenous prostaglandin F-2 alpha and activation of TP receptors', EUROPEAN JOURNAL OF PHARMACOLOGY, 319 261-267 (1997)
1995KNIGHT DA, STEWART GA, LAI ML, THOMPSON PJ, 'EPITHELIUM-DERIVED INHIBITORY PROSTAGLANDINS MODULATE HUMAN BRONCHIAL SMOOTH-MUSCLE RESPONSES TO HISTAMINE', EUROPEAN JOURNAL OF PHARMACOLOGY, 272 1-11 (1995)
1995KNIGHT DA, STEWART GA, THOMPSON PJ, 'PROSTAGLANDIN E(2), BUT NOT PROSTACYCLIN INHIBITS HISTAMINE-INDUCED CONTRACTION OF HUMAN BRONCHIAL SMOOTH-MUSCLE', EUROPEAN JOURNAL OF PHARMACOLOGY, 272 13-19 (1995)
1994KNIGHT DA, STEWART GA, THOMPSON PJ, 'THE RESPIRATORY EPITHELIUM AND AIRWAY SMOOTH-MUSCLE HOMEOSTASIS - ITS RELEVANCE TO ASTHMA', CLINICAL AND EXPERIMENTAL ALLERGY, 24 698-706 (1994)
1993KNIGHT DA, THOMPSON PJ, STEWART GA, 'PGE2 BUT NOT PGI2 ACCOUNTS FOR THE INHIBITORY EFFECT OF PROSTAGLANDINS (PG) IN HISTAMINE TACHYPHYLAXIS (HT) ON HUMAN BRONCHIAL SMOOTH-MUSCLE (HBSM)', AMERICAN REVIEW OF RESPIRATORY DISEASE, 147 A449-A449 (1993)
1992KNIGHT DA, STEWART GA, THOMPSON PJ, 'HISTAMINE TACHYPHYLAXIS IN HUMAN AIRWAY SMOOTH-MUSCLE - THE ROLE OF H-2-RECEPTORS AND THE BRONCHIAL EPITHELIUM', AMERICAN REVIEW OF RESPIRATORY DISEASE, 146 137-140 (1992)
1991KNIGHT DA, PHILLIPS MJ, STEWART GA, THOMPSON PJ, 'THE INTERACTION OF ACETYLCHOLINE AND HISTAMINE ON HUMAN BRONCHIAL SMOOTH-MUSCLE CONTRACTION', EUROPEAN RESPIRATORY JOURNAL, 4 985-991 (1991)
1988FERNANDES LB, KNIGHT DA, RIGBY PJ, SPINA D, PATERSON JW, GOLDIE RG, 'BETA-ADRENOCEPTOR DESENSITIZATION IN GUINEA-PIG ISOLATED TRACHEA', EUROPEAN JOURNAL OF PHARMACOLOGY, 157 135-145 (1988)
Show 95 more

Review (15 outputs)

YearCitationAltmetricsLink
2012Knight D, Yang IA, Ko FWS, Lim TK, 'Year in review 2011: Asthma, chronic obstructive pulmonary disease and airway biology', Respirology (2012) [D1]
2012Roth HM, Wadsworth SJ, Kahn M, Knight DA, 'The airway epithelium in asthma: Developmental issues that scar the airways for life?', Pulmonary Pharmacology and Therapeutics (2012) [D1]
2011Reddel HK, Lim TK, Mishima M, Wainwright CE, Knight D, 'Year-in-review 2010: Asthma, COPD, cystic fibrosis and airway biology', Respirology (2011) [D1]
2011Hirota JA, Hackett T-L, Inman MD, Knight D, 'Modeling asthma in mice: What have we learned about the airway epithelium?', American Journal of Respiratory Cell and Molecular Biology (2011) [D1]
2010Knight D, Rossi FM, Hackett T-L, 'Mesenchymal stem cells for repair of the airway epithelium in asthma', Expert Review of Respiratory Medicine (2010) [D1]
2010Hackett TL, Knight D, Sin DD, 'Potential role of stem cells in management of COPD', International Journal of COPD (2010) [D1]
2008Warner SM, Knight D, 'Airway modeling and remodeling in the pathogenesis of asthma', Current Opinion in Allergy and Clinical Immunology (2008) [D1]
2007Hackett T-L, Knight D, 'The role of epithelial injury and repair in the origins of asthma', Current Opinion in Allergy and Clinical Immunology (2007) [D1]
2007An SS, Bai TR, Bates JHT, Black JL, Brown RH, Brusasco V, et al., 'Airway smooth muscle dynamics: A common pathway of airway obstruction in asthma', European Respiratory Journal (2007) [D1]
2005Bai TR, Knight DA, 'Structural changes in the airways in asthma: Observations and consequences', Clinical Science: an international journal of translational science and medicine (2005) [D1]
2004Knight DA, 'Talniflumate (Genaera)', Current Opinion in Investigational Drugs (Print) (2004) [D1]
2004Mutsaers SE, McAnulty RJ, Laurent GJ, Knight DA, 'Evaluation of experimental models of idiopathic pulmonary fibrosis', Drug Discovery Today: Disease Models (2004) [D1]
2003Knight DA, Holgate ST, 'The airway epithelium: Structural and functional properties in health and disease', Respirology (2003) [D1]
2003Knight DA, Ernst M, Anderson GP, Moodley YP, Mutsaers SE, 'The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: Critical determinants of disease susceptibility and progression?', Pharmacology & Therapeutics (2003) [D1]
2003O'Hara KA, Kedda M-A, Thompson PJ, Knight DA, 'Oncostatin M: An interleukin-6-like cytokine relevant to airway remodelling and the pathogenesis of asthma', Clinical and Experimental Allergy (2003) [D1]
Show 12 more

Conference (10 outputs)

YearCitationAltmetricsLink
2013Looi K, Larcombe A, Zosky G, Rigby P, Knight DA, Stick SM, Kicic A, 'HUMAN RHINOVIRUS INFECTION INITIATES AIRWAY EPITHELIAL TIGHT JUNCTION DISASSEMBLY RESULTING IN BARRIER FUNCTION DISRUPTION', RESPIROLOGY (2013) [E3]
2013Looi K, Larcombe A, Zosky G, Rigby P, Knight DA, Stick SM, Kicic A, 'HUMAN RHINOVIRUS INFECTION OF ASTHMATIC AIRWAY EPITHELIAL CELLS CAUSES TIGHT JUNCTION DISASSEMBLY RESULTING IN INCREASED PERMEABILITY', RESPIROLOGY (2013) [E3]
2011Abraham T, Hirota J, Elliot M, Knight D, Hogg J, 'How Multiphoton and Harmonic Generation Microscopy Methods are Useful in Understanding Lung Structure and Related Diseases', Microscopy and Microanalysis, Nashville, Tennessee, USA (2011) [E1]
2010O'Donoghue RJJ, Knight DA, Jarnicki AG, Jones J, Anderson GP, Mutsaers SE, Ernst M, 'Interleukin-6-induced STAT3 signaling links inflammation to chronic lung disease in mice', CYTOKINE, Chicago, IL (2010) [E3]
2010Cooper DM, Hackett TL, Boivin WA, Knight DA, Granville DJ, 'Granzymes and Wound Repair', ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, San Francisco, CA (2010) [E3]
2009Hackett T-L, Stefanowicz D, Shaheen F, Pechkovsky D, Warner SM, Murray L, et al., 'Epithelial-Mesenchymal Transition Occurs in Undifferentiated Basal Airway Epithelial Cells Derived from Normal and Asthmatic Subjects.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
2009Pechkovsky DV, Hackett TL, Shaheen F, Hogaboam CM, Selman M, McAnulty RJ, et al., 'Altered Level of STAT3 Basal Activity Influences Lung Fibroblast Thy-1 and alpha v beta 3 Integrin Expression', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
2009Shaheen F, Hackett TL, Knight DA, Pechkovsky DV, 'Blockade of ALK5 in Normal Lung Parenchymal Fibroblasts Inhibits Exaggerated Smad3 and JNK Signaling and Reverses Their Myofibroblast-Like Phenotype Compared with Paired Bronchial Wall-Derived Fibroblasts.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
2009Stefanowicz D, Hackett T-L, Avila L, Neumann S, Kicic A, Stick S, et al., 'DNA Methylation Profiles of Asthmatic Airway Epithelial Cells.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
2002Lee YCG, Knight DA, Lane KB, Cheng DS, Koay MA, Teixeira IR, et al., 'Activation of protease activated receptor-2 in mesothelial cells: A novel mechanism of pleural inflammation', THORAX, LONDON, ENGLAND (2002)
Show 7 more
Edit

Grants and Funding

Summary

Number of grants48
Total funding$7,950,531

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (6 grants)

A novel approach to understanding Asthma: Focus on the epithelium $617,209
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Darryl Knight, Professor Phil Hansbro, Professor Stephen Stick, Dr Anthony Kicic
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$617,20920142017
GNo:G1300212

The Nanostring nCounter System$75,000
Funding Body: Ramaciotti Foundations

Project Team
Professor Darryl Knight, Professor Phil Hansbro, Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeRole
Major Equipment AwardChief Investigator
Total AmountFunding StartFunding Finish
$75,00020142014
GNo:G1300853

The Nanostring nCounter System$40,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Darryl Knight, Professor Phil Hansbro, Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$40,00020142014
GNo:G1301083

Mechanisms of dysregulated antiviral signallings to influenza infection in chronic obstructive pulmonary disease$27,512
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Doctor Alan Hsu, Doctor Fatemeh Moheimani, Professor Darryl Knight, Conjoint Professor Peter Wark
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$27,51220142014
GNo:G1400435

Immunosenescence in chronic obstructive pulmonary disease leads to abnormal innate immune responses to human rhinovirus infection$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Professor Peter Wark, Professor Darryl Knight
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020142014
GNo:G1301331

The Nanostring nCounter System$20,000
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Professor Darryl Knight, Professor Phil Hansbro, Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020142014
GNo:G1301084

2013 (2 grants)

Defective cell migration as a mechanism of dysregulated asthmatic airway repair$595,430
Funding Body: NHMRC (National Health & Medical Research Council)

SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$595,43020132015
GNo:182475611

Role of the transcriptional co-activator p300 in resetting epithelial differentiation: A potential pathway involved in asthma prevention and therapy$10,000
Funding Body: University of Newcastle

Project Team
Doctor Fatemeh Moheimani, Professor Darryl Knight, Miss Kirsty Wark, Doctor Alan Hsu, Mr Malcolm Starkey
SchemeRole
Early Career Researcher GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020132013
GNo:G1301174

2012 (1 grants)

Airway epithelial barrier function, asthma and aero?allergen sensitization.$510,000
Funding Body: NHMRC (National Health & Medical Research Council)

SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$510,00020122014
GNo:182142026

2011 (3 grants)

Inhaled Corticosteroids as risk factors for severe viral infections in asthmatics: lessons from the H1N1 epidemic$130,558
Funding Body: Canadian Institutes of Health Research

SchemeRole
Operating Grant Investigator
Total AmountFunding StartFunding Finish
$130,55820112013
GNo:182141977

Resetting epithelial differentiation as a novel therapeutic approach to treating asthma$120,407
Funding Body: Canadian Institutes of Health Research

SchemeRole
Operating Grant Chief Investigator
Total AmountFunding StartFunding Finish
$120,40720112013
GNo:182141945

Heart and Lung Health FEST 2011$7,500
Funding Body: Canadian Institutes of Health Research

SchemeRole
Meetings, Planning and Dissemination Grant: Circulatory and Respiratory Health Chief Investigator
Total AmountFunding StartFunding Finish
$7,50020112011
GNo:182040299

2010 (3 grants)

Exacerbation of H1N1 Influenza infection with inhaled therapeutics in primary epithelial cells and ex vivo tissue from asthma patients: clarification of primary treatment strategies during pandemic in$94,155
Funding Body: Canadian Institutes of Health Research

SchemeRole
Operating Grant: Health Systems Research on H1N1 Chief Investigator
Total AmountFunding StartFunding Finish
$94,15520102011
GNo:182040344

Defining phenotypes of fibroblasts within the human airways and lung parenchyma for better understanding of fibrotic diseases$25,000
Funding Body: British Columbia Lung Association

SchemeRole
Funds GrantedInvestigator
Total AmountFunding StartFunding Finish
$25,00020102012
GNo:182164534

New emerging paradigm in asthma: The role of E-cadherin in aberrant airway epithelial repair$25,000
Funding Body: British Columbia Lung Association

SchemeRole
Funds GrantedInvestigator
Total AmountFunding StartFunding Finish
$25,00020102012
GNo:182164542

2009 (3 grants)

Dysregulated STAT-3 activation underlies lung fibroblast heterogeneity: Implications for idiopathic pulmonary fibrosis$464,649
Funding Body: Canadian Institutes of Health Research

SchemeRole
Operating GrantChief Investigator
Total AmountFunding StartFunding Finish
$464,64920092013
GNo:182142001

Canada Research Chairholder$375,000
Funding Body: Canadian Institutes of Health Research

SchemeRole
Canada Research Chairs - CIHR Funded - Tier 2 Chief Investigator
Total AmountFunding StartFunding Finish
$375,00020092013
GNo:182141920

Regulation of mesenchymal cell behaviour by versican: Implications of arterial remodeling$108,800
Funding Body: Heart & Stroke Foundation

SchemeRole
Funds GrantedInvestigator
Total AmountFunding StartFunding Finish
$108,80020092012
GNo:182164550

2008 (1 grants)

Novel Therapy for Pulmonary Fibrosis$150,000
Funding Body: Canadian Institutes of Health Research

SchemeRole
Proof of Principle Program - Phase I Chief Investigator
Total AmountFunding StartFunding Finish
$150,00020082009
GNo:182040313

2007 (3 grants)

The role of gp130 receptor mediated signalling in fibrotic pulmonary diseases.$544,500
Funding Body: NHMRC (National Health & Medical Research Council)

SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$544,50020072009
GNo:182040162

Dysregulated epithelial repair in pediatric asthma$100,000
Funding Body: Johnson & Johnson

SchemeRole
Funds GrantedChief Investigator
Total AmountFunding StartFunding Finish
$100,00020072010
GNo:182164558

Dysregulated STAT-3 activation in the Pathogenesis of IPF$20,000
Funding Body: British Columbia Lung Association

SchemeRole
Funds GrantedChief Investigator
Total AmountFunding StartFunding Finish
$20,00020072009
GNo:182164566

2006 (2 grants)

Genetic and epigenetic determinants of asthmatic epithelial cell Phenotype$369,000
Funding Body: Canadian Institutes of Health Research

SchemeRole
Operating Grant Investigator
Total AmountFunding StartFunding Finish
$369,00020062010
GNo:182141985

Environmental impact on the epithelial immune barrier in asthma$344,151
Funding Body: Canadian Institutes of Health Research

SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$344,15120062008
GNo:182040270

2005 (4 grants)

Regulation of gp130 signaling by STAT-3 in the pathogenesis of pulmonary fibrosis$251,084
Funding Body: Canadian Institutes of Health Research

SchemeRole
Operating Grant Chief Investigator
Total AmountFunding StartFunding Finish
$251,08420052009
GNo:182141953

Role and regulation of the proteoglycan, versican, in vascular injury and repair$110,666
Funding Body: Heart & Stroke Foundation

SchemeRole
Funds GrantedInvestigator
Total AmountFunding StartFunding Finish
$110,66620052008
GNo:182164582

Regulation of gp130 signaling by STAT-3 in the pathogenesis of pulmonary fibrosis$50,000
Funding Body: Canadian Institutes of Health Research

SchemeRole
Operating Grant -PA: Inst of Circulatory and Respiratory Health - Bridge FundingChief Investigator
Total AmountFunding StartFunding Finish
$50,00020052006
GNo:182141937

Regulation of gp130 signaling of gp130 in the pathogenesis of pulmonary fibrosis$15,000
Funding Body: Providence Health Care

SchemeRole
Funds GrantedChief Investigator
Total AmountFunding StartFunding Finish
$15,00020052006
GNo:182164574

2004 (7 grants)

Canada Research Chairholder$500,000
Funding Body: Canadian Institutes of Health Research

SchemeRole
Canada Research Chairs - CIHR Funded - Tier 2 Chief Investigator
Total AmountFunding StartFunding Finish
$500,00020042010
GNo:182141929

Altered signalling by a common cytokine receptor is important in the development of fibrotic lung diseases.$449,750
Funding Body: NHMRC (National Health & Medical Research Council)

SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$449,75020042006
GNo:182040248

Establishment Grant$301,000
Funding Body: Canadian Institutes of Health Research

SchemeRole
Institutional Establishment Grant (IEG) ProgramChief Investigator
Total AmountFunding StartFunding Finish
$301,00020042004
GNo:182142018

The airway epithelium, atopy and asthma$259,750
Funding Body: NHMRC (National Health & Medical Research Council)

SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$259,75020042006
GNo:182040230

Role Of Zinc In The Respiratory Epithelium and asthma$220,500
Funding Body: NHMRC (National Health & Medical Research Council)

SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$220,50020042006
GNo:182040220

Mechanisms of Airway Disease$114,416
Funding Body: Canadian Foundation for Innovation

SchemeRole
Canada Research Chairs Infrastructure FundChief Investigator
Total AmountFunding StartFunding Finish
$114,41620042004
GNo:182142039

Integrin-growth factor interactions in the development of airway wall remodeling$29,420
Funding Body: British Columbia Lung Association

SchemeRole
Funds GrantedChief Investigator
Total AmountFunding StartFunding Finish
$29,42020042006
GNo:182164590

2003 (4 grants)

Regulation of the structural changes in the airways of chronic asthmatics$384,000
Funding Body: NHMRC (National Health & Medical Research Council)

SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$384,00020032005
GNo:182040257

Equipment grant$73,000
Funding Body: NHMRC (National Health & Medical Research Council)

SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$73,00020032003
GNo:182164598

Infrastructure grant$36,098
Funding Body: Medical and Health Research Infrastructure Council

SchemeRole
Infrastructure grantChief Investigator
Total AmountFunding StartFunding Finish
$36,09820032003
GNo:182164606

Equipment grant$16,000
Funding Body: Rebecca Cooper Foundation

SchemeRole
Funds GrantedChief Investigator
Total AmountFunding StartFunding Finish
$16,00020032003
GNo:182164614

2002 (2 grants)

Three-dimensional confocal analysis of sensory nerves, neuroendocrine cells and dendritic cells in human airways.$10,000
Funding Body: Sir Charles Gairdner Hospital

SchemeRole
Funds GrantedChief Investigator
Total AmountFunding StartFunding Finish
$10,00020022002
GNo:182164630

University of Western Australia$5,000
Funding Body: University of Western Australia

SchemeRole
Funds GrantedInvestigator
Total AmountFunding StartFunding Finish
$5,00020022002
GNo:182164622

2001 (2 grants)

The Immunobiology of Asthma with particular reference to the Respiratory Epithelium$61,500
Funding Body: Sir Charles Gairdner Hospital

SchemeRole
Funds GrantedInvestigator
Total AmountFunding StartFunding Finish
$61,50020012002
GNo:182164638

Interleukin (IL-) 11 and IL-6 differentially influence fibroblast proliferation and apoptosis: Implications for airway inflammation and airway remodeling$43,900
Funding Body: Asthma Foundation of Western Australia

SchemeRole
Funds GrantedChief Investigator
Total AmountFunding StartFunding Finish
$43,90020012001
GNo:182164654

2000 (1 grants)

Epithelium-fibroblast interactions in response to allergic airway inflammation$76,700
Funding Body: NHMRC (National Health & Medical Research Council)

SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$76,70020002002
GNo:182164646

1999 (3 grants)

The role of Oncostatin M and Leukemia Inhibitory Factor in airway remodeling$48,576
Funding Body: NHMRC (National Health & Medical Research Council)

SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$48,57619992001
GNo:182164686

The effects of house dust mite allergens on the activation of submucosal glands and mucus secretion in human isolated airways: The modulatory role of Oncostatin M and Leukemia Inhibitory Factor.$22,900
Funding Body: Asthma Foundation of Western Australia

SchemeRole
Funds GrantedChief Investigator
Total AmountFunding StartFunding Finish
$22,90019991999
GNo:182164662

Assessment of the effects of chronic inflammation on structural remodelling and functional responses of human airways in vitro.$20,000
Funding Body: Australian Lung Foundation

SchemeRole
SharedChief Investigator
Total AmountFunding StartFunding Finish
$20,00019992000
GNo:182164670

1998 (1 grants)

A novel explant model to investigate epithelial damage and airway remodelling in human airways. $57,400
Funding Body: Raine Medical Research Foundation

SchemeRole
Funds GrantedChief Investigator
Total AmountFunding StartFunding Finish
$57,40019981999
GNo:182164678
Edit

Research Supervision

Number of current supervisions0

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Past Supervision

YearProgramSupervisor TypeResearch Title
2011Masters Health
University of British Columbia
Principal SupervisorRole of STAT-3 in regulating fibroblast function
2011Post-Doctoral Fellowship Health
University of British Columbia
Principal SupervisorRegulation of epithelial cell differentiation
2009PHD Health
University of Western Australia
Principal SupervisorCharacterising factors that regulate epithelial proliferation in childhood asthma
2008PHD Health
University of Western Australia
Principal SupervisorRole of Gp130/STAT-3 in pulmonary fibrosis
2007PHD Health
University of Western Australia
Co-SupervisorAirway epithelium and particular matter air pollutuion
2007Post-Doctoral Fellowship Health
University of British Columbia
Principal SupervisorHB-EGF, TGF? and epithelial function
2006PHD Health
University of Western Australia
Principal SupervisorCharacterising the role of oncostatin M in human lung
2006PHD Health
University of Western Australia
Co-SupervisorPaediatric airway epithelial cells in asthma
2005PHD Health
University of Western Australia
Principal SupervisorInteraction between integrins and growth factors of fibroblast function
2004PHD Health
University of Western Australia
Principal SupervisorGp130/STAT3 activation in pulmonary fibrosis
2003Honours Health
University of Western Australia
Principal SupervisorIntegrins and growth Factors and epithelial cells
2003Post-Doctoral Fellowship Health
University of Western Australia
Principal SupervisorIntegrins and epithelial function
2002Honours Health
University of Western Australia
Principal SupervisorInteraction between viruses and oncostatin M in human airway epithelium
Edit

Professor Darryl Knight

Work Phone(02) 4921 7485
Fax(02) 4921 7403
Email
PositionHead of School
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Office
MS606,
Medical Sciences Building,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/darryl-knight