Profile Image

Professor Darryl Knight

Head of School

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

Professor Darryl Knight joins the University of Newcastle as the Head of the School of Biomedical Sciences and Pharmacy. Having received his BSc Honours degree in Pharmacology and his PhD from the University of Western Australia, Prof Knight undertook post-doctoral training at the University of British Columbia from 1995-1997. From 1997 to 2001 he was a Senior Research Officer in the Asthma & Allergy Research Institute (now the Lung Institute of Western Australia) at the University of Western Australia and was Head of the Experimental Biology division of the Institute from 2002-2004. In 2004, Prof Knight was recruited back to the University of British Columbia as the Canada Research Chair in Airway Disease and Associate Professor of Pharmacology. In 2007, Prof Knight was awarded a Michael Smith Foundation for Health Research Senior Scholar Career Investigator award and was named the William Thurlbeck Distinguished Lecturer by the Churg Foundation. He was also chosen as the recipient of funds from an endowment fund made to the University from a prominent local businessman, Peter Dhillon, in memory of his father who died of pulmonary fibrosis. In 2008, and assumed the role of Associate Director of the UBC James Hogg Research Centre and in 2009 was promoted to Full Professor. Prof Knight has had an outstanding research career with over 100 published papers and 2500+ citations (H-index = 27), and is focused on his research interests of pulmonary pharmacology and pathology and how they impact on airway and lung function.

Research Expertise
Prof Knight’s primary fields of teaching and research interest are centered on pulmonary pharmacology and pathology and how they impact on airway and lung function. Asthma and Interstitial lung diseases are his primary research interests. Prof Knight’s research program is focused on two independent but interrelated themes designed to increase our understanding of how the abnormal repair responses within the lung i) develop ii) contribute to the severity and chronicity of disease and iii) impact on treatment. These themes are focused the respiratory epithelium and adjacent fibroblasts. This microenvironment is the critical site for the initiation and perpetuation of the pathologic processes which contribute to fibrotic pulmonary diseases. His research program involves the investigation of two diseases, Asthma and idiopathic pulmonary fibrosis, both of which are intimately associated with remodelling and fibrosis. The research is performed at molecular, cellular levels as well as intact animal models in the belief that no single disease perspective or methodology will yield complete insights into the nature of the interaction between these two cell types. He also links to clinical investigators who bring his work directly into the context of patients suffering from these diseases.

Teaching Expertise
Prof Knight’s teaching experience spans Honours, Masters, and PhD and Post Doctorial students. He supervised students across all of these levels, with many receiving awards and over 90% were self-funded while under his tutelage. He also examined theses and lectured in Pharmacology and Therapeutics at the University of British Columbia from 2004-2012. While at the University of British Columbia, Prof Knight also served on many Graduate Student Advisory Committees and Graduate Student Comprehensive Exam Committees.

Administrative Expertise
Prof Knight has extensive administrative experience, most recently as Associate Director of the James Hogg Research Centre (JHRC) at the University of British Columbia. This role required him to work closely with the Centre Director and executive research leaders team to enhance the quality, quantity and recognition of research at Providence Health Care and the University. Prof Knight was also responsible for human, capital, financial and information resources to ensure that research objectives are achieved, while seeking partnership opportunities and developing strong relationships within the health community. From September-December 2012, Prof Knight filled the role of Interim Director of the JHRC. From 2008-2011, Prof Knight held the position of Chair of the Graduate Program Committee (Department of Anaesthesiology, Pharmacology and Therapeutics). As chair, he was the Graduate Advisor for the department and designed a modular course for graduate students in the department that was implemented in September 2010.

Collaborations
Prof Knight has several ongoing collaborations with investigators locally as well as both nationally and internationally, including laboratories in the United Kingdom, Australia, USA and Mexico. These collaborations are all productive, yielding several manuscripts in high impact factor journals and competitively funded grant applications.


Qualifications

  • PhD, University of Western Australia
  • Bachelor of Science (Honours), University of Western Australia

Keywords

  • Asthma and Interstitial lung diseases
  • pulmonary pathology
  • pulmonary pharmacology

Fields of Research

CodeDescriptionPercentage
110203Respiratory Diseases100

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2014 - ProfessorUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2012 - Editorial Board - Faculty of 1000Faculty of 1000
Australia
1/01/2011 - Editor - Experimental Lung ResearchExperimental Lung Research
Australia
1/01/2011 - 1/12/2012Chair (Basic Science Grant Review Committee)Canadian Lung Association
Canada
1/01/2010 - Editor - International Journal Biochemistry and Cell BiologyInternational Journal Biochemistry and Cell Biology
Australia
1/12/2009 - 1/12/2012Research Steering CommitteeCanadian Lung Association
Canada
1/01/2009 - Editor - American Journal of Respiratory Cell and Molecular Biology American Journal of Respiratory Cell and Molecular Biology
United States
1/01/2009 - Editor - RespirologyRespirology
Australia
1/01/2008 - 1/12/2011Chair (Department of Anesthesiology, Pharmacology and Therapeutics) Graduate Program CommitteeUniversity of British Columbia
Canada
1/01/2008 - Membership - Canadian Thoracic SocietyCanadian Thoracic Society
Canada
1/01/2007 - Editor - Journal of Epithelial Biology and PharmacologyJournal of Epithelial Biology and Pharmacology
Australia
1/01/2007 - 31/12/2012Membership - Institute for Heart and Lung Health Executive CommitteeInstitute for Heart and Lung Health
Australia
1/01/2006 - 31/12/2011Editor - Pulmonary Pharmacology and Therapeutics Pulmonary Pharmacology and Therapeutics
Australia
1/01/2006 - 31/12/2012Membership - Canadian Institutes of Health Research Respiratory System (RS) Grants CommitteeCanadian Institutes of Health Research Respiratory System (RS) Grants Committee
Canada
1/01/2004 - 1/01/2013Canada Research Chair in Airway Disease
The Canada Research Chairs program
Government of Canada
Canada
1/01/2004 - 31/12/2007Membership - American Society for Biochemistry and Molecular BiologyAmerican Society for Biochemistry and Molecular Biology
United States
1/01/2003 - 31/12/2004Membership - National Advisory Committee, Australian Lung FoundationAustralian Lung Foundation
1/01/2003 - 31/12/2010Membership - American Society for Cell BiologyAmerican Society for Cell Biology
United States
1/01/1995 - Membership - American Thoracic SocietyAmerican Thoracic Society
United States
1/01/1991 - 31/12/2005Membership - Australian Lung FoundationAustralian Lung Foundation
1/01/1991 - 31/12/2005Membership - Thoracic Society of Australia and New ZealandThoracic Society of Australia and New Zealand

Membership

DatesTitleOrganisation / Department
Program Advisory Committee Member and Chair of the HQP Committe - Allergen NCE 6th Annual Research ConferenceProgram Advisory and Scientific committee
Australia
Member - Program Advisory and Scientific Committee 16th International Colloquium on Lung and Airway FibrosisProgram Advisory and Scientific committee
Australia
Member - Program Advisory and Local Organizing Committee – CIHR/ICRH Young Investigators ForumProgram Advisory and Scientific committee
Australia

Awards

Research Award

YearAward
2010Career Investigator Award (Senior Scholar)
Michael Smith Foundation for Health Research
2007Rashpal Dhillon Fund for Idiopathic Pulmonary Fibrosis (IPF) Research
Rashpal Dhillon Fund for Idiopathic Pulmonary Fibrosis (IPR) Research
2007The William Thurlbeck Distinguished Researcher Award
Wolfe and Gita Churg Foundation
2001New Investigator Infrastructure support award
Medical and Health Research Infrastructure Council (MHRIC)
1998Career Development Award
The Australian Lung foundation
1994Encouragement award for Clinical Research
Sandoz Australia
1994Young Investigator of the Year
The Thoracic Society of Australia and New Zealand

Invitations

Participant

YearTitle / Rationale
2013Severe Asthma – Is it also an epithelial disease?
Organisation: Thoracic Society of Australia and New Zealand Annual Scientific Conference
2012Thematic Poster Session on pathways regulating airway cell differentiation
Organisation: American Thoracic Society Annual Scientific Conference Description:
2012Symposium session on the Regulation of the ECM in lung disease.
Organisation: American Thoracic Society Annual Scientific Conference Description:
2012Breakout session on future of IPF research
Organisation: 17th International Colloquium on Lung and airway fibrosis.
2011Insights into the pathogenesis of lung fibrosis and granulomas
Organisation: American Thoracic Society Annual Scientific Conference Description:
2011Thematic Poster Session on pathways Regulating fibroblast gene expression
Organisation: American Thoracic Society Annual Scientific Conference Description:
2011The role of the Epithelium in Chronic Inflammatory Lung Disease
Organisation: Spring 2011 Pulmonary Research Group Symposium Description:

Speaker

YearTitle / Rationale
2013The epithelial innate and adaptive immune profile
Organisation: AbCam Symposium on Allergy and Asthma
2013Stem Cells for repair of the human airway epithelium.
Organisation: Keystone Symposium on Pathogenic processes in asthma and COPD Description:
2012The epithelium in asthma – how did it get to be so bad?
Organisation: Simon Fraser University Invited Lecture Series Description:
2012Whats in a STAT?
Organisation: Northwestern University Invited Lecture Series Description:
2012Role of gp130/STAT3 in extracellular matrix
Organisation: Transatlantic Airway Conference, Lung Injury and Repair
2012Disturbing Double Entendres: Disrupting the fine control of epithelial differentiation in Asthma
Organisation: Meakins-Christie Laboratory 15th Annual International workshop on recent advances in Asthma and COPD Description:
2012Regenerative Medicine for the treatment of Asthma
Organisation: UBC Celebrate Research Week Description:
2012Fibroblast heterogeneity in lung fibrosis
Organisation: Canadian Respiratory Conference Description:
2012Exogenous control of the ECM, is this an unrealistic goal?
Organisation: American Thoracic Society Annual Scientific Conference Description:
2012The epithelium in asthma: How not to be an effective barrier.
Organisation: Federation of Clinical Immunology Societies (FOCIS) Annual Scientific Conference Description:
2011New strategies applied to old cells in IPF.
Organisation: Medimmune, Cambridge Description:
2011When is a myofibroblast not a myofibroblast?
Organisation: University of Nottingham Description:
2011Epithelial differentiation as a novel target for asthma therapy.
Organisation: National Heart and Lung Institute Description:
2011The epithelium in asthma – should it just grow up or is it OK as it is?
Organisation: University of Calgary, Asthma and Allergy Research Group Description:
2011Journey to the Centre of the lung in search of a myofibroblasts.
Organisation: Meakins-Christie Laboratory 14th Annual International workshop on recent advances in Asthma and COPD Description:
2011The role of the epithelium in airway remodeling.
Organisation: Injury and Repair Mechanisms in Chronic Airway Disease Description:
2011Epithelial repair and Airway remodeling.
Organisation: Pulmonary Research Group Symposium on the Role of the Epithelium in Chronic Inflammatory Lung Disease Description:
2010Journey to the Centre of the lung in search of a cause for IPF
Organisation: Woolcock Institute for Respiratory Medicine
2010Epigenetic influences on epithelial function in asthma.
Organisation: Meakins-Christie Laboratory 13th Annual International workshop on recent advances in Asthma and COPD
2010Molecular Aspects of the origins of IPF
Organisation: BC Lung Health Forum Description:
2010When is a myofibroblast not a myofibroblast?
Organisation: 16th International Colloquium on Lung and airway fibrosis Description:
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (4 outputs)

YearCitationAltmetricsLink
2011Hackett T-L, Warner S, Stefanowicz D, Knight D, 'Epithelial cells', Inflammation and Allergy Drug Design, Wiley-Blackwell, Oxford, United Kingdom 139-148 (2011) [B1]
2009Murray LA, Knight D, Laurent GJ, 'Fibroblasts', Asthma and COPD : Basic Mechanisms and Clinical Management, Academic, London, United Kingdom 193-200 (2009) [B1]
2006Knight DA, 'ONCOSTATIN M', Encyclopedia of Respiratory Medicine, Academic Press, London, United Kingdom 254-258 (2006) [B1]
DOI10.1016/B0-12-370879-6/00282-9
2001Bai TR, Knight DA, 'Role of the Airway Nervous System in Airway Remodeling', Airway Remodeling, Marcel Dekker, New York, United States 147-167 (2001) [B1]
Show 1 more chapter

Journal article (109 outputs)

YearCitationAltmetricsLink
2015Garratt LW, Sutanto EN, Ling K-M, Looi K, Iosifidis T, Martinovich KM, et al., 'Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis', European Respiratory Journal, (2015)
DOI10.1183/09031936.00212114
2015Hirota JA, Gold MJ, Hiebert PR, Parkinson LG, Wee T, Smith D, et al., 'The nucleotide-binding domain, leucine-rich repeat protein 3 inflammasome/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate matter under 10 µm', American Journal of Respiratory Cell and Molecular Biology, 52 96-105 (2015) [C1]

Exposure to particulate matter (PM), a major component of air pollution, contributes to increased morbidity and mortality worldwide. Inhaled PM induces innate immune responses by ... [more]

Exposure to particulate matter (PM), a major component of air pollution, contributes to increased morbidity and mortality worldwide. Inhaled PM induces innate immune responses by airway epithelial cells that may lead to the exacerbation or de novo development of airway disease. We have previously shown that 10-mm PM (PM10) activates the nucleotide-binding domain, leucine-rich repeat protein (NLRP) 3 inflammasome in human airway epithelial cells. Our objective was to determine the innate and adaptive immune responses mediated by the airway epithelium NLRP3 inflammasome in response to PM10 exposure. Using in vitro cultures of human airway epithelial cells and in vivo studies with wild-type and Nlrp3-/- mice, we investigated the downstream consequences of PM10-induced NLPR3 inflammasome activation on cytokine production, cellular inflammation, dendritic cell activation, and PM10-facilitated allergic sensitization. PM10 activates an NLRP3 inflammasome/IL-1 receptor I (IL-1RI) axis in airway epithelial cells, resulting in IL-1b, CC chemokine ligand-20, and granulocyte/macrophage colony-stimulating factor production, which is associated with dendritic cell activation and lung neutrophilia. Despite these profound innate immune responses in the airway epithelium, the NLRP3 inflammasome/IL-1RI axis is dispensable for PM10-facilitated allergic sensitization. We demonstrate the importance of the lung NLRP3 inflammasome in mediating PM10 exposure-associated innate, but not adaptive, immune responses. Our study highlights a mechanism by which PM10 exposure can contribute to the exacerbation of airway disease, but not PM10-facilitated allergic sensitization.

DOI10.1165/rcmb.2014-0158OC
Co-authorsPhilip Hansbro
2015Hirota JA, Gold MJ, Hiebert PR, Parkinson LG, Wee T, Smith D, et al., 'The Nucleotide-Binding Domain, Leucine-Rich Repeat Protein 3 Inflammasome/IL-1 Receptor I Axis Mediates Innate, but Not Adaptive, Immune Responses after Exposure to Particulate Matter under 10 mu m', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 52 96-105 (2015) [C1]
DOI10.1165/rcmb.2014-0158OCAuthor URL
Co-authorsPhilip Hansbro
2015Chen-Yu Hsu A, Starkey MR, Hanish I, Parsons K, Haw TJ, Howland LJ, et al., 'Targeting PI3K-p110a Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease.', Am J Respir Crit Care Med, 191 1012-1023 (2015)
DOI10.1164/rccm.201501-0188OCAuthor URL
Co-authorsMalcolm Starkey, Philip Hansbro, Paul Foster, Peter Wark, Alan Hsu
2015Hatchwell L, Collison A, Girkin J, Parsons K, Li J, Zhang J, et al., 'Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia.', Thorax, (2015)
DOI10.1136/thoraxjnl-2014-205465Author URL
Co-authorsPaul Foster
2014Murray LA, Zhang H, Oak SR, Coelho AL, Herath A, Flaherty KR, et al., 'Targeting Interleukin-13 with Tralokinumab Attenuates Lung Fibrosis and Epithelial Damage in a Humanized SCID Idiopathic Pulmonary Fibrosis Model', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 50 985-994 (2014) [C1]
DOI10.1165/rcmb.2013-0342OCAuthor URL
CitationsScopus - 9Web of Science - 4
2014Hirota JA, Alexis NE, Pui M, Wong S, Fung E, Hansbro P, et al., 'PM10-stimulated airway epithelial cells activate primary human dendritic cells independent of uric acid: Application of an in vitro model system exposing dendritic cells to airway epithelial cell-conditioned media', Respirology, 19 881-890 (2014) [C1]

Background and objective Airway epithelial cells represent the first line of defence against inhaled insults, including air pollution. Air pollution can activate innate immune sig... [more]

Background and objective Airway epithelial cells represent the first line of defence against inhaled insults, including air pollution. Air pollution can activate innate immune signalling in airway epithelial cells leading to the production of soluble mediators that can influence downstream inflammatory cells. Our objective was to develop and validate a model of dendritic cell exposure to airway epithelial cell-conditioned media. After establishing the model, we explored how soluble mediators released from airway epithelial cells in response to air pollution influenced the phenotype of dendritic cells. Methods Human airway epithelial cells were cultured under control and urban particulate matter (PM10) exposure conditions with or without pharmacological inhibitors of the uric acid pathway. Culture supernatants were collected for conditioned media experiments with peripheral blood mononuclear cell-derived dendritic cells analysed by flow cytometry. Results Monocytes derived from peripheral blood mononuclear cells cultured in interleukin-4 and granulocyte macrophage colony stimulating factor differentiated into immature dendritic cells that phenotypically differentiated into mature dendritic cells in response to conditioned media from phorbol myristate acetate-activated THP-1 monocytes. Exposure of immature dendritic cells to conditioned media from airway epithelial cells exposed to PM10 resulted in dendritic cell maturation that was independent of uric acid. Conclusions We present a conditioned media model useful for interrogating the contribution of soluble mediators produced by airway epithelial cells to dendritic cell phenotype and function. Furthermore, we demonstrate that PM10 exposure induces airway epithelial cell production of soluble mediators that induce maturation of dendritic cells independent of uric acid. We developed and validated a model of airway epithelial cell conditioned media exposure to primary human dendritic cells. Using this model, we then tested the hypothesis that urban particulate matter exposure to airway epithelial cells resulted in production of soluble mediators capable of inducing dendritic cell maturation. © 2014 Asian Pacific Society of Respirology.

DOI10.1111/resp.12316
CitationsScopus - 1Web of Science - 1
Co-authorsPhilip Hansbro
2014Hirota JA, Sin DD, Pui M, Wong S, Fung E, Carlsten C, et al., 'PM10-stimulated airway epithelial cells activate primary human dendritic cells independent of uric acid: Application of an in vitro model system exposing dendritic cells to airway epithelial cell-conditioned media', Respirology, 19 881-890 (2014)
DOI10.1111/resp.12316
Co-authorsPhilip Hansbro
2014Hallstrand TS, Hackett TL, Altemeier WA, Matute-Bello G, Hansbro PM, Knight DA, 'Airway epithelial regulation of pulmonary immune homeostasis and inflammation', Clinical Immunology, 151 1-15 (2014) [C1]

Recent genetic, structural and functional studies have identified the airway and lung epithelium as a key orchestrator of the immune response. Further, there is now strong evidenc... [more]

Recent genetic, structural and functional studies have identified the airway and lung epithelium as a key orchestrator of the immune response. Further, there is now strong evidence that epithelium dysfunction is involved in the development of inflammatory disorders of the lung. Here we review the characteristic immune responses that are orchestrated by the epithelium in response to diverse triggers such as pollutants, cigarette smoke, bacterial peptides, and viruses. We focus in part on the role of epithelium-derived interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), as well as CC family chemokines as critical regulators of the immune response. We cite examples of the function of the epithelium in host defense and the role of epithelium dysfunction in the development of inflammatory diseases. © 2013 Elsevier Inc.

DOI10.1016/j.clim.2013.12.003
CitationsScopus - 15Web of Science - 15
Co-authorsPhilip Hansbro
2013Christenson SA, Brandsma C-A, Campbell JD, Knight DA, Pechkovsky DV, Hogg JC, et al., 'MiR-638 regulates gene expression networks associated with emphysematous lung destruction', Genome Medicine, 5 (2013) [C1]
DOI10.1186/gm519
CitationsScopus - 7Web of Science - 5
2013Wei W, Hou J, Alder O, Ye X, Lee S, Cullum R, et al., 'Genome-wide microRNA and messenger RNA profiling in rodent liver development implicates mir302b and mir20a in repressing transforming growth factor-beta signaling', HEPATOLOGY, 57 2491-2501 (2013) [C1]
DOI10.1002/hep.26252Author URL
CitationsScopus - 7Web of Science - 7
2013Hirota JA, Hiebert PR, Gold M, Wu D, Graydon C, Smith JA, et al., 'Granzyme B Deficiency Exacerbates Lung Inflammation in Mice after Acute Lung Injury', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 49 453-462 (2013) [C1]
DOI10.1165/rcmb.2012-0512OCAuthor URL
CitationsScopus - 4Web of Science - 4
2013Warner SMB, Hackett T-L, Shaheen F, Hallstrand TS, Kicic A, Stick SM, Knight DA, 'Transcription Factor p63 Regulates Key Genes and Wound Repair in Human Airway Epithelial Basal Cells', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 49 978-988 (2013) [C1]
DOI10.1165/rcmb.2012-0447OCAuthor URL
CitationsScopus - 4Web of Science - 4
2013Hansbro PM, Knight DA, 'Are Lymphoid Follicles Important in the Pathogenesis of Chronic Obstructive Pulmonary Disease?', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 188 267-269 (2013) [C3]
DOI10.1164/rccm.201306-1073EDAuthor URL
CitationsScopus - 1Web of Science - 1
Co-authorsPhilip Hansbro
2013Murray LA, Knight DA, 'Advances in industry for chronic respiratory diseases', Inflammation and Allergy - Drug Targets, 12 79-80 (2013) [C3]
DOI10.2174/1871528111312020001
2012Dunmore R, Carruthers AM, Bell MJ, Zhang H, Hogaboam CM, Peng X, et al., 'An Assessment of Epithelial and Mesenchymal Phenotypes in Experimental and Clinical Pulmonary Fibrosis', ISRN Pulmonology, 2012 1-11 (2012)
DOI10.5402/2012/153971
2012Pechkovsky DV, Prele CM, Wong J, Hogaboam CM, McAnulty RJ, Laurent GJ, et al., 'STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF', American Journal of Pathology, 180 1398-1412 (2012) [C1]
DOI10.1016/j.ajpath.2011.12.022
CitationsScopus - 15Web of Science - 13
2012Cruz-Sanchez TM, Haddrell AE, Hackett TL, Singhera GK, Marchant D, Lekivetz R, et al., 'Formation of a Stable Mimic of Ambient Particulate Matter Containing Viable Infectious Respiratory Syncytial Virus and Its Dry-Deposition Directly onto Cell Cultures', Analytical Chemistry, 85 898-906 (2012) [C1]
DOI10.1021/ac302174y
CitationsScopus - 1
2012Asdaghi N, Kilani RT, Hosseini-Tabatabaei A, Odemuyiwa SO, Hackett T-L, Knight D, et al., 'Extracellular 14-3-3 from human lung epithelial cells enhances MMP-1 expression', Molecular and Cellular Biochemistry: an international journal for chemical biology in health and disease, 360 261-270 (2012) [C1]
DOI10.1007/s11010-011-1065-1
CitationsScopus - 4Web of Science - 3
2012Hirota JA, Hirota SA, Warner SM, Stefanowicz D, Shaheen F, Beck PL, et al., 'The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter', Journal of Allergy and Clinical Immunology, 129 1116-1125 (2012) [C1]
DOI10.1016/j.jaci.2011.11.033
CitationsScopus - 37Web of Science - 34
2012Hirota JA, Knight DA, 'Human airway epithelial cell innate immunity: relevance to asthma', Current Opinion in Immunology, 24 740-746 (2012) [C1]
DOI10.1016/j.coi.2012.08.012
CitationsScopus - 8Web of Science - 6
2012Dudas PL, De Garavilla L, Lundblad LKA, Knight DA, 'The role of the epithelium in chronic inflammatory airway disease', Pulmonary Pharmacology and Therapeutics, 25 413-414 (2012) [C1]
DOI10.1016/j.pupt.2012.10.005
2012Prele MC, Yao E, O'Donoghue RJJ, Mutsaers SE, Knight D, 'STAT3 A Central Mediator of Pulmonary Fibrosis?', Proceedings of the Ameican Thoracic Society, 9 177-182 (2012) [C1]
DOI10.1513/pats.201201-007AW
CitationsScopus - 7
2012Hallstrand TS, Woodruff PG, Holgate ST, Knight DA, 'Function of the Airway Epithelium in Asthma', Journal of Allergy, 2012 1-89 (2012) [C6]
2012Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma C-A, et al., 'A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK', Genome Medicine: medicine in the post-genomic era, 4 67-67 (2012) [C1]
DOI10.1186/gm367
CitationsScopus - 21Web of Science - 18
2012O'Donoghue RJ, Knight D, Richards CD, Prele CM, Lau HL, Jarnicki AG, et al., 'Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis', EMBO Molecular Medicine, 4 939-951 (2012) [C1]
DOI10.1002/emmm.201100604
CitationsScopus - 17Web of Science - 11
2012Boivin WA, Shackleford M, Vanden Hoek A, Zhao H, Hackett TL, Knight D, Granville DJ, 'Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-ß1', PLoS One, 7 (2012) [C1]
DOI10.1371/journal.pone.0033163
CitationsScopus - 28Web of Science - 26
2012Stefanowicz D, Hackett T-L, Garmaroudi FS, Gunther OP, Neumann S, Sutanto EN, et al., 'DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children', PLoS One, 7 (2012) [C1]
DOI10.1371/journal.pone.0044213
CitationsScopus - 15Web of Science - 14
2012Banerjee B, Musk M, Sutanto EN, Yerkovich ST, Hopkins P, Knight DA, et al., 'Regional Differences in Susceptibiity of Bronchial Epithelium to Mesenchymal Transition and Inhibition by the Macrolide Antibiotic Azithromycin', PLoS One, 7 (2012) [C1]
DOI10.1371/journal.pone.0052309
CitationsScopus - 2Web of Science - 3
2011Oak SR, Murray L, Herath A, Sleeman M, Anderson I, Joshi AD, et al., 'A micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosis', PLoS One, 6 (2011) [C1]
DOI10.1371/journal.pone.0021253
CitationsScopus - 28Web of Science - 24
2011Cooper DM, Petchkovsky DV, Hackett TL, Knight D, Granville DJ, 'Granzyme K activates protease-activated receptor-1', PLoS One, 6 (2011) [C1]
DOI10.1371/journal.pone.0021484
CitationsScopus - 13Web of Science - 12
2011Oosthuizen JL, Gomez P, Ruan J, Hackett T-L, Moore MM, Knight D, Tebbutt SJ, 'Dual organism transcriptomics of airway epithelial cells interacting with conidia of Aspergillus fumigatus', PLoS One, 6 (2011) [C1]
DOI10.1371/journal.pone.0020527
CitationsScopus - 14Web of Science - 14
2011Murgia C, Grosser D, Truong-Tran AQ, Roscioli E, Michalczyk A, Ackland ML, et al., 'Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation', Nutrients, 3 910-928 (2011) [C1]
DOI10.3390/nu3110910
CitationsScopus - 8Web of Science - 8
2011Moreira AP, Cavassani KA, Ismailoglu UB, Hullinger R, Dunleavy MP, Knight D, et al., 'The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A', Journal of Clinical Investigation, 121 4420-4432 (2011) [C1]
DOI10.1172/JCI44999
CitationsScopus - 34Web of Science - 32
2011Knight D, Stick SM, Hackett T-L, 'Defective function at the epithelial junction: A novel therapeutic frontier in asthma?', Journal of Allergy and Clinical Immunology, 128 557-558 (2011) [C3]
DOI10.1016/j.jaci.2011.07.031
CitationsScopus - 5Web of Science - 5
2011Hackett T-L, Singhera GK, Shaheen F, Hayden P, Jackson GR, Hegele RG, et al., 'Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution', American Journal of Respiratory Cell and Molecular Biology, 45 1090-1100 (2011) [C1]
DOI10.1165/rcmb.2011-0031OC
CitationsScopus - 48Web of Science - 48
2011Sutanto EN, Kicic A, Foo CJ, Stevens PT, Mullane D, Knight D, Stick SM, 'Innate inflammatory responses of pediatric cystic fibrosis airway epithelial cells: Effects of nonviral and viral stimulation', American Journal of Respiratory Cell and Molecular Biology, 44 761-767 (2011) [C1]
DOI10.1165/rcmb.2010-0368OC
CitationsScopus - 25Web of Science - 23
2011Abraham T, Hirota JA, Wadsworth S, Knight D, 'Minimally invasive multiphoton and harmonic generation imaging of extracellular matrix structures in lung airway and related diseases', Pulmonary Pharmacology and Therapeutics, 24 487-496 (2011) [C1]
DOI10.1016/j.pupt.2011.03.008
CitationsScopus - 6Web of Science - 5
2011Knight D, Mutsaers SE, Prele CM, 'STAT3 in tissue fibrosis: Is there a role in the lung?', Pulmonary Pharmacology and Therapeutics, 24 193-198 (2011) [C1]
DOI10.1016/j.pupt.2010.10.005
CitationsScopus - 16Web of Science - 13
2010Murray LA, Kramer MS, Hesson DP, Watkins BA, Fey EG, Argentieri RL, et al., 'Serum amyloid P ameliorates radiation-induced oral mucositis and fibrosis', Fibrogenesis and Tissue Repair, 3 11 (2010) [C1]
DOI10.1186/1755-1536-3-11
CitationsScopus - 15
2010Henderson Jr WR, Chi EY, Ye X, Nguyen C, Tien Y-T, Zhou B, et al., 'Inhibition of Wnt/ß-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis', Proceedings of the National Academy of Sciences of USA, 107 4309-4314 (2010) [C1]
DOI10.1073/pnas.1001520107
CitationsScopus - 122Web of Science - 118
2010Pechkovsky DV, Hackett TL, An SS, Shaheen F, Murray LA, Knight D, 'Human lung parenchyma but not proximal bronchi produces fibroblasts with enhanced TGF-ß signaling and a-SMA expression', American Journal of Respiratory Cell and Molecular Biology, 43 641-651 (2010) [C1]
DOI10.1165/rcmb.2009-0318OC
CitationsScopus - 22Web of Science - 21
2010Stefanowicz D, Hackett T, Pare P, Knight DA, 'Alterations In Histone Acetylation In Asthmatic Airway Epithelial Cells', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 181 (2010) [E3]
Author URL
2010Kicic A, Hallstrand TS, Sutanto EN, Stevens PT, Kobor MS, Taplin C, et al., 'Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium', American Journal of Respiratory and Critical Care Medicine, 181 889-898 (2010) [C1]
DOI10.1164/rccm.200907-1071OC
CitationsScopus - 49Web of Science - 45
2010Gomez P, Hackett TL, Moore MM, Knight D, Tebbutt SJ, 'Functional genomics of human bronchial epithelial cells directly interacting with conidia of Aspergillus fumigatus', BMC Genomics, 11 358 (2010) [C1]
DOI10.1186/1471-2164-11-358
CitationsScopus - 8Web of Science - 10
2009He J-Q, Hallstrand TS, Knight D, Chan-Yeung M, Sandford A, Tripp B, et al., 'A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness', Journal of Allergy and Clinical Immunology, 124 222-229 (2009) [C1]
DOI10.1016/j.jaci.2009.04.018
CitationsScopus - 43Web of Science - 41
2009Hackett T-L, Warner SM, Stefanowicz D, Shaheen F, Pechkovsky DV, Murray LA, et al., 'Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-ß1', American Journal of Respiratory and Critical Care Medicine, 180 122-133 (2009) [C1]
DOI10.1164/rccm.200811-1730OC
CitationsScopus - 119Web of Science - 112
2008Allahverdian S, Harada N, Singhera GK, Knight D, Dorscheid DR, 'Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF', American Journal of Respiratory Cell and Molecular Biology, 38 153-160 (2008) [C1]
DOI10.1165/rcmb.2007-0173OC
CitationsScopus - 46Web of Science - 46
2008Hackett T-L, Shaheen F, Johnson A, Wadsworth S, Pechkovsky DV, Jacoby DB, et al., 'Characterization of side population cells from human airway epithelium', Stem Cells, 26 2576-2585 (2008) [C1]
DOI10.1634/stemcells.2008-0171
CitationsScopus - 60Web of Science - 52
2008Murray LA, Knight D, McAlonan L, Argentieri R, Joshi A, Shaheen F, et al., 'Deleterious role of TLR3 during hyperoxia-induced acute lung injury', American Journal of Respiratory and Critical Care Medicine, 178 1227-1237 (2008) [C1]
DOI10.1164/rccm.200807-1020OC
CitationsScopus - 37
2008Murray LA, Hackett TL, Warner SM, Shaheen F, Argentieri RL, Dudas P, et al., 'BMP-7 does not protect against bleomycin-induced lung or skin fibrosis', PLoS One, 3 4039 (2008) [C1]
DOI10.1371/journal.pone.0004039
CitationsScopus - 35Web of Science - 29
2008Pechkovsky DV, Scaffidi AK, Hackett TL, Ballard J, Shaheen F, Thompson PJ, et al., 'Transforming growth factor ß1 induces avß3 integrin expression in human lung fibroblasts via a ß3 integrin-, c-Src-, and p38 MAPK-dependent pathway', Journal of Biological Chemistry, 283 2898-2908 (2008) [C1]
DOI10.1074/jbc.M708226200
CitationsScopus - 44Web of Science - 42
2008He J-Q, Sandford AJ, Wang I-M, Stepaniants S, Knight D, Kicic A, et al., 'Selection of housekeeping genes for real-time PCR in atopic human bronchial epithelial cells', European Respiratory Journal, 32 755-762 (2008) [C1]
DOI10.1183/09031936.00129107
CitationsScopus - 22Web of Science - 20
2008Stevens PT, Kicic A, Sutanto EN, Knight D, Stick SM, 'Dysregulated repair in asthmatic paediatric airway epithelial cells: The role of plasminogen activator inhibitor-1', Clinical and Experimental Allergy, 38 1901-1910 (2008) [C1]
DOI10.1111/j.1365-2222.2008.03093.x
CitationsScopus - 36Web of Science - 30
2007Lang C, Murgia C, Leong M, Tan L-W, Perozzi G, Knight D, et al., 'Anti-inflammatory effects of zinc and alterations in zinc transporter mRNA in mouse models of allergic inflammation', American Journal of Physiology: Lung Cellular and Molecular Physiology, 292 L577-L584 (2007) [C1]
DOI10.1152/ajplung.00280.2006
CitationsScopus - 56Web of Science - 47
2007McWhinnie R, Pechkovsky DV, Zhou D, Lane D, Halayko AJ, Knight D, Bai TR, 'Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells', American Journal of Physiology: Lung Cellular and Molecular Physiology, 292 L278-L286 (2007) [C1]
DOI10.1152/ajplung.00111.2006
CitationsScopus - 37Web of Science - 36
2007Bateman RM, Hodgson KC, Kohli K, Knight D, Walley KR, 'Endotoxemia increases the clearance of mPEGylated 5000-MW quantum dots as revealed by multiphoton microvascular imaging', Journal of Biomedical Optics, 12 (2007) [C1]
DOI10.1117/1.2822882
CitationsScopus - 7Web of Science - 7
2006Moeller A, Horak Jr F, Lane C, Knight D, Kicic A, Brennan S, et al., 'Inducible NO synthase expression is low in airway epithelium from young children with cystic fibrosis', Thorax, 61 514-520 (2006) [C1]
DOI10.1136/thx.2005.054643
CitationsScopus - 32
2006Petrovic N, Knight D, Bomalaski JS, Thompson PJ, Misso NLA, 'Concomitant activation of extracellular signal-regulated kinase and induction of COX-2 stimulates maximum prostaglandin E2 synthesis in human airway epithelial cells', Prostaglandins and Other Lipid Mediators, 81 126-135 (2006) [C1]
DOI10.1016/j.prostaglandins.2006.08.006
CitationsScopus - 9Web of Science - 8
2006Knight D, 'Editorial: New drug targets for the treatment of asthma', Current Drug Targets, 7 523-523 (2006) [C1]
DOI10.2174/138945006776818665
2006Knight DA, 'New Drug Targets for the Treatment of Asthma', Current Drug Targets, 7 523-523 (2006) [C1]
DOI10.2174/138945006776818665
2006Kicic A, Sutanto EN, Stevens PT, Knight D, Stick SM, 'Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma', American Journal of Respiratory and Critical Care Medicine, 174 1110-1118 (2006) [C1]
DOI10.1164/rccm.200603-392OC
CitationsWeb of Science - 67
2005O'Hara KA, Kedda M-A, Fogel-Petrovic M, Thompson PJ, Abraham LJ, Knight DA, 'Characterization of the Human Oncostatin M (OSM) Receptort Sub-Unit, OSMBR', INFLAMMATION RESEARCH, 54 S157-S157 (2005)
Author URL
2005Fonceca AM, Sutanto EN, Kicic A, Knight DA, Stick SM, 'Cellular microenvironment: A defining role for TLR4 location and expression in vivo', INFLAMMATION RESEARCH, 54 S187-S187 (2005)
Author URL
2005Lee YCG, Knight DA, Lane KB, Cheng DS, Koay MA, Teixeira LR, et al., 'Activation of proteinase-activated receptor-2 in mesothelial cells induces pleural inflammation', American Journal of Physiology: Lung Cellular and Molecular Physiology, 288 L734-L740 (2005) [C1]
DOI10.1152/ajplung.00173.2004
CitationsScopus - 12Web of Science - 8
2005Weichselbaum M, Sparrow MP, Hamilton EJ, Thompson PJ, Knight DA, 'A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium', Respiratory Research, 6 1-30 (2005) [C1]
DOI10.1186/1465-9921-6-115
CitationsScopus - 26Web of Science - 23
2005Lane C, Burgess S, Kicic A, Knight DA, Stick S, 'The use of non-bronchoscopic brushings to study the paediatric airway', Respiratory Research, 6 1-10 (2005) [C1]
DOI10.1186/1465-9921-6-53
CitationsScopus - 19
2004Scaffidi AK, Petrovic N, Moodley YP, Fogel-Petrovic M, Kroeger KM, Seeber RM, et al., 'avß3 integrin interacts with the transforming growth factor ß (TGFß) type II receptor to potentiate the proliferative effects of TGFß1 in living human lung fibroblasts', Journal of Biological Chemistry, 279 7726-7733 (2004) [C1]
DOI10.1074/jbc.M403010200
CitationsScopus - 59Web of Science - 54
2004Moodley YP, Caterina P, Scaffidi AK, Misso NL, Papadimitrou JM, McAnulty RJ, et al., 'Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL-induced apoptosis', Journal of Pathology, 202 486-495 (2004) [C1]
DOI10.1002/path.1531
CitationsScopus - 55Web of Science - 49
2004Lane C, Burgess S, Franklin P, Horak F, Legg J, Moeller A, et al., 'Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath', Thorax, 59 757-760 (2004) [C1]
DOI10.1136/thx.2003.014894
CitationsScopus - 116
2004Fogel-Petrovic M, Long JA, Knight DA, Thompson PJ, Upham JW, 'Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2', Immunology and Cell Biology, 82 47-54 (2004) [C1]
DOI10.1111/j.1440-1711.2004.01213.x
CitationsScopus - 29Web of Science - 25
2004Long JA, Fogel-Petrovic M, Knight DA, Thompson PJ, Upham JW, 'Higher prostaglandin E2 production by dendritic cells from subjects with asthma compared with normal subjects', American Journal of Respiratory and Critical Care Medicine, 170 485-491 (2004) [C1]
DOI10.1164/rccm.200311-1595OC
CitationsWeb of Science - 22
2004Knight DA, Lane CL, Stick SM, 'Does aberrant activation of the epithelial-mesenchymal trophic unit play a key role in asthma or is it an unimportant sideshow?', Current Opinion in Pharmacology, 4 251-256 (2004) [C1]
DOI10.1016/j.coph.2004.02.002
CitationsScopus - 26Web of Science - 24
2003Moodley Y, Rigby P, Bundell C, Bunt S, Hayashi H, Misso N, et al., 'Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36', American Journal of Pathology, 162 771-779 (2003) [C1]
CitationsScopus - 68
2003Laurent GJ, Mutsaers SE, Thompson PJ, Knight DA, Moodley YP, Scaffidi AK, et al., 'Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation', American Journal of Pathology, 163 345-354 (2003) [C1]
CitationsScopus - 64Web of Science - 59
2003Moodley YP, Misso NLA, Scaffidi AK, Fogel-Petrovic M, McAnulty RJ, Laurent GJ, et al., 'Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs', American Journal of Respiratory Cell and Molecular Biology, 29 490-498 (2003) [C1]
DOI10.1165/rcmb.2002-0262OC
2002Asokananthan N, Graham PT, Fink J, Knight DA, Bakker AJ, McWilliam AS, et al., 'Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E 2 release from human respiratory epithelial cells', Journal of Immunology, 168 3577-3585 (2002) [C1]
CitationsScopus - 254Web of Science - 245
2002Knight DA, 'Increased permeability of asthmatic epithelial cells to pollutants. Does this mean that they are intrinsically abnormal?', Clinical and Experimental Allergy, 32 1263-1265 (2002) [C1]
DOI10.1046/j.1365-2745.2002.01486.x
2002Scaffidi AK, Mutsaers SE, Moodley YP, McAnulty RJ, Laurent GJ, Thompson PJ, Knight DA, 'Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts', British Journal of Pharmacology, 136 793-801 (2002) [C1]
CitationsWeb of Science - 39
2001Lan RS, Knight DA, Stewart GA, Henry PJ, 'Role of PGE 2 in protease-activated receptor-1, -2 and -4 mediated relaxation in the mouse isolated trachea', British Journal of Pharmacology, 132 93-100 (2001) [C1]
CitationsScopus - 56Web of Science - 57
2001Scaffidi AK, Moodley YP, Weichselbaum M, Thompson PJ, Knight DA, 'Regulation of human lung fibroblast phenotype and function by vitronectin and vitronectin integrins', Journal of Cell Science, 114 3507-3516 (2001) [C1]
CitationsScopus - 46Web of Science - 45
2001Knight DA, Lim S, Scaffidi AK, Roche N, Chung KF, Stewart GA, Thompson PJ, 'Protease-activated receptors in human airways: Upregulation of PAR-2 in respiratory epithelium from patients with asthma', Journal of Allergy and Clinical Immunology, 108 797-803 (2001) [C1]
DOI10.1067/mai.2001.119025
CitationsScopus - 170Web of Science - 162
2001Knight DA, 'Epithelium-fibroblast interactions in response to airway inflammation', Immunology and Cell Biology, 79 160-164 (2001) [C1]
DOI10.1046/j.1440-1711.2001.00988.x
CitationsScopus - 76
2001Tulic MK, Knight DA, Holt PG, Sly PD, 'Lipopolysaccharide inhibits the late-phase response to allergen by altering nitric oxide synthase activity and interleukin-10', American Journal of Respiratory Cell and Molecular Biology, 24 640-646 (2001) [C1]
CitationsScopus - 27Web of Science - 23
2001Knight DA, 'Leukaemia Inhibitory Factor (LIF): A cytokine of emerging importance in chronic airway inflammation', Pulmonary Pharmacology and Therapeutics, 14 169-176 (2001) [C1]
DOI10.1006/pupt.2001.0282
CitationsScopus - 27
2001Thompson PJ, Asokananthan N, Knight DA, Stewart GA, 'Protease-activated receptors and the airway epithelium', Clinical and Experimental Allergy Reviews, 1 107-110 (2001) [C1]
DOI10.1046/j.1472-9725.2001.00018.x
CitationsScopus - 4
2000Knight DA, Asokananthan N, Watkins DN, Misso NLA, Thompson PJ, Stewart GA, 'Oncostatin M synergises with house dust mite proteases to induce the production of PGE 2 from cultured lung epithelial cells', British Journal of Pharmacology, 131 465-472 (2000) [C1]
CitationsScopus - 15Web of Science - 14
2000Knight DA, D'Aprile AC, Spalding LJ, Goldie RG, Thompson PJ, 'Leukaemia inhibitory factor (LIF) upregulates excitatory non-adrenergic non-cholinergic and maintains cholinergic neural function in tracheal explants', British Journal of Pharmacology, 130 975-979 (2000) [C1]
CitationsScopus - 11Web of Science - 9
1999Zheng XY, Knight DA, Zhou DY, Weir TD, Peacock C, Schellenberg RR, Bai TR, 'Leukemia inhibitory factor is synthesized and released by human eosinophils and modulates activation state and chemotaxis', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 104 136-144 (1999)
DOI10.1016/S0091-6749(99)70125-9Author URL
CitationsScopus - 23Web of Science - 19
1999Knight D, Bai T, 'Roles for leukemia inhibitory factor in lung biology', Drug News and Perspectives, 12 261-269 (1999)

Leukemia inhibitory factor (LIF) is a multifunctional polypeptide cytokine/growth factor. It displays biological activities ranging from the differentiation of myeloid leukemic ce... [more]

Leukemia inhibitory factor (LIF) is a multifunctional polypeptide cytokine/growth factor. It displays biological activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin-6 (IL-6) family of cytokines. A variety of specific agents are known to induce the transcription and release of LIF; however, the agents that inhibit the cellular production of LIF and their mechanisms of actions have not been extensively studied. In vivo studies have revealed that LIF is absolutely essential for fetal development; it also plays a role in sepsis, arthritis, hematopoiesis, in the cardiovascular system, and in the central nervous system and peripheral nervous tissue, as well as in local regulation of airway inflammation. Furthermore, new data suggest that under conditions of neural injury, kidney damage or fertility abnormalities, LIF may be a useful therapeutic agent. However, before these hypotheses are realized, much more research is required into understanding its physiology and control.

DOI10.1358/dnp.1999.12.5.863620
CitationsScopus - 2
1999Watkins DN, Peroni DJ, Lenzo JC, Knight DA, Garlepp MJ, Thompson PJ, 'Expression and localization of COX-2 in human airways and cultured airway epithelial cells', EUROPEAN RESPIRATORY JOURNAL, 13 999-1007 (1999)
DOI10.1034/j.1399-3003.1999.13e12.xAuthor URL
CitationsWeb of Science - 36
1999Knight DA, Lydell CP, Zhou DY, Weir TD, Schellenberg RR, Bai TR, 'Leukemia inhibitory factor (LIF) and LIF receptor in human lung distribution and regulation of LIF release', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 20 834-841 (1999)
Author URL
CitationsWeb of Science - 44
1999Thompson PJ, Knight DA, Nithinanthan A, Stewart GA, 'The presence of proteinase activated receptors (PAR) in cultured human airway epithelial cells: Differential effects on PGE(2) release.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A98-A98 (1999)
Author URL
CitationsWeb of Science - 4
1999Knight DA, Nithinanthan A, Watkins DN, Thompson PJ, Stewart GA, 'Synergy between oncostatin M (OSM) and house dust mite (HDM) allergens in stimulating PGE(2) release from epithelial cells.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A334-A334 (1999)
Author URL
1999Knight DA, D'Aprile AC, Thompson PJ, Goldie RG, 'Leukemia inhibitory factor (LIF) but not oncostatin M (OSM) upregulates eNANC and maintains cholinergic neural activity in tracheal explants.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A334-A334 (1999)
Author URL
1999Knight D, Nithiananthan A, Thompson P, Stewart G, 'The presence of proteinase activated receptors (PAR) in cultured human airway epithelial cells: Differential effects on PGE2 release', Respirology, 4 (1999)

PAR are a recently identified family of G-protein linked receptors which activate a variety of cellular functions, once cleaved by proteinases. To date, 4 PAR have been identified... [more]

PAR are a recently identified family of G-protein linked receptors which activate a variety of cellular functions, once cleaved by proteinases. To date, 4 PAR have been identified and differentiated by their activation by different proteinases. We examined the presence of PAR mRNA and the effects of activation of PARs by specific activating peptides using the human cultured lung epithelial cell line A549. Methods: Serum-depleted A549 cells were exposed to the active peptide (6 amino acids) or control peptide. The presence of specific PAR mRNA was examined by RT-PCR. Cells were exposed to activating peptides for PAR 1-4 at concentrations of 50 and 500 nM and after 48 hr PGE2 was measured by EIA. Results: The presence of mRNA for PAR was confirmed following 40 cycles of RT-PCR. Unstimulated cells produced 14.3±3 pg of PGEz/105 cells. Exposure to activating peptides for PAR 1 and 2 produced a dose-dependent increase in PGEz production with the rank order of PAR-2>PAR-1. Maximal activation of PAR-2 produced 37±5 pg/105 cells (p<0.05). Activation of PAR-3 and PAR-4 did not evoke the release of significant amounts of PGEz compared to control levels. Similarly, exposure to the inactive peptides did not induce significant levels of PGEz production. Conclusion: These results demonstrate firstly that PAR are present on cultured human airway epithelial cells and that activation of PAR2 will preferentially lead to PGEz release. The release of PGEz following activation of PAR-2 by proteinases may represent a mechanism which serves to dampen proteolytic damage that may occur during airway inflammation.

1999Knight D, Lenzo J, James A, Thompson P, Carroll N, 'Localisation of oncostatin M receptors (OSMR) in human airways by immunohistochemistry: Altered pattern of distribution in asthma', Respirology, 4 (1999)

Oncostatin M (OSM) is a member of the IL-6 family of cytokines and to date has been demonstrated to be released by activated T-cells and macrophages. OSM is a potent inducer of ep... [more]

Oncostatin M (OSM) is a member of the IL-6 family of cytokines and to date has been demonstrated to be released by activated T-cells and macrophages. OSM is a potent inducer of epithelial anti-proteinases as well as tissue inhibitor of metalloproteinases, suggesting an anti-proteolytic function. However, the distribution of OSMR in human airways is unknown. We hypothesised that due to these effects, OSMR would be present in human airway epithelium and that the expression and pattern of OSMR distribution would be upregulated in asthma. Methods: Transverse sections (n=3) of large airways were obtained at autopsy from cases of fatal asthma (FA, n=7) and from non-smoking controls (con, n=4). Sections were stained for OSMR using a specific polyclonal antibody (provided by Immunex, Seattle, WA). Positive staining for OSMR was scored semi-quantitatively for intensity (0-4) and distribution (0-4) in the epithelium (epi), basement membrane (bm), smooth muscle (asm), sub-mucosal glands (smg), vasculature (bv), mononuclear (mono) and multinuclear cells (poly) Results: The mean ±S.D. scoring intensity is shown below. epi bm asm smg bv mono, poly FA T3±1.3# T5±1.6 2.8±1.8# 1.4±0.7 1.9±1~5~ 2.0±12~ 0.3±1.1 Con 0.6±1.2 1.4±1.6 1.1±1.8 1.2±1.8 1.3+1.8 1.6±1.5 0.3±1.1 #P<0.01 vs con. The distribution of staining score showed similar trends. Conclusion: These results show for the first time that OSMR are present in human airways and that the pattern of expression is altered in asthma. The distribution of staining suggests that OSM may play an important role in airway inflammation associated with asthma.

1999Knight D, Zheng X, Bai T, Thompson P, 'Leukemia inhibitory factor is synthesised and released by human eosinophils and modulates their activation state', Respirology, 4 (1999)

Recently we have demonstrated that: LI F modulates the chemotactic activity of eosinophils (Eos) to tachykinins; LIF is released by several cell types in human airways adjacent to... [more]

Recently we have demonstrated that: LI F modulates the chemotactic activity of eosinophils (Eos) to tachykinins; LIF is released by several cell types in human airways adjacent to tachykinin-containing nerves in response to inflammatory stimuli and that LIF receptors are localized to numerous cell types including Eos. However, it is not known whether Eos themselves produce LIF and whether LIF has an autocrine role on Eos function. Methods: Peripheral blood Eos were purified from 5 healthy atopic and 5 non-atopic donors by negative selection using immunomagnetic beads with purity > 97%. Expression of LIF and LIF receptor (LIFR) mRNA was assessed by RT-PCR. Release of LIF and eosinophil peroxidase (EPO) was measured by ELISA and colorimetric analysis respectively. Results: LIF and LIFR mRNA was observed in Eos taken from normal and atopic volunteers. However, Eos taken from non-atopies did not spontaneously release LIF and only 5.3±1.8 pg/10B cells was measured in response to stimulation with calcium ionophore. In contrast, Eos taken from atopic volunteers had a higher basal release of LIF (45±38 pg/106 cells) and stimulation with calcium ionophore induced a 10-fold increase in LIF production (415±190 pg/10e cells, p<0.05) within 30 min. Pré-incubation of Eos with LIF (5ng/ml) for 1 hr increased the release of EPO by 4-fold and increased the expression of the activation marker CD69. Conclusion: These data demonstrate that human eosinophils synthesise, store and release LIF and the amounts are influenced by the atopic status of the individual. By augmenting the release of EPO and CD69 expression, the results suggest that LIF may have pro-inflammatory functions in eosinophil dependent airway diseases.

1997Knight D, McKay K, Wiggs B, Schellenberg R, Bai T, 'Localization of leukaemia inhibitory factor to airway epithelium and its amplification of contractile responses to tachykinins', British Journal of Pharmacology, 120 883-891 (1997)

1. In neural tissue, leukaemia inhibitory factor (LIF) is an important trophic cytokine. In this investigation, we determined if LIF was present in human and guinea-pig airways an... [more]

1. In neural tissue, leukaemia inhibitory factor (LIF) is an important trophic cytokine. In this investigation, we determined if LIF was present in human and guinea-pig airways and examined the role of this cytokine in modulating airway responses to endogenous and exogenous tachykinins as well as muscarinic receptor and ß-adrenoceptor stimulation. 2. The presence of LIF in both human and guinea-pig airways was determined by immunohistochemistry. Guinea-pig tracheal explants were incubated in CRML-1066 media containing LIF (0.5, 5 or 50 ng ml-1) for periods of 3, 6, 24 and 48 h. Tracheal rings were then transferred to organ baths for measurement of isometric force in response to carbachol, capsaicin, the neurokinin, (NK1) receptor agonist [Sar9,Met(O2)11]-substance P (SP), the NK2 receptor agonist neurokinin A (NKA) and isoprenaline. 3. LIF immunoreactivity was observed primarily in basally situated cells in the airway epithelium of both large and small airways. Less intense immunoreactivity was observed in vascular endothelium and glandular epithelium. 4. Treatment with LIF (0.5 ng ml-1) for 3 and 6 h significantly increased contractile responses to capsaicin by 42% and 43%, respectively, compared to time controls, whereas higher concentrations of LIF (5 and 50 ng ml-1) enhanced capsaicin-induced contractions only after 6 h. After 24 h, responses to capsaicin were not significantly different from 0 h control. Contractile responses to capsaicin following exposure to LIF at any concentration for 24 h were not significantly different from relative time control values. 5. Responses to [Sar9,Met()O2)11]-SP, carbachol and isoprenaline were not influenced by time in culture or by exposure to LIF for up to 48 h. Contractile responses induced by NKA were not influenced by 3 or 6 h exposure to LIF, but at 24 and 48 h the mean maximum contractile responses to NKA were significantly increased by 33% and 35%, respectively, compared to control. 6. These results demonstrate that LIF is present in guinea-pig and human airway epithelium, and modulates airway responses to tachykinins. In the acute setting LIF augments the capsaicin-induced release of endogenous tachykinins, whilst in the longer term (> 24 h), LIF increases airway smooth muscle responses to tachykinins via an NK2 receptor selective mechanism. We conclude that LIF may be an important effector molecule in the response of airways to injury or inflammation.

DOI10.1038/sj.bjp.0700965
CitationsScopus - 22
1997Knight DA, Stewart GA, Thompson PJ, 'Histamine-induced contraction of human isolated bronchus is enhanced by endogenous prostaglandin F-2 alpha and activation of TP receptors', EUROPEAN JOURNAL OF PHARMACOLOGY, 319 261-267 (1997)
DOI10.1016/S0014-2999(96)00870-9Author URL
CitationsScopus - 3Web of Science - 2
1997Knight D, Zheng X, Rocchini C, Jacobson M, Bai T, Walker B, 'Adenosine A 3 receptor stimulation inhibits migration of human eosinophils', Journal of Leukocyte Biology, 62 465-468 (1997)

Activation of adenosine A 3 receptors (A 3-R) produced a dose-dependent reduction in the chemotaxis of human eosinophils to platele... [more]

Activation of adenosine A

3 receptors (A

3-R) produced a dose-dependent reduction in the chemotaxis of human eosinophils to platelet-activating factor (PAF), RANTES, and leukotriene B

4 (LTB

4) to a maximum of 58, 48, and 52%, respectively (P< 0.02). This effect was completely reversed by selective A

3-R antagonists. In contrast, activation of A

1 or A(2a)-R did not affect PAF-induced eosinophil chemotaxis. PAF up-regulated the expression of CDllb/CD18, down-regulated L-selectin, and also increased F-actin assembly in eosinophils. The expression of these activation markers was not influenced by A

3-R, A(2a), or A

1-R stimulation. Activation of A

3-R may play an important role in inflammation by inhibiting eosinophil migration.

CitationsScopus - 81
1997Walker BAM, Jacobson MA, Knight DA, Salvatore CA, Weir T, Zhou DY, Bai TR, 'Adenosine A(3) receptor expression and function in eosinophils', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 16 531-537 (1997)
Author URL
CitationsWeb of Science - 128
1995KNIGHT DA, STEWART GA, LAI ML, THOMPSON PJ, 'EPITHELIUM-DERIVED INHIBITORY PROSTAGLANDINS MODULATE HUMAN BRONCHIAL SMOOTH-MUSCLE RESPONSES TO HISTAMINE', EUROPEAN JOURNAL OF PHARMACOLOGY, 272 1-11 (1995)
DOI10.1016/0014-2999(94)00601-3Author URL
CitationsWeb of Science - 20
1995KNIGHT DA, STEWART GA, THOMPSON PJ, 'PROSTAGLANDIN E(2), BUT NOT PROSTACYCLIN INHIBITS HISTAMINE-INDUCED CONTRACTION OF HUMAN BRONCHIAL SMOOTH-MUSCLE', EUROPEAN JOURNAL OF PHARMACOLOGY, 272 13-19 (1995)
DOI10.1016/0014-2999(94)00602-4Author URL
CitationsWeb of Science - 24
1994KNIGHT DA, STEWART GA, THOMPSON PJ, 'THE RESPIRATORY EPITHELIUM AND AIRWAY SMOOTH-MUSCLE HOMEOSTASIS - ITS RELEVANCE TO ASTHMA', CLINICAL AND EXPERIMENTAL ALLERGY, 24 698-706 (1994)
DOI10.1111/j.1365-2222.1994.tb00980.xAuthor URL
CitationsWeb of Science - 13
1993KNIGHT DA, THOMPSON PJ, STEWART GA, 'PGE2 BUT NOT PGI2 ACCOUNTS FOR THE INHIBITORY EFFECT OF PROSTAGLANDINS (PG) IN HISTAMINE TACHYPHYLAXIS (HT) ON HUMAN BRONCHIAL SMOOTH-MUSCLE (HBSM)', AMERICAN REVIEW OF RESPIRATORY DISEASE, 147 A449-A449 (1993)
Author URL
CitationsWeb of Science - 1
1992KNIGHT DA, STEWART GA, THOMPSON PJ, 'HISTAMINE TACHYPHYLAXIS IN HUMAN AIRWAY SMOOTH-MUSCLE - THE ROLE OF H-2-RECEPTORS AND THE BRONCHIAL EPITHELIUM', AMERICAN REVIEW OF RESPIRATORY DISEASE, 146 137-140 (1992)
Author URL
CitationsScopus - 22Web of Science - 24
1991KNIGHT DA, PHILLIPS MJ, STEWART GA, THOMPSON PJ, 'THE INTERACTION OF ACETYLCHOLINE AND HISTAMINE ON HUMAN BRONCHIAL SMOOTH-MUSCLE CONTRACTION', EUROPEAN RESPIRATORY JOURNAL, 4 985-991 (1991)
Author URL
CitationsWeb of Science - 7
1988FERNANDES LB, KNIGHT DA, RIGBY PJ, SPINA D, PATERSON JW, GOLDIE RG, 'BETA-ADRENOCEPTOR DESENSITIZATION IN GUINEA-PIG ISOLATED TRACHEA', EUROPEAN JOURNAL OF PHARMACOLOGY, 157 135-145 (1988)
DOI10.1016/0014-2999(88)90376-7Author URL
CitationsScopus - 15Web of Science - 22
Show 106 more journal articles

Review (15 outputs)

YearCitationAltmetricsLink
2012Roth HM, Wadsworth SJ, Kahn M, Knight DA, 'The airway epithelium in asthma: Developmental issues that scar the airways for life?', Pulmonary Pharmacology and Therapeutics (2012) [D1]
DOI10.1016/j.pupt.2012.09.004
CitationsScopus - 1Web of Science - 2
2012Knight D, Yang IA, Ko FWS, Lim TK, 'Year in review 2011: Asthma, chronic obstructive pulmonary disease and airway biology', Respirology (2012) [D1]
DOI10.1111/j.1440-1843.2012.02126.x
CitationsScopus - 4Web of Science - 4
2011Hirota JA, Hackett T-L, Inman MD, Knight D, 'Modeling asthma in mice: What have we learned about the airway epithelium?', American Journal of Respiratory Cell and Molecular Biology (2011) [D1]
DOI10.1165/rcmb.2010-0146TR
CitationsScopus - 14Web of Science - 11
2011Reddel HK, Lim TK, Mishima M, Wainwright CE, Knight D, 'Year-in-review 2010: Asthma, COPD, cystic fibrosis and airway biology', Respirology (2011) [D1]
DOI10.1111/j.1440-1843.2011.01949.x
CitationsScopus - 2Web of Science - 1
2010Knight D, Rossi FM, Hackett T-L, 'Mesenchymal stem cells for repair of the airway epithelium in asthma', Expert Review of Respiratory Medicine (2010) [D1]
DOI10.1586/ers.10.72
CitationsScopus - 5
2010Hackett TL, Knight D, Sin DD, 'Potential role of stem cells in management of COPD', International Journal of COPD (2010) [D1]
CitationsScopus - 10
2008Warner SM, Knight D, 'Airway modeling and remodeling in the pathogenesis of asthma', Current Opinion in Allergy and Clinical Immunology (2008) [D1]
DOI10.1097/ACI.0b013e3282f3b5cb
CitationsScopus - 28Web of Science - 23
2007An SS, Bai TR, Bates JHT, Black JL, Brown RH, Brusasco V, et al., 'Airway smooth muscle dynamics: A common pathway of airway obstruction in asthma', European Respiratory Journal (2007) [D1]
DOI10.1183/09031936.00112606
CitationsScopus - 185Web of Science - 185
2007Hackett T-L, Knight D, 'The role of epithelial injury and repair in the origins of asthma', Current Opinion in Allergy and Clinical Immunology (2007) [D1]
DOI10.1097/ACI.0b013e328013d61b
CitationsScopus - 59Web of Science - 49
2005Bai TR, Knight DA, 'Structural changes in the airways in asthma: Observations and consequences', Clinical Science: an international journal of translational science and medicine (2005) [D1]
DOI10.1042/CS20040342
CitationsScopus - 92Web of Science - 86
2004Knight DA, 'Talniflumate (Genaera)', Current Opinion in Investigational Drugs (Print) (2004) [D1]
CitationsScopus - 10
2004Mutsaers SE, McAnulty RJ, Laurent GJ, Knight DA, 'Evaluation of experimental models of idiopathic pulmonary fibrosis', Drug Discovery Today: Disease Models (2004) [D1]
DOI10.1016/j.ddmod.2004.11.007
CitationsScopus - 7
2003Knight DA, Ernst M, Anderson GP, Moodley YP, Mutsaers SE, 'The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: Critical determinants of disease susceptibility and progression?', Pharmacology & Therapeutics (2003) [D1]
DOI10.1016/S0163-7258(03)00095-0
CitationsScopus - 23Web of Science - 24
2003O'Hara KA, Kedda M-A, Thompson PJ, Knight DA, 'Oncostatin M: An interleukin-6-like cytokine relevant to airway remodelling and the pathogenesis of asthma', Clinical and Experimental Allergy (2003) [D1]
DOI10.1046/j.1365-2222.2003.01714.x
2003Knight DA, Holgate ST, 'The airway epithelium: Structural and functional properties in health and disease', Respirology (2003) [D1]
DOI10.1046/j.1440-1843.2003.00493.x
CitationsScopus - 212Web of Science - 190
Show 12 more reviews

Conference (13 outputs)

YearCitationAltmetricsLink
2014Goggins B, Minahan K, Marks E, Mateer S, Cardona J, Knight D, et al., 'Hypoxia inducible factor (HIF)-1 accelerates epithelial wound healing through integrin regulation', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsJay Horvat
2014Starkey M, Hanish I, Dua K, Nair P, Haw T, Hsu A, et al., 'Interleukin-13 predisposes mice to more severe influenza infection by suppressing interferon responses and activating microRNA-21/PI3K', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
DOI10.1016/j.cyto2014.07.182Author URL
Co-authorsPeter Wark, Philip Hansbro, Alan Hsu, Malcolm Starkey, Jay Horvat, Paul Foster
2014Garratt LW, Sutanto EN, Ling KM, Looi K, Kicic-Starcevich E, Iosifidis T, et al., 'IDENTIFICATION OF MMP DYSREGULATION IN EARLY CF - EVIDENCE BASED RATIONALE FOR ANTI-PROTEASE THERAPY', RESPIROLOGY (2014) [E3]
Author URL
2013Looi K, Larcombe A, Zosky G, Rigby P, Knight DA, Stick SM, Kicic A, 'HUMAN RHINOVIRUS INFECTION INITIATES AIRWAY EPITHELIAL TIGHT JUNCTION DISASSEMBLY RESULTING IN BARRIER FUNCTION DISRUPTION', RESPIROLOGY (2013) [E3]
Author URL
2013Looi K, Larcombe A, Zosky G, Rigby P, Knight DA, Stick SM, Kicic A, 'HUMAN RHINOVIRUS INFECTION OF ASTHMATIC AIRWAY EPITHELIAL CELLS CAUSES TIGHT JUNCTION DISASSEMBLY RESULTING IN INCREASED PERMEABILITY', RESPIROLOGY (2013) [E3]
DOI10.1111/resp.12183_18Author URL
2011Abraham T, Hirota J, Elliot M, Knight D, Hogg J, 'How Multiphoton and Harmonic Generation Microscopy Methods are Useful in Understanding Lung Structure and Related Diseases', Microscopy and Microanalysis, Nashville, Tennessee, USA (2011) [E1]
DOI10.1017/S1431927611002261
2010O'Donoghue RJJ, Knight DA, Jarnicki AG, Jones J, Anderson GP, Mutsaers SE, Ernst M, 'Interleukin-6-induced STAT3 signaling links inflammation to chronic lung disease in mice', CYTOKINE, Chicago, IL (2010) [E3]
DOI10.1016/j.cyto.2010.07.317Author URL
2010Cooper DM, Hackett TL, Boivin WA, Knight DA, Granville DJ, 'Granzymes and Wound Repair', ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, San Francisco, CA (2010) [E3]
Author URL
2009Pechkovsky DV, Hackett TL, Shaheen F, Hogaboam CM, Selman M, McAnulty RJ, et al., 'Altered Level of STAT3 Basal Activity Influences Lung Fibroblast Thy-1 and alpha v beta 3 Integrin Expression', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
Author URL
2009Shaheen F, Hackett TL, Knight DA, Pechkovsky DV, 'Blockade of ALK5 in Normal Lung Parenchymal Fibroblasts Inhibits Exaggerated Smad3 and JNK Signaling and Reverses Their Myofibroblast-Like Phenotype Compared with Paired Bronchial Wall-Derived Fibroblasts.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
Author URL
2009Stefanowicz D, Hackett T-L, Avila L, Neumann S, Kicic A, Stick S, et al., 'DNA Methylation Profiles of Asthmatic Airway Epithelial Cells.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
Author URL
2009Hackett T-L, Stefanowicz D, Shaheen F, Pechkovsky D, Warner SM, Murray L, et al., 'Epithelial-Mesenchymal Transition Occurs in Undifferentiated Basal Airway Epithelial Cells Derived from Normal and Asthmatic Subjects.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
Author URL
2002Lee YCG, Knight DA, Lane KB, Cheng DS, Koay MA, Teixeira IR, et al., 'Activation of protease activated receptor-2 in mesothelial cells: A novel mechanism of pleural inflammation', THORAX, LONDON, ENGLAND (2002)
Author URL
Show 10 more conferences
Edit

Grants and Funding

Summary

Number of grants51
Total funding$9,074,507

Click on a grant title below to expand the full details for that specific grant.


20152 grants / $1,101,476

Modifying epigenetics as a novel treatment in COPD$1,076,254

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Professor Darryl Knight, Conjoint Professor Peter Wark, Professor Ian Adcock
SchemeProject Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1400006
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Do viral infection and bronchoconstriction interact during exacerbation of asthma prolonging viral infection and worsening disease in the long term?$25,222

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamConjoint Associate Professor Christopher Grainge, Professor Darryl Knight
SchemeResearch Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1500546
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20147 grants / $822,221

A novel approach to understanding Asthma: Focus on the epithelium $617,209

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Professor Stephen Stick, Dr Anthony Kicic
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300212
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The Nanostring nCounter System$75,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeMajor Equipment Award
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300853
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

The Nanostring nCounter System$40,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeEquipment Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1301083
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Mechanisms of dysregulated antiviral signallings to influenza infection in chronic obstructive pulmonary disease$27,512

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamDoctor Alan Hsu, Doctor Fatemeh Moheimani, Professor Darryl Knight, Conjoint Professor Peter Wark
SchemeResearch Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1400435
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Do asthma attacks worsen asthma in the long term?$22,500

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Associate Professor Christopher Grainge, Professor Darryl Knight
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1401402
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

The Nanostring nCounter System$20,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeResearch Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1301084
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Immunosenescence in chronic obstructive pulmonary disease leads to abnormal innate immune responses to human rhinovirus infection$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Wark, Professor Darryl Knight
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301331
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20132 grants / $605,430

Defective cell migration as a mechanism of dysregulated asthmatic airway repair$595,430

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleInvestigator
Funding Start2013
Funding Finish2015
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

Role of the transcriptional co-activator p300 in resetting epithelial differentiation: A potential pathway involved in asthma prevention and therapy$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Fatemeh Moheimani, Professor Darryl Knight, Miss Kirsty Wark, Doctor Alan Hsu, Doctor Malcolm Starkey
SchemeEarly Career Researcher Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1301174
Type Of FundingInternal
CategoryINTE
UONY

20121 grants / $510,000

Airway epithelial barrier function, asthma and aero?allergen sensitization.$510,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2014
GNo
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20113 grants / $258,465

Inhaled Corticosteroids as risk factors for severe viral infections in asthmatics: lessons from the H1N1 epidemic$130,558

Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project Team
SchemeOperating Grant
RoleInvestigator
Funding Start2011
Funding Finish2013
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

Resetting epithelial differentiation as a novel therapeutic approach to treating asthma$120,407

Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project Team
SchemeOperating Grant
RoleLead
Funding Start2011
Funding Finish2013
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

Heart and Lung Health FEST 2011$7,500

Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project Team
SchemeMeetings, Planning and Dissemination Grant: Circulatory and Respiratory Health
RoleLead
Funding Start2011
Funding Finish2011
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

20103 grants / $144,155

Exacerbation of H1N1 Influenza infection with inhaled therapeutics in primary epithelial cells and ex vivo tissue from asthma patients: clarification of primary treatment strategies during pandemic in$94,155

Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project Team
SchemeOperating Grant: Health Systems Research on H1N1
RoleLead
Funding Start2010
Funding Finish2011
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

Defining phenotypes of fibroblasts within the human airways and lung parenchyma for better understanding of fibrotic diseases$25,000

Funding body: British Columbia Lung Association

Funding bodyBritish Columbia Lung Association
Project Team
SchemeFunds Granted
RoleInvestigator
Funding Start2010
Funding Finish2012
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

New emerging paradigm in asthma: The role of E-cadherin in aberrant airway epithelial repair$25,000

Funding body: British Columbia Lung Association

Funding bodyBritish Columbia Lung Association
Project Team
SchemeFunds Granted
RoleInvestigator
Funding Start2010
Funding Finish2012
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

20093 grants / $948,449

Dysregulated STAT-3 activation underlies lung fibroblast heterogeneity: Implications for idiopathic pulmonary fibrosis$464,649

Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project Team
SchemeOperating Grant
RoleLead
Funding Start2009
Funding Finish2013
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

Canada Research Chairholder$375,000

Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project Team
SchemeCanada Research Chairs - CIHR Funded - Tier 2
RoleLead
Funding Start2009
Funding Finish2013
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

Regulation of mesenchymal cell behaviour by versican: Implications of arterial remodeling$108,800

Funding body: Heart & Stroke Foundation

Funding bodyHeart & Stroke Foundation
Project Team
SchemeFunds Granted
RoleInvestigator
Funding Start2009
Funding Finish2012
GNo
Type Of FundingInternational - Non Competitive
Category3IFB
UONY

20081 grants / $150,000

Novel Therapy for Pulmonary Fibrosis$150,000

Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project Team
SchemeProof of Principle Program - Phase I
RoleLead
Funding Start2008
Funding Finish2009
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

20073 grants / $664,500

The role of gp130 receptor mediated signalling in fibrotic pulmonary diseases.$544,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleLead
Funding Start2007
Funding Finish2009
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

Dysregulated epithelial repair in pediatric asthma$100,000

Funding body: Johnson & Johnson Medical Education Foundation

Funding bodyJohnson & Johnson Medical Education Foundation
Project Team
SchemeFunds Granted
RoleLead
Funding Start2007
Funding Finish2010
GNo
Type Of FundingInternational - Non Competitive
Category3IFB
UONY

Dysregulated STAT-3 activation in the Pathogenesis of IPF$20,000

Funding body: British Columbia Lung Association

Funding bodyBritish Columbia Lung Association
Project Team
SchemeFunds Granted
RoleLead
Funding Start2007
Funding Finish2009
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

20062 grants / $713,151

Genetic and epigenetic determinants of asthmatic epithelial cell Phenotype$369,000

Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project Team
SchemeOperating Grant
RoleInvestigator
Funding Start2006
Funding Finish2010
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

Environmental impact on the epithelial immune barrier in asthma$344,151

Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project Team
SchemeProject Grant
RoleLead
Funding Start2006
Funding Finish2008
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

20054 grants / $426,750

Regulation of gp130 signaling by STAT-3 in the pathogenesis of pulmonary fibrosis$251,084

Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project Team
SchemeOperating Grant
RoleLead
Funding Start2005
Funding Finish2009
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

Role and regulation of the proteoglycan, versican, in vascular injury and repair$110,666

Funding body: Heart & Stroke Foundation

Funding bodyHeart & Stroke Foundation
Project Team
SchemeFunds Granted
RoleInvestigator
Funding Start2005
Funding Finish2008
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

Regulation of gp130 signaling by STAT-3 in the pathogenesis of pulmonary fibrosis$50,000

Funding Body: Canadian Institutes of Health Research Funding Scheme: Operating Grant -PA: Inst of Circulatory and Respiratory Health - Bridge Funding Description: .
Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project Team
SchemeOperating Grant -PA: Inst of Circulatory and Respiratory Health - Bridge Funding
RoleLead
Funding Start2005
Funding Finish2006
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

Regulation of gp130 signaling of gp130 in the pathogenesis of pulmonary fibrosis$15,000

Funding body: Providence Health Care

Funding bodyProvidence Health Care
Project Team
SchemeFunds Granted
RoleLead
Funding Start2005
Funding Finish2006
GNo
Type Of FundingInternational - Non Competitive
Category3IFB
UONY

20047 grants / $1,874,836

Canada Research Chairholder$500,000

Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project Team
SchemeCanada Research Chairs - CIHR Funded - Tier 2
RoleLead
Funding Start2004
Funding Finish2010
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

Altered signalling by a common cytokine receptor is important in the development of fibrotic lung diseases.$449,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2006
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

Establishment Grant$301,000

Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project Team
SchemeInstitutional Establishment Grant (IEG) Program
RoleLead
Funding Start2004
Funding Finish2004
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

The airway epithelium, atopy and asthma$259,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2006
GNo
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Role Of Zinc In The Respiratory Epithelium and asthma$220,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2006
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

Mechanisms of Airway Disease$114,416

Funding body: Canadian Foundation for Innovation

Funding bodyCanadian Foundation for Innovation
Project Team
SchemeCanada Research Chairs Infrastructure Fund
RoleLead
Funding Start2004
Funding Finish2004
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

Integrin-growth factor interactions in the development of airway wall remodeling$29,420

Funding body: British Columbia Lung Association

Funding bodyBritish Columbia Lung Association
Project Team
SchemeFunds Granted
RoleLead
Funding Start2004
Funding Finish2006
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

20034 grants / $509,098

Regulation of the structural changes in the airways of chronic asthmatics$384,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleLead
Funding Start2003
Funding Finish2005
GNo
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Equipment grant$73,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeEquipment Grant
RoleInvestigator
Funding Start2003
Funding Finish2003
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

Infrastructure grant$36,098

Funding body: Medical and Health Research Infrastructure Council (MHRIC)

Funding bodyMedical and Health Research Infrastructure Council (MHRIC)
Project Team
SchemeInfrastructure grant
RoleLead
Funding Start2003
Funding Finish2003
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

Equipment grant$16,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding bodyRebecca L Cooper Medical Research Foundation Ltd
Project Team
SchemeFunds Granted
RoleLead
Funding Start2003
Funding Finish2003
GNo
Type Of FundingInternational - Non Competitive
Category3IFB
UONY

20022 grants / $15,000

Three-dimensional confocal analysis of sensory nerves, neuroendocrine cells and dendritic cells in human airways.$10,000

Funding body: Sir Charles Gairdner Hospital

Funding bodySir Charles Gairdner Hospital
Project Team
SchemeFunds Granted
RoleLead
Funding Start2002
Funding Finish2002
GNo
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

University of Western Australia$5,000

Funding body: University of Western Australia

Funding bodyUniversity of Western Australia
Project Team
SchemeFunds Granted
RoleInvestigator
Funding Start2002
Funding Finish2002
GNo
Type Of FundingInternal
CategoryINTE
UONY

20012 grants / $105,400

The Immunobiology of Asthma with particular reference to the Respiratory Epithelium$61,500

Funding body: Sir Charles Gairdner Hospital

Funding bodySir Charles Gairdner Hospital
Project Team
SchemeFunds Granted
RoleInvestigator
Funding Start2001
Funding Finish2002
GNo
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Interleukin (IL-) 11 and IL-6 differentially influence fibroblast proliferation and apoptosis: Implications for airway inflammation and airway remodeling$43,900

Funding body: Asthma Foundation of Western Australia

Funding bodyAsthma Foundation of Western Australia
Project Team
SchemeFunds Granted
RoleLead
Funding Start2001
Funding Finish2001
GNo
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

20001 grants / $76,700

Epithelium-fibroblast interactions in response to allergic airway inflammation$76,700

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleLead
Funding Start2000
Funding Finish2002
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

19993 grants / $91,476

The role of Oncostatin M and Leukemia Inhibitory Factor in airway remodeling$48,576

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleLead
Funding Start1999
Funding Finish2001
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

The effects of house dust mite allergens on the activation of submucosal glands and mucus secretion in human isolated airways: The modulatory role of Oncostatin M and Leukemia Inhibitory Factor.$22,900

Funding body: Asthma Foundation of Western Australia

Funding bodyAsthma Foundation of Western Australia
Project Team
SchemeFunds Granted
RoleLead
Funding Start1999
Funding Finish1999
GNo
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Assessment of the effects of chronic inflammation on structural remodelling and functional responses of human airways in vitro.$20,000

Funding body: Australian Lung Foundation

Funding bodyAustralian Lung Foundation
Project Team
SchemeShared
RoleLead
Funding Start1999
Funding Finish2000
GNo
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

19981 grants / $57,400

A novel explant model to investigate epithelial damage and airway remodelling in human airways. $57,400

Funding body: Raine Medical Research Foundation

Funding bodyRaine Medical Research Foundation
Project Team
SchemeFunds Granted
RoleLead
Funding Start1998
Funding Finish1999
GNo
Type Of FundingNot Known
CategoryUNKN
UONY
Edit

Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Contribution of Cell Death to the Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2015Investigation of Novel Immune Molecules in the Pathogenesis of Female Chlamydia Genital Tract Infections
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2015To assess the role of IFNe in modulating innate immune responses and protecting against Chlamydia infection in human tissues
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2015Role of Mechanical Forces in Asthma Pathogenesis
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2014Hypoxia Inducible Factor (HIF)-1 mediates epithelial wound healing through integrin regulation
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2014Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2011Regulation of epithelial cell differentiation
Health, University of British Columbia
Principal Supervisor
2011Role of STAT-3 in regulating fibroblast function
Health, University of British Columbia
Principal Supervisor
2009Characterising factors that regulate epithelial proliferation in childhood asthma
Health, University of Western Australia
Principal Supervisor
2008Role of Gp130/STAT-3 in pulmonary fibrosis
Health, University of Western Australia
Principal Supervisor
2007HB-EGF, TGF? and epithelial function
Health, University of British Columbia
Principal Supervisor
2007Airway epithelium and particular matter air pollutuion
Health, University of Western Australia
Co-Supervisor
2006Paediatric airway epithelial cells in asthma
Health, University of Western Australia
Co-Supervisor
2006Characterising the role of oncostatin M in human lung
Health, University of Western Australia
Principal Supervisor
2005Interaction between integrins and growth factors of fibroblast function
Health, University of Western Australia
Principal Supervisor
2004Gp130/STAT3 activation in pulmonary fibrosis
Health, University of Western Australia
Principal Supervisor
2003Integrins and epithelial function
Health, University of Western Australia
Principal Supervisor
2003Integrins and growth Factors and epithelial cells
Health, University of Western Australia
Principal Supervisor
2002Interaction between viruses and oncostatin M in human airway epithelium
Health, University of Western Australia
Principal Supervisor
Edit

News

PhD Scholarship - Role of mechanical forces in asthma pathogenesis

PhD Scholarship - Role of mechanical forces in asthma pathogenesis

July 30, 2014

Applications are open for a PhD scholarship at the University of Newcastle. As the successful applicant you will undertake your doctoral studies in the Priority Research Centre for Asthma and Respiratory Disease at the Hunter Medical Research Institute in Newcastle.

Professor Darryl Knight

Position

Head of School
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Contact Details

Emaildarryl.knight@newcastle.edu.au
Phone(02) 4921 7485
Fax(02) 4921 7403

Office

RoomMS606
BuildingMedical Sciences Building
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
Edit