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Professor Darryl Knight

Head of School

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

Professor Darryl Knight joins the University of Newcastle as the Head of the School of Biomedical Sciences and Pharmacy. Having received his BSc Honours degree in Pharmacology and his PhD from the University of Western Australia, Prof Knight undertook post-doctoral training at the University of British Columbia from 1995-1997. From 1997 to 2001 he was a Senior Research Officer in the Asthma & Allergy Research Institute (now the Lung Institute of Western Australia) at the University of Western Australia and was Head of the Experimental Biology division of the Institute from 2002-2004. In 2004, Prof Knight was recruited back to the University of British Columbia as the Canada Research Chair in Airway Disease and Associate Professor of Pharmacology. In 2007, Prof Knight was awarded a Michael Smith Foundation for Health Research Senior Scholar Career Investigator award and was named the William Thurlbeck Distinguished Lecturer by the Churg Foundation. He was also chosen as the recipient of funds from an endowment fund made to the University from a prominent local businessman, Peter Dhillon, in memory of his father who died of pulmonary fibrosis. In 2008, and assumed the role of Associate Director of the UBC James Hogg Research Centre and in 2009 was promoted to Full Professor. Prof Knight has had an outstanding research career with over 145 published papers and 3500+ citations (H-index = 40), and is focused on his research interests of pulmonary pharmacology and pathology and how they impact on airway and lung function.

Research Expertise
Prof Knight’s primary fields of teaching and research interest are centered on pulmonary pharmacology and pathology and how they impact on airway and lung function. Asthma and Interstitial lung diseases are his primary research interests. Prof Knight’s research program is focused on two independent but interrelated themes designed to increase our understanding of how the abnormal repair responses within the lung i) develop ii) contribute to the severity and chronicity of disease and iii) impact on treatment. These themes are focused the respiratory epithelium and adjacent fibroblasts. This microenvironment is the critical site for the initiation and perpetuation of the pathologic processes which contribute to fibrotic pulmonary diseases. His research program involves the investigation of two diseases, Asthma and idiopathic pulmonary fibrosis, both of which are intimately associated with remodelling and fibrosis. The research is performed at molecular, cellular levels as well as intact animal models in the belief that no single disease perspective or methodology will yield complete insights into the nature of the interaction between these two cell types. He also links to clinical investigators who bring his work directly into the context of patients suffering from these diseases.

Teaching Expertise
Prof Knight’s teaching experience spans Honours, Masters, and PhD and Post Doctorial students. He supervised students across all of these levels, with many receiving awards and over 90% were self-funded while under his tutelage. He also examined theses and lectured in Pharmacology and Therapeutics at the University of British Columbia from 2004-2012. While at the University of British Columbia, Prof Knight also served on many Graduate Student Advisory Committees and Graduate Student Comprehensive Exam Committees.

Administrative Expertise
Prof Knight has extensive administrative experience, most recently as Associate Director of the James Hogg Research Centre (JHRC) at the University of British Columbia. This role required him to work closely with the Centre Director and executive research leaders team to enhance the quality, quantity and recognition of research at Providence Health Care and the University. Prof Knight was also responsible for human, capital, financial and information resources to ensure that research objectives are achieved, while seeking partnership opportunities and developing strong relationships within the health community. From September-December 2012, Prof Knight filled the role of Interim Director of the JHRC. From 2008-2011, Prof Knight held the position of Chair of the Graduate Program Committee (Department of Anaesthesiology, Pharmacology and Therapeutics). As chair, he was the Graduate Advisor for the department and designed a modular course for graduate students in the department that was implemented in September 2010.

Collaborations
Prof Knight has several ongoing collaborations with investigators locally as well as both nationally and internationally, including laboratories in the United Kingdom, Australia, USA and Mexico. These collaborations are all productive, yielding several manuscripts in high impact factor journals and competitively funded grant applications.


Qualifications

  • PhD, University of Western Australia
  • Bachelor of Science (Honours), University of Western Australia

Keywords

  • Asthma and Interstitial lung diseases
  • pulmonary pathology
  • pulmonary pharmacology

Fields of Research

Code Description Percentage
110203 Respiratory Diseases 100

Professional Experience

UON Appointment

Title Organisation / Department
Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/01/2012 -  Editorial Board - Faculty of 1000 Faculty of 1000
Australia
1/01/2011 -  Editor - Experimental Lung Research Experimental Lung Research
Australia
1/01/2011 - 1/12/2012 Chair (Basic Science Grant Review Committee) Canadian Lung Association
Canada
1/01/2010 -  Editor - International Journal Biochemistry and Cell Biology International Journal Biochemistry and Cell Biology
Australia
1/12/2009 - 1/12/2012 Research Steering Committee Canadian Lung Association
Canada
1/01/2009 -  Editor - American Journal of Respiratory Cell and Molecular Biology American Journal of Respiratory Cell and Molecular Biology
United States
1/01/2009 -  Editor - Respirology Respirology
Australia
1/01/2008 - 1/12/2011 Chair (Department of Anesthesiology, Pharmacology and Therapeutics) Graduate Program Committee University of British Columbia
Canada
1/01/2008 -  Membership - Canadian Thoracic Society Canadian Thoracic Society
Canada
1/01/2007 -  Editor - Journal of Epithelial Biology and Pharmacology Journal of Epithelial Biology and Pharmacology
Australia
1/01/2007 - 31/12/2012 Membership - Institute for Heart and Lung Health Executive Committee Institute for Heart and Lung Health
Australia
1/01/2006 - 31/12/2011 Editor - Pulmonary Pharmacology and Therapeutics Pulmonary Pharmacology and Therapeutics
Australia
1/01/2006 - 31/12/2012 Membership - Canadian Institutes of Health Research Respiratory System (RS) Grants Committee Canadian Institutes of Health Research Respiratory System (RS) Grants Committee
Canada
1/01/2004 - 1/01/2013 Canada Research Chair in Airway Disease

The Canada Research Chairs program

Government of Canada
Canada
1/01/2004 - 31/12/2007 Membership - American Society for Biochemistry and Molecular Biology American Society for Biochemistry and Molecular Biology
United States
1/01/2003 - 31/12/2004 Membership - National Advisory Committee, Australian Lung Foundation Lung Foundation Australia
1/01/2003 - 31/12/2010 Membership - American Society for Cell Biology American Society for Cell Biology
United States
1/01/1995 -  Membership - American Thoracic Society American Thoracic Society
United States
1/01/1991 - 31/12/2005 Membership - Australian Lung Foundation Lung Foundation Australia
1/01/1991 - 31/12/2005 Membership - Thoracic Society of Australia and New Zealand Thoracic Society of Australia and New Zealand

Membership

Dates Title Organisation / Department
Program Advisory Committee Member and Chair of the HQP Committe - Allergen NCE 6th Annual Research Conference Program Advisory and Scientific committee
Australia
Member - Program Advisory and Scientific Committee 16th International Colloquium on Lung and Airway Fibrosis Program Advisory and Scientific committee
Australia
Member - Program Advisory and Local Organizing Committee – CIHR/ICRH Young Investigators Forum Program Advisory and Scientific committee
Australia

Awards

Research Award

Year Award
2010 Career Investigator Award (Senior Scholar)
Michael Smith Foundation for Health Research
2007 Rashpal Dhillon Fund for Idiopathic Pulmonary Fibrosis (IPF) Research
Rashpal Dhillon Fund for Idiopathic Pulmonary Fibrosis (IPR) Research
2007 The William Thurlbeck Distinguished Researcher Award
Wolfe and Gita Churg Foundation
2001 New Investigator Infrastructure support award
Medical and Health Research Infrastructure Council (MHRIC)
1998 Career Development Award
The Australian Lung foundation
1994 Encouragement award for Clinical Research
Sandoz Australia
1994 Young Investigator of the Year
The Thoracic Society of Australia and New Zealand

Invitations

Participant

Year Title / Rationale
2013 Severe Asthma – Is it also an epithelial disease?
Organisation: Thoracic Society of Australia and New Zealand Annual Scientific Conference
2012 Thematic Poster Session on pathways regulating airway cell differentiation
Organisation: American Thoracic Society Annual Scientific Conference Description:
2012 Symposium session on the Regulation of the ECM in lung disease.
Organisation: American Thoracic Society Annual Scientific Conference Description:
2012 Breakout session on future of IPF research
Organisation: 17th International Colloquium on Lung and airway fibrosis.
2011 Insights into the pathogenesis of lung fibrosis and granulomas
Organisation: American Thoracic Society Annual Scientific Conference Description:
2011 Thematic Poster Session on pathways Regulating fibroblast gene expression
Organisation: American Thoracic Society Annual Scientific Conference Description:
2011 The role of the Epithelium in Chronic Inflammatory Lung Disease
Organisation: Spring 2011 Pulmonary Research Group Symposium Description:

Speaker

Year Title / Rationale
2013 The epithelial innate and adaptive immune profile
Organisation: AbCam Symposium on Allergy and Asthma
2013 Stem Cells for repair of the human airway epithelium.
Organisation: Keystone Symposium on Pathogenic processes in asthma and COPD Description:
2012 The epithelium in asthma – how did it get to be so bad?
Organisation: Simon Fraser University Invited Lecture Series Description:
2012 Whats in a STAT?
Organisation: Northwestern University Invited Lecture Series Description:
2012 Role of gp130/STAT3 in extracellular matrix
Organisation: Transatlantic Airway Conference, Lung Injury and Repair
2012 Disturbing Double Entendres: Disrupting the fine control of epithelial differentiation in Asthma
Organisation: Meakins-Christie Laboratory 15th Annual International workshop on recent advances in Asthma and COPD Description:
2012 Regenerative Medicine for the treatment of Asthma
Organisation: UBC Celebrate Research Week Description:
2012 Fibroblast heterogeneity in lung fibrosis
Organisation: Canadian Respiratory Conference Description:
2012 Exogenous control of the ECM, is this an unrealistic goal?
Organisation: American Thoracic Society Annual Scientific Conference Description:
2012 The epithelium in asthma: How not to be an effective barrier.
Organisation: Federation of Clinical Immunology Societies (FOCIS) Annual Scientific Conference Description:
2011 New strategies applied to old cells in IPF.
Organisation: Medimmune, Cambridge Description:
2011 When is a myofibroblast not a myofibroblast?
Organisation: University of Nottingham Description:
2011 Epithelial differentiation as a novel target for asthma therapy.
Organisation: National Heart and Lung Institute Description:
2011 The epithelium in asthma – should it just grow up or is it OK as it is?
Organisation: University of Calgary, Asthma and Allergy Research Group Description:
2011 Journey to the Centre of the lung in search of a myofibroblasts.
Organisation: Meakins-Christie Laboratory 14th Annual International workshop on recent advances in Asthma and COPD Description:
2011 The role of the epithelium in airway remodeling.
Organisation: Injury and Repair Mechanisms in Chronic Airway Disease Description:
2011 Epithelial repair and Airway remodeling.
Organisation: Pulmonary Research Group Symposium on the Role of the Epithelium in Chronic Inflammatory Lung Disease Description:
2010 Journey to the Centre of the lung in search of a cause for IPF
Organisation: Woolcock Institute for Respiratory Medicine
2010 Epigenetic influences on epithelial function in asthma.
Organisation: Meakins-Christie Laboratory 13th Annual International workshop on recent advances in Asthma and COPD
2010 Molecular Aspects of the origins of IPF
Organisation: BC Lung Health Forum Description:
2010 When is a myofibroblast not a myofibroblast?
Organisation: 16th International Colloquium on Lung and airway fibrosis Description:
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (4 outputs)

Year Citation Altmetrics Link
2011 Hackett T-L, Warner S, Stefanowicz D, Knight D, 'Epithelial cells', Inflammation and Allergy Drug Design, Wiley-Blackwell, Oxford, United Kingdom 139-148 (2011) [B1]
2009 Murray LA, Knight D, Laurent GJ, 'Fibroblasts', Asthma and COPD : Basic Mechanisms and Clinical Management, Academic, London, United Kingdom 193-200 (2009) [B1]
2006 Knight DA, 'ONCOSTATIN M', Encyclopedia of Respiratory Medicine, Academic Press, London, United Kingdom 254-258 (2006) [B1]
DOI 10.1016/B0-12-370879-6/00282-9
2001 Bai TR, Knight DA, 'Role of the Airway Nervous System in Airway Remodeling', Airway Remodeling, Marcel Dekker, New York, United States 147-167 (2001) [B1]
Show 1 more chapter

Journal article (114 outputs)

Year Citation Altmetrics Link
2015 Garratt LW, Sutanto EN, Ling K-M, Looi K, Iosifidis T, Martinovich KM, et al., 'Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis', European Respiratory Journal, 46 384-394 (2015)
DOI 10.1183/09031936.00212114
2015 Garratt LW, Sutanto EN, Ling K-M, Looi K, Iosifidis T, Martinovich KM, et al., 'Alpha 1-antitrypsin Mitigates the Inhibition of Airway Epithelial Cell Repair by Neutrophil Elastase', American Journal of Respiratory Cell and Molecular Biology, 150729115141006-150729115141006 (2015)
DOI 10.1165/rcmb.2015-0074OC
2015 Hirota JA, Gold MJ, Hiebert PR, Parkinson LG, Wee T, Smith D, et al., 'The nucleotide-binding domain, leucine-rich repeat protein 3 inflammasome/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate matter under 10 µm', American Journal of Respiratory Cell and Molecular Biology, 52 96-105 (2015) [C1]

Exposure to particulate matter (PM), a major component of air pollution, contributes to increased morbidity and mortality worldwide. Inhaled PM induces innate immune responses by ... [more]

Exposure to particulate matter (PM), a major component of air pollution, contributes to increased morbidity and mortality worldwide. Inhaled PM induces innate immune responses by airway epithelial cells that may lead to the exacerbation or de novo development of airway disease. We have previously shown that 10-mm PM (PM10) activates the nucleotide-binding domain, leucine-rich repeat protein (NLRP) 3 inflammasome in human airway epithelial cells. Our objective was to determine the innate and adaptive immune responses mediated by the airway epithelium NLRP3 inflammasome in response to PM10 exposure. Using in vitro cultures of human airway epithelial cells and in vivo studies with wild-type and Nlrp3-/- mice, we investigated the downstream consequences of PM10-induced NLPR3 inflammasome activation on cytokine production, cellular inflammation, dendritic cell activation, and PM10-facilitated allergic sensitization. PM10 activates an NLRP3 inflammasome/IL-1 receptor I (IL-1RI) axis in airway epithelial cells, resulting in IL-1b, CC chemokine ligand-20, and granulocyte/macrophage colony-stimulating factor production, which is associated with dendritic cell activation and lung neutrophilia. Despite these profound innate immune responses in the airway epithelium, the NLRP3 inflammasome/IL-1RI axis is dispensable for PM10-facilitated allergic sensitization. We demonstrate the importance of the lung NLRP3 inflammasome in mediating PM10 exposure-associated innate, but not adaptive, immune responses. Our study highlights a mechanism by which PM10 exposure can contribute to the exacerbation of airway disease, but not PM10-facilitated allergic sensitization.

DOI 10.1165/rcmb.2014-0158OC
Co-authors Philip Hansbro
2015 Hirota JA, Marchant DJ, Singhera GK, Moheimani F, Dorscheid DR, Carlsten C, et al., 'Urban particulate matter increases human airway epithelial cell IL-1ß secretion following scratch wounding and H1N1 influenza A exposure in vitro.', Exp Lung Res, 41 353-362 (2015)
DOI 10.3109/01902148.2015.1040528
Co-authors Fatemeh Moheimani
2015 Hirota JA, Gold MJ, Hiebert PR, Parkinson LG, Wee T, Smith D, et al., 'The Nucleotide-Binding Domain, Leucine-Rich Repeat Protein 3 Inflammasome/IL-1 Receptor I Axis Mediates Innate, but Not Adaptive, Immune Responses after Exposure to Particulate Matter under 10 mu m', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 52 96-105 (2015) [C1]
DOI 10.1165/rcmb.2014-0158OC
Citations Scopus - 1
Co-authors Philip Hansbro
2015 Stefanowicz D, Lee JY, Lee K, Shaheen F, Koo H-K, Booth S, et al., 'Elevated H3K18 acetylation in airway epithelial cells of asthmatic subjects', Respiratory Research, 16 (2015)
DOI 10.1186/s12931-015-0254-y
2015 Carthy JM, Meredith AJ, Boroomand S, Abraham T, Luo Z, Knight D, McManus BM, 'Versican V1 Overexpression Induces a Myofibroblast-Like Phenotype in Cultured Fibroblasts.', PLoS One, 10 e0133056 (2015)
DOI 10.1371/journal.pone.0133056
2015 Chen-Yu Hsu A, Starkey MR, Hanish I, Parsons K, Haw TJ, Howland LJ, et al., 'Targeting PI3K-p110a Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease.', Am J Respir Crit Care Med, 191 1012-1023 (2015)
DOI 10.1164/rccm.201501-0188OC
Co-authors Paul Foster, Peter Wark, Alan Hsu, Philip Hansbro, Malcolm Starkey
2015 Hatchwell L, Collison A, Girkin J, Parsons K, Li J, Zhang J, et al., 'Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia.', Thorax, 70 854-861 (2015)
DOI 10.1136/thoraxjnl-2014-205465
Co-authors Paul Foster, Nathan Bartlett, Joerg Mattes
2015 Hirota JA, Marchant DJ, Singhera GK, Moheimani F, Dorscheid DR, Carlsten C, et al., 'Urban particulate matter increases human airway epithelial cell IL-1ß secretion following scratch wounding and H1N1 influenza A exposure in vitro', Experimental Lung Research, 150707113454006-150707113454006 (2015)
DOI 10.3109/01902148.2015.1040528
2014 Murray LA, Zhang H, Oak SR, Coelho AL, Herath A, Flaherty KR, et al., 'Targeting Interleukin-13 with Tralokinumab Attenuates Lung Fibrosis and Epithelial Damage in a Humanized SCID Idiopathic Pulmonary Fibrosis Model', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 50 985-994 (2014) [C1]
DOI 10.1165/rcmb.2013-0342OC
Citations Scopus - 14Web of Science - 4
2014 Hirota JA, Alexis NE, Pui M, Wong S, Fung E, Hansbro P, et al., 'PM10-stimulated airway epithelial cells activate primary human dendritic cells independent of uric acid: Application of an in vitro model system exposing dendritic cells to airway epithelial cell-conditioned media', Respirology, 19 881-890 (2014) [C1]

Background and objective Airway epithelial cells represent the first line of defence against inhaled insults, including air pollution. Air pollution can activate innate immune sig... [more]

Background and objective Airway epithelial cells represent the first line of defence against inhaled insults, including air pollution. Air pollution can activate innate immune signalling in airway epithelial cells leading to the production of soluble mediators that can influence downstream inflammatory cells. Our objective was to develop and validate a model of dendritic cell exposure to airway epithelial cell-conditioned media. After establishing the model, we explored how soluble mediators released from airway epithelial cells in response to air pollution influenced the phenotype of dendritic cells. Methods Human airway epithelial cells were cultured under control and urban particulate matter (PM10) exposure conditions with or without pharmacological inhibitors of the uric acid pathway. Culture supernatants were collected for conditioned media experiments with peripheral blood mononuclear cell-derived dendritic cells analysed by flow cytometry. Results Monocytes derived from peripheral blood mononuclear cells cultured in interleukin-4 and granulocyte macrophage colony stimulating factor differentiated into immature dendritic cells that phenotypically differentiated into mature dendritic cells in response to conditioned media from phorbol myristate acetate-activated THP-1 monocytes. Exposure of immature dendritic cells to conditioned media from airway epithelial cells exposed to PM10 resulted in dendritic cell maturation that was independent of uric acid. Conclusions We present a conditioned media model useful for interrogating the contribution of soluble mediators produced by airway epithelial cells to dendritic cell phenotype and function. Furthermore, we demonstrate that PM10 exposure induces airway epithelial cell production of soluble mediators that induce maturation of dendritic cells independent of uric acid. We developed and validated a model of airway epithelial cell conditioned media exposure to primary human dendritic cells. Using this model, we then tested the hypothesis that urban particulate matter exposure to airway epithelial cells resulted in production of soluble mediators capable of inducing dendritic cell maturation. © 2014 Asian Pacific Society of Respirology.

DOI 10.1111/resp.12316
Citations Scopus - 1Web of Science - 1
Co-authors Philip Hansbro
2014 Hirota JA, Sin DD, Pui M, Wong S, Fung E, Carlsten C, et al., 'PM10-stimulated airway epithelial cells activate primary human dendritic cells independent of uric acid: Application of an in vitro model system exposing dendritic cells to airway epithelial cell-conditioned media', Respirology, 19 881-890 (2014)
DOI 10.1111/resp.12316
Co-authors Philip Hansbro
2014 Hallstrand TS, Hackett TL, Altemeier WA, Matute-Bello G, Hansbro PM, Knight DA, 'Airway epithelial regulation of pulmonary immune homeostasis and inflammation', Clinical Immunology, 151 1-15 (2014) [C1]

Recent genetic, structural and functional studies have identified the airway and lung epithelium as a key orchestrator of the immune response. Further, there is now strong evidenc... [more]

Recent genetic, structural and functional studies have identified the airway and lung epithelium as a key orchestrator of the immune response. Further, there is now strong evidence that epithelium dysfunction is involved in the development of inflammatory disorders of the lung. Here we review the characteristic immune responses that are orchestrated by the epithelium in response to diverse triggers such as pollutants, cigarette smoke, bacterial peptides, and viruses. We focus in part on the role of epithelium-derived interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), as well as CC family chemokines as critical regulators of the immune response. We cite examples of the function of the epithelium in host defense and the role of epithelium dysfunction in the development of inflammatory diseases. © 2013 Elsevier Inc.

DOI 10.1016/j.clim.2013.12.003
Citations Scopus - 16Web of Science - 16
Co-authors Philip Hansbro
2013 Christenson SA, Brandsma C-A, Campbell JD, Knight DA, Pechkovsky DV, Hogg JC, et al., 'MiR-638 regulates gene expression networks associated with emphysematous lung destruction', Genome Medicine, 5 (2013) [C1]
DOI 10.1186/gm519
Citations Scopus - 8Web of Science - 6
2013 Wei W, Hou J, Alder O, Ye X, Lee S, Cullum R, et al., 'Genome-wide microRNA and messenger RNA profiling in rodent liver development implicates mir302b and mir20a in repressing transforming growth factor-beta signaling', HEPATOLOGY, 57 2491-2501 (2013) [C1]
DOI 10.1002/hep.26252
Citations Scopus - 7Web of Science - 7
2013 Hirota JA, Hiebert PR, Gold M, Wu D, Graydon C, Smith JA, et al., 'Granzyme B Deficiency Exacerbates Lung Inflammation in Mice after Acute Lung Injury', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 49 453-462 (2013) [C1]
DOI 10.1165/rcmb.2012-0512OC
Citations Scopus - 4Web of Science - 4
2013 Warner SMB, Hackett T-L, Shaheen F, Hallstrand TS, Kicic A, Stick SM, Knight DA, 'Transcription Factor p63 Regulates Key Genes and Wound Repair in Human Airway Epithelial Basal Cells', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 49 978-988 (2013) [C1]
DOI 10.1165/rcmb.2012-0447OC
Citations Scopus - 5Web of Science - 5
2013 Hansbro PM, Knight DA, 'Are Lymphoid Follicles Important in the Pathogenesis of Chronic Obstructive Pulmonary Disease?', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 188 267-269 (2013) [C3]
DOI 10.1164/rccm.201306-1073ED
Citations Scopus - 1Web of Science - 1
Co-authors Philip Hansbro
2013 Murray LA, Knight DA, 'Advances in industry for chronic respiratory diseases', Inflammation and Allergy - Drug Targets, 12 79-80 (2013) [C3]
DOI 10.2174/1871528111312020001
2012 Dunmore R, Carruthers AM, Bell MJ, Zhang H, Hogaboam CM, Peng X, et al., 'An Assessment of Epithelial and Mesenchymal Phenotypes in Experimental and Clinical Pulmonary Fibrosis', ISRN Pulmonology, 2012 1-11 (2012)
DOI 10.5402/2012/153971
2012 Pechkovsky DV, Prele CM, Wong J, Hogaboam CM, McAnulty RJ, Laurent GJ, et al., 'STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF', American Journal of Pathology, 180 1398-1412 (2012) [C1]
DOI 10.1016/j.ajpath.2011.12.022
Citations Scopus - 16Web of Science - 13
2012 Cruz-Sanchez TM, Haddrell AE, Hackett TL, Singhera GK, Marchant D, Lekivetz R, et al., 'Formation of a Stable Mimic of Ambient Particulate Matter Containing Viable Infectious Respiratory Syncytial Virus and Its Dry-Deposition Directly onto Cell Cultures', Analytical Chemistry, 85 898-906 (2012) [C1]
DOI 10.1021/ac302174y
Citations Scopus - 1Web of Science - 1
2012 Asdaghi N, Kilani RT, Hosseini-Tabatabaei A, Odemuyiwa SO, Hackett T-L, Knight D, et al., 'Extracellular 14-3-3 from human lung epithelial cells enhances MMP-1 expression', Molecular and Cellular Biochemistry: an international journal for chemical biology in health and disease, 360 261-270 (2012) [C1]
DOI 10.1007/s11010-011-1065-1
Citations Scopus - 5Web of Science - 5
2012 Hirota JA, Hirota SA, Warner SM, Stefanowicz D, Shaheen F, Beck PL, et al., 'The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter', Journal of Allergy and Clinical Immunology, 129 1116-1125 (2012) [C1]
DOI 10.1016/j.jaci.2011.11.033
Citations Scopus - 40Web of Science - 37
2012 Hirota JA, Knight DA, 'Human airway epithelial cell innate immunity: relevance to asthma', Current Opinion in Immunology, 24 740-746 (2012) [C1]
DOI 10.1016/j.coi.2012.08.012
Citations Scopus - 9Web of Science - 6
2012 Dudas PL, De Garavilla L, Lundblad LKA, Knight DA, 'The role of the epithelium in chronic inflammatory airway disease', Pulmonary Pharmacology and Therapeutics, 25 413-414 (2012) [C1]
DOI 10.1016/j.pupt.2012.10.005
2012 Prele MC, Yao E, O'Donoghue RJJ, Mutsaers SE, Knight D, 'STAT3 A Central Mediator of Pulmonary Fibrosis?', Proceedings of the Ameican Thoracic Society, 9 177-182 (2012) [C1]
DOI 10.1513/pats.201201-007AW
Citations Scopus - 7
2012 Hallstrand TS, Woodruff PG, Holgate ST, Knight DA, 'Function of the Airway Epithelium in Asthma', Journal of Allergy, 2012 1-89 (2012) [C6]
2012 Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma C-A, et al., 'A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK', Genome Medicine: medicine in the post-genomic era, 4 67-67 (2012) [C1]
DOI 10.1186/gm367
Citations Scopus - 24Web of Science - 20
2012 O'Donoghue RJ, Knight D, Richards CD, Prele CM, Lau HL, Jarnicki AG, et al., 'Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis', EMBO Molecular Medicine, 4 939-951 (2012) [C1]
DOI 10.1002/emmm.201100604
Citations Scopus - 18Web of Science - 13
2012 Boivin WA, Shackleford M, Vanden Hoek A, Zhao H, Hackett TL, Knight D, Granville DJ, 'Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-ß1', PLoS One, 7 (2012) [C1]
DOI 10.1371/journal.pone.0033163
Citations Scopus - 28Web of Science - 27
2012 Stefanowicz D, Hackett T-L, Garmaroudi FS, Gunther OP, Neumann S, Sutanto EN, et al., 'DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children', PLoS One, 7 (2012) [C1]
DOI 10.1371/journal.pone.0044213
Citations Scopus - 18Web of Science - 17
2012 Banerjee B, Musk M, Sutanto EN, Yerkovich ST, Hopkins P, Knight DA, et al., 'Regional Differences in Susceptibiity of Bronchial Epithelium to Mesenchymal Transition and Inhibition by the Macrolide Antibiotic Azithromycin', PLoS One, 7 (2012) [C1]
DOI 10.1371/journal.pone.0052309
Citations Scopus - 2Web of Science - 3
2011 Oak SR, Murray L, Herath A, Sleeman M, Anderson I, Joshi AD, et al., 'A micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosis', PLoS One, 6 (2011) [C1]
DOI 10.1371/journal.pone.0021253
Citations Scopus - 32Web of Science - 26
2011 Cooper DM, Petchkovsky DV, Hackett TL, Knight D, Granville DJ, 'Granzyme K activates protease-activated receptor-1', PLoS One, 6 (2011) [C1]
DOI 10.1371/journal.pone.0021484
Citations Scopus - 14Web of Science - 13
2011 Oosthuizen JL, Gomez P, Ruan J, Hackett T-L, Moore MM, Knight D, Tebbutt SJ, 'Dual organism transcriptomics of airway epithelial cells interacting with conidia of Aspergillus fumigatus', PLoS One, 6 (2011) [C1]
DOI 10.1371/journal.pone.0020527
Citations Scopus - 15Web of Science - 14
2011 Murgia C, Grosser D, Truong-Tran AQ, Roscioli E, Michalczyk A, Ackland ML, et al., 'Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation', Nutrients, 3 910-928 (2011) [C1]
DOI 10.3390/nu3110910
Citations Scopus - 9Web of Science - 8
2011 Moreira AP, Cavassani KA, Ismailoglu UB, Hullinger R, Dunleavy MP, Knight D, et al., 'The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A', Journal of Clinical Investigation, 121 4420-4432 (2011) [C1]
DOI 10.1172/JCI44999
Citations Scopus - 35Web of Science - 34
2011 Knight D, Stick SM, Hackett T-L, 'Defective function at the epithelial junction: A novel therapeutic frontier in asthma?', Journal of Allergy and Clinical Immunology, 128 557-558 (2011) [C3]
DOI 10.1016/j.jaci.2011.07.031
Citations Scopus - 5Web of Science - 5
2011 Hackett T-L, Singhera GK, Shaheen F, Hayden P, Jackson GR, Hegele RG, et al., 'Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution', American Journal of Respiratory Cell and Molecular Biology, 45 1090-1100 (2011) [C1]
DOI 10.1165/rcmb.2011-0031OC
Citations Scopus - 54Web of Science - 50
2011 Sutanto EN, Kicic A, Foo CJ, Stevens PT, Mullane D, Knight D, Stick SM, 'Innate inflammatory responses of pediatric cystic fibrosis airway epithelial cells: Effects of nonviral and viral stimulation', American Journal of Respiratory Cell and Molecular Biology, 44 761-767 (2011) [C1]
DOI 10.1165/rcmb.2010-0368OC
Citations Scopus - 27Web of Science - 25
2011 Abraham T, Hirota JA, Wadsworth S, Knight D, 'Minimally invasive multiphoton and harmonic generation imaging of extracellular matrix structures in lung airway and related diseases', Pulmonary Pharmacology and Therapeutics, 24 487-496 (2011) [C1]
DOI 10.1016/j.pupt.2011.03.008
Citations Scopus - 7Web of Science - 6
2011 Knight D, Mutsaers SE, Prele CM, 'STAT3 in tissue fibrosis: Is there a role in the lung?', Pulmonary Pharmacology and Therapeutics, 24 193-198 (2011) [C1]
DOI 10.1016/j.pupt.2010.10.005
Citations Scopus - 16Web of Science - 13
2010 Murray LA, Kramer MS, Hesson DP, Watkins BA, Fey EG, Argentieri RL, et al., 'Serum amyloid P ameliorates radiation-induced oral mucositis and fibrosis', Fibrogenesis and Tissue Repair, 3 11 (2010) [C1]
DOI 10.1186/1755-1536-3-11
Citations Scopus - 16
2010 Henderson Jr WR, Chi EY, Ye X, Nguyen C, Tien Y-T, Zhou B, et al., 'Inhibition of Wnt/ß-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis', Proceedings of the National Academy of Sciences of USA, 107 4309-4314 (2010) [C1]
DOI 10.1073/pnas.1001520107
Citations Scopus - 129Web of Science - 119
2010 Pechkovsky DV, Hackett TL, An SS, Shaheen F, Murray LA, Knight D, 'Human lung parenchyma but not proximal bronchi produces fibroblasts with enhanced TGF-ß signaling and a-SMA expression', American Journal of Respiratory Cell and Molecular Biology, 43 641-651 (2010) [C1]
DOI 10.1165/rcmb.2009-0318OC
Citations Scopus - 22Web of Science - 21
2010 Stefanowicz D, Hackett T, Pare P, Knight DA, 'Alterations In Histone Acetylation In Asthmatic Airway Epithelial Cells', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 181 (2010) [E3]
2010 Kicic A, Hallstrand TS, Sutanto EN, Stevens PT, Kobor MS, Taplin C, et al., 'Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium', American Journal of Respiratory and Critical Care Medicine, 181 889-898 (2010) [C1]
DOI 10.1164/rccm.200907-1071OC
Citations Scopus - 49Web of Science - 46
2010 Gomez P, Hackett TL, Moore MM, Knight D, Tebbutt SJ, 'Functional genomics of human bronchial epithelial cells directly interacting with conidia of Aspergillus fumigatus', BMC Genomics, 11 358 (2010) [C1]
DOI 10.1186/1471-2164-11-358
Citations Scopus - 8Web of Science - 10
2009 He J-Q, Hallstrand TS, Knight D, Chan-Yeung M, Sandford A, Tripp B, et al., 'A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness', Journal of Allergy and Clinical Immunology, 124 222-229 (2009) [C1]
DOI 10.1016/j.jaci.2009.04.018
Citations Scopus - 46Web of Science - 42
2009 Hackett T-L, Warner SM, Stefanowicz D, Shaheen F, Pechkovsky DV, Murray LA, et al., 'Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-ß1', American Journal of Respiratory and Critical Care Medicine, 180 122-133 (2009) [C1]
DOI 10.1164/rccm.200811-1730OC
Citations Scopus - 124Web of Science - 114
2008 Allahverdian S, Harada N, Singhera GK, Knight D, Dorscheid DR, 'Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF', American Journal of Respiratory Cell and Molecular Biology, 38 153-160 (2008) [C1]
DOI 10.1165/rcmb.2007-0173OC
Citations Scopus - 48Web of Science - 46
2008 Hackett T-L, Shaheen F, Johnson A, Wadsworth S, Pechkovsky DV, Jacoby DB, et al., 'Characterization of side population cells from human airway epithelium', Stem Cells, 26 2576-2585 (2008) [C1]
DOI 10.1634/stemcells.2008-0171
Citations Scopus - 61Web of Science - 52
2008 Murray LA, Knight D, McAlonan L, Argentieri R, Joshi A, Shaheen F, et al., 'Deleterious role of TLR3 during hyperoxia-induced acute lung injury', American Journal of Respiratory and Critical Care Medicine, 178 1227-1237 (2008) [C1]
DOI 10.1164/rccm.200807-1020OC
Citations Scopus - 37
2008 Murray LA, Hackett TL, Warner SM, Shaheen F, Argentieri RL, Dudas P, et al., 'BMP-7 does not protect against bleomycin-induced lung or skin fibrosis', PLoS One, 3 4039 (2008) [C1]
DOI 10.1371/journal.pone.0004039
Citations Scopus - 35Web of Science - 29
2008 Pechkovsky DV, Scaffidi AK, Hackett TL, Ballard J, Shaheen F, Thompson PJ, et al., 'Transforming growth factor ß1 induces avß3 integrin expression in human lung fibroblasts via a ß3 integrin-, c-Src-, and p38 MAPK-dependent pathway', Journal of Biological Chemistry, 283 2898-2908 (2008) [C1]
DOI 10.1074/jbc.M708226200
Citations Scopus - 45Web of Science - 42
2008 He J-Q, Sandford AJ, Wang I-M, Stepaniants S, Knight D, Kicic A, et al., 'Selection of housekeeping genes for real-time PCR in atopic human bronchial epithelial cells', European Respiratory Journal, 32 755-762 (2008) [C1]
DOI 10.1183/09031936.00129107
Citations Scopus - 24Web of Science - 20
2008 Stevens PT, Kicic A, Sutanto EN, Knight D, Stick SM, 'Dysregulated repair in asthmatic paediatric airway epithelial cells: The role of plasminogen activator inhibitor-1', Clinical and Experimental Allergy, 38 1901-1910 (2008) [C1]
DOI 10.1111/j.1365-2222.2008.03093.x
Citations Scopus - 37Web of Science - 32
2007 Lang C, Murgia C, Leong M, Tan L-W, Perozzi G, Knight D, et al., 'Anti-inflammatory effects of zinc and alterations in zinc transporter mRNA in mouse models of allergic inflammation', American Journal of Physiology: Lung Cellular and Molecular Physiology, 292 L577-L584 (2007) [C1]
DOI 10.1152/ajplung.00280.2006
Citations Scopus - 57Web of Science - 47
2007 McWhinnie R, Pechkovsky DV, Zhou D, Lane D, Halayko AJ, Knight D, Bai TR, 'Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells', American Journal of Physiology: Lung Cellular and Molecular Physiology, 292 L278-L286 (2007) [C1]
DOI 10.1152/ajplung.00111.2006
Citations Scopus - 39Web of Science - 36
2007 Bateman RM, Hodgson KC, Kohli K, Knight D, Walley KR, 'Endotoxemia increases the clearance of mPEGylated 5000-MW quantum dots as revealed by multiphoton microvascular imaging', Journal of Biomedical Optics, 12 (2007) [C1]
DOI 10.1117/1.2822882
Citations Scopus - 7Web of Science - 7
2006 Moeller A, Horak Jr F, Lane C, Knight D, Kicic A, Brennan S, et al., 'Inducible NO synthase expression is low in airway epithelium from young children with cystic fibrosis', Thorax, 61 514-520 (2006) [C1]
DOI 10.1136/thx.2005.054643
Citations Scopus - 32
2006 Petrovic N, Knight D, Bomalaski JS, Thompson PJ, Misso NLA, 'Concomitant activation of extracellular signal-regulated kinase and induction of COX-2 stimulates maximum prostaglandin E2 synthesis in human airway epithelial cells', Prostaglandins and Other Lipid Mediators, 81 126-135 (2006) [C1]
DOI 10.1016/j.prostaglandins.2006.08.006
Citations Scopus - 9Web of Science - 8
2006 Knight D, 'Editorial: New drug targets for the treatment of asthma', Current Drug Targets, 7 523-523 (2006) [C1]
DOI 10.2174/138945006776818665
2006 Knight DA, 'New Drug Targets for the Treatment of Asthma', Current Drug Targets, 7 523-523 (2006) [C1]
DOI 10.2174/138945006776818665
2006 Kicic A, Sutanto EN, Stevens PT, Knight D, Stick SM, 'Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma', American Journal of Respiratory and Critical Care Medicine, 174 1110-1118 (2006) [C1]
DOI 10.1164/rccm.200603-392OC
Citations Web of Science - 68
2005 O'Hara KA, Kedda M-A, Fogel-Petrovic M, Thompson PJ, Abraham LJ, Knight DA, 'Characterization of the Human Oncostatin M (OSM) Receptort Sub-Unit, OSMBR', INFLAMMATION RESEARCH, 54 S157-S157 (2005)
2005 Fonceca AM, Sutanto EN, Kicic A, Knight DA, Stick SM, 'Cellular microenvironment: A defining role for TLR4 location and expression in vivo', INFLAMMATION RESEARCH, 54 S187-S187 (2005)
2005 Lee YCG, Knight DA, Lane KB, Cheng DS, Koay MA, Teixeira LR, et al., 'Activation of proteinase-activated receptor-2 in mesothelial cells induces pleural inflammation', American Journal of Physiology: Lung Cellular and Molecular Physiology, 288 L734-L740 (2005) [C1]
DOI 10.1152/ajplung.00173.2004
Citations Scopus - 12Web of Science - 9
2005 Weichselbaum M, Sparrow MP, Hamilton EJ, Thompson PJ, Knight DA, 'A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium', Respiratory Research, 6 1-30 (2005) [C1]
DOI 10.1186/1465-9921-6-115
Citations Scopus - 27Web of Science - 24
2005 Lane C, Burgess S, Kicic A, Knight DA, Stick S, 'The use of non-bronchoscopic brushings to study the paediatric airway', Respiratory Research, 6 1-10 (2005) [C1]
DOI 10.1186/1465-9921-6-53
Citations Scopus - 19
2004 Scaffidi AK, Petrovic N, Moodley YP, Fogel-Petrovic M, Kroeger KM, Seeber RM, et al., 'avß3 integrin interacts with the transforming growth factor ß (TGFß) type II receptor to potentiate the proliferative effects of TGFß1 in living human lung fibroblasts', Journal of Biological Chemistry, 279 7726-7733 (2004) [C1]
DOI 10.1074/jbc.M403010200
Citations Scopus - 60Web of Science - 55
2004 Moodley YP, Caterina P, Scaffidi AK, Misso NL, Papadimitrou JM, McAnulty RJ, et al., 'Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL-induced apoptosis', Journal of Pathology, 202 486-495 (2004) [C1]
DOI 10.1002/path.1531
Citations Scopus - 55Web of Science - 49
2004 Lane C, Burgess S, Franklin P, Horak F, Legg J, Moeller A, et al., 'Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath', Thorax, 59 757-760 (2004) [C1]
DOI 10.1136/thx.2003.014894
Citations Scopus - 118
2004 Fogel-Petrovic M, Long JA, Knight DA, Thompson PJ, Upham JW, 'Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2', Immunology and Cell Biology, 82 47-54 (2004) [C1]
DOI 10.1111/j.1440-1711.2004.01213.x
Citations Scopus - 30Web of Science - 25
2004 Long JA, Fogel-Petrovic M, Knight DA, Thompson PJ, Upham JW, 'Higher prostaglandin E2 production by dendritic cells from subjects with asthma compared with normal subjects', American Journal of Respiratory and Critical Care Medicine, 170 485-491 (2004) [C1]
DOI 10.1164/rccm.200311-1595OC
Citations Web of Science - 22
2004 Knight DA, Lane CL, Stick SM, 'Does aberrant activation of the epithelial-mesenchymal trophic unit play a key role in asthma or is it an unimportant sideshow?', Current Opinion in Pharmacology, 4 251-256 (2004) [C1]
DOI 10.1016/j.coph.2004.02.002
Citations Scopus - 26Web of Science - 24
2003 Moodley Y, Rigby P, Bundell C, Bunt S, Hayashi H, Misso N, et al., 'Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36', American Journal of Pathology, 162 771-779 (2003) [C1]
Citations Scopus - 69
2003 Laurent GJ, Mutsaers SE, Thompson PJ, Knight DA, Moodley YP, Scaffidi AK, et al., 'Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation', American Journal of Pathology, 163 345-354 (2003) [C1]
Citations Scopus - 64Web of Science - 59
2003 Moodley YP, Misso NLA, Scaffidi AK, Fogel-Petrovic M, McAnulty RJ, Laurent GJ, et al., 'Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs', American Journal of Respiratory Cell and Molecular Biology, 29 490-498 (2003) [C1]
DOI 10.1165/rcmb.2002-0262OC
2002 Asokananthan N, Graham PT, Fink J, Knight DA, Bakker AJ, McWilliam AS, et al., 'Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E 2 release from human respiratory epithelial cells', Journal of Immunology, 168 3577-3585 (2002) [C1]
Citations Scopus - 258Web of Science - 247
2002 Knight DA, 'Increased permeability of asthmatic epithelial cells to pollutants. Does this mean that they are intrinsically abnormal?', Clinical and Experimental Allergy, 32 1263-1265 (2002) [C1]
DOI 10.1046/j.1365-2745.2002.01486.x
2002 Scaffidi AK, Mutsaers SE, Moodley YP, McAnulty RJ, Laurent GJ, Thompson PJ, Knight DA, 'Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts', British Journal of Pharmacology, 136 793-801 (2002) [C1]
Citations Web of Science - 40
2001 Lan RS, Knight DA, Stewart GA, Henry PJ, 'Role of PGE 2 in protease-activated receptor-1, -2 and -4 mediated relaxation in the mouse isolated trachea', British Journal of Pharmacology, 132 93-100 (2001) [C1]
Citations Scopus - 57Web of Science - 58
2001 Scaffidi AK, Moodley YP, Weichselbaum M, Thompson PJ, Knight DA, 'Regulation of human lung fibroblast phenotype and function by vitronectin and vitronectin integrins', Journal of Cell Science, 114 3507-3516 (2001) [C1]
Citations Scopus - 47Web of Science - 45
2001 Knight DA, Lim S, Scaffidi AK, Roche N, Chung KF, Stewart GA, Thompson PJ, 'Protease-activated receptors in human airways: Upregulation of PAR-2 in respiratory epithelium from patients with asthma', Journal of Allergy and Clinical Immunology, 108 797-803 (2001) [C1]
DOI 10.1067/mai.2001.119025
Citations Scopus - 171Web of Science - 163
2001 Knight DA, 'Epithelium-fibroblast interactions in response to airway inflammation', Immunology and Cell Biology, 79 160-164 (2001) [C1]
DOI 10.1046/j.1440-1711.2001.00988.x
Citations Scopus - 77
2001 Tulic MK, Knight DA, Holt PG, Sly PD, 'Lipopolysaccharide inhibits the late-phase response to allergen by altering nitric oxide synthase activity and interleukin-10', American Journal of Respiratory Cell and Molecular Biology, 24 640-646 (2001) [C1]
Citations Scopus - 27Web of Science - 23
2001 Knight DA, 'Leukaemia Inhibitory Factor (LIF): A cytokine of emerging importance in chronic airway inflammation', Pulmonary Pharmacology and Therapeutics, 14 169-176 (2001) [C1]
DOI 10.1006/pupt.2001.0282
Citations Scopus - 28
2001 Thompson PJ, Asokananthan N, Knight DA, Stewart GA, 'Protease-activated receptors and the airway epithelium', Clinical and Experimental Allergy Reviews, 1 107-110 (2001) [C1]
DOI 10.1046/j.1472-9725.2001.00018.x
Citations Scopus - 4
2000 Knight DA, Asokananthan N, Watkins DN, Misso NLA, Thompson PJ, Stewart GA, 'Oncostatin M synergises with house dust mite proteases to induce the production of PGE 2 from cultured lung epithelial cells', British Journal of Pharmacology, 131 465-472 (2000) [C1]
Citations Scopus - 15Web of Science - 14
2000 Knight DA, D'Aprile AC, Spalding LJ, Goldie RG, Thompson PJ, 'Leukaemia inhibitory factor (LIF) upregulates excitatory non-adrenergic non-cholinergic and maintains cholinergic neural function in tracheal explants', British Journal of Pharmacology, 130 975-979 (2000) [C1]
Citations Scopus - 11Web of Science - 9
1999 Zheng XY, Knight DA, Zhou DY, Weir TD, Peacock C, Schellenberg RR, Bai TR, 'Leukemia inhibitory factor is synthesized and released by human eosinophils and modulates activation state and chemotaxis', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 104 136-144 (1999)
DOI 10.1016/S0091-6749(99)70125-9
Citations Scopus - 23Web of Science - 19
1999 Knight D, Bai T, 'Roles for leukemia inhibitory factor in lung biology', Drug News and Perspectives, 12 261-269 (1999)

Leukemia inhibitory factor (LIF) is a multifunctional polypeptide cytokine/growth factor. It displays biological activities ranging from the differentiation of myeloid leukemic ce... [more]

Leukemia inhibitory factor (LIF) is a multifunctional polypeptide cytokine/growth factor. It displays biological activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin-6 (IL-6) family of cytokines. A variety of specific agents are known to induce the transcription and release of LIF; however, the agents that inhibit the cellular production of LIF and their mechanisms of actions have not been extensively studied. In vivo studies have revealed that LIF is absolutely essential for fetal development; it also plays a role in sepsis, arthritis, hematopoiesis, in the cardiovascular system, and in the central nervous system and peripheral nervous tissue, as well as in local regulation of airway inflammation. Furthermore, new data suggest that under conditions of neural injury, kidney damage or fertility abnormalities, LIF may be a useful therapeutic agent. However, before these hypotheses are realized, much more research is required into understanding its physiology and control.

DOI 10.1358/dnp.1999.12.5.863620
Citations Scopus - 2
1999 Watkins DN, Peroni DJ, Lenzo JC, Knight DA, Garlepp MJ, Thompson PJ, 'Expression and localization of COX-2 in human airways and cultured airway epithelial cells', EUROPEAN RESPIRATORY JOURNAL, 13 999-1007 (1999)
DOI 10.1034/j.1399-3003.1999.13e12.x
Citations Web of Science - 36
1999 Knight DA, Lydell CP, Zhou DY, Weir TD, Schellenberg RR, Bai TR, 'Leukemia inhibitory factor (LIF) and LIF receptor in human lung distribution and regulation of LIF release', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 20 834-841 (1999)
Citations Web of Science - 44
1999 Thompson PJ, Knight DA, Nithinanthan A, Stewart GA, 'The presence of proteinase activated receptors (PAR) in cultured human airway epithelial cells: Differential effects on PGE(2) release.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A98-A98 (1999)
Citations Web of Science - 4
1999 Knight DA, Nithinanthan A, Watkins DN, Thompson PJ, Stewart GA, 'Synergy between oncostatin M (OSM) and house dust mite (HDM) allergens in stimulating PGE(2) release from epithelial cells.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A334-A334 (1999)
1999 Knight DA, D'Aprile AC, Thompson PJ, Goldie RG, 'Leukemia inhibitory factor (LIF) but not oncostatin M (OSM) upregulates eNANC and maintains cholinergic neural activity in tracheal explants.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A334-A334 (1999)
1999 Knight D, Nithiananthan A, Thompson P, Stewart G, 'The presence of proteinase activated receptors (PAR) in cultured human airway epithelial cells: Differential effects on PGE2 release', Respirology, 4 (1999)

PAR are a recently identified family of G-protein linked receptors which activate a variety of cellular functions, once cleaved by proteinases. To date, 4 PAR have been identified... [more]

PAR are a recently identified family of G-protein linked receptors which activate a variety of cellular functions, once cleaved by proteinases. To date, 4 PAR have been identified and differentiated by their activation by different proteinases. We examined the presence of PAR mRNA and the effects of activation of PARs by specific activating peptides using the human cultured lung epithelial cell line A549. Methods: Serum-depleted A549 cells were exposed to the active peptide (6 amino acids) or control peptide. The presence of specific PAR mRNA was examined by RT-PCR. Cells were exposed to activating peptides for PAR 1-4 at concentrations of 50 and 500 nM and after 48 hr PGE2 was measured by EIA. Results: The presence of mRNA for PAR was confirmed following 40 cycles of RT-PCR. Unstimulated cells produced 14.3±3 pg of PGEz/105 cells. Exposure to activating peptides for PAR 1 and 2 produced a dose-dependent increase in PGEz production with the rank order of PAR-2>PAR-1. Maximal activation of PAR-2 produced 37±5 pg/105 cells (p<0.05). Activation of PAR-3 and PAR-4 did not evoke the release of significant amounts of PGEz compared to control levels. Similarly, exposure to the inactive peptides did not induce significant levels of PGEz production. Conclusion: These results demonstrate firstly that PAR are present on cultured human airway epithelial cells and that activation of PAR2 will preferentially lead to PGEz release. The release of PGEz following activation of PAR-2 by proteinases may represent a mechanism which serves to dampen proteolytic damage that may occur during airway inflammation.

1999 Knight D, Lenzo J, James A, Thompson P, Carroll N, 'Localisation of oncostatin M receptors (OSMR) in human airways by immunohistochemistry: Altered pattern of distribution in asthma', Respirology, 4 (1999)

Oncostatin M (OSM) is a member of the IL-6 family of cytokines and to date has been demonstrated to be released by activated T-cells and macrophages. OSM is a potent inducer of ep... [more]

Oncostatin M (OSM) is a member of the IL-6 family of cytokines and to date has been demonstrated to be released by activated T-cells and macrophages. OSM is a potent inducer of epithelial anti-proteinases as well as tissue inhibitor of metalloproteinases, suggesting an anti-proteolytic function. However, the distribution of OSMR in human airways is unknown. We hypothesised that due to these effects, OSMR would be present in human airway epithelium and that the expression and pattern of OSMR distribution would be upregulated in asthma. Methods: Transverse sections (n=3) of large airways were obtained at autopsy from cases of fatal asthma (FA, n=7) and from non-smoking controls (con, n=4). Sections were stained for OSMR using a specific polyclonal antibody (provided by Immunex, Seattle, WA). Positive staining for OSMR was scored semi-quantitatively for intensity (0-4) and distribution (0-4) in the epithelium (epi), basement membrane (bm), smooth muscle (asm), sub-mucosal glands (smg), vasculature (bv), mononuclear (mono) and multinuclear cells (poly) Results: The mean ±S.D. scoring intensity is shown below. epi bm asm smg bv mono, poly FA T3±1.3# T5±1.6 2.8±1.8# 1.4±0.7 1.9±1~5~ 2.0±12~ 0.3±1.1 Con 0.6±1.2 1.4±1.6 1.1±1.8 1.2±1.8 1.3+1.8 1.6±1.5 0.3±1.1 #P<0.01 vs con. The distribution of staining score showed similar trends. Conclusion: These results show for the first time that OSMR are present in human airways and that the pattern of expression is altered in asthma. The distribution of staining suggests that OSM may play an important role in airway inflammation associated with asthma.

1999 Knight D, Zheng X, Bai T, Thompson P, 'Leukemia inhibitory factor is synthesised and released by human eosinophils and modulates their activation state', Respirology, 4 (1999)

Recently we have demonstrated that: LI F modulates the chemotactic activity of eosinophils (Eos) to tachykinins; LIF is released by several cell types in human airways adjacent to... [more]

Recently we have demonstrated that: LI F modulates the chemotactic activity of eosinophils (Eos) to tachykinins; LIF is released by several cell types in human airways adjacent to tachykinin-containing nerves in response to inflammatory stimuli and that LIF receptors are localized to numerous cell types including Eos. However, it is not known whether Eos themselves produce LIF and whether LIF has an autocrine role on Eos function. Methods: Peripheral blood Eos were purified from 5 healthy atopic and 5 non-atopic donors by negative selection using immunomagnetic beads with purity > 97%. Expression of LIF and LIF receptor (LIFR) mRNA was assessed by RT-PCR. Release of LIF and eosinophil peroxidase (EPO) was measured by ELISA and colorimetric analysis respectively. Results: LIF and LIFR mRNA was observed in Eos taken from normal and atopic volunteers. However, Eos taken from non-atopies did not spontaneously release LIF and only 5.3±1.8 pg/10B cells was measured in response to stimulation with calcium ionophore. In contrast, Eos taken from atopic volunteers had a higher basal release of LIF (45±38 pg/106 cells) and stimulation with calcium ionophore induced a 10-fold increase in LIF production (415±190 pg/10e cells, p<0.05) within 30 min. Pré-incubation of Eos with LIF (5ng/ml) for 1 hr increased the release of EPO by 4-fold and increased the expression of the activation marker CD69. Conclusion: These data demonstrate that human eosinophils synthesise, store and release LIF and the amounts are influenced by the atopic status of the individual. By augmenting the release of EPO and CD69 expression, the results suggest that LIF may have pro-inflammatory functions in eosinophil dependent airway diseases.

1997 Knight D, McKay K, Wiggs B, Schellenberg R, Bai T, 'Localization of leukaemia inhibitory factor to airway epithelium and its amplification of contractile responses to tachykinins', British Journal of Pharmacology, 120 883-891 (1997)

1. In neural tissue, leukaemia inhibitory factor (LIF) is an important trophic cytokine. In this investigation, we determined if LIF was present in human and guinea-pig airways an... [more]

1. In neural tissue, leukaemia inhibitory factor (LIF) is an important trophic cytokine. In this investigation, we determined if LIF was present in human and guinea-pig airways and examined the role of this cytokine in modulating airway responses to endogenous and exogenous tachykinins as well as muscarinic receptor and ß-adrenoceptor stimulation. 2. The presence of LIF in both human and guinea-pig airways was determined by immunohistochemistry. Guinea-pig tracheal explants were incubated in CRML-1066 media containing LIF (0.5, 5 or 50 ng ml-1) for periods of 3, 6, 24 and 48 h. Tracheal rings were then transferred to organ baths for measurement of isometric force in response to carbachol, capsaicin, the neurokinin, (NK1) receptor agonist [Sar9,Met(O2)11]-substance P (SP), the NK2 receptor agonist neurokinin A (NKA) and isoprenaline. 3. LIF immunoreactivity was observed primarily in basally situated cells in the airway epithelium of both large and small airways. Less intense immunoreactivity was observed in vascular endothelium and glandular epithelium. 4. Treatment with LIF (0.5 ng ml-1) for 3 and 6 h significantly increased contractile responses to capsaicin by 42% and 43%, respectively, compared to time controls, whereas higher concentrations of LIF (5 and 50 ng ml-1) enhanced capsaicin-induced contractions only after 6 h. After 24 h, responses to capsaicin were not significantly different from 0 h control. Contractile responses to capsaicin following exposure to LIF at any concentration for 24 h were not significantly different from relative time control values. 5. Responses to [Sar9,Met()O2)11]-SP, carbachol and isoprenaline were not influenced by time in culture or by exposure to LIF for up to 48 h. Contractile responses induced by NKA were not influenced by 3 or 6 h exposure to LIF, but at 24 and 48 h the mean maximum contractile responses to NKA were significantly increased by 33% and 35%, respectively, compared to control. 6. These results demonstrate that LIF is present in guinea-pig and human airway epithelium, and modulates airway responses to tachykinins. In the acute setting LIF augments the capsaicin-induced release of endogenous tachykinins, whilst in the longer term (> 24 h), LIF increases airway smooth muscle responses to tachykinins via an NK2 receptor selective mechanism. We conclude that LIF may be an important effector molecule in the response of airways to injury or inflammation.

DOI 10.1038/sj.bjp.0700965
Citations Scopus - 22
1997 Knight DA, Stewart GA, Thompson PJ, 'Histamine-induced contraction of human isolated bronchus is enhanced by endogenous prostaglandin F-2 alpha and activation of TP receptors', EUROPEAN JOURNAL OF PHARMACOLOGY, 319 261-267 (1997)
DOI 10.1016/S0014-2999(96)00870-9
Citations Scopus - 3Web of Science - 2
1997 Knight D, Zheng X, Rocchini C, Jacobson M, Bai T, Walker B, 'Adenosine A 3 receptor stimulation inhibits migration of human eosinophils', Journal of Leukocyte Biology, 62 465-468 (1997)

Activation of adenosine A 3 receptors (A 3-R) produced a dose-dependent reduction in the chemotaxis of human eosinophils to platele... [more]

Activation of adenosine A 3 receptors (A 3-R) produced a dose-dependent reduction in the chemotaxis of human eosinophils to platelet-activating factor (PAF), RANTES, and leukotriene B 4 (LTB 4) to a maximum of 58, 48, and 52%, respectively (P< 0.02). This effect was completely reversed by selective A 3-R antagonists. In contrast, activation of A 1 or A(2a)-R did not affect PAF-induced eosinophil chemotaxis. PAF up-regulated the expression of CDllb/CD18, down-regulated L-selectin, and also increased F-actin assembly in eosinophils. The expression of these activation markers was not influenced by A 3-R, A(2a), or A 1-R stimulation. Activation of A 3-R may play an important role in inflammation by inhibiting eosinophil migration.

Citations Scopus - 81
1997 Walker BAM, Jacobson MA, Knight DA, Salvatore CA, Weir T, Zhou DY, Bai TR, 'Adenosine A(3) receptor expression and function in eosinophils', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 16 531-537 (1997)
Citations Web of Science - 128
1995 KNIGHT DA, STEWART GA, LAI ML, THOMPSON PJ, 'EPITHELIUM-DERIVED INHIBITORY PROSTAGLANDINS MODULATE HUMAN BRONCHIAL SMOOTH-MUSCLE RESPONSES TO HISTAMINE', EUROPEAN JOURNAL OF PHARMACOLOGY, 272 1-11 (1995)
DOI 10.1016/0014-2999(94)00601-3
Citations Web of Science - 20
1995 KNIGHT DA, STEWART GA, THOMPSON PJ, 'PROSTAGLANDIN E(2), BUT NOT PROSTACYCLIN INHIBITS HISTAMINE-INDUCED CONTRACTION OF HUMAN BRONCHIAL SMOOTH-MUSCLE', EUROPEAN JOURNAL OF PHARMACOLOGY, 272 13-19 (1995)
DOI 10.1016/0014-2999(94)00602-4
Citations Web of Science - 24
1994 KNIGHT DA, STEWART GA, THOMPSON PJ, 'THE RESPIRATORY EPITHELIUM AND AIRWAY SMOOTH-MUSCLE HOMEOSTASIS - ITS RELEVANCE TO ASTHMA', CLINICAL AND EXPERIMENTAL ALLERGY, 24 698-706 (1994)
DOI 10.1111/j.1365-2222.1994.tb00980.x
Citations Web of Science - 13
1993 KNIGHT DA, THOMPSON PJ, STEWART GA, 'PGE2 BUT NOT PGI2 ACCOUNTS FOR THE INHIBITORY EFFECT OF PROSTAGLANDINS (PG) IN HISTAMINE TACHYPHYLAXIS (HT) ON HUMAN BRONCHIAL SMOOTH-MUSCLE (HBSM)', AMERICAN REVIEW OF RESPIRATORY DISEASE, 147 A449-A449 (1993)
Citations Web of Science - 1
1992 KNIGHT DA, STEWART GA, THOMPSON PJ, 'HISTAMINE TACHYPHYLAXIS IN HUMAN AIRWAY SMOOTH-MUSCLE - THE ROLE OF H-2-RECEPTORS AND THE BRONCHIAL EPITHELIUM', AMERICAN REVIEW OF RESPIRATORY DISEASE, 146 137-140 (1992)
Citations Scopus - 22Web of Science - 24
1991 KNIGHT DA, PHILLIPS MJ, STEWART GA, THOMPSON PJ, 'THE INTERACTION OF ACETYLCHOLINE AND HISTAMINE ON HUMAN BRONCHIAL SMOOTH-MUSCLE CONTRACTION', EUROPEAN RESPIRATORY JOURNAL, 4 985-991 (1991)
Citations Web of Science - 7
1988 FERNANDES LB, KNIGHT DA, RIGBY PJ, SPINA D, PATERSON JW, GOLDIE RG, 'BETA-ADRENOCEPTOR DESENSITIZATION IN GUINEA-PIG ISOLATED TRACHEA', EUROPEAN JOURNAL OF PHARMACOLOGY, 157 135-145 (1988)
DOI 10.1016/0014-2999(88)90376-7
Citations Scopus - 16Web of Science - 22
Show 111 more journal articles

Review (15 outputs)

Year Citation Altmetrics Link
2012 Roth HM, Wadsworth SJ, Kahn M, Knight DA, 'The airway epithelium in asthma: Developmental issues that scar the airways for life?', Pulmonary Pharmacology and Therapeutics (2012) [D1]
DOI 10.1016/j.pupt.2012.09.004
Citations Scopus - 2Web of Science - 2
2012 Knight D, Yang IA, Ko FWS, Lim TK, 'Year in review 2011: Asthma, chronic obstructive pulmonary disease and airway biology', Respirology (2012) [D1]
DOI 10.1111/j.1440-1843.2012.02126.x
Citations Scopus - 4Web of Science - 4
2011 Hirota JA, Hackett T-L, Inman MD, Knight D, 'Modeling asthma in mice: What have we learned about the airway epithelium?', American Journal of Respiratory Cell and Molecular Biology (2011) [D1]
DOI 10.1165/rcmb.2010-0146TR
Citations Scopus - 14Web of Science - 12
2011 Reddel HK, Lim TK, Mishima M, Wainwright CE, Knight D, 'Year-in-review 2010: Asthma, COPD, cystic fibrosis and airway biology', Respirology (2011) [D1]
DOI 10.1111/j.1440-1843.2011.01949.x
Citations Scopus - 3Web of Science - 1
2010 Knight D, Rossi FM, Hackett T-L, 'Mesenchymal stem cells for repair of the airway epithelium in asthma', Expert Review of Respiratory Medicine (2010) [D1]
DOI 10.1586/ers.10.72
Citations Scopus - 5
2010 Hackett TL, Knight D, Sin DD, 'Potential role of stem cells in management of COPD', International Journal of COPD (2010) [D1]
Citations Scopus - 11
2008 Warner SM, Knight D, 'Airway modeling and remodeling in the pathogenesis of asthma', Current Opinion in Allergy and Clinical Immunology (2008) [D1]
DOI 10.1097/ACI.0b013e3282f3b5cb
Citations Scopus - 28Web of Science - 23
2007 An SS, Bai TR, Bates JHT, Black JL, Brown RH, Brusasco V, et al., 'Airway smooth muscle dynamics: A common pathway of airway obstruction in asthma', European Respiratory Journal (2007) [D1]
DOI 10.1183/09031936.00112606
Citations Scopus - 188Web of Science - 187
2007 Hackett T-L, Knight D, 'The role of epithelial injury and repair in the origins of asthma', Current Opinion in Allergy and Clinical Immunology (2007) [D1]
DOI 10.1097/ACI.0b013e328013d61b
Citations Scopus - 60Web of Science - 50
2005 Bai TR, Knight DA, 'Structural changes in the airways in asthma: Observations and consequences', Clinical Science: an international journal of translational science and medicine (2005) [D1]
DOI 10.1042/CS20040342
Citations Scopus - 95Web of Science - 88
2004 Knight DA, 'Talniflumate (Genaera)', Current Opinion in Investigational Drugs (Print) (2004) [D1]
Citations Scopus - 10
2004 Mutsaers SE, McAnulty RJ, Laurent GJ, Knight DA, 'Evaluation of experimental models of idiopathic pulmonary fibrosis', Drug Discovery Today: Disease Models (2004) [D1]
DOI 10.1016/j.ddmod.2004.11.007
Citations Scopus - 7
2003 Knight DA, Ernst M, Anderson GP, Moodley YP, Mutsaers SE, 'The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: Critical determinants of disease susceptibility and progression?', Pharmacology & Therapeutics (2003) [D1]
DOI 10.1016/S0163-7258(03)00095-0
Citations Scopus - 25Web of Science - 24
2003 O'Hara KA, Kedda M-A, Thompson PJ, Knight DA, 'Oncostatin M: An interleukin-6-like cytokine relevant to airway remodelling and the pathogenesis of asthma', Clinical and Experimental Allergy (2003) [D1]
DOI 10.1046/j.1365-2222.2003.01714.x
2003 Knight DA, Holgate ST, 'The airway epithelium: Structural and functional properties in health and disease', Respirology (2003) [D1]
DOI 10.1046/j.1440-1843.2003.00493.x
Citations Scopus - 219Web of Science - 194
Show 12 more reviews

Conference (13 outputs)

Year Citation Altmetrics Link
2014 Goggins B, Minahan K, Marks E, Mateer S, Cardona J, Knight D, et al., 'Hypoxia inducible factor (HIF)-1 accelerates epithelial wound healing through integrin regulation', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Jay Horvat
2014 Starkey M, Hanish I, Dua K, Nair P, Haw T, Hsu A, et al., 'Interleukin-13 predisposes mice to more severe influenza infection by suppressing interferon responses and activating microRNA-21/PI3K', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
DOI 10.1016/j.cyto2014.07.182
Co-authors Peter Wark, Philip Hansbro, Alan Hsu, Malcolm Starkey, Jay Horvat, Paul Foster
2014 Garratt LW, Sutanto EN, Ling KM, Looi K, Kicic-Starcevich E, Iosifidis T, et al., 'IDENTIFICATION OF MMP DYSREGULATION IN EARLY CF - EVIDENCE BASED RATIONALE FOR ANTI-PROTEASE THERAPY', RESPIROLOGY (2014) [E3]
2013 Looi K, Larcombe A, Zosky G, Rigby P, Knight DA, Stick SM, Kicic A, 'HUMAN RHINOVIRUS INFECTION INITIATES AIRWAY EPITHELIAL TIGHT JUNCTION DISASSEMBLY RESULTING IN BARRIER FUNCTION DISRUPTION', RESPIROLOGY (2013) [E3]
2013 Looi K, Larcombe A, Zosky G, Rigby P, Knight DA, Stick SM, Kicic A, 'HUMAN RHINOVIRUS INFECTION OF ASTHMATIC AIRWAY EPITHELIAL CELLS CAUSES TIGHT JUNCTION DISASSEMBLY RESULTING IN INCREASED PERMEABILITY', RESPIROLOGY (2013) [E3]
DOI 10.1111/resp.12183_18
2011 Abraham T, Hirota J, Elliot M, Knight D, Hogg J, 'How Multiphoton and Harmonic Generation Microscopy Methods are Useful in Understanding Lung Structure and Related Diseases', Microscopy and Microanalysis, Nashville, Tennessee, USA (2011) [E1]
DOI 10.1017/S1431927611002261
2010 O'Donoghue RJJ, Knight DA, Jarnicki AG, Jones J, Anderson GP, Mutsaers SE, Ernst M, 'Interleukin-6-induced STAT3 signaling links inflammation to chronic lung disease in mice', CYTOKINE, Chicago, IL (2010) [E3]
DOI 10.1016/j.cyto.2010.07.317
2010 Cooper DM, Hackett TL, Boivin WA, Knight DA, Granville DJ, 'Granzymes and Wound Repair', ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, San Francisco, CA (2010) [E3]
2009 Pechkovsky DV, Hackett TL, Shaheen F, Hogaboam CM, Selman M, McAnulty RJ, et al., 'Altered Level of STAT3 Basal Activity Influences Lung Fibroblast Thy-1 and alpha v beta 3 Integrin Expression', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
2009 Shaheen F, Hackett TL, Knight DA, Pechkovsky DV, 'Blockade of ALK5 in Normal Lung Parenchymal Fibroblasts Inhibits Exaggerated Smad3 and JNK Signaling and Reverses Their Myofibroblast-Like Phenotype Compared with Paired Bronchial Wall-Derived Fibroblasts.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
2009 Stefanowicz D, Hackett T-L, Avila L, Neumann S, Kicic A, Stick S, et al., 'DNA Methylation Profiles of Asthmatic Airway Epithelial Cells.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
2009 Hackett T-L, Stefanowicz D, Shaheen F, Pechkovsky D, Warner SM, Murray L, et al., 'Epithelial-Mesenchymal Transition Occurs in Undifferentiated Basal Airway Epithelial Cells Derived from Normal and Asthmatic Subjects.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
2002 Lee YCG, Knight DA, Lane KB, Cheng DS, Koay MA, Teixeira IR, et al., 'Activation of protease activated receptor-2 in mesothelial cells: A novel mechanism of pleural inflammation', THORAX, LONDON, ENGLAND (2002)
Show 10 more conferences
Edit

Grants and Funding

Summary

Number of grants 52
Total funding $9,098,073

Click on a grant title below to expand the full details for that specific grant.


20152 grants / $1,101,476

Modifying epigenetics as a novel treatment in COPD$1,076,254

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Professor Darryl Knight, Conjoint Professor Peter Wark, Professor Ian Adcock
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1400006
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Do viral infection and bronchoconstriction interact during exacerbation of asthma prolonging viral infection and worsening disease in the long term?$25,222

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Conjoint Associate Professor Christopher Grainge, Professor Darryl Knight
Scheme Research Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1500546
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20148 grants / $845,787

A novel approach to understanding Asthma: Focus on the epithelium $617,209

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Darryl Knight, Professor Phil Hansbro, Professor Stephen Stick, Dr Anthony Kicic
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1300212
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The Nanostring nCounter System$75,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
Scheme Major Equipment Award
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1300853
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The Nanostring nCounter System$40,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
Scheme Equipment Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1301083
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Mechanisms of dysregulated antiviral signallings to influenza infection in chronic obstructive pulmonary disease$27,512

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Doctor Alan Hsu, Doctor Fatemeh Moheimani, Professor Darryl Knight, Conjoint Professor Peter Wark
Scheme Research Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1400435
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Miltenyi Biotec GentleMACS Octo Dissociator with Heaters $23,566

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Darryl Knight, Professor Dirk Van Helden, Professor Joerg Mattes, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Associate Professor Liz Milward, Dr NATHAN Bartlett, Doctor Simon Keely, Doctor Steven Maltby, Doctor Andrew Jarnicki, Doctor Malcolm Starkey, Doctor Adam Collison, Ms Shaan Gellatly
Scheme Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1500861
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Do asthma attacks worsen asthma in the long term?$22,500

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Associate Professor Christopher Grainge, Professor Darryl Knight
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401402
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The Nanostring nCounter System$20,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Professor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
Scheme Research Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1301084
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Immunosenescence in chronic obstructive pulmonary disease leads to abnormal innate immune responses to human rhinovirus infection$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Wark, Professor Darryl Knight
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301331
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20132 grants / $605,430

Defective cell migration as a mechanism of dysregulated asthmatic airway repair$595,430

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Project Grant
Role Investigator
Funding Start 2013
Funding Finish 2015
GNo
Type Of Funding Not Known
Category UNKN
UON Y

Role of the transcriptional co-activator p300 in resetting epithelial differentiation: A potential pathway involved in asthma prevention and therapy$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Fatemeh Moheimani, Professor Darryl Knight, Miss Kirsty Wark, Doctor Alan Hsu, Doctor Malcolm Starkey
Scheme Early Career Researcher Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1301174
Type Of Funding Internal
Category INTE
UON Y

20121 grants / $510,000

Airway epithelial barrier function, asthma and aero?allergen sensitization.$510,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2014
GNo
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20113 grants / $258,465

Inhaled Corticosteroids as risk factors for severe viral infections in asthmatics: lessons from the H1N1 epidemic$130,558

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Project Team
Scheme Operating Grant
Role Investigator
Funding Start 2011
Funding Finish 2013
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

Resetting epithelial differentiation as a novel therapeutic approach to treating asthma$120,407

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Project Team
Scheme Operating Grant
Role Lead
Funding Start 2011
Funding Finish 2013
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

Heart and Lung Health FEST 2011$7,500

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Project Team
Scheme Meetings, Planning and Dissemination Grant: Circulatory and Respiratory Health
Role Lead
Funding Start 2011
Funding Finish 2011
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

20103 grants / $144,155

Exacerbation of H1N1 Influenza infection with inhaled therapeutics in primary epithelial cells and ex vivo tissue from asthma patients: clarification of primary treatment strategies during pandemic in$94,155

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Project Team
Scheme Operating Grant: Health Systems Research on H1N1
Role Lead
Funding Start 2010
Funding Finish 2011
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

Defining phenotypes of fibroblasts within the human airways and lung parenchyma for better understanding of fibrotic diseases$25,000

Funding body: British Columbia Lung Association

Funding body British Columbia Lung Association
Project Team
Scheme Funds Granted
Role Investigator
Funding Start 2010
Funding Finish 2012
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

New emerging paradigm in asthma: The role of E-cadherin in aberrant airway epithelial repair$25,000

Funding body: British Columbia Lung Association

Funding body British Columbia Lung Association
Project Team
Scheme Funds Granted
Role Investigator
Funding Start 2010
Funding Finish 2012
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

20093 grants / $948,449

Dysregulated STAT-3 activation underlies lung fibroblast heterogeneity: Implications for idiopathic pulmonary fibrosis$464,649

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Project Team
Scheme Operating Grant
Role Lead
Funding Start 2009
Funding Finish 2013
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

Canada Research Chairholder$375,000

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Project Team
Scheme Canada Research Chairs - CIHR Funded - Tier 2
Role Lead
Funding Start 2009
Funding Finish 2013
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

Regulation of mesenchymal cell behaviour by versican: Implications of arterial remodeling$108,800

Funding body: Heart & Stroke Foundation

Funding body Heart & Stroke Foundation
Project Team
Scheme Funds Granted
Role Investigator
Funding Start 2009
Funding Finish 2012
GNo
Type Of Funding International - Non Competitive
Category 3IFB
UON Y

20081 grants / $150,000

Novel Therapy for Pulmonary Fibrosis$150,000

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Project Team
Scheme Proof of Principle Program - Phase I
Role Lead
Funding Start 2008
Funding Finish 2009
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

20073 grants / $664,500

The role of gp130 receptor mediated signalling in fibrotic pulmonary diseases.$544,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Project Grant
Role Lead
Funding Start 2007
Funding Finish 2009
GNo
Type Of Funding Not Known
Category UNKN
UON Y

Dysregulated epithelial repair in pediatric asthma$100,000

Funding body: Johnson & Johnson Medical Education Foundation

Funding body Johnson & Johnson Medical Education Foundation
Project Team
Scheme Funds Granted
Role Lead
Funding Start 2007
Funding Finish 2010
GNo
Type Of Funding International - Non Competitive
Category 3IFB
UON Y

Dysregulated STAT-3 activation in the Pathogenesis of IPF$20,000

Funding body: British Columbia Lung Association

Funding body British Columbia Lung Association
Project Team
Scheme Funds Granted
Role Lead
Funding Start 2007
Funding Finish 2009
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

20062 grants / $713,151

Genetic and epigenetic determinants of asthmatic epithelial cell Phenotype$369,000

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Project Team
Scheme Operating Grant
Role Investigator
Funding Start 2006
Funding Finish 2010
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

Environmental impact on the epithelial immune barrier in asthma$344,151

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Project Team
Scheme Project Grant
Role Lead
Funding Start 2006
Funding Finish 2008
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

20054 grants / $426,750

Regulation of gp130 signaling by STAT-3 in the pathogenesis of pulmonary fibrosis$251,084

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Project Team
Scheme Operating Grant
Role Lead
Funding Start 2005
Funding Finish 2009
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

Role and regulation of the proteoglycan, versican, in vascular injury and repair$110,666

Funding body: Heart & Stroke Foundation

Funding body Heart & Stroke Foundation
Project Team
Scheme Funds Granted
Role Investigator
Funding Start 2005
Funding Finish 2008
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

Regulation of gp130 signaling by STAT-3 in the pathogenesis of pulmonary fibrosis$50,000

Funding Body: Canadian Institutes of Health Research Funding Scheme: Operating Grant -PA: Inst of Circulatory and Respiratory Health - Bridge Funding Description: .

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Project Team
Scheme Operating Grant -PA: Inst of Circulatory and Respiratory Health - Bridge Funding
Role Lead
Funding Start 2005
Funding Finish 2006
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

Regulation of gp130 signaling of gp130 in the pathogenesis of pulmonary fibrosis$15,000

Funding body: Providence Health Care

Funding body Providence Health Care
Project Team
Scheme Funds Granted
Role Lead
Funding Start 2005
Funding Finish 2006
GNo
Type Of Funding International - Non Competitive
Category 3IFB
UON Y

20047 grants / $1,874,836

Canada Research Chairholder$500,000

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Project Team
Scheme Canada Research Chairs - CIHR Funded - Tier 2
Role Lead
Funding Start 2004
Funding Finish 2010
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

Altered signalling by a common cytokine receptor is important in the development of fibrotic lung diseases.$449,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2006
GNo
Type Of Funding Not Known
Category UNKN
UON Y

Establishment Grant$301,000

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Project Team
Scheme Institutional Establishment Grant (IEG) Program
Role Lead
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

The airway epithelium, atopy and asthma$259,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2006
GNo
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Role Of Zinc In The Respiratory Epithelium and asthma$220,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2006
GNo
Type Of Funding Not Known
Category UNKN
UON Y

Mechanisms of Airway Disease$114,416

Funding body: Canadian Foundation for Innovation

Funding body Canadian Foundation for Innovation
Project Team
Scheme Canada Research Chairs Infrastructure Fund
Role Lead
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

Integrin-growth factor interactions in the development of airway wall remodeling$29,420

Funding body: British Columbia Lung Association

Funding body British Columbia Lung Association
Project Team
Scheme Funds Granted
Role Lead
Funding Start 2004
Funding Finish 2006
GNo
Type Of Funding International - Competitive
Category 3IFA
UON Y

20034 grants / $509,098

Regulation of the structural changes in the airways of chronic asthmatics$384,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Project Grant
Role Lead
Funding Start 2003
Funding Finish 2005
GNo
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Equipment grant$73,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Equipment Grant
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo
Type Of Funding Not Known
Category UNKN
UON Y

Infrastructure grant$36,098

Funding body: Medical and Health Research Infrastructure Council (MHRIC)

Funding body Medical and Health Research Infrastructure Council (MHRIC)
Project Team
Scheme Infrastructure grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo
Type Of Funding Not Known
Category UNKN
UON Y

Equipment grant$16,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding body Rebecca L Cooper Medical Research Foundation Ltd
Project Team
Scheme Funds Granted
Role Lead
Funding Start 2003
Funding Finish 2003
GNo
Type Of Funding International - Non Competitive
Category 3IFB
UON Y

20022 grants / $15,000

Three-dimensional confocal analysis of sensory nerves, neuroendocrine cells and dendritic cells in human airways.$10,000

Funding body: Sir Charles Gairdner Hospital

Funding body Sir Charles Gairdner Hospital
Project Team
Scheme Funds Granted
Role Lead
Funding Start 2002
Funding Finish 2002
GNo
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

University of Western Australia$5,000

Funding body: University of Western Australia

Funding body University of Western Australia
Project Team
Scheme Funds Granted
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo
Type Of Funding Internal
Category INTE
UON Y

20012 grants / $105,400

The Immunobiology of Asthma with particular reference to the Respiratory Epithelium$61,500

Funding body: Sir Charles Gairdner Hospital

Funding body Sir Charles Gairdner Hospital
Project Team
Scheme Funds Granted
Role Investigator
Funding Start 2001
Funding Finish 2002
GNo
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Interleukin (IL-) 11 and IL-6 differentially influence fibroblast proliferation and apoptosis: Implications for airway inflammation and airway remodeling$43,900

Funding body: Asthma Foundation of Western Australia

Funding body Asthma Foundation of Western Australia
Project Team
Scheme Funds Granted
Role Lead
Funding Start 2001
Funding Finish 2001
GNo
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

20001 grants / $76,700

Epithelium-fibroblast interactions in response to allergic airway inflammation$76,700

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Project Grant
Role Lead
Funding Start 2000
Funding Finish 2002
GNo
Type Of Funding Not Known
Category UNKN
UON Y

19993 grants / $91,476

The role of Oncostatin M and Leukemia Inhibitory Factor in airway remodeling$48,576

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Project Grant
Role Lead
Funding Start 1999
Funding Finish 2001
GNo
Type Of Funding Not Known
Category UNKN
UON Y

The effects of house dust mite allergens on the activation of submucosal glands and mucus secretion in human isolated airways: The modulatory role of Oncostatin M and Leukemia Inhibitory Factor.$22,900

Funding body: Asthma Foundation of Western Australia

Funding body Asthma Foundation of Western Australia
Project Team
Scheme Funds Granted
Role Lead
Funding Start 1999
Funding Finish 1999
GNo
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Assessment of the effects of chronic inflammation on structural remodelling and functional responses of human airways in vitro.$20,000

Funding body: Lung Foundation Australia

Funding body Lung Foundation Australia
Project Team
Scheme Shared
Role Lead
Funding Start 1999
Funding Finish 2000
GNo
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

19981 grants / $57,400

A novel explant model to investigate epithelial damage and airway remodelling in human airways. $57,400

Funding body: Raine Medical Research Foundation

Funding body Raine Medical Research Foundation
Project Team
Scheme Funds Granted
Role Lead
Funding Start 1998
Funding Finish 1999
GNo
Type Of Funding Not Known
Category UNKN
UON Y
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Research Supervision

Number of supervisions

Completed13
Current7

Total current UON EFTSL

PhD1.05

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2015 PhD Epigenetics of Lung Cancer
Microbiology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD Contribution of Cell Death to the Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD Investigation of Novel Immune Molecules in the Pathogenesis of Female Chlamydia Genital Tract Infections
Microbiology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD To assess the role of IFNe in modulating innate immune responses and protecting against Chlamydia infection in human tissues
Microbiology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD Role of Mechanical Forces in Asthma Pathogenesis
General Medicine, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Hypoxia Inducible Factor (HIF)-1 mediates epithelial wound healing through integrin regulation
Microbiology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2011 Post-Doctoral Fellowship Regulation of epithelial cell differentiation
Health, University of British Columbia
Principal Supervisor
2011 Masters Role of STAT-3 in regulating fibroblast function
Health, University of British Columbia
Principal Supervisor
2009 PhD Characterising factors that regulate epithelial proliferation in childhood asthma
Health, University of Western Australia
Principal Supervisor
2008 PhD Role of Gp130/STAT-3 in pulmonary fibrosis
Health, University of Western Australia
Principal Supervisor
2007 Post-Doctoral Fellowship HB-EGF, TGF? and epithelial function
Health, University of British Columbia
Principal Supervisor
2007 PhD Airway epithelium and particular matter air pollutuion
Health, University of Western Australia
Co-Supervisor
2006 PhD Paediatric airway epithelial cells in asthma
Health, University of Western Australia
Co-Supervisor
2006 PhD Characterising the role of oncostatin M in human lung
Health, University of Western Australia
Principal Supervisor
2005 PhD Interaction between integrins and growth factors of fibroblast function
Health, University of Western Australia
Principal Supervisor
2004 PhD Gp130/STAT3 activation in pulmonary fibrosis
Health, University of Western Australia
Principal Supervisor
2003 Post-Doctoral Fellowship Integrins and epithelial function
Health, University of Western Australia
Principal Supervisor
2003 Honours Integrins and growth Factors and epithelial cells
Health, University of Western Australia
Principal Supervisor
2002 Honours Interaction between viruses and oncostatin M in human airway epithelium
Health, University of Western Australia
Principal Supervisor
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News

PhD Scholarship - Role of mechanical forces in asthma pathogenesis

PhD Scholarship - Role of mechanical forces in asthma pathogenesis

July 30, 2014

Applications are open for a PhD scholarship at the University of Newcastle. As the successful applicant you will undertake your doctoral studies in the Priority Research Centre for Asthma and Respiratory Disease at the Hunter Medical Research Institute in Newcastle.

Professor Darryl Knight

Position

Head of School
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Contact Details

Email darryl.knight@newcastle.edu.au
Phone (02) 4921 7485
Fax (02) 4921 7403

Office

Room MS606
Building Medical Sciences Building
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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