Staff Profile
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Career Summary
Qualifications
- PhD, University of Newcastle, 11/05/1991
- Bachelor of Science (Honours), University of Newcastle, 03/05/1986
Research
Research keywords
- Carcinogenesis
- Microbiology
- Oncology
- Oncolytic Virotherapy
- Virology
Research expertise
- Virology and Oncolytic Virotherapy.
- The molecular biology of picornaviruses, and the potential use of viruses as anti-cancer agents.
Fields of Research
| Code | Description | Percentage |
|---|---|---|
| 111200 | Oncology And Carcinogenesis | 50 |
| 110399 | Clinical Sciences Not Elsewhere Classified | 35 |
| 030499 | Medicinal And Biomolecular Chemistry Not Elsewhere Classified | 15 |
Memberships
NHMRC Committee
- Group review panel member NHMRC 2001-2003
Awards
HMRI Young Medical Researcher of the Year
| 1998 | HMRI Young Medical Researcher of the Year Hunter Medical Institute (Australia) |
|---|
Invitations
| 3rd International Conference on Oncolytic Viruses as Cancer Therapeutics Mayo Clinic, Canada (Conference Presentation - non published.) | 2005 |
Edit
- Indicates that the researcher may be seeking students for this project.HMRI - Viruses, Infection/Immunity, Vaccines and Asthma Research Program$692,213
Characteristics and mechanisms of persistent asthma after common cold virus infection$400,250
A study of the epidemiology and virulence of enterovirus 71 strains from the Asia-Pacific region$90,000
9th World Congress on Cancer of the Skin, Seville 7-10 May, 2003$2,400
Ultra Low Temperature Upright Freezer including Racks and Storage box for Viral Laboratory establishment$20,613
Recombinant Coxsackievirus A21 as a vector for the delivery of melanoma antigen MAGE-10$9,000
Modulation of virus-cellular receptor interactions in picornaviral pathogenesis.$420,380
Virus induced asthma: mechanisms and management.$390,475
Development of an Elisa-based detection system for Listeria spp. and Listeria monocytogenes utilizing recombinant antibodies$45,000
Thermo Labsystem Luminoskan Ascent - Microplate Luminometer$23,031
Control of melanoma progression by a prime/boost vaccination protocol against melanoma antigen (MART-1).$18,000
Development of an Elisa-based detection system for Listeria spp. and Listeria monocytogenes utilizing recombinant antibodies$10,000
5th Annual Meeting of the European Society of Clinical Virology, Finland 2-6 September 2001$2,400
Viruses Interacting with Melanoma.$230,178
Inverted Fluoresence Microscope.$12,000
Visitor Grant Ms Susanna Johansson, From 1 October 2000 to 22 November 2000.$5,006
VIIIth International Metastasis Research Society Congress, UK 24-27 September 2000$2,400
Virus receptor cooperativity$393,577
Virus Receptor Down Regulation: A Possible Cure for the Common Cold$25,000
Soluble virus receptors as antivirals.$13,500
Generation and characterisation of viral cell receptor escape mutants.$13,000
EUROPIC 98$2,500
Generation and characterisation of viral cell receptor escape mutants$12,000
Receptor Co-operativity in viral cell entry.$308,631
1st European Meeting of Virology (Germany) - 10-13 September 1995$2,400
Australian Society of Microbiology - Melbourne - 25-30 September 1994$787
Extending the Host Range of common cold Viruses$14,000
'IX Intern. Congress of Virology', Glasgow, Scotland, 9 - 14 August 1993$2,500
Replication of HIV in mice via chimeric virus receptors$177,647
Identification Of The Pseudocaspsular Antigens Of In Vivo Propogated Staphylococcus Aureus.$8,000
Extending The Host Range Of Common Cold Viruses$6,300
Grants and Funding
Summary
| Number of grants | 31 |
|---|---|
| Total funding | $3,353,188 |
For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.
Click on a grant title below to expand the full details for that specific grant.
2007 (1 grants)
HMRI - Viruses, Infection/Immunity, Vaccines and Asthma Research Program$692,213
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Stephen Graves, Associate Professor Darren Shafren | ||
| Scheme | Role | |
| MRSP Infrastructure Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $692,213 | 2007 | 2009 |
| GNo:G0187930 | ||
2004 (1 grants)
Characteristics and mechanisms of persistent asthma after common cold virus infection$400,250
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Professor Peter Gibson, Associate Professor Darren Shafren, Emeritus Professor Michael Hensley | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $400,250 | 2004 | 2006 |
| GNo:G0182884 | ||
2003 (2 grants)
A study of the epidemiology and virulence of enterovirus 71 strains from the Asia-Pacific region$90,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $90,000 | 2003 | 2005 |
| GNo:G0183208 | ||
9th World Congress on Cancer of the Skin, Seville 7-10 May, 2003$2,400
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,400 | 2003 | 2003 |
| GNo:G0183047 | ||
2002 (2 grants)
Ultra Low Temperature Upright Freezer including Racks and Storage box for Viral Laboratory establishment$20,613
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle, Emeritus Professor Michael Hensley, Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,613 | 2002 | 2002 |
| GNo:G0181920 | ||
Recombinant Coxsackievirus A21 as a vector for the delivery of melanoma antigen MAGE-10$9,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $9,000 | 2002 | 2002 |
| GNo:G0181318 | ||
2001 (7 grants)
Modulation of virus-cellular receptor interactions in picornaviral pathogenesis.$420,380
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $420,380 | 2001 | 2003 |
| GNo:G0179693 | ||
Virus induced asthma: mechanisms and management.$390,475
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle, Emeritus Professor Michael Hensley, Conjoint Professor Peter Jones, Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $390,475 | 2001 | 2003 |
| GNo:G0179694 | ||
Development of an Elisa-based detection system for Listeria spp. and Listeria monocytogenes utilizing recombinant antibodies$45,000
Funding Body: Tecra International Pty Ltd
| Project Team | ||
|---|---|---|
| Professor Phil Hansbro, Associate Professor Darren Shafren | ||
| Scheme | Role | |
| University Grant Partner funding | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $45,000 | 2001 | 2003 |
| GNo:G0181526 | ||
Thermo Labsystem Luminoskan Ascent - Microplate Luminometer$23,031
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle, Emeritus Professor Michael Hensley, Conjoint Professor Peter Jones, Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $23,031 | 2001 | 2001 |
| GNo:G0181176 | ||
Control of melanoma progression by a prime/boost vaccination protocol against melanoma antigen (MART-1).$18,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren, Conjoint Associate Professor Alistair Ramsay | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $18,000 | 2001 | 2001 |
| GNo:G0180126 | ||
Development of an Elisa-based detection system for Listeria spp. and Listeria monocytogenes utilizing recombinant antibodies$10,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Phil Hansbro, Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Collaborative Research Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2001 | 2001 |
| GNo:G0181525 | ||
5th Annual Meeting of the European Society of Clinical Virology, Finland 2-6 September 2001$2,400
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,400 | 2001 | 2001 |
| GNo:G0181419 | ||
2000 (4 grants)
Viruses Interacting with Melanoma.$230,178
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Greater Newcastle Permanent | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $230,178 | 2000 | 2002 |
| GNo:G0180198 | ||
Inverted Fluoresence Microscope.$12,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren, Conjoint Associate Professor Alistair Ramsay, Conjoint Professor Kenneth Beagley | ||
| Scheme | Role | |
| Equipment Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $12,000 | 2000 | 2000 |
| GNo:G0179168 | ||
Visitor Grant Ms Susanna Johansson, From 1 October 2000 to 22 November 2000.$5,006
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Visitor Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $5,006 | 2000 | 2000 |
| GNo:G0179925 | ||
VIIIth International Metastasis Research Society Congress, UK 24-27 September 2000$2,400
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,400 | 2000 | 2000 |
| GNo:G0180186 | ||
1999 (3 grants)
Virus receptor cooperativity$393,577
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $393,577 | 1999 | 2001 |
| GNo:G0178355 | ||
Virus Receptor Down Regulation: A Possible Cure for the Common Cold$25,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Research Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $25,000 | 1999 | 1999 |
| GNo:G0178395 | ||
Soluble virus receptors as antivirals.$13,500
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $13,500 | 1999 | 1999 |
| GNo:G0178121 | ||
1998 (2 grants)
Generation and characterisation of viral cell receptor escape mutants.$13,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $13,000 | 1998 | 1998 |
| GNo:G0177357 | ||
EUROPIC 98$2,500
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,500 | 1998 | 1998 |
| GNo:G0180597 | ||
1997 (1 grants)
Generation and characterisation of viral cell receptor escape mutants$12,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $12,000 | 1997 | 1997 |
| GNo:G0176715 | ||
1996 (1 grants)
Receptor Co-operativity in viral cell entry.$308,631
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren, Professor Gordon Burns, Conjoint Professor Richard Barry | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $308,631 | 1996 | 1998 |
| GNo:G0175381 | ||
1995 (1 grants)
1st European Meeting of Virology (Germany) - 10-13 September 1995$2,400
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,400 | 1995 | 1995 |
| GNo:G0175627 | ||
1994 (1 grants)
Australian Society of Microbiology - Melbourne - 25-30 September 1994$787
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $787 | 1994 | 1994 |
| GNo:G0175136 | ||
1993 (2 grants)
Extending the Host Range of common cold Viruses$14,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $14,000 | 1993 | 1993 |
| GNo:G0172758 | ||
'IX Intern. Congress of Virology', Glasgow, Scotland, 9 - 14 August 1993$2,500
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,500 | 1993 | 1993 |
| GNo:G0174386 | ||
1992 (3 grants)
Replication of HIV in mice via chimeric virus receptors$177,647
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Commonwealth AIDS Research Grants (CARG) (Defunct) | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $177,647 | 1992 | 1995 |
| GNo:G0175452 | ||
Identification Of The Pseudocaspsular Antigens Of In Vivo Propogated Staphylococcus Aureus.$8,000
Funding Body: CSIRO - Research Management Committee
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Collaborative Research Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $8,000 | 1992 | 1992 |
| GNo:G0173689 | ||
Extending The Host Range Of Common Cold Viruses$6,300
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Darren Shafren | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $6,300 | 1992 | 1992 |
| GNo:G0174221 | ||
Edit
Research Supervision
| Number of current supervisions | 3 |
|---|---|
| Total current UoN PhD EFTSL | 1.1 |
For supervisions undertaken at an institution other that the University of Newcastle, details are shown in italics, and the institution name is listed below the program name.
Current Supervision
| Commenced | Proposed Completion | Program | Supervisor Type | Research Title |
|---|---|---|---|---|
| 2011 | 2015 | PhD (Immunology & Microbiol) | Co-Supervisor | Combination of Oncolytic Coxsackievirus A21 with Conventional Chemotherapy for the Treatment of Melanoma |
| 2011 | 2015 | PhD (Immunology & Microbiol) | Co-Supervisor | Investigation of Oncolytic Coxsackievirus A21 as a Potential Treatment for Lung Cancer |
| 2010 | 2014 | PhD (Immunology & Microbiol) | Co-Supervisor | Low Pathogenic Human Enteroviruses as Novel Anti-Cancer Agents Against Human Malignant Glioma |
Past Supervision
| Year | Program | Supervisor Type | Research Title |
|---|---|---|---|
| 2009 | PhD (Immunology & Microbiol) | Principal Supervisor | Enteroviral-Mediated Oncolysis of Cancer: Evaluation of Efficacy and Obstacles to Therapeutic Success |
| 2009 | PhD (Immunology & Microbiol) | Principal Supervisor | Enteroviruses as Novel Oncolytic Agents for the Control of Human Prostate Cancer |
| 2008 | PhD (Immunology & Microbiol) | Principal Supervisor | Viral Oncolysis of Human Breast Cancer |
| 2005 | PhD (Immunology & Microbiol) | Principal Supervisor | Control of Cancer Progression by Virotherapy |
| 2003 | PhD (Immunology & Microbiol) | Sole Supervisor | Mechanisms of Cell Entry and Release of Coxsackievirus B3 (CVB3) |
| 2003 | PhD (Immunology & Microbiol) | Principal Supervisor | Cellular Receptor Interactions of C Cluster Coxsackie A Viruses |
Edit
Associate Professor Darren Shafren
| Work Phone | (02) 4913 8158 |
|---|---|
| Fax | (02) 4913 8814 |
| Darren.Shafren@newcastle.edu.au | |
| Position | Associate Professor School of Biomedical Sciences and Pharmacy Faculty of Health and Medicine |
| Focus Area | Immunology and Microbiology |
| Office | DMB305, David Maddison Clinical Sciences Building, David Maddison Clinical Sciences Building |
| URL: | www.newcastle.edu.au/profile/darren-shafren |
