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Conjoint Professor Chris Levi

Conjoint Professor

School of Medicine and Public Health

Stroke of Genius

Internationally renowned stroke clinical researcher, Conjoint Professor Chris Levi is on a medical mission: "Cure more, improve more, harm less".

Professor Chris Levi with patient

Working on more than eight ground-breaking research projects improving stroke treatment options for patients, Professor Levi is on target to meet his goal, launching what he has described as "the most important acute stroke trial globally".

A clot-busting drug, Tenecteplase (TNK) will be trialled at 50 major hospitals around the world. Its potential to cure stroke in some patients has earned TNK the nickname 'The New Kid' on the stroke block.

Professor Levi and fellow University of Newcastle researcher Professor Mark Parsons, are the principal investigators on this global acute stroke trial.

"One in six people will experience a stroke in their lifetime. In Australia alone, there are 50,000 strokes every year - enough to fill the Sydney Cricket Ground," Professor Levi said.

"TNK is a clot-dissolving drug developed by industry and derived from a naturally occurring protein from the blood vessel wall. The trial will test TNK against the current standard clot-busting drug Alteplase," he said.

"Alteplase is good if it works. However, we need better, more effective and safer treatments.  Alteplase carries a small, but significant, risk of bleeding and only dissolves the clot in 30-40% of cases. TNK in Phase 2 Trial looks considerably better. We saw patients affected by stroke making almost miraculous recoveries on TNK."

Published in the prestigious New England Journal of Medicine, findings from Phase 2 Trial showed that two-thirds of patients treated with TNK displayed major improvement within 24 hours, and 72 per cent showed excellent recovery within three months after their stroke.

The TNK Phase 3 Trial begins in Australia and New Zealand in February 2014 and in Europe and Asia in mid-2014.

Australia's No 1 cause of disability 

Following his arrival at the University of Newcastle in 1999 to establish the Hunter Medical Research Institute (HMRI) Stroke Research Group, Professor Levi led the group to its current position, recognised globally as one of the leading teams for stroke research in imaging, clinical trials, health systems research and stroke genetics. Professor Levi is also the Director of the University of Newcastle's Priority Research Centre for Translational Neuroscience and Mental Health.

"Ten thousand people die from stroke each year in Australia. A quarter of those people are aged under 55," Professor Levi said.

"Death is one thing, disability is another. With 20,000 people left disabled by stroke in Australia, it's a major problem and the number one cause of disability. It is truly sad to see the impact of stroke on the patients and their families and communities.

"Frustration has been my driver. As a clinician, not being able to do enough for my patients or knowing that our health systems could be better is what drives me in research. The problem stares me in the face every day. "

Stroke of genes 

Part of a team of researchers from the University of Newcastle credited with making a major genetic discovery in stroke, Professor Levi said the future is in tailored medical care.

"We're using genetics to unravel the complex biology of the brain and to see if it can give us a clue to pre-determining factors of stroke," Professor Levi said.

Published in Nature Genetics in 2012, the discovery of the signal located within a regulatory DNA on Chromosome 6 (6p21.1) is strongly associated with large artery atherosclerotic stroke, which represent one quarter of acute strokes.

"We don't know very much about the genetics of stroke as yet. It's a very complex disease genetically, influenced by many genes and environmental factors. Most of these genetic factors are unknown but once we learn enough about them we'll be able to better profile people and advise if they are at risk of stroke."

Part of an International Stroke Genetics Consortium, Meta-Stroke, Professor Levi and his team are also collecting samples from patients with acute stroke, investigating genetic factors that could influence responsiveness to clot-busting treatment. 

"It's not just about whether you will have a stroke, we're also looking at how well you might do after a stroke and what treatment plan might work best for you."

"The body's enzyme systems are all under genetic control. Our genes basically set the plan for all of our body function and drugs. Pharmacological agents are influenced in both their efficacy and their safety by our enzyme systems in our body, which are influenced by our genes."

Setting the standard for stroke care

Professor Levi's drive and stellar reputation led him to being selected by the Australian Government to help set the upcoming national standards for treatment for stroke patients, as part of the Australian Commission for Quality and Safety in Health Care Clinical Standards and Indicators Group.  

"We're moving into an era in stroke medicine where it will be treatment tailored to the patient. Why? It's because every stroke is a bit different, every cause is a little different and it's not a one-size-fits-all-situation," Professor Levi said.

"Alteplase has been guideline approved for years, it's been out there on the market, but the proportion of stroke patients that get access to it across the country is only about five per cent. It should be in the order of 20 to 25 per cent.

"The Newcastle health system has been re-engineered over the past seven years so that 20 to 30 per cent are receiving clot-busting drugs within the 4.5 hour treatment window. We have achieved this through a number of initiatives."

Working with Stroke Awareness, Professor Levi's team has been promoting the FAST: Face, Arms, Speech and Time to call 000 message to raise community awareness of the signs of stroke and the importance of acting quickly to get treatment.

At the next stage, a Pre-hospital Acute Stroke Triage (PAST) program was introduced to both metropolitan and rural regions establishing systems to improve pre-hospital care and enhance access to clot-busting drugs. Techniques included bypass of smaller hospitals, helicopter transfer where needed, ambulance guidelines and cutting red tape. The system was introduced in the Hunter Region in 2007 and in 2013 was adopted across the state of New South Wales.

In the stroke of time

Professor Levi is also involved in two health systems studies, one aiming to improve diagnosis and treatment of transient ischaemic attack and minor stroke patients in general practices and hospitals, the other aiming to better implement clot-busting treatment.

INSIST, a National Health and Medical Research Council funded comparison study of Trans Ischemic Attacks (TIA) and minor strokes compares treatment of TIA patients from 20 different general practices in the Hunter Region to data collected by Oxford and Auckland Universities. The study assesses how GPs determine if someone is having a stroke, what happens to the patient, how they are looked after and what the long-term outcomes are.

The Thrombolysis ImPlementation in Stroke (TIPS) trial is a cluster-randomised trial that is testing strategies to boost the implementation of clot-busting drug treatment. It is testing various strategies including advanced training, education, behaviour change, executive support and more. The TIPS trial is running across 20 hospitals in QLD, NSW and Victoria.

Imaging in one stroke

The stroke research team have world leading expertise in the application of advanced CT imaging technology to acute stroke diagnosis and treatment.

Under the leadership of colleague Prof Mark Parsons, and working as a Toshiba International Luminary Site, the group have pioneered how brain perfusion imaging can better select individual patients for clot-busting treatment by identifying how much brain tissue remains viable at different time points after the onset of stroke.

The imaging analysis techniques and their applications are a world-first. Professor Levi is also investigating how combining CT imaging and ultrasound (fusion ultrasound) can be used to determine precisely when a clot has been dissolved and a blocked artery opens.

Professor Levi credits the integrated health care system in operation between the local community, John Hunter and Mater Hospitals, HMRI and the University as key to his group's success across many areas of stroke research. The various national, international and local research networks they have built is another reason for their achievements.

"Across the University and medical sector, we have people working with the Stroke Research Group in cognitive issues and depression post-stroke, imaging, nutrition, physical activity and more."

"By working together in an integrated system, we are making huge advances. The army of people we have pooled together is helping to win the battle against this crippling condition."

Stroke of Genius

Internationally renowned stroke clinical researcher, Conjoint Professor Chris Levi is on a medical mission: "Cure more, improve more, harm less".Working on more than eight ground-breaking research projects improving stroke treatment options for patients, Professor Levi is on target to meet…

Read more

Agent of change

The stroke treatments pioneered by Professor Chris Levi and his team have transformed lives and medical practice.

As a clinician, Conjoint Professor Chris Levi sees evidence of the benefits of his research every time he sends a healthy patient home. 

The internationally recognised stroke neurologist and researcher and the stroke research team at John Hunter Hospital, have driven breakthroughs in treatments and developed protocols that have vastly improved the outcomes for hundreds of stroke sufferers in the Hunter region. These approaches are now being adopted across Australia.

"For the right candidate, our treatment is dramatic – it is a cure for stroke," Levi says. "Twenty years ago, I would have said that was impossible."

Levi is the director of Acute Stroke Services at John Hunter Hospital and a co-director of the University's Centre for Translational Neuroscience and Mental Health Research.

The groundbreaking model of care developed by his team of medical researchers and clinicians combines the use of thrombolytic therapy, or 'clot-busting' drugs, with CT imaging of the brain. In suitable patients the clot-busting drug tPA can dissolve the blockage in their brain that has caused the stroke and prevent further damage. CT imaging is undertaken first to identify the areas of the brain that are salvageable.

Another integral part of the care model is a triage protocol that arms frontline health workers with the skills to identify stroke sufferers eligible for the treatment and fast track their passage to the acute stroke unit at the John Hunter Hospital. There is narrow four-and-a-half-hour window of opportunity for effective clot-busting therapy.

"By combining the treatments with our triage protocol we have improved our implementation of clot-busting therapy at John Hunter Hospital from 4 per cent of patients to over 20 per cent, which means more than 100 patients a year are receiving this therapy,'' Levi says.

"When successful, the treatment has great benefits for the patient – it can mean the difference between living dependently or independently.

"From a community perspective, it is also highly beneficial. With an estimated cost of up to $500,000 for a stroke patient with high care needs, the effective use of tPA is significantly reducing pressure on the health care budget."

Levi's stroke research group has attracted National Health and Medical Research Council grants to implement in hospitals across three states the combination of thrombolytic therapy and brain imaging. Hospitals across Sydney are also implementing the Hunter New England Health stroke treatment protocol.

Only about one third of stroke sufferers are suitable for tPA, and to receive it they must arrive at a hospital equipped to deliver the treatment within four and a half hours. The other two thirds of patients may be ineligible for a variety of reasons, including risk of excessive bleeding, past illnesses or contradictory drug treatments.

Because of this, Levi and his team are also leading research into treatments for those not eligible for thrombolytic therapy. One project is a joint study with Harbin Medical University in China, into methods of cooling the brain after a stroke.

The brain is put into hibernation, which 'buys' time for the clot to break up by itself. Researchers at Harbin are developing a helmet that works locally to cool the brain, while members of the team in Newcastle are experimenting with whole body cooling.

Newcastle researchers are also leading an international multi-centre trial of a new-generation clot-busting drug called tenecteplase or TNK, which they have shown in early trials to be more effective than alteplase or tPA.

Another exciting project is the Australian Stroke Genetics Initiative, led by Newcastle stroke researchers in collaboration with the University's Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine. Its first study, published this year in Nature Genetics, established a previously undiscovered genetic signal associated with a particular type of stroke.

"The wide range of research and the significant improvements to patient outcomes across all facets of stroke treatment verifies Newcastle's leadership role in this area," Levi says.

"Working at the nexus of stroke research and treatment, working with patients every day, spurs us on to keep moving developments from the lab and into clinical practice."

Professor Levi researches in collaboration with the Hunter Medical Research Institute's (HMRI) Brain and Mental Health Program. HMRI is a partnership between the University, the Hunter New England Local Health District and the community.

Visit the Centre for Translational Neuroscience and Mental Health website

Visit the HMRI website

Professor Chris Levi with medical equipment

Agent of change

The stroke treatments pioneered by Professor Chris Levi and his team have transformed lives and medical practice.

Read more

Career Summary

Biography

As a conjoint academic under a full-time Area Health Service employment contract, the encroachment of clinical management responsibilities in to research time is significant. Time has had to be devoted to establishing research infrastructure and development of capacity within the Department of Neurology to undertake and sustain research activities. It is pertinent that at the time of appointment in 1998 there was no significant research program within the Department of Neurology and no activity whatsoever in the field of stroke research. With ten years of development and growth the Stroke Research Group now attracts regular competitive grant funding. Nationally and internationally recognised senior clinical researches along with research management, brain imaging and research nurse support staff.

Involvement in state and national administrative and academic roles has assisted in supporting the growth of the Newcastle Stroke Research Group at the expense of additional time pressures on research productivity. As director of the Hunter Medical Research Institute/University of Newcastle Priority Centre for Brain and Mental Health Research, Professor Levi oversees the Stroke Research Program along with programs investigating schizophrenia, affective and addictive disorders, pain and sensory disorders, ageing and cognition and models of care for mental illness. The Stroke Research program, which he estabished now supports 25 staff, including two post-doctoral stroke neurologists, two Australian Research Council Future Fellows, six current PhD students, two Honours students and one B Med Science student. Professor Levi oversees a broad portfolio of stroke research within his group ranging across animal modelling of stroke, epidemiological and observational studies, phase 2 and phase 3 clinical trials, through to population surveillance of stroke events.

His direct leadership and research activity is focused on the areas of clinical trials in acute stroke, stroke genetics, advanced acute imaging, and cluster randomised trials focusing on implementation of evidence-based stroke care. He founded the Australian Stroke Genetics Collaborative to conduct large scale national research into candidate genes to target for stroke prevention in the thrombolytic system. This research is supported by the award of a $1.3m NHMRC project grant. He has been a chief investigator and steering committee member on six NHMRC-funded randomised trials of stroke interventions over the past 10 years. He was principal investigator on the recently completed NHMRC-funded national multicentre phase 3 clinical trial Dextran In Carotid Endarterectomy (DICE), which concluded that the drug Dextran administered intravenously reduces embolic signals within three hours of carotid surgery. He was also chief investigator and steering committee member on the National Heart Foundation and NHMRC-funded acute stroke thrombolysis trial known as EPITHET (Echoplanar Imaging Thrombolytic Evaluation Trial) which evaluated the use of MRI scanning in patient selection for acute stroke treatment. A further recent study is evaluating the efficacy of a new generation “clot-busting” drug tenecteplase or TNK which looks likely to proceed to Phase 3 clinical trials. All this research, which has resulted in over 115 peer-reviewed publications in leading international journals, reflects Professor Levi’s goal of translating results into improved clinical practice. Professor Levi’s dedication to bridging the gap between research the real world is also reflected in his heavy community commitments including a five year administrative appointment as medical director of the National Stroke Foundation (NSF) and remains a member of the NSF Clinical Council. He sat on the NHMRC Project Grant Review Panels in 2008/2009 and will again sit in 2011.

Research Expertise
Clinical research across the domains of observational epidemiology (case control studies, cohort studies, prevalence and incident studies), interventional clinical trials (trials in antithrombotic therapy in stroke prevention, acute stroke therapy trials), health services work (cluster randomised trials of health services interventions, health service redesign), brain imaging research (neurovascular ultrasound particularly transcranial Doppler embolus protection, multi-module CT imaging and MRI brain imaging). Research activities have been spread approximately equally across the above domains with an emphasis on clinical trials and stroke imaging.

Teaching Expertise
Undergraduate Undergraduate teaching in the form of formal lectures, small group tutorials, bedside tutorials and one on one clinical teaching on clinical wards and outpatients clinics. Postgraduate Formal lectures, small group tutorials bedside tutorials and formal mentoring of FRACP candidates.

Administrative Expertise
Current Administrative Appointments " Director, Priority Research Centre for Brain and Mental Health, University of Newcastle, Hunter Medical Research Institute with responsibility for oversight of the six programs of research within the centre. " Director, Acute Stroke Services, John Hunter Hospital with responsibility for the operational management of the Acute Stroke Service including the Stroke Unit and acute stroke interventional team. " Member, Clinical Council, National Stroke Foundation. Responsible for medical advice, medial liaison, Board presentations, strategic planning and policy directions setting for the national peak non-government organisation for stroke. Previous Admin Expertise " Director of Operations Acute Hospital Network, Hunter New England Health, December 2005 March 2006. Responsible for operations of all acute hospitals across the Hunter New England Area Health Service. " Chairman, Division of Medicine, John Hunter Hospital with responsibility for operational and strategic management of eight departments of Medicine across a tertiary referral hospital " Co-Chairman Australasian Stroke Unit Network a sub-committee of the Stroke Society of Australasia. Responsible for coordination, policy and strategic planning for this national multidisciplinary professional grouping. Involved in the organisation of stroke care and rollout of stroke units.

Collaborations
Director of the Priority Centre for Brain & Mental Health Research, overseeing the Stroke Research Program along with programs investigating Schizophrenia, Affective and Addictive disorders, Pain, Development, Aging & Cognition and Translation & Models of Care in Mental Health. Stroke researcher with principle interests in brain vascular imaging, acute stroke therapies and stroke genetics. He leads the NHMRC funded Australian Stroke Genetics Collaborative, is also Principal Investigator on the recently completed NHMRC funded national multicentre phase III clinical trial Dextran In Carotid Endarterectomy (DICE), and Chief Investigator and Steering Committee member on the recently completed NHF and NHMRC funded MRI based acute stroke thrombolysis trial EPITHET. He is Chief Investigator on two current NHMRC funded acute stroke trials (IST3, 457343; Tenecteplase in acute ischaemic stroke, 510722) and the NHF funded Cerebral Hypothermia in Ischaemic Lesion (CHIL) trial. The past five years has seen increasing involvement in implementation and health systems research in stroke where he is CI on two current NHMRC project grants (353803, 510275) investigating novel models of enhanced stroke unit care and enhanced delivery of stroke thrombolysis. He is a Honorary Senior Research Fellow for Florey Neurosciences Institute (FNI), University of Melbourne and has strong and ongoing collaborations with FNI. His leadership of statewide and national stroke health services research project have led to the formation of collaborative networks across Australian academic stroke neurology. The overarching research effort in stroke is aimed at the discovery and translation of experimental stroke therapies into the clinical domain, the discovery of new genetic variants relevant to stroke occurrence and outcome, and the implementation of effective stroke therapies.


Qualifications

  • Bachelor of Medicine, Bachelor of Surgery (Hons), University of New South Wales
  • Bachelor of Medical Science, University of New South Wales

Keywords

  • Acute stroke therapies
  • Basic Neurosciences
  • Brain imaging
  • Hypothermia
  • Neurology
  • Stroke
  • Stroke genetics
  • Transcranial Doppler

Fields of Research

Code Description Percentage
111799 Public Health and Health Services not elsewhere classified 30
110999 Neurosciences not elsewhere classified 70

Professional Experience

Academic appointment

Dates Title Organisation / Department
1/01/2013 -  Fellow

NHMRC -

Practitioner Fellowships (Formerly Practioner Fellowships Scheme)

NHMRC (National Health & Medical Research Council)
1/01/2007 -  Honorary Senior Research Fellow The University of Melbourne
Florey Neurosciences Institute
Australia
1/01/2000 -  Conjoint Professor

Neurology

University of Newcastle
School of Medicine and Public Health
Australia
1/01/1999 - 1/12/2002 Member Hunter Area Research Ethics Committee
Australia

Membership

Dates Title Organisation / Department
Member - Stroke Society of Australasia Stroke Society of Australasia
Australia
Expert Advisory Sub-committee Member to the Federal Health Minister Australian Population Health Development Principle Committee (APHDPC)
Australia

Awards

Research Award

Year Award
2005 Dudley Homer Vose Research Award
Heart Foundation

Invitations

Participant

Year Title / Rationale
2005 Cholesterol and Stroke
Organisation: World Congress of Neurology
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (217 outputs)

Year Citation Altmetrics Link
2015 Rannikmäe K, Davies G, Thomson PA, Bevan S, Devan WJ, Falcone GJ, et al., 'Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease', Neurology, 84 918-926 (2015)

Objectives: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease. Methods: We conducted met... [more]

Objectives: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease. Methods: We conducted meta-analyses of existing genotype data among individuals of European ancestry to determine associations of 1,070 common single nucleotide polymorphisms (SNPs) in the COL4A1/COL4A2 genomic region with the following: intracerebral hemorrhage and its subtypes (deep, lobar) (1,545 cases, 1,485 controls); ischemic stroke and its subtypes (cardioembolic, large vessel disease, lacunar) (12,389 cases, 62,004 controls); and white matter hyperintensities (2,733 individuals with ischemic stroke and 9,361 from population-based cohorts with brain MRI data). We calculated a statistical significance threshold that accounted for multiple testing and linkage disequilibrium between SNPs (p < 0.000084). Results: Three intronic SNPs in COL4A2 were significantly associated with deep intracerebral hemorrhage (lead SNP odds ratio [OR] 1.29, 95% confidence interval [CI] 1.14-1.46, p = 0.00003; r2 > 0.9 between SNPs). Although SNPs associated with deep intracerebral hemorrhage did not reach our significance threshold for association with lacunar ischemic stroke (lead SNP OR 1.10, 95% CI 1.03-1.18, p = 0.0073), and with white matter hyperintensity volume in symptomatic ischemic stroke patients (lead SNP OR 1.07, 95% CI 1.01-1.13, p = 0.016), the direction of association was the same. There was no convincing evidence of association with white matter hyperintensities in population-based studies or with non-small vessel disease cerebrovascular phenotypes. Conclusions: Our results indicate an association between common variation in the COL4A2 gene and symptomatic small vessel disease, particularly deep intracerebral hemorrhage. These findings merit replication studies, including in ethnic groups of non-European ancestry.

DOI 10.1212/WNL.0000000000001309
Co-authors John Attia, Liz Holliday
2015 Campbell BCV, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, et al., 'Endovascular therapy for ischemic stroke with perfusion-imaging selection', New England Journal of Medicine, 372 1009-1018 (2015)

Background: Trials of endovascular therapy for ischemic stroke have produced variable results. We conducted this study to test whether more advanced imaging selection, recently de... [more]

Background: Trials of endovascular therapy for ischemic stroke have produced variable results. We conducted this study to test whether more advanced imaging selection, recently developed devices, and earlier intervention improve outcomes. Methods: We randomly assigned patients with ischemic stroke who were receiving 0.9 mg of alteplase per kilogram of body weight less than 4.5 hours after the onset of ischemic stroke either to undergo endovascular thrombectomy with the Solitaire FR (Flow Restoration) stent retriever or to continue receiving alteplase alone. All the patients had occlusion of the internal carotid or middle cerebral artery and evidence of salvageable brain tissue and ischemic core of less than 70 ml on computed tomographic (CT) perfusion imaging. The coprimary outcomes were reperfusion at 24 hours and early neurologic improvement (.8-point reduction on the National Institutes of Health Stroke Scale or a score of 0 or 1 at day 3). Secondary outcomes included the functional score on the modified Rankin scale at 90 days. Results: The trial was stopped early because of efficacy after 70 patients had undergone randomization (35 patients in each group). The percentage of ischemic territory that had undergone reperfusion at 24 hours was greater in the endovascular-therapy group than in the alteplase-only group (median, 100% vs. 37%; P<0.001). Endovascular therapy, initiated at a median of 210 minutes after the onset of stroke, increased early neurologic improvement at 3 days (80% vs. 37%, P = 0.002) and improved the functional outcome at 90 days, with more patients achieving functional independence (score of 0 to 2 on the modified Rankin scale, 71% vs. 40%; P = 0.01). There were no significant differences in rates of death or symptomatic intracerebral hemorrhage. Conclusions: In patients with ischemic stroke with a proximal cerebral arterial occlusion and salvageable tissue on CT perfusion imaging, early thrombectomy with the Solitaire FR stent retriever, as compared with alteplase alone, improved reperfusion, early neurologic recovery, and functional outcome. (Funded by the Australian National Health and Medical Research Council and others; EXTEND-IA ClinicalTrials.gov number, NCT01492725, and Australian New Zealand Clinical Trials Registry number, ACTRN12611000969965.)

DOI 10.1056/NEJMoa1414792
Citations Scopus - 50Web of Science - 53
Co-authors Mark Parsons
2015 Adib-Samii P, Devan W, Traylor M, Lanfranconi S, Zhang CR, Cloonan L, et al., 'Genetic Architecture of White Matter Hyperintensities Differs in Hypertensive and Nonhypertensive Ischemic Stroke', STROKE, 46 348-353 (2015)
DOI 10.1161/STROKEAHA.114.006849
Citations Web of Science - 1
2015 Markus HS, Hayter E, Levi C, Feldman A, Venables G, Norris J, et al., 'Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial', LANCET NEUROLOGY, 14 361-367 (2015)
DOI 10.1016/S1474-4422(16)70018-9
Citations Web of Science - 4
2015 Gardner AJ, Iverson GL, Quinn TN, Makdissi M, Levi CL, Shultz SR, et al., 'A preliminary video analysis of concussion in the National Rugby League', Brain Injury, 1-4 (2015)
DOI 10.3109/02699052.2015.1034179
Co-authors Peter Stanwell
2015 Magin P, Dunbabin J, Goode S, Valderas JM, Levi C, D'Souza M, et al., 'Patients' responses to transient ischaemic attack symptoms: a cross-sectional questionnaire study in Australian general practices.', Br J Gen Pract, 65 e24-e31 (2015)
DOI 10.3399/bjgp15X683125
Citations Scopus - 1Web of Science - 1
Co-authors Parker Magin
2015 Tomkins AJ, Schleicher N, Murtha L, Kaps M, Levi CR, Nedelmann M, Spratt NJ, 'Platelet rich clots are resistant to lysis by thrombolytic therapy in a rat model of embolic stroke.', Exp Transl Stroke Med, 7 2 (2015)
DOI 10.1186/s13231-014-0014-y
Co-authors Neil Spratt
2015 Holliday EG, Traylor M, Malik R, Bevan S, Falcone G, Hopewell JC, et al., 'Genetic overlap between diagnostic subtypes of ischemic stroke.', Stroke, 46 615-619 (2015)
DOI 10.1161/STROKEAHA.114.007930
Co-authors Jane Maguire, Lisa Lincz, John Attia, Rodney Scott, Liz Holliday, Christopher Oldmeadow
2015 Dale S, Levi C, Ward J, Grimshaw JM, Jammali-Blasi A, D'Este C, et al., 'Barriers and Enablers to Implementing Clinical Treatment Protocols for Fever, Hyperglycaemia, and Swallowing Dysfunction in the Quality in Acute Stroke Care (QASC) Project-A Mixed Methods Study', WORLDVIEWS ON EVIDENCE-BASED NURSING, 12 41-50 (2015)
DOI 10.1111/wvn.12078
Co-authors Catherine Deste
2015 Berling I, Brown SGA, Miteff F, Levi C, Isbister GK, 'Australian elapid envenoming and intracranial haemorrhage', CLINICAL TOXICOLOGY, 53 237-237 (2015)
Co-authors Geoff Isbister
2015 Gardner A, Iverson GL, Levi CR, Schofield PW, Kay-Lambkin F, Kohler RMN, Stanwell P, 'A systematic review of concussion in rugby league', British Journal of Sports Medicine, 49 495-498 (2015)

Objectives: Concussion remains one of the inherent risks of participation in rugby league. While other injuries incurred by rugby league players have been well studied, less focus... [more]

Objectives: Concussion remains one of the inherent risks of participation in rugby league. While other injuries incurred by rugby league players have been well studied, less focus and attention has been directed towards concussion. Review method: The current review examined all articles published in English from 1900 up to June 2013 pertaining to concussion in rugby league players. Data sources: Publications were retrieved via six databases using the key search terms: rugby league, league, football; in combination with injury terms: athletic injuries, concussion, sports concussion, sports-related concussion, brain concussion, brain injury, brain injuries, mild traumatic brain injury, mTBI, traumatic brain injury, TBI, craniocerebral trauma, head injury and brain damage. Observational, cohort, correlational, cross-sectional and longitudinal studies were all included. Results: 199 rugby league injury publications were identified. 39 (20%) were related in some way to concussion. Of the 39 identified articles, 6 (15%) had the main aim of evaluating concussion, while the other 33 reported on concussion incidence as part of overall injury data analyses. Rugby league concussion incidence rates vary widely from 0.0 to 40.0/1000 playing hours, depending on the definition of injury (time loss vs no time loss). The incidence rates vary across match play versus training session, seasons (winter vs summer) and playing position (forwards vs backs). The ball carrier has been found to be at greater risk for injury than tacklers. Concussion accounts for 29% of all injuries associated with illegal play, but only 9% of injuries sustained in legal play. Conclusions: In comparison with other collision sports, research evaluating concussion in rugby league is limited. With such limited published rugby league data, there are many aspects of concussion that require attention, and future research may be directed towards these unanswered questions.

DOI 10.1136/bjsports-2013-093102
Citations Scopus - 1
Co-authors Peter Stanwell, Peter Schofield
2015 Gardner AJ, Iverson GL, Quinn TN, Makdissi M, Levi CR, Shultz SR, et al., 'A preliminary video analysis of concussion in the National Rugby League.', Brain Inj, 1-4 (2015)
DOI 10.3109/02699052.2015.1034179
Co-authors Peter Stanwell
2015 Mcleod DD, Parsons MW, Hood R, Hiles B, Allen J, Mccann SK, et al., 'Perfusion computed tomography thresholds defining ischemic penumbra and infarct core: Studies in a rat stroke model', International Journal of Stroke, 10 553-559 (2015)

Background: Perfusion computed tomography is becoming more widely used as a clinical imaging tool to predict potentially salvageable tissue (ischemic penumbra) after ischemic stro... [more]

Background: Perfusion computed tomography is becoming more widely used as a clinical imaging tool to predict potentially salvageable tissue (ischemic penumbra) after ischemic stroke and guide reperfusion therapies. Aims: The study aims to determine whether there are important changes in perfusion computed tomography thresholds defining ischemic penumbra and infarct core over time following stroke. Methods: Permanent middle cerebral artery occlusion was performed in adult outbred Wistar rats (n=6) and serial perfusion computed tomography scans were taken every 30 mins for 2h. To define infarction thresholds at 1h and 2h post-stroke, separate groups of rats underwent 1h (n=6) and 2h (n=6) of middle cerebral artery occlusion followed by reperfusion. Infarct volumes were defined by histology at 24h. Co-registration with perfusion computed tomography maps (cerebral blood flow, cerebral blood volume, and mean transit time) permitted pixel-based analysis of thresholds defining infarction, using receiver operating characteristic curves. Results: Relative cerebral blood flow was the perfusion computed tomography parameter that most accurately predicted penumbra (area under the curve=0·698) and also infarct core (area under the curve=0·750). A relative cerebral blood flow threshold of <75% of mean contralateral cerebral blood flow most accurately predicted penumbral tissue at 0·5h (area under the curve=0·660), 1h (area under the curve=0·659), 1·5h (area under the curve=0·636), and 2h (area under the curve=0·664) after stroke onset. A relative cerebral blood flow threshold of <55% of mean contralateral most accurately predicted infarct core at 1h (area under the curve=0·765) and at 2h (area under the curve=0·689) after middle cerebral artery occlusion. Conclusions: The data provide perfusion computed tomography defined relative cerebral blood flow thresholds for infarct core and ischemic penumbra within the first two hours after experimental stroke in rats. These thresholds were shown to be stable to define the volume of infarct core and penumbra within this time window.

DOI 10.1111/ijs.12147
Citations Scopus - 1
Co-authors Neil Spratt, Damian Mcleod
2015 Huang Y, Sharma VK, Robinson T, Lindley RI, Chen X, Kim JS, et al., 'Rationale, design, and progress of the ENhanced Control of Hypertension ANd Thrombolysis strokE stuDy (ENCHANTED) trial: An international multicenter 2x2 quasi-factorial randomized controlled trial of low- vs. standard-dose rt-PA and early intensive vs. guideline-recommended blood pressure lowering in patients with acute ischaemic stroke eligible for thrombolysis treatment', INTERNATIONAL JOURNAL OF STROKE, 10 778-788 (2015)
DOI 10.1111/ijs.12486
2015 Grady AM, Bryant J, Carey ML, Paul CL, Sanson-Fisher RW, Levi CR, 'Agreement with evidence for tissue Plasminogen Activator use among emergency physicians: A cross-sectional survey', BMC Research Notes, 8 (2015)

Background: Emergency department staff play a crucial role in the triage of stroke patients and therefore the capacity to deliver time-dependent treatments such as tissue Plasmino... [more]

Background: Emergency department staff play a crucial role in the triage of stroke patients and therefore the capacity to deliver time-dependent treatments such as tissue Plasminogen Activator. This study aimed to identify among emergency physicians, (1) rates of agreement with evidence supporting tissue Plasminogen Activator use in acute stroke care; and (2) individual and hospital factors associated with high agreement with evidence supporting tissue Plasminogen Activator use. Methods: Australian fellows and trainees of the Australasian College for Emergency Medicine were invited to complete an online cross-sectional survey assessing perceptions of tissue Plasminogen Activator use in acute stroke. Demographic and hospital characteristics were also collected. Results: 429 Australasian College for Emergency Medicine members responded (13% response rate). Almost half (47.2%) did not agree with any statements regarding the benefits of tissue Plasminogen Activator use for acute stroke. Perceived routine administration of tissue Plasminogen Activator by the head of respondents' emergency department was significantly associated with high agreement with the evidence supporting tissue Plasminogen Activator use in acute stroke. Conclusions: Agreement with evidence supporting tissue Plasminogen Activator use in acute stroke is not high among responding Australian emergency physicians. In order for tissue Plasminogen Activator treatment to become widely accepted and adopted in emergency settings, beliefs and attitudes towards treatment need to be in accordance with clinical practice guidelines.

DOI 10.1186/s13104-015-1242-5
Co-authors Chris Paul
2015 Lindley RI, Levi CR, 'The spectacular recent trials of urgent neurointervention for acute stroke: fuel for a revolution.', Med J Aust, 203 58-60 (2015)
2015 Menon BK, Campbell BCV, Levi C, Goyal M, 'Role of Imaging in Current Acute Ischemic Stroke Workflow for Endovascular Therapy', STROKE, 46 1453-1461 (2015)
DOI 10.1161/STROKEAHA.115.009160
2015 Rutten-Jacobs LCA, Traylor M, Adib-Samii P, Thijs V, Sudlow C, Rothwell PM, et al., 'Common NOTCH3 Variants and Cerebral Small-Vessel Disease', STROKE, 46 1482-+ (2015)
DOI 10.1161/STROKEAHA.114.008540
2015 Grady AM, Bryant J, Carey ML, Paul CL, Sanson-Fisher RW, Levi CR, 'Agreement with evidence for tissue Plasminogen Activator use among emergency physicians: a cross-sectional survey.', BMC Res Notes, 8 267 (2015)
DOI 10.1186/s13104-015-1242-5
Co-authors Chris Paul, Rob Sanson-Fisher, Mariko Carey
2014 Paul CL, Levi CR, D'Este CA, Parsons MW, Bladin CF, Lindley RI, et al., 'Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care', Implementation Science, 9 (2014) [C3]

Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy w... [more]

Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy with tissue plasminogen activator (tPA), if given within 4.5 hours of onset to appropriate cases of ischaemic stroke.Objectives: To test the effectiveness of a multi-component multidisciplinary collaborative approach compared to usual care as a strategy for increasing thrombolysis rates for all stroke patients at intervention hospitals, while maintaining accepted benchmarks for low rates of intracranial haemorrhage and high rates of functional outcomes for both groups at three months.Methods and design: A cluster randomised controlled trial of 20 hospitals across 3 Australian states with 2 groups: multi- component multidisciplinary collaborative intervention as the experimental group and usual care as the control group. The intervention is based on behavioural theory and analysis of the steps, roles and barriers relating to rapid assessment for thrombolysis eligibility; it involves a comprehensive range of strategies addressing individual-level and system-level change at each site. The primary outcome is the difference in tPA rates between the two groups post-intervention. The secondary outcome is the proportion of tPA treated patients in both groups with good functional outcomes (modified Rankin Score (mRS <2) and the proportion with intracranial haemorrhage (mRS =2), compared to international benchmarks.Discussion: TIPS will trial a comprehensive, multi-component and multidisciplinary collaborative approach to improving thrombolysis rates at multiple sites. The trial has the potential to identify methods for optimal care which can be implemented for stroke patients during the acute phase. Study findings will include barriers and solutions to effective thrombolysis implementation and trial outcomes will be published whether significant or not.Trial registration: Australian New Zealand Clinical Trials Registry: ACTRN12613000939796. © 2014 Paul et al.; licensee BioMed Central Ltd.

DOI 10.1186/1748-5908-9-38
Citations Web of Science - 1
Co-authors Mark Parsons, Chris Paul, Catherine Deste, Frans Henskens, Rob Sanson-Fisher, John Attia
2014 Traylor M, Mäkelä KM, Kilarski LL, Holliday EG, Devan WJ, Nalls MA, et al., 'A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.', PLoS Genet, 10 e1004469 (2014) [C1]
DOI 10.1371/journal.pgen.1004469
Citations Scopus - 5Web of Science - 5
Co-authors Jane Maguire, John Attia, Liz Holliday
2014 Bivard A, Krishnamurthy V, Stanwell P, Levi C, Spratt NJ, Davis S, Parsons M, 'Arterial Spin Labeling Versus Bolus-Tracking Perfusion in Hyperacute Stroke', Stroke, 45 127-133 (2014)
DOI 10.1161/STROKEAHA.113.003218
Co-authors Mark Parsons, Neil Spratt, Peter Stanwell
2014 Meretoja A, Churilov L, Campbell BCV, Aviv RI, Yassi N, Barras C, et al., 'The Spot sign and Tranexamic acid On Preventing ICH growth - AUStralasia Trial (STOP-AUST): Protocol of a phase II randomized, placebo-controlled, double-blind, multicenter trial', International Journal of Stroke, 9 519-524 (2014) [C3]

Rationale: No evidence-based acute therapies exist for intracerebral hemorrhage. Intracerebral hemorrhage growth is an important determinant of patient outcome. Tranexamic acid is... [more]

Rationale: No evidence-based acute therapies exist for intracerebral hemorrhage. Intracerebral hemorrhage growth is an important determinant of patient outcome. Tranexamic acid is known to reduce hemorrhage in other conditions. Aim: The study aims to test the hypothesis that intracerebral hemorrhage patients selected with computed tomography angiography contrast extravasation 'spot sign' will have lower rates of hematoma growth when treated with intravenous tranexamic acid within 4·5-hours of stroke onset compared with placebo. Design: The Spot sign and Tranexamic acid On Preventing ICH growth - AUStralasia Trial is a multicenter, prospective, 1:1 randomized, double-blind, placebo-controlled, investigator-initiated, academic Phase II trial. Intracerebral hemorrhage patients fulfilling clinical criteria (e.g. Glasgow Coma Scale >7, intracerebral hemorrhage volume <70ml, no identified secondary cause of intracerebral hemorrhage, no thrombotic events within the previous 12 months, no planned surgery) and demonstrating contrast extravasation on computed tomography angiography will receive either intravenous tranexamic acid 1g 10-min bolus followed by 1g eight-hour infusion or placebo. A second computed tomography will be performed at 24 ± 3 hours to evaluate intracerebral hemorrhage growth and patients followed up for three-months. Study outcomes: The primary outcome measure is presence of intracerebral hemorrhage growth by 24 ± 3 hours, defined as either >33% or >6ml increase from baseline, and will be adjusted for baseline intracerebral hemorrhage volume. Secondary outcome measures include growth as a continuous measure, thromboembolic events, and the three-month modified Rankin Scale score. Discussion: This is the first trial to evaluate the efficacy of tranexamic acid in intracerebral hemorrhage patients selected based on an imaging biomarker of high likelihood of hematoma growth. The trial is registered as NCT01702636. © 2013 World Stroke Organization.

DOI 10.1111/ijs.12132
Citations Web of Science - 3
Co-authors Mark Parsons, Neil Spratt
2014 Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, et al., 'Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12', NEUROLOGY, 83 678-685 (2014) [C1]
Citations Scopus - 11Web of Science - 13
Co-authors Liz Holliday
2014 Ay H, Arsava EM, Andsberg G, Benner T, Brown RD, Chapman SN, et al., 'Pathogenic Ischemic Stroke Phenotypes in the NINDS-Stroke Genetics Network', STROKE, 45 3589-3596 (2014) [C1]
DOI 10.1161/STROKEAHA.114.007362
Citations Web of Science - 1
2014 Holliday EG, Traylor M, Malik R, Bevan S, Maguire J, Koblar SA, et al., 'Polygenic Overlap Between Kidney Function and Large Artery Atherosclerotic Stroke', STROKE, 45 3508-+ (2014) [C1]
DOI 10.1161/STROKEAHA.114.006609
Co-authors John Attia, Liz Holliday, Christopher Oldmeadow, Rodney Scott, Jane Maguire
2014 Bivard A, Krishnamurthy V, Stanwell P, Levi C, Spratt NJ, Davis S, Parsons M, 'Arterial Spin Labeling Versus Bolus-Tracking Perfusion in Hyperacute Stroke', Stroke, 45 127-133 (2014) [C1]
DOI 10.1161/STROKEAHA.113.003218
Citations Scopus - 4Web of Science - 4
Co-authors Neil Spratt, Mark Parsons, Peter Stanwell
2014 Dichgans M, Malik R, König IR, Rosand J, Clarke R, Gretarsdottir S, et al., 'Shared genetic susceptibility to ischemic stroke and coronary artery disease : A genome-wide analysis of common variants', Stroke, 45 24-36 (2014) [C1]

Background and Purpose-Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analys... [more]

Background and Purpose-Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases. Methods-Genome-wide association data were obtained from the METASTROKE, Coronary Artery Disease Genomewide Replication and Meta-analysis (CARDIoGRAM), and Coronary Artery Disease (C4D) Genetics consortia. We first analyzed common variants reaching a nominal threshold of significance (P<0.01) for CAD for their association with IS and vice versa. We then examined specific overlap across phenotypes for variants that reached a high threshold of significance. Finally, we conducted a joint meta-analysis on the combined phenotype of IS or CAD. Corresponding analyses were performed restricted to the 2167 individuals with the ischemic large artery stroke (LAS) subtype. Results-Common variants associated with CAD at P<0.01 were associated with a significant excess risk for IS and for LAS and vice versa. Among the 42 known genome-wide significant loci for CAD, 3 and 5 loci were significantly associated with IS and LAS, respectively. In the joint meta-analyses, 15 loci passed genome-wide significance (P<5×10-8) for the combined phenotype of IS or CAD and 17 loci passed genome-wide significance for LAS or CAD. Because these loci had prior evidence for genome-wide significance for CAD, we specifically analyzed the respective signals for IS and LAS and found evidence for association at chr12q24/SH2B3 (PIS=1.62×10-7) and ABO (PIS=2.6×10-4), as well as at HDAC9 (PLAS=2.32×10-12), 9p21 (PLAS=3.70×10-6), RAI1-PEMT-RASD1 (PLAS=2.69×10-5), EDNRA (PLAS=7.29×10-4), and CYP17A1-CNNM2-NT5C2 (PLAS=4.9×10-4). Conclusions-Our results demonstrate substantial overlap in the genetic risk of IS and particularly the LAS subtype with CAD. © 2013 American Heart Association, Inc.

DOI 10.1161/STROKEAHA.113.002707
Citations Scopus - 23Web of Science - 24
2014 Malik R, Bevan S, Nalls MA, Holliday EG, Devan WJ, Cheng Y-C, et al., 'Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies', Stroke, 45 394-402 (2014) [C1]

Background and Purpose - Genome-wide association studies have revealed multiple common variants associated with known risk factors for ischemic stroke (IS). However, their aggrega... [more]

Background and Purpose - Genome-wide association studies have revealed multiple common variants associated with known risk factors for ischemic stroke (IS). However, their aggregate effect on risk is uncertain. We aimed to generate a multilocus genetic risk score (GRS) for IS based on genome-wide association studies data from clinical-based samples and to establish its external validity in prospective population-based cohorts. Methods - Three thousand five hundred forty-eight clinic-based IS cases and 6399 controls from the Wellcome Trust Case Control Consortium 2 were used for derivation of the GRS. Subjects from the METASTROKE consortium served as a replication sample. The validation sample consisted of 22 751 participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. We selected variants that had reached genome-wide significance in previous association studies on established risk factors for IS. Results - A combined GRS for atrial fibrillation, coronary artery disease, hypertension, and systolic blood pressure significantly associated with IS both in the case-control samples and in the prospective population-based studies. Subjects in the top quintile of the combined GRS had >2-fold increased risk of IS compared with subjects in the lowest quintile. Addition of the combined GRS to a simple model based on sex significantly improved the prediction of IS in the combined clinic-based samples but not in the population-based studies, and there was no significant improvement in net reclassification. Conclusions - A multilocus GRS based on common variants for established cardiovascular risk factors was significantly associated with IS both in clinic-based samples and in the general population. However, the improvement in clinical risk prediction was found to be small. © 2014 American Heart Association, Inc.

DOI 10.1161/STROKEAHA.113.002938
Citations Scopus - 10Web of Science - 7
Co-authors Liz Holliday
2014 Golledge J, Clancy P, Maguire J, Lincz L, Koblar S, Mcevoy M, et al., 'Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence', Stroke, 45 1064-1068 (2014) [C1]
DOI 10.1161/STROKEAHA.113.004339
Citations Scopus - 1
Co-authors Jane Maguire, Lisa Lincz, John Attia
2014 Amarenco P, Davis S, Jones EF, Cohen AA, Heiss W-D, Kaste M, et al., 'Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques', Stroke, 45 1248-1257 (2014)

BACKGROUND AND PURPOSE-: Severe atherosclerosis in the aortic arch is associated with a high risk of recurrent vascular events, but the optimal antithrombotic strategy is unclear.... [more]

BACKGROUND AND PURPOSE-: Severe atherosclerosis in the aortic arch is associated with a high risk of recurrent vascular events, but the optimal antithrombotic strategy is unclear. METHODS-: This prospective randomized controlled, open-labeled trial, with blinded end point evaluation (PROBE design) tested superiority of aspirin 75 to 150 mg/d plus clopidogrel 75 mg/d (A+C) over warfarin therapy (international normalized ratio 2-3) in patients with ischemic stroke, transient ischemic attack, or peripheral embolism with plaque in the thoracic aorta >4 mm and no other identified embolic source. The primary end point included cerebral infarction, myocardial infarction, peripheral embolism, vascular death, or intracranial hemorrhage. Follow-up visits occurred at 1 month and then every 4 months post randomization. RESULTS-: The trial was stopped after 349 patients were randomized during a period of 8 years and 3 months. After a median follow-up of 3.4 years, the primary end point occurred in 7.6% (13/172) and 11.3% (20/177) of patients on A+C and on warfarin, respectively (log-rank, P=0.2). The adjusted hazard ratio was 0.76 (95% confidence interval, 0.36-1.61; P=0.5). Major hemorrhages including intracranial hemorrhages occurred in 4 and 6 patients in the A+C and warfarin groups, respectively. Vascular deaths occurred in 0 patients in A+C arm compared with 6 (3.4%) patients in the warfarin arm (log-rank, P=0.013). Time in therapeutic range (67% of the time for international normalized ratio 2-3) analysis by tertiles showed no significant differences across groups. CONCLUSIONS-: Because of lack of power, this trial was inconclusive and results should be taken as hypothesis generating. © 2014 American Heart Association, Inc.

DOI 10.1161/STROKEAHA.113.004251
Citations Scopus - 7
2014 Lin L, Bivard A, Levi CR, Parsons MW, 'Comparison of computed tomographic and magnetic resonance perfusion measurements in acute ischemic stroke: Back-to-back quantitative analysis', Stroke, 45 1727-1732 (2014) [C1]

Background and Purpose: Magnetic resonance perfusion (MRP) and computed tomographic perfusion (CTP) are being increasingly applied in acute stroke trials and clinical practice, ye... [more]

Background and Purpose: Magnetic resonance perfusion (MRP) and computed tomographic perfusion (CTP) are being increasingly applied in acute stroke trials and clinical practice, yet the comparability of their perfusion values is not well validated. The aim of this study was to validate the comparability of CTP and MRP measures. METHODS-: A 3-step approach was used. Step 1 was a derivation step, where we analyzed 45 patients with acute ischemic stroke who had both CTP and MRP performed within 2 hours of each other and within 9 hours of stroke onset. In this step, we derived the optimal perfusion map with the least difference between MRP and CTP. In step 2, the optimal map was validated on whole-brain perfusion data of 15 patients. Step 3 was to apply the optimal perfusion map to define cross-modality reperfusion from acute CTP to 24-hour MRP in 45 patients and, in turn, to assess how accurately this predicted 3-month clinical outcome. RESULTS-: Among 8 different perfusion maps included in this study, time to peak of the residual function (Tmax) was the only one with a nonsignificant difference between CTP and MRP in delineating perfusion defects. This was validated on whole-brain perfusion data, showing high concordance of Tmax between the 2 modalities (concordance correlation coefficient of Lin, >0.91); the best concordance was at 6 s. At T max>6 s threshold, MRP and CTP reached substantial agreement in mismatch classification (¿ >0.61). Cross-modality reperfusion calculated by Tmax>6 s strongly predicted good functional outcome at 3 months (area under the curve, 0.979; P<0.05). CONCLUSIONS-: MRP and CTP can be used interchangeably if one uses Tmax measurement. © 2014 American Heart Association, Inc.

DOI 10.1161/STROKEAHA.114.005419
Citations Scopus - 3Web of Science - 4
Co-authors Mark Parsons
2014 Bivard A, Levi C, Krishnamurthy V, Hislop-Jambrich J, Salazar P, Jackson B, et al., 'Defining acute ischemic stroke tissue pathophysiology with whole brain CT perfusion', JOURNAL OF NEURORADIOLOGY, 41 307-315 (2014) [C1]
DOI 10.1016/j.neurad.2013.11.006
Citations Scopus - 2Web of Science - 1
Co-authors Mark Parsons
2014 Bivard A, Krishnamurthy V, Stanwell P, Yassi N, Spratt NJ, Nilsson M, et al., 'Spectroscopy of reperfused tissue after stroke reveals heightened metabolism in patients with good clinical outcomes', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 34 1944-1950 (2014) [C1]
DOI 10.1038/jcbfm.2014.166
Co-authors Mark Parsons, Neil Spratt, Peter Stanwell
2014 Williams FMK, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, et al., 'Ischemic stroke is associated with the ABO locus: The EuroCLOT study (vol 73, pg 16, 2013)', ANNALS OF NEUROLOGY, 75 166-167 (2014)
DOI 10.1002/ana.24105
Co-authors Rodney Scott, Liz Holliday, John Attia
2014 Gunathilake R, Krishnamurthy V, Oldmeadow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables, and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', AUSTRALASIAN JOURNAL ON AGEING, 33 19-19 (2014) [E3]
Co-authors Christopher Oldmeadow, Mark Parsons, John Attia
2014 Freeland J, Levi C, Hunter M, 'Thalamic Stroke: Precursors and Outcomes for Ten Patients', BRAIN IMPAIRMENT, 15 51-57 (2014) [C1]
DOI 10.1017/BrImp.2014.4
Co-authors Mick Hunter
2014 Drury P, Levi C, McInnes E, Hardy J, Ward J, Grimshaw JM, et al., 'Management of fever, hyperglycemia, and swallowing dysfunction following hospital admission for acute stroke in New South Wales, Australia', INTERNATIONAL JOURNAL OF STROKE, 9 23-31 (2014) [C1]
DOI 10.1111/ijs.12194
Citations Scopus - 1Web of Science - 1
Co-authors Catherine Deste
2014 Campbell BCV, Mitchell PJ, Yan B, Parsons MW, Christensen S, Churilov L, et al., 'A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits with Intra-Arterial therapy (EXTEND-IA)', INTERNATIONAL JOURNAL OF STROKE, 9 126-132 (2014) [C3]
DOI 10.1111/ijs.12206
Citations Scopus - 10Web of Science - 9
Co-authors Mark Parsons
2014 Chan DKY, Levi C, Cordato D, O'Rourke F, Chen J, Redmond H, et al., 'Health service management study for stroke: A randomized controlled trial to evaluate two models of stroke care', INTERNATIONAL JOURNAL OF STROKE, 9 400-405 (2014) [C1]
DOI 10.1111/ijs.12240
Citations Scopus - 1
2014 Maguire J, Lindgren A, Bevan S, Fernandez-Cadenas I, Hankey G, Jern C, et al., 'GISCOME - Genetic Influences on Ischaemic Stroke Functional Outcome: A genome wide association study', INTERNATIONAL JOURNAL OF STROKE, 9 23-23 (2014)
Co-authors Rodney Scott, Jane Maguire
2014 Gunathilake R, Krishnamurthy V, Oldmedow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', INTERNATIONAL JOURNAL OF STROKE, 9 35-35 (2014)
Co-authors Christopher Oldmeadow, Mark Parsons, John Attia
2014 Picanço MR, Christensen S, Campbell BCV, Churilov L, Parsons MW, Desmond PM, et al., 'Reperfusion after 4·5 hours reduces infarct growth and improves clinical outcomes', International Journal of Stroke, 9 266-269 (2014)
DOI 10.1111/ijs.12209
Citations Scopus - 1
Co-authors Mark Parsons
2014 Picanço MR, Christensen S, Campbell BCV, Churilov L, Parsons MW, Desmond PM, et al., 'Reperfusion after 4·5 hours reduces infarct growth and improves clinical outcomes', International Journal of Stroke, 9 266-269 (2014) [C1]

Background: The currently proven time window for thrombolysis in ischemic stroke is 4·5h. Beyond this, the risks and benefits of thrombolysis are uncertain. Aims: To determine wh... [more]

Background: The currently proven time window for thrombolysis in ischemic stroke is 4·5h. Beyond this, the risks and benefits of thrombolysis are uncertain. Aims: To determine whether thrombolysis and reperfusion were beneficial after 4·5h, we examined clinical and radiological outcomes in patients treated with tissue plasminogen activator or placebo within 4·5-6h, using data from the Echoplanar Imaging Thrombolytic Evaluation Trial. Methods: In the Echoplanar Imaging Thrombolytic Evaluation Trial, ischemic stroke patients presenting three to six-hours after stroke onset were randomized to tissue plasminogen activator or placebo, without knowledge of magnetic resonance imaging results. This analysis was restricted to patients treated between 4·5 and 6h. The effect of tissue plasminogen activator and reperfusion on infarct growth between baseline diffusion-weighted imaging and day 90 T2 imaging was assessed, along with good neurological outcome (=8 point reduction or reaching 0-1 at 90 days on National Institutes of Health Stroke Scale) and functional outcome (modified Rankin scale). The effect of tissue plasminogen activator on reperfusion was also analyzed. Results: Sixty-nine patients were treated 4·5-6h after onset, and infarct growth was assessed in 63. Tissue plasminogen activator was associated with lower relative growth (94% vs. 168%, P=0·03) and a trend to lower absolute growth (-0·17ml versus 9·6ml, P=0·07). Reperfusion was increased in the tissue plasminogen activator group (58% versus 25%, P=0·03) and was associated with increased rates of good neurological (86% versus 28% P<0·001) and functional (modified Rankin scale 0-2 73% versus 34%, P=0·01) outcomes. Reperfusion was strongly associated with lower relative (80% versus 189%, P<0·001) and absolute (-2·5ml versus 40ml, P<0·001) infarct growth. Conclusions: Thrombolysis 4·5-6h after stroke onset reduced infarct growth and increased the rate of reperfusion, which was associated with good neurological and functional outcome. © 2013 World Stroke Organization.

DOI 10.1111/ijs.12209
Citations Scopus - 1Web of Science - 1
Co-authors Mark Parsons
2014 Sheedy R, Bernhardt J, Churilov L, Kilkenny MF, Cadilhac DA, Levi CR, Longworth M, 'Are patients with intracerebral haemorrhage disadvantaged in hospitals?', International Journal of Stroke, 9 437-442 (2014)
DOI 10.1111/ijs.12223
2014 Sheedy R, Bernhardt J, Levi CR, Longworth M, Churilov L, Kilkenny MF, Cadilhac DA, 'Are patients with intracerebral haemorrhage disadvantaged in hospitals?', International Journal of Stroke, 9 437-442 (2014) [C1]

Background and Aims: Providing evidence-based clinical care reduces disability and mortality rates following stroke. We examined if compliance with evidence-based processes of car... [more]

Background and Aims: Providing evidence-based clinical care reduces disability and mortality rates following stroke. We examined if compliance with evidence-based processes of care were different for patients with intracerebral haemorrhage when compared with ischemic stroke and sought to describe differences in health outcomes during hospitalization and at time of discharge for these stroke subtypes. Methods: The New South Wales acute stroke dataset was used. This included data from 50-100 consecutively admitted patients' medical records collected from 32 New South Wales hospitals between 2003 and 2010. Multivariable logistic regression analyses were conducted taking into account patient factors and clustering of patients by hospital. Results: Ischemic stroke and intracerebral haemorrhage cases had similar demographic features (ischemic stroke n=3467, mean age 74 years [standard deviation 13], 50% female; intracerebral haemorrhage n=275, mean age 74 years [standard deviation 13], 48% female). Following multivariable analyses patients with intracerebral haemorrhage were less likely to be admitted to a stroke unit (adjusted odds ratio 0·65; 95% confidence interval 0·45-0·94) or receive an assessment from allied health (adjusted odds ratio 0·54; 95% confidence interval 0·33-0·89) than patients with ischemic stroke. Patients with intracerebral haemorrhage are also less likely to be independent (adjusted odds ratio 0·36; 95% confidence interval 0·3-0·5) at time of hospital discharge and had a greater odds of dying in hospital (adjusted odds ratio 2·1; 95% confidence interval 1·3-3·5). Patients that were admitted to a stroke unit had a greater odds of being independent (modified Rankin Score 0-2) at day 7-10 irrespective of stroke type or severity on admission (adjusted odds ratio 1·3; 95% confidence interval 1·01-1·66). Conclusions: Following intracerebral haemorrhage, patients were less likely to be admitted to an acute stroke unit and receive allied health interventions. Admission to stroke units improved the likelihood of being independent at days 7-10 and, therefore, more should be done to encourage evidence-based care for intracerebral haemorrhage. © 2013 World Stroke Organization.

DOI 10.1111/ijs.12223
Citations Scopus - 1Web of Science - 2
2014 Murtha LA, Mcleod DD, Mccann SK, Pepperall D, Chung S, Levi CR, et al., 'Short-duration hypothermia after ischemic stroke prevents delayed intracranial pressure rise', International Journal of Stroke, 9 553-559 (2014)
DOI 10.1111/ijs.12181
Citations Scopus - 1
Co-authors Damian Mcleod, Neil Spratt
2014 Murtha LA, Mcleod DD, Mccann SK, Pepperall D, Chung S, Levi CR, et al., 'Short-duration hypothermia after ischemic stroke prevents delayed intracranial pressure rise', International Journal of Stroke, 9 553-559 (2014) [C1]

Background: Intracranial pressure elevation, peaking three to seven post-stroke is well recognized following large strokes. Data following small-moderate stroke are limited. Thera... [more]

Background: Intracranial pressure elevation, peaking three to seven post-stroke is well recognized following large strokes. Data following small-moderate stroke are limited. Therapeutic hypothermia improves outcome after cardiac arrest, is strongly neuroprotective in experimental stroke, and is under clinical trial in stroke. Hypothermia lowers elevated intracranial pressure; however, rebound intracranial pressure elevation and neurological deterioration may occur during rewarming. Hypotheses: (1) Intracranial pressure increases 24h after moderate and small strokes. (2) Short-duration hypothermia-rewarming, instituted before intracranial pressure elevation, prevents this 24h intracranial pressure elevation. Methods: Long-Evans rats with two hour middle cerebral artery occlusion or outbred Wistar rats with three hour middle cerebral artery occlusion had intracranial pressure measured at baseline and 24h. Wistars were randomized to 2·5h hypothermia (32·5°C) or normothermia, commencing 1h after stroke. Results: In Long-Evans rats (n=5), intracranial pressure increased from 10·9±4·6mmHg at baseline to 32·4±11·4mmHg at 24h, infarct volume was 84·3±15·9mm3. In normothermic Wistars (n=10), intracranial pressure increased from 6·7±2·3mmHg to 31·6±9·3mmHg, infarct volume was 31·3±18·4mm3. In hypothermia-treated Wistars (n=10), 24h intracranial pressure did not increase (7·0±2·8mmHg, P<0·001 vs. normothermia), and infarct volume was smaller (15·4±11·8mm3, P<0·05). Conclusions: We saw major intracranial pressure elevation 24h after stroke in two rat strains, even after small strokes. Short-duration hypothermia prevented the intracranial pressure rise, an effect sustained for at least 18h after rewarming. The findings have potentially important implications for design of future clinical trials. © 2013 The Authors. International Journal of Stroke © 2013 World Stroke Organization.

DOI 10.1111/ijs.12181
Citations Scopus - 6Web of Science - 5
Co-authors Damian Mcleod, Neil Spratt
2014 Drury P, Levi C, D'Este C, Mcelduff P, Mcinnes E, Hardy J, et al., 'Quality in Acute Stroke Care (QASC): Process evaluation of an intervention to improve the management of fever, hyperglycemia, and swallowing dysfunction following acute stroke', International Journal of Stroke, 9 766-776 (2014) [C1]

Background: Our randomized controlled trial of a multifaceted evidence-based intervention for improving the inpatient management of fever, hyperglycemia, and swallowing dysfunctio... [more]

Background: Our randomized controlled trial of a multifaceted evidence-based intervention for improving the inpatient management of fever, hyperglycemia, and swallowing dysfunction in the first three-days following stroke improved outcomes at 90 days by 15%. We designed a quantitative process evaluation to further explain and illuminate this finding. Methods: Blinded retrospective medical record audits were undertaken for patients from 19 stroke units prior to and following the implementation of three multidisciplinary evidence-based protocols (supported by team-building workshops, and site-based education and support) for the management of fever (temperature =37·5°C), hyperglycemia (glucose >11mmol/l), and swallowing dysfunction in intervention stroke units. Results: Data from 1804 patients (718 preintervention; 1086 postintervention) showed that significantly more patients admitted to hospitals allocated to the intervention group received care according to the fever (n=186 of 603, 31% vs. n=74 of 483, 15%, P<0·001), hyperglycemia (n=22 of 603, 3·7% vs. n=3 of 483, 0·6%, P=0·01), and swallowing dysfunction protocols (n=241 of 603, 40% vs. n=19 of 483, 4·0%, P=0·001). Significantly more patients in these intervention stroke units received four-hourly temperature monitoring (n=222 of 603, 37% vs. n=90 of 483, 19%, P<0·001) and six-hourly glucose monitoring (194 of 603, 32% vs. 46 of 483, 9·5%, P<0·001) within 72 hours of admission to a stroke unit, and a swallowing screen (242 of 522, 46% vs. 24 of 350, 6·8%, P=0·0001) within the first 24 hours of admission to hospital. There was no difference between the groups in the treatment of patients with fever with paracetamol (22 of 105, 21% vs. 38 of 131, 29%, P=0·78) or their hyperglycemia with insulin (40 of 100, 40% vs. 17 of 57, 30%, P=0·49). Interpretation: Our intervention resulted in better protocol adherence in intervention stroke units, which explains our main trial findings of improved patient 90-day outcomes. Although monitoring practices significantly improved, there was no difference between the groups in the treatment of fever and hyperglycemia following acute stroke. A significant link between improved treatment practices and improved outcomes would have explained further the success of our intervention, and we are still unable to explain definitively the large improvements in death and dependency found in the main trial results. One potential explanation is that improved monitoring may have led to better overall surveillance of deteriorating patients and faster initiation of treatments not measured as part of the main trial. © 2013 World Stroke Organization.

DOI 10.1111/ijs.12202
Citations Scopus - 2Web of Science - 2
Co-authors Catherine Deste
2014 Drury P, Levi C, D'Este C, Mcelduff P, Mcinnes E, Hardy J, et al., 'Quality in Acute Stroke Care (QASC): Process evaluation of an intervention to improve the management of fever, hyperglycemia, and swallowing dysfunction following acute stroke', International Journal of Stroke, 9 766-776 (2014) [C1]
DOI 10.1111/ijs.12202
Citations Scopus - 2
Co-authors Catherine Deste
2014 Gunathilake R, Krishnamurthy V, Oldmeadow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables, and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', International Journal of Stroke, 9 E36-E37 (2014) [O1]
DOI 10.1111/ijs.12347
Co-authors John Attia, Mark Parsons, Christopher Oldmeadow
2014 Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, Pare G, 'Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12', Neurology, 83 678-685 (2014) [C1]

Results: In an overall analysis of 17,970 cases of ischemic stroke and 70,764 controls, we identified a novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.... [more]

Results: In an overall analysis of 17,970 cases of ischemic stroke and 70,764 controls, we identified a novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.07-1.13], p 5 7.12 3 10-11) with ischemic stroke. The association was with all ischemic stroke rather than an individual stroke subtype, with similar effect sizes seen in different stroke subtypes. There was no association with intracerebral hemorrhage (OR 1.03 [0.90-1.17], p 5 0.695).

Citations Scopus - 11Web of Science - 12
Co-authors Liz Holliday
2014 Golledge J, Clancy P, Maguire J, Lincz L, Koblar S, Mcevoy M, et al., 'Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence', Stroke, 45 1064-1068 (2014) [C1]

BACKGROUND AND PURPOSE - : Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the associati... [more]

BACKGROUND AND PURPOSE - : Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome. METHODS - : Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined. RESULTS - : Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26-9.53 compared with 17.36; interquartile range, 14.01-22.46 ng/mL; P<0.001) and remained associated with stroke after adjustment for other risk factors. Plasma Angpt1 concentrations on admission were lower in patients who had severe disability or died at 3 months (median, 5.52; interquartile range, 3.81-8.75 ng/mL for modified Rankin scale 3-6; n=91) compared with those with minor disability (median, 7.04; interquartile range, 4.75-9.92 ng/mL for modified Rankin scale 0-2; n=194), P=0.012, and remained negatively associated with severe disability or death after adjusting for other risk factors. Plasma Angpt1 was not predictive of stroke incidence in community-dwelling older men. CONCLUSIONS - : Plasma Angpt1 concentrations are low after ischemic stroke particularly in patients with poor stroke outcomes at 3 months. Interventions effective at upregulating Angpt1 could potentially improve stroke outcomes. © 2014 American Heart Association, Inc.

DOI 10.1161/STROKEAHA.113.004339
Citations Scopus - 1Web of Science - 1
Co-authors Jane Maguire, Lisa Lincz, John Attia
2014 Gardner A, Iverson GL, Levi CR, Schofield PW, Kay-Lambkin F, Kohler RMN, Stanwell P, 'A systematic review of concussion in rugby league', British Journal of Sports Medicine, (2014)

Objectives Concussion remains one of the inherent risks of participation in rugby league. While other injuries incurred by rugby league players have been well studied, less focus ... [more]

Objectives Concussion remains one of the inherent risks of participation in rugby league. While other injuries incurred by rugby league players have been well studied, less focus and attention has been directed towards concussion. Review method The current review examined all articles published in English from 1900 up to June 2013 pertaining to concussion in rugby league players. Data sources Publications were retrieved via six databases using the key search terms: rugby league, league, football; in combination with injury terms: athletic injuries, concussion, sports concussion, sports-related concussion, brain concussion, brain injury, brain injuries, mild traumatic brain injury, mTBI, traumatic brain injury, TBI, craniocerebral trauma, head injury and brain damage. Observational, cohort, correlational, cross-sectional and longitudinal studies were all included. Results 199 rugby league injury publications were identified. 39 (20%) were related in some way to concussion. Of the 39 identified articles, 6 (15%) had the main aim of evaluating concussion, while the other 33 reported on concussion incidence as part of overall injury data analyses. Rugby league concussion incidence rates vary widely from 0.0 to 40.0/1000 playing hours, depending on the definition of injury (time loss vs no time loss). The incidence rates vary across match play versus training session, seasons (winter vs summer) and playing position (forwards vs backs). The ball carrier has been found to be at greater risk for injury than tacklers. Concussion accounts for 29% of all injuries associated with illegal play, but only 9% of injuries sustained in legal play. Conclusions In comparison with other collision sports, research evaluating concussion in rugby league is limited. With such limited published rugby league data, there are many aspects of concussion that require attention, and future research may be directed towards these unanswered questions. © 2014 BMJ Publishing Group Ltd & British Association of Sport and Exercise Medicine.

DOI 10.1136/bjsports-2013-093102
Citations Web of Science - 2
Co-authors Peter Stanwell, F Kaylambkin, Peter Schofield
2014 Sales M, Quain D, Lasserson D, Levi C, Oldmeadow C, Jiwa M, et al., 'Quality of Referrals and Guideline Compliance for Time to Consultation at an Acute Neurovascular Clinic', Journal of Stroke and Cerebrovascular Diseases, (2014)

Background: The Age, Blood pressure, Clinical features, Duration of symptoms, Diabetes (ABCD2) score can be used to predict early recurrent stroke risk following Transient ischemi... [more]

Background: The Age, Blood pressure, Clinical features, Duration of symptoms, Diabetes (ABCD2) score can be used to predict early recurrent stroke risk following Transient ischemic attack (TIA). Given that recurrent stroke risk can be as high as 20% in the first week, international guidelines recommend "high-risk" TIAs (ABCD2 >3) be seen by specialist services such as dedicated acute neurovascular clinics within 24hours. The goal of this study was to examine the associations of both quality of referrals to a specialist acute clinic and of "guideline congruence" of time-to-clinic consultation after TIA/minor stroke. We hypothesized high-quality referrals containing key clinical elements would be associated with greater guideline congruence. Methods: A retrospective analysis of referrals to an acute neurovascular clinic within a tertiary care hospital of consecutive patients with TIA/minor stroke. Quality of general practitioner and emergency department referrals was defined on the basis of information content enabling ABCD2-based risk stratification by the clinic triage service. Time-to-clinic consultation was used to define "guideline congruence.". Results: Referrals of 148 consecutive eligible patients were reviewed. Sixty-six percent of cases were subsequently neurologist-diagnosed as TIA or minor stroke. Seventy-nine percent were referred by general practitioners. Fifty-three percent of referrals were of high quality, but quality was not associated with guideline congruence. Of the high-risk patients, only 3.6% were seen at the clinic within 24hours of index event and 31.3% within 24hours of referral. Conclusions: Current guidelines are pathophysiologically logical and evidence based, but are difficult toimplement. Improving quality of primary-secondary communication by improved referral quality is unlikely to improve guideline compliance. Alternativestrategies are needed to reduce recurrent stroke risk after TIA/minor stroke.

DOI 10.1016/j.jstrokecerebrovasdis.2014.12.004
Co-authors Parker Magin, Christopher Oldmeadow
2014 Gardner AJ, Tan CO, Ainslie PN, van Donkelaar P, Stanwell P, Levi CR, Iverson GL, 'Cerebrovascular reactivity assessed by transcranial Doppler ultrasound in sport-related concussion: a systematic review.', Br J Sports Med, (2014)
DOI 10.1136/bjsports-2014-093901
Co-authors Peter Stanwell
2014 Clarey J, Lasserson D, Levi C, Parsons M, Dewey H, Barber PA, et al., 'Absolute cardiovascular risk and GP decision making in TIA and minor stroke.', Fam Pract, 31 664-669 (2014) [C1]
DOI 10.1093/fampra/cmu054
Co-authors Mark Parsons, Parker Magin
2014 Murtha LA, Yang Q, Parsons MW, Levi CR, Beard DJ, Spratt NJ, McLeod DD, 'Cerebrospinal fluid is drained primarily via the spinal canal and olfactory route in young and aged spontaneously hypertensive rats', Fluids and Barriers of the CNS, 11 (2014) [C1]

Background: Many aspects of CSF dynamics are poorly understood due to the difficulties involved in quantification and visualization. In particular, there is debate surrounding the... [more]

Background: Many aspects of CSF dynamics are poorly understood due to the difficulties involved in quantification and visualization. In particular, there is debate surrounding the route of CSF drainage. Our aim was to quantify CSF flow, volume, and drainage route dynamics in vivo in young and aged spontaneously hypertensive rats (SHR) using a novel contrast-enhanced computed tomography (CT) method.Methods: ICP was recorded in young (2-5 months) and aged (16 months) SHR. Contrast was administered into the lateral ventricles bilaterally and sequential CT imaging was used to visualize the entire intracranial CSF system and CSF drainage routes. A customized contrast decay software module was used to quantify CSF flow at multiple locations.Results: ICP was significantly higher in aged rats than in young rats (11.52 ± 2.36 mmHg, versus 7.04 ± 2.89 mmHg, p = 0.03). Contrast was observed throughout the entire intracranial CSF system and was seen to enter the spinal canal and cross the cribriform plate into the olfactory mucosa within 9.1 ± 6.1 and 22.2 ± 7.1 minutes, respectively. No contrast was observed adjacent to the sagittal sinus. There were no significant differences between young and aged rats in either contrast distribution times or CSF flow rates. Mean flow rates (combined young and aged) were 3.0 ± 1.5 µL/min at the cerebral aqueduct; 3.5 ± 1.4 µL/min at the 3rd ventric= and 2.8 ± 0.9 µL/min at the 4th ventricle. Intracranial CSF volumes (and as percentage total brain volume) were 204 ± 97 µL (8.8 ± 4.3%) in the young and 275 ± 35 µL (10.8 ± 1.9%) in the aged animals (NS).Conclusions: We have demonstrated a contrast-enhanced CT technique for measuring and visualising CSF dynamics in vivo. These results indicate substantial drainage of CSF via spinal and olfactory routes, but there was little evidence of drainage via sagittal sinus arachnoid granulations in either young or aged animals. The data suggests that spinal and olfactory routes are the primary routes of CSF drainage and that sagittal sinus arachnoid granulations play a minor role, even in aged rats with higher ICP. © 2014 Murtha et al.; licensee BioMed Central Ltd.

DOI 10.1186/2045-8118-11-12
Citations Scopus - 5
Co-authors Mark Parsons, Damian Mcleod, Neil Spratt
2014 Thomas LC, Rivett DA, Parsons M, Levi C, 'Risk factors, radiological features, and infarct topography of craniocervical arterial dissection.', International Journal of Stroke, 9 1073-1082 (2014) [C1]
DOI 10.1111/j.1747-4949.2012.00912.x
Co-authors Lucy Thomas, Mark Parsons, Darren Rivett
2013 Thomas LC, Rivett DA, Bateman G, Stanwell P, Levi CR, 'Effect of Selected Manual Therapy Interventions for Mechanical Neck Pain on Vertebral and Internal Carotid Arterial Blood Flow and Cerebral Inflow', PHYSICAL THERAPY, 93 1563-1574 (2013) [C1]
DOI 10.2522/ptj.20120477
Citations Scopus - 3Web of Science - 1
Co-authors Peter Stanwell, Darren Rivett, Lucy Thomas
2013 Bivard A, Levi C, Spratt N, Parsons M, 'Perfusion CT in Acute Stroke: A Comprehensive Analysis of Infarct and Penumbra', RADIOLOGY, 267 543-550 (2013) [C1]
DOI 10.1148/radiol.12120971
Citations Scopus - 28Web of Science - 24
Co-authors Neil Spratt, Mark Parsons
2013 Cadilhac DA, Purvis T, Kilkenny MF, Longworth M, Mohr K, Pollack M, Levi CR, 'Evaluation of Rural Stroke Services Does Implementation of Coordinators and Pathways Improve Care in Rural Hospitals?', STROKE, 44 2848-2853 (2013) [C1]
DOI 10.1161/STROKEAHA.113.001258
Citations Scopus - 5Web of Science - 4
2013 Magin P, Victoire A, Zhen XM, Furler J, Pirotta M, Lasserson DS, et al., 'Under-Reporting of Socioeconomic Status of Patients in Stroke Trials Adherence to Consort Principles', STROKE, 44 2920-2922 (2013) [C1]
DOI 10.1161/STROKEAHA.113.002414
Citations Scopus - 1Web of Science - 1
Co-authors Parker Magin
2013 Kilkenny MF, Longworth M, Pollack M, Levi C, Cadilhac DA, 'Factors Associated With 28-Day Hospital Readmission After Stroke in Australia', STROKE, 44 2260-2268 (2013) [C1]
DOI 10.1161/STROKEAHA.111.000531
Citations Scopus - 4Web of Science - 4
2013 Yassi N, Parsons MW, Christensen S, Sharma G, Bivard A, Donnan GA, et al., 'Prediction of Poststroke Hemorrhagic Transformation Using Computed Tomography Perfusion', Stroke, 44 3039-3043 (2013) [C1]
DOI 10.1161/STROKEAHA.113.002396
Citations Scopus - 3Web of Science - 3
Co-authors Mark Parsons
2013 Adib-Samii P, Rost N, Traylor M, Devan W, Biffi A, Lanfranconi S, et al., '17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status', Stroke, 44 1609-1615 (2013) [C1]
Citations Scopus - 11Web of Science - 13
Co-authors Liz Holliday, Jane Maguire
2013 Campbell BCV, Christensen S, Tress BM, Churilov L, Desmond PM, Parsons MW, et al., 'Failure of collateral blood flow is associated with infarct growth in ischemic stroke', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 33 1168-1172 (2013) [C1]
DOI 10.1038/jcbfm.2013.77
Citations Scopus - 19Web of Science - 22
Co-authors Mark Parsons
2013 Menon BK, O'Brien B, Bivard A, Spratt NJ, Demchuk AM, Miteff F, et al., 'Assessment of leptomeningeal collaterals using dynamic CT angiography in patients with acute ischemic stroke', Journal of Cerebral Blood Flow and Metabolism, 33 365-371 (2013) [C1]
Citations Scopus - 30Web of Science - 30
Co-authors Neil Spratt, Mark Parsons
2013 Campbell BCV, Christensen S, Parsons MW, Churilov L, Desmond PM, Barber PA, et al., 'Advanced imaging improves prediction of hemorrhage after stroke thrombolysis', ANNALS OF NEUROLOGY, 73 510-519 (2013) [C1]
DOI 10.1002/ana.23837
Citations Scopus - 13Web of Science - 12
Co-authors Mark Parsons
2013 Williams FMK, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, et al., 'Ischemic stroke is associated with the ABO locus: The EuroCLOT Study', Annals of Neurology, 73 16-31 (2013) [C1]
Citations Scopus - 19Web of Science - 20
Co-authors Liz Holliday, Rodney Scott, John Attia
2013 Lannin NA, Anderson C, Lim J, Paice K, Price C, Faux S, et al., 'Telephone follow-up was more expensive but more efficient than postal in a national stroke registry', JOURNAL OF CLINICAL EPIDEMIOLOGY, 66 896-902 (2013) [C1]
DOI 10.1016/j.jclinepi.2013.03.005
Citations Scopus - 3Web of Science - 3
2013 Williams JM, Navin TJ, Jude MR, Levi CR, 'Recombinant tissue plasminogen activator (rt-PA) utilisation by rural clinicians in acute ischaemic stroke: An audit of current practice and clinical outcomes', AUSTRALIAN JOURNAL OF RURAL HEALTH, 21 203-207 (2013) [C1]
DOI 10.1111/ajr.12038
Citations Web of Science - 1
2013 Williams JM, Jude MR, Levi CR, 'Recombinant tissue plasminogen activator (rt-PA) utilisation by rural clinicians in acute ischaemic stroke: A survey of barriers and enablers', Australian Journal of Rural Health, 21 262-267 (2013) [C1]

Objective: This paper identified barriers which prevent rural health care providers from utilising rt-PA in acute ischaemic stroke and proposes possible support mechanisms to incr... [more]

Objective: This paper identified barriers which prevent rural health care providers from utilising rt-PA in acute ischaemic stroke and proposes possible support mechanisms to increase its utilisation. Methods: This descriptive study uses data from anonymous surveys distributed to health care providers involved in acute stroke patient care in three rural hospitals with rt-PA pathways. Saturation sampling was used. Surveys gathered self assessed ratings of experience, practice environment, attitudes, existing support, barriers and possible enablers regarding rt-PA use in acute stroke. Results: Physicians reported the strongest barriers to the use of rt-PA in acute stroke as pre-hospital delays (91%), risk of intracerebral haemorrhage (ICH) (73%) and clinical diagnostic uncertainty (60%). They reported high levels of confidence in the support received from their stroke units (90%). Nurses identified a poor level of stroke education and knowledge on rt-PA utilisation in acute stroke. A third of nurses could correctly list six different stroke signs. The risk of ICH following rt-PA administration in stroke was also a significant barrier for nurses. Response rate from physicians was 26% (10/38) and 19% (13/69) for nurses. Conclusions: To reduce barriers to rt-PA utilisation in rural facilities physicians require education on the calculated risk of ICH as well as exposure and experience to improve their ability to confidently diagnose stroke patients who are eligible for rt-PA treatment. Education for nurses on symptoms of stroke and rt-PA utilisation and administration is recommended. © National Rural Health Alliance Inc.

DOI 10.1111/ajr.12052
2013 Bivard A, Stanwell PT, Levi CR, Parsons MW, 'Arterial spin labeling identifies tissue salvage and good clinical recovery after acute ischemic stroke', Journal of Neuroimaging, 23 391-396 (2013) [C1]
Citations Scopus - 8Web of Science - 10
Co-authors Peter Stanwell, Mark Parsons
2013 Marsden DL, Dunn A, Callister R, Levi CR, Spratt NJ, 'Characteristics of Exercise Training Interventions to Improve Cardiorespiratory Fitness After Stroke: A Systematic Review With Meta-analysis', NEUROREHABILITATION AND NEURAL REPAIR, 27 775-788 (2013) [C1]
DOI 10.1177/1545968313496329
Citations Scopus - 6Web of Science - 2
Co-authors Robin Callister, Neil Spratt
2013 Jolly TAD, Bateman GA, Levi CR, Parsons MW, Michie PT, Karayanidis F, 'Early detection of microstructural white matter changes associated with arterial pulsatility', FRONTIERS IN HUMAN NEUROSCIENCE, 7 (2013) [C1]
DOI 10.3389/fnhum.2013.00782
Citations Scopus - 2Web of Science - 3
Co-authors Pat Michie, Frini Karayanidis, Mark Parsons
2013 Bladin C, Levi C, Parsons M, 'Stroke thrombolysis: Leaving the past, understanding the present and moving forward ...', EMERGENCY MEDICINE AUSTRALASIA, 25 195-196 (2013) [C3]
DOI 10.1111/1742-6723.12025
Citations Web of Science - 3
Co-authors Mark Parsons
2013 Zareie H, Quain DA, Parsons M, Inder KJ, McElduff P, Miteff F, et al., 'The influence of anterior cerebral artery flow diversion measured by transcranial Doppler on acute infarct volume and clinical outcome in anterior circulation stroke', INTERNATIONAL JOURNAL OF STROKE, 8 228-234 (2013) [C1]
DOI 10.1111/j.1747-4949.2012.00801.x
Citations Scopus - 2Web of Science - 2
Co-authors Mark Parsons, Kerry Inder, Neil Spratt
2013 Chan DKY, Cordato D, O'Rourke F, Chan DL, Pollack M, Middleton S, Levi C, 'Comprehensive stroke units: a review of comparative evidence and experience', INTERNATIONAL JOURNAL OF STROKE, 8 260-264 (2013) [C1]
DOI 10.1111/j.1747-4949.2012.00850.x
Citations Scopus - 8Web of Science - 6
2013 Churilov L, Liu D, Ma H, Christensen S, Nagakane Y, Campbell B, et al., 'Multiattribute selection of acute stroke imaging software platform for Extending the Time for Thrombolysis in Emergency Neurological Deficits (EXTEND) clinical trial', International Journal of Stroke, 8 204-210 (2013) [C1]
DOI 10.1111/j.1747-4949.2012.00787.x
Citations Scopus - 5Web of Science - 5
Co-authors Mark Parsons
2013 Meretoja A, Davis SM, Campbell BCV, Yassi N, Yan B, Churilov L, et al., 'The Spot sign and Tranexamic acid On Preventing ICH growth - AUStralasia Trial (STOP-AUST): Protocol of a phase II randomized, placebo-controlled, double-blind, multicenter trial', International Journal of Stroke, (2013) [C3]

Rationale: No evidence-based acute therapies exist for intracerebral hemorrhage. Intracerebral hemorrhage growth is an important determinant of patient outcome. Tranexamic acid is... [more]

Rationale: No evidence-based acute therapies exist for intracerebral hemorrhage. Intracerebral hemorrhage growth is an important determinant of patient outcome. Tranexamic acid is known to reduce hemorrhage in other conditions. Aim: The study aims to test the hypothesis that intracerebral hemorrhage patients selected with computed tomography angiography contrast extravasation 'spot sign' will have lower rates of hematoma growth when treated with intravenous tranexamic acid within 4·5-hours of stroke onset compared with placebo. Design: The Spot sign and Tranexamic acid On Preventing ICH growth - AUStralasia Trial is a multicenter, prospective, 1:1 randomized, double-blind, placebo-controlled, investigator-initiated, academic Phase II trial. Intracerebral hemorrhage patients fulfilling clinical criteria (e.g. Glasgow Coma Scale >7, intracerebral hemorrhage volume <70ml, no identified secondary cause of intracerebral hemorrhage, no thrombotic events within the previous 12 months, no planned surgery) and demonstrating contrast extravasation on computed tomography angiography will receive either intravenous tranexamic acid 1g 10-min bolus followed by 1g eight-hour infusion or placebo. A second computed tomography will be performed at 24 ± 3 hours to evaluate intracerebral hemorrhage growth and patients followed up for three-months. Study outcomes: The primary outcome measure is presence of intracerebral hemorrhage growth by 24 ± 3 hours, defined as either >33% or >6ml increase from baseline, and will be adjusted for baseline intracerebral hemorrhage volume. Secondary outcome measures include growth as a continuous measure, thromboembolic events, and the three-month modified Rankin Scale score. Discussion: This is the first trial to evaluate the efficacy of tranexamic acid in intracerebral hemorrhage patients selected based on an imaging biomarker of high likelihood of hematoma growth. The trial is registered as NCT01702636. © 2013 World Stroke Organization.

DOI 10.1111/ijs.12132
Citations Web of Science - 3
Co-authors Mark Parsons, Neil Spratt
2013 Mcleod DD, Parsons MW, Hood R, Hiles B, Allen J, Mccann SK, et al., 'Perfusion computed tomography thresholds defining ischemic penumbra and infarct core: Studies in a rat stroke model', International Journal of Stroke, (2013)

Background: Perfusion computed tomography is becoming more widely used as a clinical imaging tool to predict potentially salvageable tissue (ischemic penumbra) after ischemic stro... [more]

Background: Perfusion computed tomography is becoming more widely used as a clinical imaging tool to predict potentially salvageable tissue (ischemic penumbra) after ischemic stroke and guide reperfusion therapies. Aims: The study aims to determine whether there are important changes in perfusion computed tomography thresholds defining ischemic penumbra and infarct core over time following stroke. Methods: Permanent middle cerebral artery occlusion was performed in adult outbred Wistar rats (n=6) and serial perfusion computed tomography scans were taken every 30 mins for 2h. To define infarction thresholds at 1h and 2h post-stroke, separate groups of rats underwent 1h (n=6) and 2h (n=6) of middle cerebral artery occlusion followed by reperfusion. Infarct volumes were defined by histology at 24h. Co-registration with perfusion computed tomography maps (cerebral blood flow, cerebral blood volume, and mean transit time) permitted pixel-based analysis of thresholds defining infarction, using receiver operating characteristic curves. Results: Relative cerebral blood flow was the perfusion computed tomography parameter that most accurately predicted penumbra (area under the curve=0·698) and also infarct core (area under the curve=0·750). A relative cerebral blood flow threshold of <75% of mean contralateral cerebral blood flow most accurately predicted penumbral tissue at 0·5h (area under the curve=0·660), 1h (area under the curve=0·659), 1·5h (area under the curve=0·636), and 2h (area under the curve=0·664) after stroke onset. A relative cerebral blood flow threshold of <55% of mean contralateral most accurately predicted infarct core at 1h (area under the curve=0·765) and at 2h (area under the curve=0·689) after middle cerebral artery occlusion. Conclusions: The data provide perfusion computed tomography defined relative cerebral blood flow thresholds for infarct core and ischemic penumbra within the first two hours after experimental stroke in rats. These thresholds were shown to be stable to define the volume of infarct core and penumbra within this time window. © 2013 World Stroke Organization.

DOI 10.1111/ijs.12147
Citations Scopus - 3
Co-authors Damian Mcleod, Mark Parsons, Neil Spratt
2013 Magin P, Lasserson D, Parsons M, Spratt N, Evans M, Russell M, et al., 'Referral and triage of patients with transient ischemic attacks to an acute access clinic: Risk stratification in an Australian setting', International Journal of Stroke, 8 81-89 (2013) [C1]

Background: Transient ischemic attacks and minor stroke entail considerable risk of completed stroke but this risk is reduced by prompt assessment and treatment. Risk can be strat... [more]

Background: Transient ischemic attacks and minor stroke entail considerable risk of completed stroke but this risk is reduced by prompt assessment and treatment. Risk can be stratified according to the ABCD2 prediction score. Current guidelines suggest specialist assessment and treatment within 24h for high-risk event (ABCD2 score 4-7) and seven-days for low-risk event (ABCD2 score =3). Aims: The study aims to establish paths to care and outcomes for patients referred by general practitioners and emergency departments to an Australian acute access transient ischemic attack service. Methods: This is a prospective audit. Primary outcomes were time from event to referral, from referral to clinic appointment, and from event to appointment. ABCD2 score was calculated for each event. Time from event was modeled using Cox proportional hazards regression. Results: There were 231 clinic attendees (general practitioner: 127; emergency department: 104). Mean time from event to referral was 9·2 days (SD 23·7, median 2), from referral to being seen in the clinic was 13·6 days (SD 19·0, median 7), and from event to being seen in the clinic was 17·2 days (SD 27·1, median 10). Of low-risk patients, 38·5% were seen within seven-days of event. Of high-risk patients, 36·7% were seen within one-day. ABCD2 score was not a significant predictor of any time interval from event to clinic attendance. There were no completed strokes prior to clinic attendance. Conclusions: Times from event to clinic assessment were in excess of current recommendations and risk stratification was suboptimal, though short-term outcomes were good. Improvements in referral mechanisms may enhance risk-stratification and triage. © 2013 World Stroke Organization.

DOI 10.1111/ijs.12014
Citations Scopus - 1Web of Science - 2
Co-authors Parker Magin, Mark Parsons, Neil Spratt
2013 McLeod DD, Beard DJ, Parsons MW, Levi CR, Calford MB, Spratt NJ, 'Inadvertent Occlusion of the Anterior Choroidal Artery Explains Infarct Variability in the Middle Cerebral Artery Thread Occlusion Stroke Model', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0075779
Citations Scopus - 3Web of Science - 2
Co-authors Mark Parsons, Damian Mcleod, Neil Spratt
2013 Hankey GJ, Levi CR, 'Standard strategies for acute ischemic stroke within the rtPA therapeutic window: Australia', Neurology: Clinical Practice, 3 215-216 (2013) [C3]
DOI 10.1212/CPJ.0b013e318296f2cf
2012 Campbell BCV, Tu HTH, Christensen S, Desmond PM, Levi CR, Bladin CF, et al., 'Assessing response to stroke thrombolysis validation of 24-Hour multimodal magnetic resonance imaging', Archives of Neurology, 69 46-50 (2012) [C1]
Citations Scopus - 21Web of Science - 20
Co-authors Mark Parsons
2012 Parsons MW, Spratt NJ, Bivard A, Campbell B, Chung K, Miteff F, et al., 'A randomized trial of tenecteplase versus alteplase for acute ischemic stroke', New England Journal of Medicine, 366 1099-1107 (2012) [C1]
Citations Scopus - 135Web of Science - 119
Co-authors Mark Parsons, Neil Spratt
2012 Parsons MW, Levi CR, Davis S, 'Tenecteplase versus alteplase for acute ischemic stroke: The authors reply', New England Journal of Medicine, 367 276 (2012) [C1]
Co-authors Mark Parsons
2012 Cheng YC, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, et al., 'Are myocardial infarction-associated single-nucleotide polymorphisms associated with ischemic stroke?', Stroke, 43 980-U143 (2012) [C1]
Citations Scopus - 11Web of Science - 11
Co-authors Jane Maguire, Lisa Lincz, Pablo Moscato, John Attia, Liz Holliday, Rodney Scott
2012 Campbell BCV, Christensen S, Levi CR, Desmond PM, Donnan GA, Davis SM, Parsons MW, 'Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke', Stroke, 43 2648-2653 (2012) [C1]
Citations Scopus - 21Web of Science - 19
Co-authors Mark Parsons
2012 Nagakane Y, Christensen S, Ogata T, Churilov L, Ma H, Parsons MW, et al., 'Moving beyond a single perfusion threshold to define penumbra: A novel probabilistic mismatch definition', Stroke, 43 1548-1555 (2012) [C1]
Citations Scopus - 10Web of Science - 12
Co-authors Mark Parsons
2012 Middleton S, D'Este C, Grimshaw J, Ward JE, Levi C, 'Team-building intervention to improve acute stroke care Reply', LANCET, 379 1390-1390 (2012) [C3]
Co-authors Catherine Deste
2012 Middleton S, D'Este CA, Grimshaw J, Ward JE, Levi CR, 'Reply: Team-building intervention to improve acute stroke care', Lancet, 379 1390 (2012) [C3]
Co-authors Catherine Deste
2012 Middleton S, Levi CR, Ward J, 'QASC trial: Swallow surveillance rates comparable with international data', Lancet, 379 1389 (2012) [C3]
2012 Parsons MW, Levi CR, 'Reperfusion trials for acute ischaemic stroke', The Lancet, 380 706-708 (2012) [C3]
Co-authors Mark Parsons
2012 Gardner AJ, Kay-Lambkin FJ, Stanwell PT, Donnelly J, Williams WH, Hiles A, et al., 'A systematic review of diffusion tensor imaging findings in sports-related concussion', Journal of Neurotrauma, 29 2521-2538 (2012) [C1]
Citations Scopus - 25Web of Science - 21
Co-authors Peter Stanwell, Peter Schofield, F Kaylambkin
2012 Bellenguez C, Bevan S, Gschwendtner A, Spencer CCA, Burgess AI, Pirinen M, et al., 'Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke', Nature Genetics, 44 328-333 (2012) [C1]
DOI 10.1038/ng.1081
Citations Scopus - 113Web of Science - 91
Co-authors John Attia, Liz Holliday
2012 Holliday EG, Maguire JM, Evans T-J, Koblar SA, Jannes J, Sturm J, et al., 'Common variants at 6p21.1 are associated with large artery atherosclerotic stroke', Nature Genetics, 44 1147-1153 (2012) [C1]
Citations Scopus - 44Web of Science - 46
Co-authors Wayne Smith, Roseanne Peel, Jane Maguire, Liz Holliday, Christopher Oldmeadow, Rodney Scott, Mark Parsons, John Attia, Pablo Moscato, Lisa Lincz
2012 O'Brien B, Lindley R, Levi CR, 'Stroke in the elderly: Predictable, preventable and treatable', Medicine Today, 13 20-24 (2012) [C3]
2012 Thomas L, Rivett DA, Attia JR, Levi CR, 'Risk factors and clinical presentation of craniocervical arterial dissection: A prospective study', BMC Musculoskeletal Disorders, 13 1-6 (2012) [C3]
Co-authors Darren Rivett, John Attia, Lucy Thomas
2012 Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng Y-C, et al., 'Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): A meta-analysis of genome-wide association studies', The Lancet Neurology, 11 951-962 (2012) [C1]
Citations Scopus - 88Web of Science - 91
Co-authors Liz Holliday, Jane Maguire
2012 Davis S, Campbell B, Christensen S, Ma H, Desmond P, Parsons MW, et al., 'Perfusion/diffusion mismatch is valid and should be used for selecting delayed interventions', Translational Stroke Research, 3 188-197 (2012) [C1]
Citations Scopus - 5Web of Science - 4
Co-authors Mark Parsons
2012 Levi CR, Zareie H, Parsons MW, 'Transcranial Doppler in acute stroke management - A 'real-time' bed-side guide to reperfusion and collateral flow', Perspectives in Medicine, 1 185-193 (2012) [C1]
Co-authors Mark Parsons
2011 Bivard A, Spratt NJ, Levi CR, Parsons MW, 'Acute stroke thrombolysis: Time to dispense with the clock and move to tissue-based decision making?', Expert Review of Cardiovascular Therapy, 9 451-461 (2011) [C1]
Citations Scopus - 6
Co-authors Neil Spratt, Mark Parsons
2011 McLeod DD, Parsons MW, Levi CR, Beautement S, Buxton D, Roworth B, Spratt NJ, 'Establishing a rodent stroke perfusion computed tomography model', International Journal of Stroke, 6 284-289 (2011) [C1]
DOI 10.1111/j.1747-4949.2010.00564.x
Citations Scopus - 10Web of Science - 9
Co-authors Mark Parsons, Neil Spratt, Damian Mcleod
2011 Bivard A, Spratt NJ, Levi CR, Parsons MW, 'Perfusion computer tomography: Imaging and clinical validation in acute ischaemic stroke', Brain, 134 3408-3416 (2011) [C1]
Citations Scopus - 33Web of Science - 36
Co-authors Mark Parsons, Neil Spratt
2011 Hunter AJ, Snodgrass SN, Quain D, Parsons MW, Levi CR, 'HOBOE (head-of-bed optimization of elevation) study: Association of higher angle with reduced cerebral blood flow velocity in acute ischemic stroke', Physical Therapy, 91 1503-1512 (2011) [C1]
DOI 10.2522/ptj.20100271
Citations Scopus - 7Web of Science - 5
Co-authors Suzanne Snodgrass, Mark Parsons
2011 Nagakane Y, Christensen S, Brekenfeld C, Ma H, Churilov L, Parsons MW, et al., 'EPITHET positive result after reanalysis using baseline diffusion-weighted imaging/perfusion-weighted imaging co-registration', Stroke, 42 59-64 (2011) [C1]
DOI 10.1161/strokeaha.110.580464
Citations Scopus - 45Web of Science - 39
Co-authors Mark Parsons
2011 Campbell BCV, Christensen S, Levi CR, Desmond PM, Donnan GA, Davis SM, Parsons MW, 'Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core', Stroke, 42 3435-3440 (2011) [C1]
DOI 10.1161/strokeaha.111.618355
Citations Scopus - 59Web of Science - 52
Co-authors Mark Parsons
2011 Middleton S, McElduff P, Ward J, Grimshaw JM, Dale S, D'Este CA, et al., 'Implementation of evidence-based treatment protocols to manage fever, hyperglycaemia, and swallowing dysfunction in acute stroke (QASC): A cluster randomised controlled trial', The Lancet, 378 1699-1706 (2011) [C1]
DOI 10.1016/s0140-6736(11)61485-2
Citations Scopus - 64Web of Science - 57
Co-authors Catherine Deste
2011 Parsons MW, Bivard A, McElduff P, Spratt NJ, Levi CR, 'Defining the extent of irreversible brain ischemia using perfusion computed tomography', Cerebrovascular Diseases, 31 238-245 (2011) [C1]
DOI 10.1159/000321897
Citations Scopus - 43Web of Science - 38
Co-authors Neil Spratt, Mark Parsons
2011 Campbell BCV, Costello C, Christensen S, Ebinger M, Parsons MW, Desmond PM, et al., 'Fluid-attenuated inversion recovery hyperintensity in acute ischemic stroke may not predict hemorrhagic transformation', Cerebrovascular Diseases, 32 401-405 (2011) [C1]
Citations Scopus - 9Web of Science - 8
Co-authors Mark Parsons
2011 Alvarez SD, Levi CR, 'Transient ischaemic attack and stroke prevention', Australian Doctor, 19-24 (2011) [C2]
2011 Maguire JM, Thakkinstian A, Levi CR, Lincz L, Bisset L, Sturm J, et al., 'Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 polymorphisms on 90-day ischemic stroke functional outcome: A novel finding', Journal of Stroke and Cerebrovascular Diseases, 20 134-144 (2011) [C1]
DOI 10.1016/j.jstrokecerebrovasdis.2009.10.011
Citations Scopus - 22Web of Science - 21
Co-authors Lisa Lincz, Jane Maguire, John Attia, Rodney Scott
2011 Thomas L, Rivett DA, Attia JR, Parsons MW, Levi CR, 'Risk factors and clinical features of craniocervical arterial dissection', Manual Therapy, 16 351-356 (2011) [C1]
DOI 10.1016/j.math.2010.12.008
Citations Scopus - 20Web of Science - 15
Co-authors Darren Rivett, John Attia, Lucy Thomas, Mark Parsons
2011 Cadilhac DA, Kilkenny MF, Longworth M, Pollack MRP, Levi CR, 'Metropolitan-rural divide for stroke outcomes: Do stroke units make a difference?', Internal Medicine Journal, 41 321-326 (2011) [C1]
DOI 10.1111/j.1445-5994.2010.02280.x
Citations Scopus - 11Web of Science - 8
2011 Middleton S, Levi CR, Ward J, Grimshaw J, Griffiths R, D'Este CA, et al., 'Death, dependency and health status 90 days following hospital admission for acute stroke in NSW', Internal Medicine Journal, 41 736-743 (2011) [C1]
DOI 10.1111/j.1445-5994.2010.02330.x
Citations Scopus - 1Web of Science - 1
Co-authors Catherine Deste
2010 Lees KR, Bluhmki E, Von Kummer R, Brott TG, Toni D, Grotta JC, et al., 'Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials', The Lancet, 375 1695-1703 (2010) [C1]
DOI 10.1016/S0140-6736(10)60491-6
Citations Scopus - 728Web of Science - 654
Co-authors Mark Parsons, John Attia
2010 Cadilhac DA, Lannin NA, Anderson CS, Levi CR, Faux S, Price C, et al., 'Protocol and pilot data for establishing the Australian Stroke Clinical Registry', International Journal of Stroke, 5 217-226 (2010) [C1]
DOI 10.1111/j.1747-4949.2010.00430.x
Citations Scopus - 10Web of Science - 9
2010 Garnett AR, Marsden DL, Parsons MW, Quain DA, Spratt NJ, Loudfoot AR, et al., 'The rural Prehospital Acute Stroke Triage (PAST) trial protocol: A controlled trial for rapid facilitated transport of rural acute stroke patients to a regional stroke centre', International Journal of Stroke, 5 506-513 (2010) [C1]
DOI 10.1111/j.1747-4949.2010.00522.x
Citations Scopus - 9Web of Science - 8
Co-authors Mark Parsons, Neil Spratt
2010 Simpson MA, Dewey HM, Churilov L, Ahmed N, Bladin CF, Schultz D, et al., 'Thrombolysis for acute stroke in Australia: Outcomes from the Safe Implementation of Thrombolysis in Stroke registry (2002-2008)', Medical Journal of Australia, 193 439-443 (2010) [C1]
Citations Scopus - 17Web of Science - 13
Co-authors Mark Parsons
2010 Chemmanam T, Campbell BCV, Christensen S, Nagakane Y, Desmond PM, Bladin CF, et al., 'Ischemic diffusion lesion reversal is uncommon and rarely alters perfusion-diffusion mismatch', Neurology, 75 1040-1047 (2010) [C1]
DOI 10.1212/WNL.0b013e3181f39ab6
Citations Scopus - 51Web of Science - 45
Co-authors Mark Parsons
2010 Lemmens R, Buysschaert I, Geelen V, Fernandez-Cadenas I, Montaner J, Schmidt H, et al., 'The Association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology', Stroke, 41 1850-1857 (2010) [C1]
DOI 10.1161/STROKEAHA.110.587980
Citations Scopus - 27Web of Science - 26
Co-authors John Attia, Jane Maguire
2010 Campbell BCV, Christensen S, Butcher KS, Gordon I, Parsons MW, Desmond PM, et al., 'Regional very low cerebral blood volume predicts hemorrhagic transformation better than diffusion-weighted imaging volume and thresholded apparent diffusion coefficient in acute ischemic stroke', Stroke, 41 82-88 (2010) [C1]
DOI 10.1161/STROKEAHA.109.562116
Citations Scopus - 52Web of Science - 47
Co-authors Mark Parsons
2010 Butcher K, Christensen S, Parsons MW, De Silva DA, Ebinger M, Levi CR, et al., 'Postthrombolysis blood pressure elevation is associated with hemorrhagic transformation', Stroke, 41 72-77 (2010) [C1]
DOI 10.1161/STROKEAHA.109.563767
Citations Scopus - 29Web of Science - 27
Co-authors Mark Parsons
2010 De Silva DA, Brekenfeld C, Ebinger M, Christensen S, Barber PA, Butcher KS, et al., 'The benefits of intravenous thrombolysis relate to the site of baseline arterial occlusion in the echoplanar imaging thrombolytic evaluation trial (EPITHET)', Stroke, 41 295-299 (2010) [C1]
DOI 10.1161/STROKEAHA.109.562827
Citations Scopus - 48Web of Science - 43
Co-authors Mark Parsons
2010 Dewey HM, Churilov L, Blacker D, Bladin C, Davis SM, Donnan GA, et al., 'Response to 'A graphic reanalysis of the NINDS Trial'', Annals of Emergency Medicine, 55 227-229 (2010) [C3]
DOI 10.1016/j.annemergmed.2009.09.026
Citations Scopus - 4Web of Science - 3
2010 Parsons MW, Christensen S, McElduff P, Levi CR, Butcher KS, De Silva DA, et al., 'Pretreatment diffusion- and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis', Journal of Cerebral Blood Flow and Metabolism, 30 1214-1225 (2010) [C1]
DOI 10.1038/jcbfm.2010.3
Citations Scopus - 90Web of Science - 80
Co-authors Mark Parsons
2010 Campbell BCV, Christensen S, Foster SJ, Desmond PM, Parsons MW, Butcher KS, et al., 'Visual assessment of perfusion-diffusion mismatch is inadequate to select patients for thrombolysis', Cerebrovascular Diseases, 29 592-596 (2010) [C1]
DOI 10.1159/000311080
Citations Scopus - 34Web of Science - 33
Co-authors Mark Parsons
2010 Tu HTH, Campbell BCV, Christensen S, Collins M, De Silva DA, Butcher KS, et al., 'Pathophysiological determinants of worse stroke outcome in atrial fibrillation', Cerebrovascular Diseases, 30 389-395 (2010) [C1]
DOI 10.1159/000316886
Citations Scopus - 34Web of Science - 25
Co-authors Mark Parsons
2010 Marsden DL, Spratt NJ, Walker R, Barker DJ, Attia JR, Pollack MR, et al., 'Trends in stroke attack rates and case fatality in the Hunter Region, Australia 1996-2008', Cerebrovascular Diseases, 30 500-507 (2010) [C1]
DOI 10.1159/000319022
Citations Scopus - 16Web of Science - 16
Co-authors John Attia, Mark Parsons, Neil Spratt
2010 De Silva DA, Ebinger M, Christensen S, Parsons MW, Levi CR, Butcher K, et al., 'Baseline diabetic status and admission blood glucose were poor prognostic factors in the EPITHET trial', Cerebrovascular Diseases, 29 14-21 (2010) [C1]
DOI 10.1159/000255969
Citations Scopus - 29Web of Science - 27
Co-authors Mark Parsons
2010 Sangvatanakul P, Hillege S, Lalor E, Levi CR, Hill K, Middleton S, 'Setting stroke research priorities: The consumer perspective', Journal of Vascular Nursing, 28 121-131 (2010) [C1]
DOI 10.1016/j.jvn.2010.09.001
Citations Scopus - 5
2010 Levi CR, 'Consultant's comment', Medicine Today, 11 15 (2010) [C3]
2010 Crimmins DS, Levi CR, Gerraty P, Beer CD, Hill KM, 'Current validity of the ABCD2 score for acute risk stratification of transient ischaemic attack patients is uncertain Reply', Internal Medicine Journal, 40 470-471 (2010) [C2]
2010 Huppatz C, Gawarikar Y, Levi CR, Kelly PM, Williams D, Dalton CB, et al., 'Should there be a standardised approach to the diagnostic workup of suspected adult encephalitis? A case series from Australia', BMC Infectious Diseases, 10 1-6 (2010) [C1]
DOI 10.1186/1471-2334-10-353
Citations Scopus - 8Web of Science - 7
Co-authors Craig Dalton, David Durrheim
2009 Middleton S, Levi CR, Ward J, Grimshaw J, Griffiths R, D'Este CA, et al., 'Fever, hyperglycaemia and swallowing dysfunction management in acute stroke: A cluster randomised controlled trial of knowledge transfer', Implementation Science, 4 1-11 (2009) [C1]
DOI 10.1186/1748-5908-4-16
Citations Scopus - 5Web of Science - 5
Co-authors Catherine Deste
2009 Levi CR, Bateman GA, Spratt NJ, McElduff P, Parsons MW, Miteff F, 'The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke', Brain, 132 2231-2238 (2009) [C1]
DOI 10.1093/brain/awp155
Citations Scopus - 109Web of Science - 104
Co-authors Neil Spratt, Mark Parsons
2009 Parsons MW, Miteff F, Bateman GA, Spratt NJ, Loiselle A, Attia JR, Levi CR, 'Acute ischemic stroke imaging-guided tenecteplase treatment in an extended time window', Neurology, 72 915-921 (2009) [C1]
DOI 10.1212/01.wnl.0000344168.05315.9d
Citations Scopus - 63Web of Science - 48
Co-authors Neil Spratt, John Attia, Mark Parsons
2009 Ebinger M, Christensen S, De Silva DA, Parsons MW, Levi CR, Butcher KS, et al., 'Expediting MRI-based proof-of-concept stroke trials using an earlier imaging end point', Stroke, 40 1353-1358 (2009) [C1]
DOI 10.1161/strokeaha.108.532622
Citations Scopus - 23Web of Science - 20
Co-authors Mark Parsons
2009 Ebinger M, Iwanaga T, Prosser JF, De Silva DA, Christensen S, Collins M, et al., 'Clinical-diffusion mismatch and benefit from thrombolysis 3 to 6 hours after acute stroke', Stroke, 40 2572-2574 (2009) [C1]
DOI 10.1161/strokeaha.109.548073
Citations Scopus - 23Web of Science - 23
Co-authors Mark Parsons
2009 De Silva DA, Fink JN, Christensen S, Ebinger M, Bladin C, Levi CR, et al., 'Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET)', Stroke, 40 2872-2874 (2009) [C1]
DOI 10.1161/strokeaha.108.543595
Citations Scopus - 46Web of Science - 39
Co-authors Mark Parsons
2009 Huppatz C, Durrheim DN, Levi CR, Dalton CB, Williams D, Clements MS, Kelly PM, 'Etiology of encephalitis in Australia, 1990-2007', Emerging Infectious Diseases, 15 1359-1365 (2009) [C1]
DOI 10.3201/eid1509.081540
Citations Scopus - 35Web of Science - 37
Co-authors David Durrheim, Craig Dalton
2009 Levi CR, Lindley R, Smith B, Bladin C, Parsons MW, Read S, et al., 'The implementation of intravenous tissue plasminogen activator in acute ischaemic stroke: A scientific position statement from the National Stroke Foundation and the Stroke Society of Australasia', Internal Medicine Journal, 39 317-324 (2009) [C1]
DOI 10.1111/j.1445-5994.2009.01938.x
Citations Scopus - 10Web of Science - 6
Co-authors Mark Parsons
2009 Crimmins DS, Levi CR, Gerraty RP, Beer CD, Hill KM, 'Acute stroke and transient ischaemic attack management: Time to act fast', Internal Medicine Journal, 39 325-331 (2009) [C1]
DOI 10.1111/j.1445-5994.2009.01935.x
Citations Scopus - 7Web of Science - 6
2009 Huppatz C, Kelly PM, Levi CR, Dalton CB, Williams D, Durrheim DN, 'Encephalitis in Australia, 1979-2006: Trends and aetiologies', Communicable Diseases Intelligence Quarterly Report, 33 192-197 (2009) [C1]
Citations Scopus - 11
Co-authors Craig Dalton, David Durrheim
2008 Davis SM, Donnan GA, Parsons MW, Levi CR, Butcher KS, Peeters A, et al., 'Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): A placebo-controlled randomised trial', The Lancet Neurology, 7 299-309 (2008) [C1]
DOI 10.1016/s1474-4422(08)70044-9
Citations Scopus - 531Web of Science - 472
Co-authors John Attia, Mark Parsons
2008 Davis SM, Donnan GA, Parsons MW, Levi CR, Butcher KS, Barber PA, et al., 'EPITHET: Where next? Authors' reply', The Lancet Neurology, 7 571-572 (2008) [C3]
DOI 10.1016/s1474-4422(08)70124-8
Citations Web of Science - 1
Co-authors Mark Parsons
2008 Cadilhac DA, Pearce DC, Levi CR, Donnan GA, 'Improvements in the quality of care and health outcomes with new stroke care units following implementation of a clinician-led, health system redesign programme in New South Wales, Australia', Quality and Safety in Health Care, 17 329-333 (2008) [C1]
DOI 10.1136/qshc.2007.024604
Citations Scopus - 24Web of Science - 25
2008 Hill K, Barber A, Beer C, Beilby J, Bernhardt J, Bladin C, et al., 'Australian Clinical Guidelines for Acute Stroke Management 2007', International Journal of Stroke, 3 120-129 (2008) [C1]
DOI 10.1111/j.1747-4949.2008.00189.x
Citations Scopus - 19Web of Science - 18
2008 Levi C, 'Response to interview with Ian Mosley', Journal of Emergency Primary Health Care, 6 (2008) [C3]
2008 White JH, Magin PJ, Attia JR, Pollack MR, Sturm J, Levi CR, 'Exploring poststroke mood changes in community-dwelling stroke survivors: A qualitative study', Archives of Physical Medicine and Rehabilitation, 89 1701-1707 (2008) [C1]
DOI 10.1016/j.apmr.2007.12.048
Citations Scopus - 12Web of Science - 9
Co-authors John Attia, Parker Magin
2008 Quain DA, Parsons MW, Loudfoot AR, Spratt NJ, Evans MK, Russell ML, et al., 'Improving access to acute stroke therapies: A controlled trial of organised pre-hospital and emergency care', Medical Journal of Australia, 189 429-433 (2008) [C1]
Citations Scopus - 59Web of Science - 50
Co-authors John Attia, Neil Spratt, Mark Parsons
2008 Bateman GA, Levi CR, Schofield PW, Wang Y, Lovett EC, 'The venous manifestations of pulse wave encephalopathy: Windkessel dysfunction in normal aging and senile dementia', Neuroradiology, 50 491-497 (2008) [C1]
DOI 10.1007/s00234-008-0374-x
Citations Scopus - 35Web of Science - 30
Co-authors Peter Schofield
2008 Maguire JM, Thakkinstian A, Sturm J, Levi CR, Lincz L, Parsons MW, et al., 'Polymorphisms in platelet glycoprotein 1b [alpha] and factor VII and risk of ischemic stroke', Stroke, 39 1710-1716 (2008) [C1]
DOI 10.1161/strokeaha.107.507228
Citations Scopus - 24Web of Science - 23
Co-authors Jane Maguire, Lisa Lincz, Mark Parsons, John Attia
2008 Middleton S, Levi CR, Dale S, 'Arrival time to stroke unit as crucial a measure as arrival time to emergency department', Stroke, 39 E5 (2008) [C3]
Citations Web of Science - 1
2007 Abbott AL, Bladin CF, Levi CR, Chambers BR, 'What should we do with asymptomatic carotid stenosis?', International Journal of Stroke, 2 27-39 (2007) [C1]
DOI 10.1111/j.1747-4949.2007.00096.x
Citations Scopus - 42Web of Science - 32
2007 Townend BS, Whyte S, Desborough T, Crimmins D, Markus R, Levi CR, Sturm JW, 'Longitudinal prevalence and determinants of early mood disorder post-stroke', Journal of Clinical Neuroscience, 14 429-434 (2007) [C1]
DOI 10.1016/j.jocn.2006.01.025
2007 Abbott AL, Levi CR, Stork JL, Donnan GA, Chambers BR, 'Timing of clinically significant microembolism after carotid endarterectomy', Cerebrovascular Diseases, 23 362-367 (2007) [C1]
DOI 10.1159/000099135
Citations Scopus - 19Web of Science - 14
2007 Attia JR, Thakkinstian A, Wang Y, Lincz L, Parsons MW, Sturm J, et al., 'The PAI-1 4G/5G gene polymorphism and ischemic stroke: An association study and meta-analysis', Journal of Stroke and Cerebrovascular Diseases, 16 173-179 (2007) [C1]
DOI 10.1016/j.jstrokecerebrovasdis.2007.03.002
Citations Scopus - 31
Co-authors Mark Parsons, John Attia, Rodney Scott, Lisa Lincz
2007 Levi CR, 'Atherothrombosis, antiplatelet therapy and ischemic stroke prevention', Medicine Today Supplement, - 4-10 (2007) [C1]
2007 White JH, Alston MK, Marquez JL, Sweetapple AL, Pollack MR, Attia JR, et al., 'Community-Dwelling Stroke Survivors: Function Is Not the Whole Story With Quality of Life', Archives of Physical Medicine and Rehabilitation, 88 1140-1146 (2007) [C1]
DOI 10.1016/j.apmr.2007.06.003
Citations Scopus - 22Web of Science - 21
Co-authors John Attia
2007 Parsons MW, Pepper EM, Bateman GA, Wang Y, Levi CR, 'Identification of the penumbra and infarct core on hyperacute noncontrast and perfusion CT', Neurology, 68 730-736 (2007) [C1]
DOI 10.1212/01.wnl.0000256366.86353.ff
Citations Scopus - 81Web of Science - 65
Co-authors Mark Parsons
2007 Donnan GA, Levi CR, 'Glucose and the ischaemic brain: too much of a good thing?', Lancet Neurology, 6 380-381 (2007) [C3]
DOI 10.1016/s1474-4422(07)70086-8
Citations Web of Science - 4
2006 Parsons MW, Pepper EM, Chan V, Siddique S, Rajaratnam S, Rajarabram S, et al., 'Toxic brainstem encephalopathy after artemisinin treatment for breast cancer - Reply', Annals of Neurology, 59 726-726 (2006) [C3]
Co-authors Mark Parsons
2006 Parsons MW, Pepper EM, Chan VWC, Siddique S, Rajaratnam S, Rajarabram S, et al., 'Reply [4] Perfusion computed tomography: prediction of final infarct extent and stroke outcome', Annals of Neurology, 59 726 (2006) [C3]
Co-authors Mark Parsons
2006 Bateman GA, Levi CR, Schofield PW, Wang Y, Lovett EC, 'Quantitative measurement of cerebral haemodynamics in early vascular dementia and Alzheimer's disease', Journal of Clinical Neuroscience, 13 563-568 (2006) [C1]
DOI 10.1016/j.jocn.2005.04.017
Citations Scopus - 30Web of Science - 24
Co-authors Peter Schofield
2006 Cadilhac DA, Lalor EE, Pearce DC, Levi CR, Donnan GA, 'Access to stroke care units in Australian public hospitals: facts and temporal progress', Internal Medicine Journal, 36 700-704 (2006) [C1]
DOI 10.1111/j.1445-5994.2006.01168.x
Citations Scopus - 22Web of Science - 19
2006 Pepper EM, Parsons MW, Bateman GA, Levi CR, 'CT perfusion source images improve identification of early ischaemic change in hyperacute stroke', Journal of Clinical Neuroscience, 13 199-205 (2006) [C1]
DOI 10.1016/j.jocn.2005.03.030
Citations Scopus - 15Web of Science - 15
Co-authors Mark Parsons
2006 Levi CR, 'Australasia', International Journal of Stroke, 1 238-239 (2006) [C3]
DOI 10.1111/j.1747-4949.2006.00055.x
2005 Levi CR, 'Christopher R Levi (on behalf of the Australasian Stroke Unit Network, the New South Wales Greater Metropolitan Clinical Taskforce Stroke Initiative, and the Towards a Safer Culture Stroke Expert Working Group)', MEDICAL JOURNAL OF AUSTRALIA, 182 45-45 (2005)
2005 Bateman GA, Levi CR, Schofield PW, Wang Y, Lovett EC, 'The pathophysiology of the aqueduct stroke volume in normal pressure hydrocephalus:can co-morbidity with other forms of dementia be excluded', Neuroradiology, 47 741-748 (2005) [C1]
DOI 10.1007/s00234-005-1418-0
Citations Scopus - 40Web of Science - 32
Co-authors Peter Schofield
2005 Levi CR, 'Tissue plasminogen activator (tPA) in acute ischaemic stroke: Time for collegiate communication consensus [reply]', Medical Journal of Australia, 182 44-45 (2005) [C3]
2005 Parsons MW, Pepper EM, Chan V, Siddique S, Rajaratnam S, Bateman GA, Levi CR, 'Perfusion computed tomography: Prediction of final infarct extent and stroke outcome', Annals of Neurology, 58 672-679 (2005) [C1]
DOI 10.1002/ana.20638
Citations Scopus - 115Web of Science - 98
Co-authors Mark Parsons
2005 Butcher K, Parsons MW, Macgregor LR, Barber PA, Chalk J, Bladin CF, et al., 'Refining the Perfusion-Diffusion Mismatch Hypothesis', Stroke, 36 1153-1159 (2005) [C1]
DOI 10.1161/01.STR.0000166181.86928.8b
Co-authors Mark Parsons
2005 Abbott AL, Chambers BR, Stork JL, Levi CR, Bladin CF, Donnan GA, 'Embolic signals and prediction of ipsilateral stroke or transient ischemic attack in asymptomatic carotid stenosis: A multicenter prospective cohort study', Stroke, 36 1128-1133 (2005) [C1]
DOI 10.1161/01.str.0000166059.30464.0a
Citations Scopus - 95Web of Science - 73
2004 Ferry CT, Fitzpatrick AM, Long PW, Levi CR, Bishop RO, 'Towards a Safer Culture: clinical pathways in acute coronary syndromes and stroke', MJA, 180 S92-S96 (2004) [C1]
Citations Scopus - 13Web of Science - 12
2004 Levi CR, 'Tissue plasminogen activator (tPA) in acute ischaemic stroke: time for collegiate and consensus', Medical Journal of Australia, 180 634-636 (2004) [C3]
Citations Scopus - 3Web of Science - 6
Co-authors Mark Parsons
2004 Saita K, Chen M, Spratt NJ, Porritt MJ, Liberatore GT, Read SJ, et al., 'Imaging the Ischemic Penumbra with F-Fluoromisonidazole in a Rat Model of Ischemic Stroke', Stroke: a journal of cerebral circulation, 35 975-980 (2004) [C1]
DOI 10.1161/01.STR.0000121647.01941.ba
Citations Scopus - 33Web of Science - 30
Co-authors Neil Spratt
2004 Wang Y, Levi CR, 'Prognostic index for stroke mortality', Journal of Clinical Epidemiology, 57 758 (2004) [C3]
DOI 10.1016/j.jclinepi.2002.06.001
2004 Attia JR, D'Este CA, Levi CR, 'The progress trial three years later. HOPE trial may shed some light', BMJ, 329 1403-1404 (2004) [C1]
DOI 10.1136/bmj.329.7479.1403-d
Co-authors John Attia, Catherine Deste
2004 Kimura K, Stork JL, Levi CR, Abbott AL, Donnan GA, Chambers BR, 'High Intensity Transient Signals in Patients with Carotid Stenosis May Persist after Carotid Endarterectomy', Cerebrovascular Diseases, 17 123-127 (2004) [C1]
DOI 10.1159/000075780
Citations Scopus - 4Web of Science - 2
2003 Wang Y, Lim L, Heller RF, Fisher J, Levi CR, 'A prediction model of 1-year mortality for acute ischemic stroke patients', Archives of Physical Medicine and Rehabilitation, 84 1006-1011 (2003) [C1]
DOI 10.1016/S0003-9993(03)00032-7
Citations Scopus - 38Web of Science - 27
2003 Turner A, Mosgrove K, Hunter M, Hudson S, Selmes CM, Levi CR, 'Processing of visual stimuli following coronary artery bypass grafting (CABG): An fMRI study', Australian Journal of Psychology, 55 110 (2003) [C3]
Co-authors Mick Hunter
2003 Donnan GA, Davis SM, Levi CR, 'Thrombolysis for acute ischaemic stroke: revisiting the evidence - Reply', MEDICAL JOURNAL OF AUSTRALIA, 179 387-387 (2003)
Citations Web of Science - 2
2003 Smith BJ, Donnan GA, Davis SM, Levi CR, Johnson KR, Bailey PM, et al., 'Thrombolysis for acute ischaemic stroke: Revisiting the evidence (multiple letters)', Medical Journal of Australia, 179 386-389 (2003)
Citations Scopus - 5
Co-authors Mark Parsons
2003 Donnan GA, Davis SM, Levi CR, 'Strategies to improve outcomes after acute stroke', Medical Journal of Australia, 178 309-310 (2003) [C3]
Citations Scopus - 11Web of Science - 10
2003 Wang Y, Levi CR, Attia JR, D'Este CA, Spratt N, Fisher JD, 'Seasonal Variation in Stroke in the Hunter Region, Australia: A 5-Year Hospital-Based Study, 1995-2000', Stroke: a journal of cerebral circulation, 34 1144-1150 (2003) [C1]
DOI 10.1161/01.STR.0000067703.71251.B6
Citations Scopus - 58Web of Science - 54
Co-authors Neil Spratt, John Attia, Catherine Deste
2003 Chambers BR, Stork J, Kimura K, Abbott A, Levi CR, Donnan GA, 'Symptomatic Carotid Artery Stenosis: Heterogeneity of Destabilizing Mechanisms?', Stroke: a journal of cerebral circulation, 34 1 (2003) [C3]
2003 Spratt N, Wang Y, Levi CR, Ng K, Evans M, Fisher JD, 'A prospective study of predictors of prolonged hospital stay and disability after stroke', Journal of Clinical Neuroscience, 10 665-669 (2003) [C1]
DOI 10.1016/j.jocn.2002.12.001
Citations Web of Science - 24
Co-authors Neil Spratt
2003 Wang Y, Levi CR, D'Este CA, Attia JR, Fisher JD, 'Variation of Stroke Attack Rates in Rural, Urban, and Coalfields Areas of the Hunter Region, Australia 1995-2000', Journal of Stroke & Cerebrovascular Diseases, 12 103-110 (2003) [C1]
DOI 10.1053/jscd.2003.12
Citations Scopus - 3
Co-authors Catherine Deste, John Attia
2002 Levi CR, Magin PJ, Nair BR, 'Primary stroke prevention: refining the "high risk" approach', The Medical Journal of Australia, 176 303-304 (2002) [C3]
Citations Scopus - 2
Co-authors Parker Magin
2002 Bull N, Selmes CM, Turner A, Mosgrove K, Doi K, Edwards JR, et al., 'Recognition of low contrast letters as a measure of post cardiac surgery brain injury', STROKE, 33 375-375 (2002)
Co-authors Mick Hunter
2002 Stork J, Levi CR, Chambers B, Abbott A, Donnan G, 'Possible Determinants of Early microembolism After Carotid Endarterectomy', Stroke: a journal of cerebral circulation, 33 2082-2085 (2002) [C1]
Citations Web of Science - 26
2002 Stork J, Kimura K, Levi CR, Chambers B, Abbott A, Donnan G, 'Source of Microembolic Signals in Patients With High-Grade Carotid Stenosis', Stroke: a journal of cerebral circulation, 33 2014-2018 (2002) [C1]
Citations Web of Science - 34
2001 Yoon SS, Heller R, Levi CR, Wiggers JH, Fitzgerald PE, 'Knowledge of stroke risk factors, warning symptoms, and treatment among an Australian urban population', Stroke, 32 1926-1930 (2001) [C1]
DOI 10.1161/01.STR.32.8.1926
Citations Scopus - 164Web of Science - 114
Co-authors John Wiggers
2001 Levi CR, Selmes C, Chambers BR, 'Transcranial ultrasound - Clinical applications in cerebral ischaemia', Australian Prescriber, 24 137-140 (2001)

Transcranial ultrasound can rapidly and non-invasively image blood flow in the major basal intracranial arteries. Its accuracy makes it acceptable for use in screening for haemody... [more]

Transcranial ultrasound can rapidly and non-invasively image blood flow in the major basal intracranial arteries. Its accuracy makes it acceptable for use in screening for haemodynamically significant intracranial stenoses or vessel occlusions. Although it has a relatively limited field of view and is not technically feasible in approximately 10% of cases, the information obtained is becoming increasingly relevant to therapeutic decision-making in the prevention and management of stroke. Transcranial Doppler ultrasound or transcranial colour-coded duplex have the advantages of relatively low cost, ease of repeatability, and excellent safety and tolerability, but they provide inferior spatial and anatomical detail in comparison to angiographic techniques.

Citations Scopus - 6
2001 Levi CR, Selmes C, Chambers B, 'Diagnostic tests: Transcranial ultrasound - clinical applications in cerebral ischaemia', Australian Prescriber, 24 137-140 (2001) [C2]
2001 Levi CR, Stork J, Chambers B, Abbott A, Cameron H, Peeters A, et al., 'Dextran Reduces Embolic Signals After Carotid Endartectomy', Annals of Neurology, 50 544-547 (2001) [C1]
Citations Scopus - 31Web of Science - 26
2001 Wang Y, Lim L, Levi CR, Heller R, Fischer J, 'A prognostic index for 30-day mortality after stroke', Journal of Clinical Epidemiology, 54 766-773 (2001) [C1]
Citations Scopus - 31Web of Science - 28
2001 Kazui S, Levi CR, Jones E, Quang L, Calafiore P, Donnan G, 'Lacunar Stroke: Transoesophageal Echocardiographic Factors Influencing Long-Term Prognosis', Cerebrovascular Diseases, 12 325-330 (2001) [C1]
Citations Web of Science - 16
2001 Wang Y, Lim L, Levi CR, Heller R, Fisher J, 'Influence of Hyperglycemia on Stroke Mortality', Journal of Stroke and Cerebrovascular Diseases, 10 11-18 (2001) [C1]
Citations Scopus - 14
2001 Yoon SS, Heller R, Levi CR, Wiggers JH, 'Knowledge and perception about stroke among an Australian urban population', BMC Public Health, 1 6 (2001) [C1]
Citations Scopus - 17Web of Science - 13
Co-authors John Wiggers
2000 Kazui S, Levi CR, Jones E, Quang L, Calafiore P, Donnan G, 'Risk factors for lacunar stroke: A case-control transesophageal echocardiographic study', Neurology, 54 1385-1387 (2000) [C1]
2000 Donnan GA, Kazui S, Levi CR, Jones EF, Chambers BR, Quang LC, 'Risk factors for lacunar stroke: A case-control transesophageal echocardiographic study', STROKE, 31 284-284 (2000)
Citations Web of Science - 1
2000 Levi CR, Chambers BR, Bladin CF, Donnan GA, Stork J, Harris A, et al., '10% dextran 40 reduces microembolic signals after carotid endarterectomy', STROKE, 31 322-322 (2000)
2000 Levi CR, Gacs Z, Schwartz R, Hudson P, Hardy D, Bull N, et al., 'The accuracy of intracranial large artery occlusive disease assessment using transcranial colour coded duplex sonography', STROKE, 31 336-336 (2000)
2000 Wang Y, Lim L, Levi CR, Heller R, Fisher J, 'Influence of Admission Body Temperature on Stroke Mortality', Stroke, 31 404-409 (2000) [C1]
Citations Scopus - 148Web of Science - 111
1999 Levi CR, Harris A, Stork J, Royle J, Chambers BR, Roberts A, et al., 'Prevention of cerebral microembolism, following carotid endarterectomy: A randomised trial using perioperative intravenous 10% dextran 40', STROKE, 30 242-242 (1999)
1999 Levi CR, Read S, Hirano T, Donnan DA, 'Panhemispheric Infarction', Journal of Stroke and Cerebrovascular Disease, 8 286-289 (1999) [C1]
1998 Read SJ, Pettigrew L, Schimmel L, Levi CR, Bladin CF, Chambers BR, Donnan GA, 'White matter medullary infarcts: Acute subcortical infarction in the centrum ovale', CEREBROVASCULAR DISEASES, 8 289-295 (1998)
DOI 10.1159/000015868
Citations Web of Science - 22
1997 Levi CR, Roberts AK, Fell G, Hoare MC, Royle JP, Chan A, et al., 'Transcranial Doppler microembolus detection in the identification of patients at high risk of perioperative stroke.', European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 14 170-176 (1997)
DOI 10.1016/s1078-5884(97)80187-6
1997 Levi CR, OMalley HM, Fell G, Roberts AK, Hoare MC, Royle JP, et al., 'Transcranial Doppler detected cerebral microembolism following carotid endarterectomy - High microembolic signal loads predict postoperative cerebral ischaemia', BRAIN, 120 621-629 (1997)
DOI 10.1093/brain/120.4.621
Citations Web of Science - 153
1996 Bladin CF, Levi CR, Alexandrov AV, 'Further debate on the measurement of carotid stenosis', STROKE, 27 1437-1438 (1996)
1994 DONNAN GA, BAIRD AE, LEVI CR, 'DIAGNOSIS AND IMAGING OF STROKE', JOURNAL OF HYPERTENSION, 12 S15-S18 (1994)
Citations Web of Science - 1
1990 LEVI CR, TYLER GR, OLSON LG, SAUNDERS NA, 'LACK OF AIRWAY RESPONSE TO NASAL IRRITATION IN NORMAL AND ASTHMATIC SUBJECTS', AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 20 578-582 (1990)
DOI 10.1111/j.1445-5994.1990.tb01317.x
Citations Scopus - 8Web of Science - 5
1990 JONES BF, HOWARTH DM, LEVI CR, GLASS JS, 'PROTEINURIA IN POLYMYOSITIS', JOURNAL OF RHEUMATOLOGY, 17 859-860 (1990)
Citations Scopus - 2Web of Science - 1
Show 214 more journal articles

Conference (169 outputs)

Year Citation Altmetrics Link
2015 Gardner AJ, Iverson GL, Wojtowicz MA, Levi CR, Makdissi M, Quinn TN, et al., 'A Systematic Video Analysis of Concussion in the National Rugby League', American Academy of Neurology, Washington, DC (2015)
Co-authors Peter Stanwell
2015 Gardner A, Levi C, Stanwell P, Iverson GL, 'A video analysis of the use of the 'concussion interchange rule' during the first year of implementation in the National Rugby League.', International Neuropsychological Society, Sydney, Australia (2015)
Co-authors Peter Stanwell
2014 Lin L, Bivard A, Krishnamurthy V, Levi C, Parsons M, 'Comparison of Whole-Brain CTP and Limited-Coverage CTP', CEREBROVASCULAR DISEASES (2014) [E3]
Co-authors Mark Parsons
2014 Ang T, Levi C, Ma H, Hsu C, Campbell B, Donnan G, et al., 'Multi-Modal CT in Acute Stroke: Wait for a Serum Creatinine Before Giving Intravenous Contrast? No!', CEREBROVASCULAR DISEASES (2014) [E3]
Co-authors Mark Parsons
2014 Lin L, Bivard A, Levi C, Parsons M, 'How to Measure Cross-Modality Reperfusion with Acute CTP and 24-Hour MRP', CEREBROVASCULAR DISEASES (2014) [E3]
Co-authors Mark Parsons
2014 Bivard A, Krishnamurthy V, Levi C, Mcelduff P, Miteff F, Spratt N, et al., 'Stroke Thrombolysis: Tissue Is More Important Than Time', CEREBROVASCULAR DISEASES (2014) [E3]
Co-authors Mark Parsons, Neil Spratt
2014 Bivard A, Krishnamurthy V, Levi C, Mcelduff P, Miteff F, Spratt N, et al., 'Does the Presence of CTP Mismatch Predict Better Outcomes in Thrombolysis-Treated Patients?', CEREBROVASCULAR DISEASES (2014) [E3]
Co-authors Mark Parsons, Neil Spratt
2014 Bivard A, Krishnamurthy V, Levi C, Mcelduff P, Miteff F, Spratt N, et al., 'Better Stroke Outcomes Despite Worse Baseline Stroke Severity with Combined Clinical and CTP Assessment', CEREBROVASCULAR DISEASES (2014) [E3]
Co-authors Neil Spratt, Mark Parsons
2014 Sewell C, Garnett A, Marsden D, McElduff P, Parsons M, Levi C, 'Validation of the 'Hunter 8' abbreviated National Institutes of Health Scale score for pre-hospital thrombolysis eligible stroke recognition', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Citations Web of Science - 1
Co-authors Mark Parsons
2014 Bhaskar S, Evans M, Kitsos G, Russel M, Stanwell P, Walker R, et al., 'The influence of initial stroke severity on the likelihood of death at 90 days following acute stroke: A tertiary hospital stroke register study', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Peter Stanwell, Neil Spratt, Mark Parsons
2014 Marsden D, Dunn A, Callister R, McElduff P, Levi C, Spratt N, 'Cardiorespiratory fitness testing and training in stroke survivors: A comparison of peak oxygen consumption results from the upright cycle test, six minute walk test and circuit exercise stations', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Neil Spratt, Robin Callister
2014 Middleton S, Comerford D, Lydtin A, Dale S, Cadilhac D, DEste C, et al., 'The Quality in Acute Stroke Care (QASC) Implementation Project: 'To improve is to change; to be perfect is to change often' Winston Churchill', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Catherine Deste
2014 Bivard A, Krishnamurthy V, Levi C, McElduff P, Miteff F, Spratt N, et al., 'Stroke thrombolysis: Tissue is more important than time', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Neil Spratt, Mark Parsons
2014 Maguire J, Lindgren A, Bevan S, Fernandez-Cadenas I, Hankey G, Jern C, et al., 'GISCOME - Genetic Influences on Ischaemic Stroke Functional Outcome: A genome wide association study', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Jane Maguire, Rodney Scott
2014 Bivard A, Krishnamurthy V, Levi C, McElduff P, Miteff F, Spratt N, et al., 'Does the presence of CTP mismatch predict better outcomes in thrombolysis-treated patients?', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Mark Parsons, Neil Spratt
2014 Zareie H, Selmes C, Kawano H, Parsons M, Spratt N, Miteff F, et al., 'Feasibility and accuracy of fusion TCCD in monitoring acute stroke treatment', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Mark Parsons, Neil Spratt
2014 Lin L, Bivard A, Krishnamurthy V, Levi C, Parsons M, 'Whole-brain CT perfusion measures the acute ischaemic lesion accurately and precisely', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Mark Parsons
2014 Bivard A, Krishnamurthy V, Levi C, McElduff P, Miteff F, Spratt N, et al., 'Better stroke outcomes despite worse baseline stroke severity - The value of a combined clinical and advanced CT selection approach to thrombolysis', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Neil Spratt, Mark Parsons
2014 Gunathilake R, Krishnamurthy V, Oldmedow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Christopher Oldmeadow, Mark Parsons, John Attia
2014 Cadilhac D, Lannin NA, Kilkenny M, Kung F, Grabsch B, Donnan G, et al., 'Stroke data collection in the Australian Stroke Clinical Registry - Progress with a purpose', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
2014 Lannin NA, Cadilhac D, Kilkenny M, Kung F, Grabsch B, Donnan G, et al., 'Life after stroke - A reflection on patients' experience using data from the Australian Stroke Clinical Registry (AuSCR)', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
2014 Kerr E, Sanson-Fisher RW, Paul CL, DEste C, Parsons M, Bladin C, et al., 'Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice: An overview of data collected during the baseline period', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Rob Sanson-Fisher, Frans Henskens, Mark Parsons, Catherine Deste, Chris Paul, John Attia
2014 Marsden D, Dunn A, Callister R, McElduff P, Levi CR, Spratt NJ, 'Can independently ambulant stroke survivors exercise for thirty minutes at a moderate intensity? An observational study', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Neil Spratt, Robin Callister
2014 Zareie H, Selmes C, Kawano H, Parsons M, Spratt N, Miteff F, et al., 'Feasibility and accuracy of fusion TCCD in acute stroke treatment', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Neil Spratt, Mark Parsons
2014 Bhaskar S, Evans MK, Kitsos G, Russell M, Stanswell P, Walker R, et al., 'The influence of initial stroke severity on the likelihood of death at 90 days following acute stroke: A tertiary hospital stroke registry study.', International Journal of Stroke, Hamilton Island, Queensland (2014)
DOI 10.1111/ijs.12297
Co-authors Mark Parsons, Neil Spratt
2013 Thomas L, Rivett DA, Levi C, 'The effect of selected manual therapy interventions for mechanical neck pain on vertebral and internal carotid arterial blood flow and cerebral inflow', APA 2013 Conference Abstracts eBook, Melbourne Convention & Exhibition Centre (2013) [E3]
Co-authors Darren Rivett, Lucy Thomas
2013 Thomas L, Rivett DA, Levi C, Stanwell P, Levi C, 'Recognition of patients presenting with or at risk of craniocervical arterial dissection: preliminary results of a prospective study', APA Conference 2013 Abstract E-Book, Melbourne Convention & Exhibition Centre (2013) [E3]
Co-authors Lucy Thomas, Darren Rivett
2013 Rennie JL, Jolly TA, Bateman GA, Michie PT, Levi CR, Parsons MW, Karayanidis F, 'Age-related decline in white matter organisation: Relationship to global cognitive changes in a longitudinal study', Frontiers in Human Neuroscience, Melbourne (2013) [E3]
DOI 10.3389/conf.fnhum.2013.212.00085
Co-authors Pat Michie, Mark Parsons, Frini Karayanidis
2013 Bladin C, Levi C, Parsons M, 'Magnetically Enhanced Diffusion (MED) for Improved Efficacy of Thrombolytic Therapy in Acute Ischemic Stroke_A Prospective First in Man Clinical Study', STROKE, Honolulu, HI (2013) [E3]
Co-authors Mark Parsons
2013 Yassi N, Campbell BC, Christensen S, Sharma G, Bivard A, Lin L, et al., 'Reduced Cerebral Blood Flow on Acute Whole Brain CT Perfusion Best Predicts Hemorrhagic Transformation', STROKE, Honolulu, HI (2013) [E3]
Co-authors Mark Parsons
2013 Campbell BC, Christensen S, Yassi N, Sharma G, Bivard A, Lin L, et al., 'Comparison of Automated Whole Brain CT Perfusion Analysis with Perfusion-Diffusion MRI in Ischemic Stroke', STROKE, Honolulu, HI (2013) [E3]
Co-authors Mark Parsons
2013 Karayanidis F, Jolly T, Michie P, Parsons M, Levi C, Heathcote A, 'AGE-RELATED CHANGES IN WHITE MATTER IN FRONTO-PARIETAL AND FRONTO-STRIATAL TRACTS ARE ASSOCIATED WITH DISTINCT MEASURES OF COGNITIVE FLEXIBILITY', PSYCHOPHYSIOLOGY, Florence, ITALY (2013) [E3]
Co-authors Pat Michie, Mark Parsons, Frini Karayanidis, Andrew Heathcote
2013 Karayanidis F, Jolly T, Michie P, Levi C, Parsons M, Heathcote A, 'AGE-RELATED CHANGES IN WHITE MATTER IN FRONTO-PARIETAL AND FRONTO-STRIATAL TRACTS ARE ASSOCIATED WITH DISTINCT MEASURES OF COGNITIVE FLEXIBILITY', JOURNAL OF COGNITIVE NEUROSCIENCE, San Francisco, CA (2013) [E3]
Co-authors Andrew Heathcote, Frini Karayanidis, Mark Parsons, Pat Michie
2013 Yassi N, Parsons MW, Donnan GA, Christensen S, Levi CR, Desmond PM, et al., 'Infarct core volume on whole brain perfusion CT is predictive of haemorrhagic transformation after stroke', CEREBROVASCULAR DISEASES (2013) [E3]
Co-authors Mark Parsons
2013 Bivard A, Krishnamurthy V, Stanwell P, Levi C, Davis S, Parsons M, '3T MR Spectroscopy assessment of metabolic changes in the recently salvaged human ischemic penumbra', CEREBROVASCULAR DISEASES (2013) [E3]
Co-authors Mark Parsons, Peter Stanwell
2013 Tomkins AJ, Schleicher N, Nedelmann M, Spratt NJ, 'PLATELET RICH CLOTS ARE RESISTANT TO LYSIS BY THROMBOLYTIC THERAPY IN A RAT MODEL OF EMBOLIC STROKE', CEREBROVASCULAR DISEASES (2013) [E3]
Co-authors Neil Spratt
2013 Bivard A, Stanwell P, Spratt N, Levi C, Krishnamurthy V, Davis S, Parsons M, 'Arterial spin labelling versus bolus-tracking CT and MR in hyper-acute ischemic stroke', CEREBROVASCULAR DISEASES (2013) [E3]
Co-authors Mark Parsons, Peter Stanwell, Neil Spratt
2013 Marsden DL, Dunn A, Callister R, Levi CR, Spratt NJ, 'Exercise training interventions that are aerobic or include an aerobic component can improve cardiorespiratory fitness after stroke: a systematic review with meta-analysis', CEREBROVASCULAR DISEASES (2013) [E3]
Co-authors Robin Callister, Neil Spratt
2013 Middleton S, Levi CR, D'Este C, Grimshaw J, Cadilhac DA, Considine J, et al., 'T-3 Trial protocol: A CRCT evaluating an organisational intervention to improve triage, treatment and transfer of stroke patients in EDs', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Citations Web of Science - 1
Co-authors Catherine Deste
2013 Bivard A, Stanwell P, Krishnamurthy V, Levi CR, Davis SM, Parsons M, 'Automated mismatch assessment of arterial spin labeling compared to conventional bolus tracking perfusion mismatch', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Co-authors Mark Parsons, Peter Stanwell
2013 Bivard A, Yassi N, Stanwell P, Krishnamurthy V, Levi CR, Davis SM, Parsons M, 'Spectroscopy of hyperperfused and mildly hypoperfused tissue following ischemic stroke', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Co-authors Mark Parsons, Peter Stanwell
2013 Lillicrap T, Tahtali M, Neely A, Wang X, Levi CR, Parsons M, et al., 'Validation of a finite element model of heat transfer in the stroke-affected brain against data from humans and non-human primates', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Co-authors Mark Parsons
2013 Thomas J, Parsons O, Traylor M, Li L, Bevan S, Sudlow C, et al., 'The impact of CCS and TOAST classification systems on genetic associations with ischaemic stroke', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Co-authors Liz Holliday, John Attia
2013 Lillicrap T, Stanwell P, Neeman T, Parsons M, Spratt N, Levi CR, Lueck C, 'Variation in regional brain temperature as measured by MR thermography in healthy volunteers', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Co-authors Neil Spratt, Mark Parsons, Peter Stanwell
2013 Marsden DL, Dunn A, Callister R, Levi CR, Spratt NJ, 'Interventions to improve cardiorespiratory fitness after stroke: a systematic review with meta-analysis', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Co-authors Neil Spratt, Robin Callister
2013 Fuentes S, Sharma V, Huang Y, Lavados P, Lindley R, Pandian J, et al., 'The Enhanced Control of Hypertension ANd Thrombolysis strokE StuDy (ENCHANTED): first year experience regarding possible selection bias', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Co-authors Mark Parsons
2013 Cadilhac DA, Lannin NA, Anderson CS, Grimly R, Middleton S, Andrew NE, et al., 'Stroke123: overview of a national initiative to monitor and improve stroke care', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
2013 Middleton S, Comerford D, Dunne J, Levi CR, Quinn C, Cadilhac DA, et al., 'Quality in Acute Stroke Care (QASC) NSW state-wide implementation project', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
2013 Marsden DL, Dunn A, Callister R, Levi CR, Spratt NJ, 'Improving cardiorespiratory fitness after stroke by using exercise interventions that are aerobic or include an aerobic component: A systematic review with meta-analysis', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Co-authors Robin Callister, Neil Spratt
2013 Middleton S, Levi C, D'Este C, Grimshaw J, Cadilhac D, Considine J, et al., 'T-3 stroke trial protocol: Triage, treatment and transfer of patients with stroke emergency departments', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Co-authors Catherine Deste
2013 Bivard A, Stanwell P, Krishnamurthy V, Levi C, Davis S, Parsons M, 'Automated mismatch assessment of arterial spin labeling compared to conventional bolus tracking perfusion mismatch', International Journal of Stroke, Darwin, NT (2013) [E3]
DOI 10.1111/ijs.12214
Co-authors Peter Stanwell, Mark Parsons
2012 Longworth M, Cadilhac DA, Pollack MR, Purvis T, Kilkenny M, Mohr K, et al., 'Building capacity for stroke services in rural locations: the effectiveness of Stroke Care Coordinators (SSCs) in Australia', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
2012 Marsden DL, Callister R, Dunn A, Levi CR, Spratt NJ, 'How fit is the stroke survivor? Assessing the fitness levels of stroke survivors by comparing four methods available in the clinical setting. The 'HowFITSS' Trial', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
Co-authors Robin Callister, Neil Spratt
2012 Marsden DL, Garnett AR, Parsons MW, Spratt NJ, Watson T, Loudfoot A, et al., 'No thrombolysis service? No worries. A controlled trial of facilitated access for rural stroke patients to a regional thrombolysis centre - The Hunter Rural PAST Protocol', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
Co-authors Neil Spratt, Mark Parsons
2012 Middleton S, Drury PM, Levi CR, D'Este CA, McElduff P, Dale S, et al., 'The Quality in Acute Stroke Care (QASC) Trial: Processes of care associated with 90-day survival and independence', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
Co-authors Catherine Deste
2012 Middleton S, Drury P, McElduff P, Ward J, Grimshaw J, Dale S, et al., 'Doing the simple things well: Good nursing care reduces death and dependency', Abstracts. 23rd International Nursing Research Congress, Brisbane, Australia (2012) [E3]
Co-authors Catherine Deste
2012 Jolly TAD, Bateman GA, Levi CR, Parsons MW, Karayanidis F, 'The relationship between arterial and venous pulsatility and microstructural white matter changes', Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia (2012) [E3]
Co-authors Mark Parsons, Frini Karayanidis
2012 Rennie JL, Jolly TAD, Michie PT, Levi CR, Parsons MW, Lenroot R, Karayanidis F, 'Measures of white matter decline and global cognitive ability in older adults', Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia (2012) [E3]
Co-authors Mark Parsons, Frini Karayanidis, Pat Michie
2012 Karayanidis F, Jolly TAD, Cooper PS, Levi CR, Parsons MW, Michie PT, 'Disruption to frontal white matter pathways on performance in the task-switching paradigm', Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia (2012) [E3]
Co-authors Mark Parsons, Frini Karayanidis, Pat Michie
2012 Jolly TAD, Fulham WR, Michie PT, Levi CR, Parsons MW, Karayanidis F, 'Disruption to frontal white matter pathways related to performance on the stop-signal task', Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia (2012) [E3]
Co-authors Mark Parsons, Frini Karayanidis, Pat Michie
2012 Cooper P, Jolly TAD, Michie PT, Parsons MW, Levi CR, Fulham WR, Karayanidis F, 'The role of white matter tract disruption on age-related decline in cognitive flexibility', Combined Abstracts of 2012 Australian Psychology Conferences, Sydney, NSW (2012) [E3]
Co-authors Pat Michie, Frini Karayanidis, Mark Parsons
2012 Thomas L, Rivett DA, Levi CR, 'Risk factors and clinical features of craniocervical arterial dissection. Preliminary results of a prospective study', Journal of Orthopaedic & Sports Physical Therapy, Quebec City, Canada (2012) [E3]
Co-authors Lucy Thomas, Darren Rivett
2012 Thomas L, Rivett DA, Levi CR, 'The effect of selected manual therapy interventions for mechanical neck pain on vertebral and internal carotid arterial blood flow and total cerebral perfusion', Journal of Orthopaedic & Sports Physical Therapy, Quebec City, Canada (2012) [E3]
Co-authors Lucy Thomas, Darren Rivett
2012 Levi CR, 'Recent advances in stroke genetics', Cerebrovascular Diseases, Tokyo, Japan (2012) [E3]
2012 Longworth M, Cadilhac DA, Pollack M, Purvis T, Kilkenny M, Mohr K, Levi CR, 'Building capacity for stroke services in rural locations: The effectiveness of Stroke Care Coordinators in Australia', INTERNATIONAL JOURNAL OF STROKE (2012) [E3]
2012 Williams JM, Navin TJ, Levi CR, Jude M, 'Recombinant tissue plasminogen activator (rt-PA) utilisation by rural clinicians in acute ischaemic stroke: An audit of current practice and clinical outcomes', INTERNATIONAL JOURNAL OF STROKE (2012) [E3]
2012 Marsden DL, Dunn A, Callister R, Levi CR, Spratt NJ, 'Measuring cardiorespiratory fitness and oxygen consumption after stroke - A Systematic Review', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authors Neil Spratt, Robin Callister
2012 Marsden DL, Dunn A, Callister R, Levi CR, Spratt NJ, 'Assessing stroke survivors' cardiorespiratory fitness - A comparison of four methods available in the clinical setting: Preliminary results from the 'How Fit is the Stroke Survivor?' (HowFITSS?) trial', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authors Neil Spratt, Robin Callister
2012 Campbell BCV, Christensen S, Tress BM, Desmond PM, Parsons MW, Barber PA, et al., 'Insights into the relationship of perfusion-diffusion mismatch and leptomeningeal collateral quality - Simultaneous assessment through novel visualization of perfusion imaging', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Citations Web of Science - 1
Co-authors Mark Parsons
2012 Thomas LH, Rivett DA, Parsons MW, Levi CR, 'Radiological features of craniocervical arterial dissection and topography of the resultant infarct: Relation with risk factors', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authors Lucy Thomas, Mark Parsons, Darren Rivett
2012 Bivard A, Parsons MW, 'Defining acute ischemic stroke tissue pathophysiology using 320 slice CT perfusion', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authors Mark Parsons
2012 Karayanidis F, Jolly TAD, Bateman GA, Michie PT, Parsons MW, Levi CR, 'Structural brain changes associated with pulse-wave encephalopathy', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authors Frini Karayanidis, Pat Michie, Mark Parsons
2012 Middleton S, Drury P, Levi CR, D'Este CA, McElduff P, Dale S, et al., 'What processes of clinical care are associated with 90-day survival and independence? Results from the Quality in Acute Stroke Care QASC Trial', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authors Catherine Deste
2012 Karayanidis F, Cooper P, Jolly TAD, Michie PT, Parsons MW, Levi CR, Fulham WR, 'The influence of white matter changes with ageing and mild ischemic attacks on cognitive flexibility', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authors Mark Parsons, Frini Karayanidis, Pat Michie
2012 Williams JM, Levi CR, Jude M, 'Recombinant tissue plasminogen activator (rt-PA) utilisation by rural clinicians in ischaemic stroke: A survey of barriers and enablers', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
2012 Dunn A, Marsden DL, Spratt NJ, Levi CR, Callister R, 'Does knee strength affect walking speed, distance and fitness levels following stroke? Preliminary results from the 'How Fit is the Stroke Survivor?' (HowFITSS?) trial', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authors Neil Spratt, Robin Callister
2012 Garnett AR, Marsden DL, Parsons MW, Spratt NJ, Watson T, Loudfoot AR, et al., 'The Hunter Rural PAST Protocol: An innovative and effective partnership between ambulance and a regional thrombolysis centre to facilitate access for rural stroke patient to thrombolysis', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authors Neil Spratt, Mark Parsons
2012 Lin L, Bivard A, Kemp D, Parsons MW, Levi CR, 'Comparison of perfusion CT and MR in hyperacute stroke', International Journal of Stroke, Sydney, N.S.W. (2012) [E3]
Co-authors Mark Parsons
2012 Bivard A, Levi CR, Parsons MW, 'Assessing the variability of CTP post processing techniques to define the acute infarct core and penumbra', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
Co-authors Mark Parsons
2012 Bivard A, Stanwell PT, Levi CR, Parsons MW, 'Clinical utility of subacute Arterial Spin Labelling in stroke', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
Co-authors Peter Stanwell, Mark Parsons
2012 Cadilhac DA, Lannin N, Lim J, Price C, Faux S, Levi CR, et al., 'Randomised comparative efficiency of telephone versus mail follow-up in the Australian Stroke Clinical Registry (AuSCR)', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
2012 Cadilhac DA, Purvis T, Kilkenny MF, Longworth M, Pollack MR, Mohr K, et al., 'The effectiveness of the Rural Stroke Project: Impact on clinical care and patient outcomes', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
2011 Maguire JM, Holliday EG, Sturm J, Golledge J, Lewis M, Koblar S, et al., 'Australian stroke genetics collaborative: Genetic associations with ischaemic stroke functional outcome', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authors Mark Parsons, Pablo Moscato, John Attia, Jane Maguire, Rodney Scott, Liz Holliday, Lisa Lincz
2011 Bivard A, Spratt NJ, Levi CR, Parsons MW, 'CTP thresholds to detect acute ischeamic stroke tissue pathophysiology', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authors Mark Parsons, Neil Spratt
2011 Cadilhac D, Kilkenny M, Purvis T, Longworth M, Gill M, Pollack M, Levi CR, 'The New South Wales Rural Stroke Project: Does implementation of stroke service enhancements improve stroke care in rural hospitals?', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011 Beath A, Bivard A, McElduff P, Parsons MW, Levi CR, 'Clinical predictors of outcome in acute ischaemic stroke patients treated with intravenous tissue plasminogen activator (tPA)', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authors Mark Parsons
2011 Cadilhac D, Lannin N, Anderson C, Kilkenny M, Lim J, Levi CR, et al., 'Australian Stroke Clinical Registry: Management and outcome of patients with transient ischaemic attack (TIA)', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011 Campbell B, Christensen S, Levi CR, Desmond P, Donnan G, Davis G, Parsons MW, 'Comparison of CT perfusion to multimodal MRI in ischemic stroke', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authors Mark Parsons
2011 Dale S, Levi CR, D'Este CA, Griffiths R, Grimshaw J, Ward J, Middleton S, 'Maximising uptake of clinical protocols to manage fever, hyperglycaemia and swallowing in acute stroke: Assessing barriers and enablers', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authors Catherine Deste
2011 Fuentes S, Huang Y, Wang J, Sharma V, Nguyen HT, Pandian J, et al., 'The Enhanced Control of Hypertension ANd Thrombolysis strokE StuDy (ENCHANTED): Part A - Rationale for a trial of low dose rtPA', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011 Fuentes S, Huang Y, Wang J, Sharma V, Nguyen HT, Pandian J, et al., 'The Enhanced Control of Hypertension ANd Thrombolysis strokE StuDy (ENCHANTED): Part B - Rationale for a trial of early intensive blood pressure lowering after use of rtPA', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authors Mark Parsons
2011 Sheedy R, Bernhardt J, Kilkenny M, Levi CR, Longworth M, Cadilhac D, 'Allied health assessments are more common for patients with acute ischaemic stroke compared to intracerebral haemorrhage', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011 Russell ML, Evans MK, Royan AT, Magin PJ, Lasserson D, Attia JR, et al., 'Referral and triage of patients with TIAs to an acute access clinic: Risk-stratification performance in an Australian setting', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authors Parker Magin, Mark Parsons, John Attia, Neil Spratt
2011 O'Brien W, Chung K, Levi CR, Spratt NJ, Parsons MW, 'Comparative study of Multimodal Computed Tomography (MdCT) and Magnetic resonance imaging (MRI) in Transient ischaemic attack and minor stroke patient', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authors Neil Spratt, Mark Parsons
2011 Menon B, O'Brien W, Bivard A, Levi CR, Spratt NJ, Parsons MW, 'Detailed anatomic and physiologic assessment of leptomeningeal collaterals in acute ischemic stroke patients using dynamic time resolved 320 slice CT angiography', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authors Neil Spratt, Mark Parsons
2011 Lannin N, Cadilhac D, Anderson C, Lim J, Price C, Faux S, et al., 'Community follow-up of stroke survivors in the Australian Stroke Clinical Registry (AuSCR)', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011 Hunter AJ, Snodgrass SN, Quain DA, Parsons MW, Levi CR, 'Orthostatic variation in transcranial Doppler measured cerebral blood flow velocity 24 hours post acute ischaemic stroke', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authors Suzanne Snodgrass, Mark Parsons
2011 Lillicrap T, Jyoti R, Levi CR, Parsons MW, Spratt NJ, Stanwell P, Lueck C, 'Temperature measurements using MR spectroscopy: Validation and calibration in healthy volunteers', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authors Mark Parsons, Neil Spratt
2011 Thomas L, Rivett DA, Levi CR, 'Risk factors and clinical presentation of craniocervical arterial dissection. A prospective study: Preliminary results', Physiotherapy: Abstracts, World Physical Therapy 2011, Amsterdam (2011) [E3]
Citations Scopus - 6Web of Science - 5
Co-authors Lucy Thomas, John Attia, Darren Rivett
2011 Thomas L, Rivett DA, Levi CR, 'Risk factors and clinical presentation of craniocervical arterial dissection: Preliminary results of a prospective study', APA Physiotherapy Conference 2011, Brisbane (2011) [E3]
Co-authors Darren Rivett, Lucy Thomas
2011 Campbell BC, Christensen S, Levi CR, Desmond PM, Donnan GA, Davis SM, Parsons MW, 'Predicting infarct core using CT perfusion - comparison of CT perfusion parameters to concurrent diffusion MRI', Stroke, Los Angeles, CA (2011) [E3]
Co-authors Mark Parsons
2011 Middleton S, Dale S, Levi CR, Griffiths R, Grimshaw J, Ward J, D'Este CA, 'Barriers and enablers to implementing protocols for fever, hyperglycaemia and swallowing dysfunction in acute stroke', Stroke, Ottawa, Canada (2011) [E3]
Co-authors Catherine Deste
2011 Menon BK, O'Brien W, Bivard A, Levi CR, Spratt NJ, Parsons MW, 'Anatomic and physiologic assessment of leptomeningeal collaterals in acute ischemic stroke patients using dynamic time resolved 320 slice CT angiography', Stroke, Ottawa, Canada (2011) [E3]
Co-authors Mark Parsons, Neil Spratt
2011 Middleton S, Ward J, Grimshaw J, Griffiths R, D'Este CA, Dale S, et al., 'Does a team base knowledge transfer intervention to manage fever, hyperglycaemia and swallowing dysfunction, improve 90-day outcomes following stroke?', Stroke, Ottawa, Canada (2011) [E3]
Co-authors Catherine Deste
2011 Bivard A, Levi CR, Spratt NJ, Parsons MW, 'Delayed perfusion predicts the volume of the perfusion lesion', Stroke, Los Angeles, CA (2011) [E3]
Co-authors Neil Spratt, Mark Parsons
2011 Christensen S, Campbell B, Parsons MW, De Silva DA, Ebinger M, Butcher K, et al., 'High tmax values on perfusion MRI often reflect low CBV - A pathophysiological link between the malignant perfusion profile and poor outcome?', Stroke, Los Angeles, CA (2011) [E3]
Citations Web of Science - 1
Co-authors Mark Parsons
2011 Campbell BC, Tu HT, Christensen S, Desmond PM, Levi CR, Bladin CF, et al., 'Diffusion imaging 24 hours after stroke onset accurately represents final infarct volume', Stroke, Los Angeles (2011) [E3]
Co-authors Mark Parsons
2011 Lannin N, Cadilhac D, Anderson C, Lim J, Price C, Faux S, et al., 'Life after Stroke: Community follow-up of Australian survivors of stroke', Proceedings of the 24th Occupational Therapy Australia National Conference, Gold Coast, QLD (2011) [E3]
2011 Bivard A, Spratt NJ, Levi CR, Parsons MW, 'Perfusion CT predicts subsequent tissue and clinical outcome in hyperacute ischemic stroke', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
Co-authors Mark Parsons, Neil Spratt
2011 Cadilhac DA, Lannin NA, Anderson CS, Levi CR, Price C, Faux S, Donnan GA, 'Management and outcome of patients admitted with transient ischaemic attack (TIA): The Australian Stroke Clinical Registry Experience', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
2011 Campbell BCV, Christensen S, Levi CR, Desmond PM, Donnan GA, Davis SM, Parsons MW, 'Predicting infarct core using CT perfusion - Cerebral blood flow thresholds perform best', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
Co-authors Mark Parsons
2011 Dale S, Middleton S, Levi CR, D'Este CA, Griffiths R, Grimshaw J, Ward J, 'Challenges of a large cluster randomised controlled trial: Barriers and enablers to implementing protocols for fever, hyperglycaemia and swallowing dysfunction in the quality in acute stroke (QASC) Project', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
Co-authors Catherine Deste
2011 Drury P, Levi CR, D'Este CA, Dale S, Griffiths R, Grimshaw J, et al., 'The QASC cluster randomised controlled trial of an intervention to improve management of fever, hyperglycaemia and swallowing dysfunction in acute stroke: Did clinician behaviour change?', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
Co-authors Catherine Deste
2011 Marsden DL, Garnett AR, Watson T, McElduff P, Levi CR, Parsons MW, 'In the field stroke assessment tool for paramedics: The 'Hunter 8'', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
Co-authors Mark Parsons
2011 Parsons MW, Bivard A, Campbell B, Chong KK, Miteff F, Bladin C, et al., 'Tenecteplase versus alteplase for acute ischaemic stroke: An imaging based efficacy trial', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
Co-authors Mark Parsons
2011 Shiue I, Marsden DL, Spratt NJ, Matzarakis A, McElduff P, Anderson CS, Levi CR, 'Psychologically equivalent temperature and stroke attack rates', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
Co-authors Neil Spratt
2011 Middleton S, Levi C, D'Este C, Dale S, Drury P, Griffiths R, et al., 'THE QASC CLUSTER RANDOMISED CONTROLLED TRIAL OF A TEAM-BASED INTERVENTION TO IMPROVE MANAGEMENT OF FEVER, HYPERGLYCAEMIA AND SWALLOWING DYSFUNCTION IN ACUTE STROKE: PATIENT 90-DAY OUTCOMES', Cerebrovascular Diseases, Hamburg (2011)
DOI 10.1159/000329448
Co-authors Catherine Deste
2010 Perez De La Ossa N, Chandra RV, Campbell BCV, Christensen S, Collins M, Parsons MW, et al., 'Leukoaraiosis is not an independent risk factor for parenchymal hemorrhage after thrombolysis', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authors Mark Parsons
2010 Middleton S, Levi CR, D'Este CA, Dale S, Griffiths R, Grimshaw J, et al., '90-Day mortality and morbidity post- acute stroke in New South Wales, Australia: pre-intervention results from the quality in acute stroke care (QASC) cluster trial', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authors Catherine Deste
2010 McVerry F, Levi CR, Muir KW, Parsons MW, 'Detection of penumbra and arterial occlusions using multimodal CT - where should therapy be targeted?', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authors Mark Parsons
2010 Levi CR, Chambers BR, Young D, Stork J, Abbott A, Wlodarczyk JH, et al., 'The efficacy and safety of 10% dextran 40 in the prevention of stroke complicating carotid endarterectomy - the dextran in carotid endarterectomy (DICE) trial', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authors Mark Parsons
2010 Hubbard IJ, Budd TW, Carey LM, McElduff P, Levi CR, Parsons MW, 'Intensive behavioural upper limb training in acute stroke: an RCT of functional outcomes and brain reorganisation', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authors Isobel Hubbard, Mark Parsons, Bill Budd
2010 Campbell BCV, Costello C, Christensen S, Ebinger M, Parsons MW, Desmond PM, et al., 'Acute infarct hyperintensity is almost universal beyond 3 hours and does not predict hemorrhagic transformation', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authors Mark Parsons
2010 Campbell BCV, Christensen S, Tu H, Desmond PM, Levi CR, Bladin CF, et al., 'Diffusion imaging 24 hours after stroke onset accurately represents final infarct volume', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authors Mark Parsons
2010 Campbell BCV, Christensen S, Desmond PM, Parsons MW, Barber PA, De Silva DA, et al., 'Major infarct growth beyond 6 hours is associated with collateral circulation failure', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authors Mark Parsons
2010 Cadilhac DA, Lannin NA, Anderson CS, Levi CR, Faux S, Price C, et al., 'The Australian Stroke Clinical Registry: achievements in the first year', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
2010 Cadilhac DA, Kilkenny MF, Longworth M, Pollack MR, Levi CR, 'The metropolitan-rural divide for stroke ourcomes and the impact of stroke units', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
2010 Bivard A, McElduff P, Spratt NJ, Levi CR, Parsons MW, 'Validating perfusion-computed tomography in defining extent of irreversible brain ischemia', Circulation, Beijing (2010) [E3]
Co-authors Mark Parsons, Neil Spratt
2010 Lillicrap T, Stanwell P, Parsons MW, Spratt NJ, Hudson S, Levi CR, 'MR spectroscopy in brain temperature measurement and application to induced hypothermia therapy', Circulation, Beijing (2010) [E3]
Co-authors Neil Spratt, Peter Stanwell, Mark Parsons
2010 Maguire JM, Thakkinstian A, Levi CR, Lincz L, Bissett KE, Sturm J, et al., 'Genetic influences on ischemic stroke 90-day functional outcome: A novel association', Circulation, Beijing (2010) [E3]
Co-authors Jane Maguire, Lisa Lincz, Rodney Scott, John Attia
2010 Tu HT, Campbell BC, Christensen S, Butcher KS, Collins M, Parsons MW, et al., 'The Effects of Atrial Fibrillation on Infarct Evolution and Outcome', STROKE, San Antonio, TX (2010) [E3]
Citations Web of Science - 1
Co-authors Mark Parsons
2010 Christensen S, Parsons MW, De Silva DA, Ebinger M, Butcher K, Fink J, et al., 'Testing the mismatch hypothesis in the randomized EPITHET data set: The effect of treatment, mismatch and their interaction on infarct growth', Stroke, San Antonio, Texas (2010) [E3]
Citations Web of Science - 3
Co-authors Mark Parsons
2010 Bivard A, McElduff P, Levi CR, Spratt NJ, Parsons MW, 'Defining the extent of irreversible brain ischemia using perfusion computed tomography', Stroke, San Antonio, Texas (2010) [E3]
Citations Web of Science - 1
Co-authors Mark Parsons, Neil Spratt
2010 Campbell BC, Christensen S, Parsons MW, Desmond PM, Barber PA, Butcher KS, et al., 'Very low cerebral blood volume predicts hemorrhagic transformation better than diffusion lesion volume in acute ischemic stroke', Stroke, San Antonio, Texas (2010) [E3]
Citations Web of Science - 1
Co-authors Mark Parsons
2010 Lillicrap TP, Hudson S, Stanwell P, Parsons MW, Spratt NJ, Levi CR, 'MR spectroscopy and diffusion-weighted MRI can accurately measure both reduced and increased brain temperature', Stroke, San Antonio, Texas (2010) [E3]
Co-authors Neil Spratt, Mark Parsons, Peter Stanwell
2009 McLeod DD, Spratt NJ, Levi CR, Beautement S, Roworth B, Buxton D, et al., 'Experimental validation of perfusion computed tomography in acute middle cerebral artery occlusion', ACBRC 2009 Abstracts, Tianjin, China (2009) [E3]
Co-authors Damian Mcleod, Mark Parsons, Neil Spratt
2009 McLeod DD, Parsons MW, Levi CR, Beautement S, Roworth B, Buxton D, et al., 'An experimental model to investigate CT brain perfusion after stroke', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authors Mark Parsons, Neil Spratt, Damian Mcleod
2009 Thomas L, Rivett DA, Levi CR, 'Risk factors and clinical features associated with craniocervical arterial dissection', APA Conference Week Abstracts, Sydney, NSW (2009) [E3]
Co-authors Darren Rivett, Lucy Thomas
2009 Butcher K, Christensen S, Parsons MW, De Silva D, Ebinger M, Levi CR, et al., 'Post-treatment blood pressure control predicts thrombolysis related hemorrhagic transformation', Stroke, San Diego, CA (2009) [E3]
DOI 10.1161/strokeaha.108.000015
Citations Web of Science - 1
Co-authors Mark Parsons
2009 Christensen S, Parsons MW, De Silva D, Ebinger M, Butcher K, Fink J, et al., 'Optimising MR criteria for penumbral selection trials', Stroke, San Diego, CA (2009) [E3]
DOI 10.1161/strokeaha.108.000015
Citations Web of Science - 6
Co-authors Mark Parsons
2009 McLeod DD, Spratt NJ, Levi CR, Beautement S, Roworth B, Buxton D, et al., 'Perfusion computed tomography for acute stroke: A model for experimental validation', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
DOI 10.1159/000221776
Co-authors Damian Mcleod, Neil Spratt, Mark Parsons
2009 Brekenfeld C, De Silva DA, Christensen S, Churilov L, Parsons MW, Levi CR, et al., 'Dual target (mismatch and vessel obstruction) at baseline MRI does not improve stroke patient selection for thrombolysis 3-6 h', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
DOI 10.1159/000221772
Co-authors Mark Parsons
2009 Butcher K, Christensen S, Parsons MW, De Silva D, Ebinger M, Levi CR, et al., 'Hemorrhagic transformation in the echoplanar imaging thrombolysis evaluation trial (EPITHET) is predicted by post-treatment blood pressure control and infarct volume', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
DOI 10.1159/000221772
Co-authors Mark Parsons
2009 Campbell BCV, Christensen S, Butcher KS, Gordon I, Parsons MW, Desmond PM, et al., 'Very low cerebral blood volume (VLCBV) predicts hemorrhagic transformation better than DWI volume in acute ischemic stroke', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
DOI 10.1159/000221773
Co-authors Mark Parsons
2009 Maguire J, Thakkinstian A, Attia JR, Lincz L, Bisset L, Sturm J, et al., 'Impact of COX-2 RS5275, RS20417 and GPIIIA RS5918 polymorphisms on 90 day ischaemic stroke functional outcome: A novel association', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
DOI 10.1159/000221772
Co-authors Lisa Lincz, John Attia, Rodney Scott
2009 Thomas L, Rivett DA, Levi CR, 'Factors affecting the safety of cervical manipulation', Manual Therapy, Edinburgh, UK (2009) [E3]
Co-authors Lucy Thomas, Darren Rivett
2008 Budd TW, Parsons MW, Hubbard IJ, Carey L, Levi CR, 'A longitudinal fMRI study of cortical sensorimotor reorganization in stroke recovery', NeuroImage, Melbourne, VIC (2008) [E3]
Co-authors Mark Parsons, Bill Budd, Isobel Hubbard
2008 Miteff F, Parsons MW, Bateman GA, Spratt NJ, Levi CR, 'Does collateral vessel status on CT angiography add to perfusion CT in the prediction of outcome after acute ischaemc stroke?', Internal Medicine Journal, Sydney, NSW (2008) [E3]
DOI 10.1111/j.1445-5994.2008.01755_7.x
Co-authors Mark Parsons, Neil Spratt
2008 Christensen S, Parsons MW, De Silva DA, Ebinger M, Butcher K, Fink J, et al., 'Optimizing mismatch definitions in acute stroke MRI: An epithet post hoc study', Internal Medicine Journal, Sydney, NSW (2008) [E3]
DOI 10.1111/j.1445-5994.2008.01755_7.x
Co-authors Mark Parsons
2008 Gill M, Marsden D, Pollack M, Levi CR, Longworth M, Cadilhac D, et al., 'From rhetoric to reality: Implementing organised stroke care in rural New South Wales (NSW): The NSW Rural Stroke Project', Internal Medicine Journal, Sydney, NSW (2008) [E3]
DOI 10.1111/j.1445-5994.2008.01756.x
2008 Selmes C, Levi CR, Parsons MW, Miteff F, 'The incidence of anterior cerebral artery flow reversal in high-grade internal carotid artery stenotic disease or occlusion', Internal Medicine Journal, Sydney, NSW (2008) [E3]
DOI 10.1111/j.1445-5994.2008.01756.x
Co-authors Mark Parsons
2008 Thomas L, Levi C, Rivett DA, 'Risk factors and natural history of craniocervical arterial dissection. Interactive poster presented.', 9th International Conference of the International Federation of Orthopaedic Manipulative Therapists (IFOMT) Absracts CD., Rotterdam, The Netherlands (2008) [E3]
Co-authors Darren Rivett, Lucy Thomas
2008 Desilva DA, Ebinger M, Christensen S, Levi CR, Parsons MW, Peeters A, et al., 'The impact of diabetes and admission in blood glucose on outcomes in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)', Cerebrovascular Diseases, Nice, France (2008) [E3]
DOI 10.1159/000132093
Co-authors Mark Parsons
2008 Ebinger M, Christensen S, Desilva DA, Parsons MW, Levi CR, Peeters A, et al., 'Expediting MRI-based proof of concept stroke trials using an earlier primary endpoint', Cerebrovascular Diseases, Nice, France (2008) [E3]
DOI 10.1159/000132088
Co-authors Mark Parsons
2007 Maguire J, Sturm J, Attia JR, Whyte S, Bisset L, Lincz L, et al., 'A case-control genetic association study to examine platelet glycoprotein polymorphisms and ischaemic stroke risk', Internal Medicine Journal, Perth, Australia (2007) [E3]
Co-authors Lisa Lincz, Mark Parsons, John Attia
2005 Selmes C, Evans MK, Levi C, Parsons M, Royan A, Russell M, et al., 'PREVALENCE OF INTRACRANIAL LARGE ARTERY DISEASE IN THE HUNTER REGION', Internal Medicine Journal, Hobart Australia (2005)
Co-authors Mark Parsons
2005 Evans MK, russell M, royan A, moore A, parsons M, levi C, 'THE ACUTE STROKE NURSE: AN INTEGRAL PART OF THE STROKE TEAM', Internal Medicine Journal, Hobart Australia (2005)
Co-authors Mark Parsons
2004 Abbott AL, Chambers BR, Stork JL, Levi CR, Selmes CM, Bladin CF, Donnan GA, 'High-grade asymptomatic carotid stenosis: Is it benign?', STROKE, SAN DIEGO, CALIFORNIA (2004)
2004 Abbott AL, Chambers BR, Stork JL, Levi CR, Selmes CM, Bladin CF, Donnan GA, 'Embolic Signal Detection and Prediction of Ipsilateral Ischaemic Symptoms in Patients with High-grade Asymptomatic Carotid Stenosis', Embolic Signal Detection and Prediction of Ipsilateral Ischaemic Symptoms in Patients with High-grade Asymptomatic Carotid Stenosis, Sydney, Australia (2004) [E3]
2004 Abbott AL, Chambers BR, Stork JL, Levi CR, Selmes CM, Bladin CF, Donnan GA, 'Plaque Features As Predictors Of Ischaemic Symptoms in Patients With High-grade Asymptomatic Carotid Stenosis', Plaque Features As Predictors Of Ischaemic Symptoms in Patients With High-grade Asymptomatic Carotid Stenosis, Sydney, Australia (2004) [E3]
2004 Wang Y, Levi CR, Parsons MW, Selmes CM, Evans M, Royan A, et al., 'Predictors of in-hospital Neurological Deterioration in Acute Ischaemic Stroke', Predictors of in-hospital Neurological Deterioration in Acute Ischaemic Stroke, Sydney Australia (2004) [E3]
Co-authors Mark Parsons
2003 Levi CR, Selmes CM, Bull N, Baker G, Hardy D, Evans M, 'Normal blood flow velocities in the intracranial large arteries as measured by transcranial colour-coded duplex', Internal Medicine Journal, Queensland Australia (2003) [E3]
2003 Pollack M, Levi CR, Wang Y, O'Dea IP, 'Influence of timing of transfer to rehabilitation on stroke outcomes', Internal Medicine Journal, Queensland Australia (2003) [E3]
2003 Evans M, Levi CR, Royan A, Wang Y, Selmes CM, 'The influence of stroke case management on patient outcomes', internal Medicine Journal, Queensland Australia (2003) [E3]
2003 Wang Y, Levi CR, D'Este CA, Attia JR, Spratt N, Fisher J, 'Seasonal variation in stroke in the Hunter Region, Australia a five-year hospital-based study, 1995-2000', STROKE, PHOENIX, ARIZONA (2003)
Co-authors Catherine Deste, John Attia, Neil Spratt
2002 Wang Y, Ng K, Spratt N, Evans MK, Royan A, Fisher J, et al., 'A prospective study on predictors of prolonged hospital stay', Journal of Clinical Neuroscience, Aukland , New Zealand (2002)
DOI 10.1054/jocn.2002.1124
2002 Wang Y, Levi CR, D'Este CA, Pollack M, Fisher J, 'Stroke incidence variations in rural, semi-rural and urban areas of the Hunter Region, Australia, 1995-2000', Not known, Not known (2002) [E3]
Co-authors Catherine Deste
2002 Evans MK, Royan A, Wang Y, Levi C, 'The use of a case management model of care in the acute stroke unit', Stroke Society of Australasia Annual Scientific Meeting, Sheraton Towers Aukland New Zealand (2002)
DOI 10.1054/jocn.2002.1124
2000 Kostulas K, Selmes C, Bull N, Evans MK, Levi C, 'Influence of Acute Carotid and Transcranial Color Coded Duplex on Assessment of Ischemic Stroke Mechanism', 4th World Stroke Congress, Melbourne Convention Centre (2000)
DOI 10.1161/01.str.31.11.2769
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Grants and Funding

Summary

Number of grants 74
Total funding $20,011,603

Click on a grant title below to expand the full details for that specific grant.


20153 grants / $6,206,616

Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation (TASTE) Trial$3,989,898

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Mark Parsons, Conjoint Professor Chris Levi, Doctor Patrick McElduff, Professor Richard Lindley, Professor Patricia Desmond, Professor Gregory Albers, Professor Werner Hacke, Professor Hugh Markus, Dr Bruce Campbell, Professor Thanh Phan
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1400012
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery$1,108,359

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Julie Bernhardt, Professor Michael Nilsson, Dr Leeanne Carey, Professor Paulette Van Vliet, Dr Dominique Cadilhac, Professor Christopher Bladin, Professor Sandy Middleton, Professor Geoff Donnan, Professor Mark Parsons, Conjoint Professor Chris Levi
Scheme Centres of Research Excellence (CRE) - Centres of Clinical Research Excellence
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1401448
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery$1,108,359

Funding body: University of Melbourne

Funding body University of Melbourne
Project Team Associate Professor Julie Bernhardt, Professor Michael Nilsson, Dr Leeanne Carey, Professor Paulette Van Vliet, Dr Dominique Cadilhac, Professor Christopher Bladin, Professor Sandy Middleton, Professor Geoff Donnan, Professor Mark Parsons, Conjoint Professor Chris Levi
Scheme Shared
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1401448
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20149 grants / $2,254,734

Does pneumococcal vaccination protect against cardiovascular disease? $1,815,627

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor John Attia, Professor Catherine D'Este, Dr Walter Abhayaratna, Professor Andrew Tonkin, Conjoint Professor Chris Levi, Conjoint Professor David Durrheim, Professor Joseph Hung, Mr Mark McEvoy, Doctor Alexis Hure
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1300127
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Altering the Rehabililtation Environment to Improve Stroke Survivor Activity (AREISSA): A Phase II Trial.$264,242

Funding body: National Heart Foundation of Australia

Funding body National Heart Foundation of Australia
Project Team Doctor Neil Spratt, Associate Professor Louise Ada, Professor Michael Nilsson, Professor Sandy Middleton, Associate Professor Julie Bernhardt, Professor Leonid Churilov, Conjoint Professor Chris Levi, Conjoint Associate Professor Michael Pollack, Associate Professor Steven Faux, Professor Lin Perry, Dr Annie McCluskey
Scheme NSW Cardiovascular Research Network Research Development Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301044
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Neuroimaging Biomarkers of Recovery: Longitudinal Imaging Study in the rehabilitation Phase post-Acute Ischemic Stroke (NEUROLISS)$50,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Andrew Bivard, Professor Mark Parsons, Conjoint Professor Chris Levi
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401437
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Mapping whole-brain metabolic networks$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Renate Thienel, Associate Professor Frini Karayanidis, Doctor Juanita Todd, Associate Professor Peter Stanwell, Professor Mark Parsons, Conjoint Professor Chris Levi
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301285
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

An Evaluation of Transitional Care for Stroke Patients$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Ashley Kable, Professor Amanda Baker, Professor Dimity Pond, Doctor Alyna Turner, Conjoint Professor Chris Levi
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301294
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Biological characterisation of genetic associations for large artery atherosclerotic stroke$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Liz Holliday, Professor Rodney Scott, Conjoint Professor Chris Levi, Professor John Attia, Associate Professor Jane Maguire
Scheme Stroke Research Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301340
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Prevent 2nd Stroke: The development and pilot testing of an online lifestyle behaviours program for stroke and TIA survivors$20,000

Funding body: National Stroke Foundation

Funding body National Stroke Foundation
Project Team Associate Professor Billie Bonevski, Dr Alyna Turner, Professor Amanda Baker, Conjoint Professor Chris Levi, Conjoint Associate Professor Michael Pollack, Mr Timothy Regan
Scheme Research Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301114
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Seasonal variation in cervical arterial dissection$19,865

Funding body: National Stroke Foundation

Funding body National Stroke Foundation
Project Team Doctor Lucy Thomas, Conjoint Professor Chris Levi, Professor Darren Rivett
Scheme Research Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301126
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation (TASTE) Trial$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Mark Parsons, Conjoint Professor Chris Levi, Doctor Patrick McElduff
Scheme Near Miss Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301401
Type Of Funding Internal
Category INTE
UON Y

20137 grants / $1,428,095

HMRI MRSP Infrastructure (12-16) – Translational Neuroscience & Mental Health$950,440

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300587
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Translational research program in stroke – from discovery to therapy to implementation and better patient outcomes$317,155

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Chris Levi
Scheme Practitioner Fellowships
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1200043
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Greater Charitable Foundation Fellows in Stroke Research$100,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Neil Spratt, Professor Mark Parsons, Conjoint Professor Chris Levi
Scheme Stroke Research Project Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300508
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Long term effect of sports-related concussion$38,500

Funding body: Brain Foundation (NSW Branch)

Funding body Brain Foundation (NSW Branch)
Project Team Conjoint Professor Chris Levi
Scheme Research Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1201198
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Dr Simon Koblar, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Associate Professor Jane Maguire
Scheme Near Miss Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300475
Type Of Funding Internal
Category INTE
UON Y

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Dr Simon Koblar, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Associate Professor Jane Maguire
Scheme Near Miss
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300704
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

2012 EIA Impact Trial travel grant$2,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300374
Type Of Funding Internal
Category INTE
UON Y

20129 grants / $1,895,818

An international comparison of systems of care, risk stratification and outcomes in TIA and minor stroke$1,149,593

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Chris Levi, Conjoint Professor Parker Magin, Dr Daniel Lasserson, Dr Jose Valderas, Associate Professor Helen Dewey, Professor Peter Barber, Professor Peter Rothwell, Doctor Neil Spratt, Dr Dominique Cadilhac, Professor Valery Feigin
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1100258
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Project EVA: an environmentally responsible facility for interdisciplinary supercomputing applications$263,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Pablo Moscato, Laureate Professor Jon Borwein, Conjoint Professor Keith Jones, Conjoint Professor Chris Levi, Professor Mark Parsons, Professor Michael Ostwald, Professor Hugh Craig, Conjoint Professor Peter Greer, Associate Professor Stephan Chalup, Associate Professor Regina Berretta
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100627
Type Of Funding Internal
Category INTE
UON Y

Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED)$212,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Craig Anderson, Professor John Chalmers, Professor Richard Lindley, Associate Professor Hisatomi Arima, Dr Jiguang Wang, Conjoint Professor Chris Levi
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200702
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

T3 Trial: Triage, Treatment and Transfer of patients with stroke in emergency departments$174,525

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Sandy Middleton, Conjoint Professor Chris Levi, Associate Professor Mark Fitzgerald, Associate Professor Julie Considine, Professor Jeremy Grimshaw, Conjoint Professor Cate d'Este, Professor Richard Gerraty, Associate Professor Ngai Wah Cheung, Dr Dominique Cadilhac, Associate Professor Elizabeth McInnes
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1201067
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Tomago Aluminium$26,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Frini Karayanidis, Conjoint Associate Professor Grant Bateman, Professor Mark Parsons, Emeritus Professor Patricia Michie, Mr Todd Jolly, Conjoint Professor Chris Levi, Ms Jaime Rennie
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200517
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

What causes unexplained encephalitis? A pilot adult encephalitis hospital-based surveillance system$20,200

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor David Durrheim, Conjoint Professor Chris Levi, Doctor Beverley Paterson
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200219
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Experimental brain imaging to investigate novel protective mechanisms of short duration body cooling after stroke$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Damian McLeod, Doctor Neil Spratt, Professor Mark Parsons, Conjoint Professor Chris Levi
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1101116
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Doctor Lisa Lincz
Scheme Near Miss Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200675
Type Of Funding Internal
Category INTE
UON Y

HMRI Exchange Visit Prize - Andrew Gardner$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Dr Andrew Gardner
Scheme Research Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200014
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20116 grants / $2,058,434

Implementation of quality use of advanced CT imaging in acute stroke$1,075,461

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Mark Parsons, Conjoint Professor Chris Levi, Professor Geoff Donnan, Professor Stephen Davis, Professor John Attia, Professor Christopher Bladin, Mr Qing Yang, Associate Professor Peter Mitchell, Associate Professor Stacy Goergen, Professor Ramamohanarao Kotagiri
Scheme Partnership Projects
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1000535
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

HMRI-MRSP Infrastructure (11-12) Centre for Brain and Mental Health Research$436,266

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1101135
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

HMRI MRSP Infrastructure Grant (10-11) - Brain and Mental Health$400,244

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100285
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Fitness Training In Stroke Trial (FiTIST): a randomised controlled assessor blind multicentre cross-over trial$85,600

Funding body: National Heart Foundation of Australia

Funding body National Heart Foundation of Australia
Project Team Doctor Neil Spratt, Conjoint Professor Chris Levi, Professor Robin Callister
Scheme Postgraduate Biomedical Research Scholarship
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1000862
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Relationships between white matter lesions and cognitive and motor functioning in patients with minor ischaemic stroke: A structural and functional brain imaging study - RhD 2yr$40,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Mr Todd Jolly, Associate Professor Frini Karayanidis, Professor Mark Parsons, Conjoint Professor Chris Levi, Emeritus Professor Patricia Michie, Conjoint Associate Professor Grant Bateman, Conjoint Associate Professor Peter Schofield
Scheme Research Higher Degree Support Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100061
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Exploring Chronic Traumatic Encephalopathy (CTE) amongst current and former professional rugby league players$20,863

Funding body: NSW Sporting Injuries Committee

Funding body NSW Sporting Injuries Committee
Project Team Doctor Frances Kay-Lambkin, Dr Andrew Gardner, Associate Professor Peter Stanwell, Conjoint Professor Chris Levi, Professor Mark Parsons
Scheme Research & Injury Prevention Scheme
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100822
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

201010 grants / $1,108,961

Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice. A cluster randomised controlled trial in acute stroke care$772,950

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Robert Sanson-Fisher, Conjoint Professor Chris Levi, Associate Professor Christine Paul, Conjoint Professor Cate d'Este, Professor Mark Parsons, Professor Christopher Bladin, Professor Richard Lindley, Professor John Attia
Scheme Partnership Projects
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0189781
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Testing stroke sonothrombolysis using an improved experimental model of thromboembolic stroke$81,386

Funding body: National Stroke Foundation

Funding body National Stroke Foundation
Project Team Doctor Neil Spratt, Conjoint Professor Chris Levi
Scheme Postgraduate Biomedical Scholarship
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0190597
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Improving patient selection for acute stroke therapies - an experimental model of CT brain perfusion after stroke$50,000

Funding body: BellBerry Limited

Funding body BellBerry Limited
Project Team Professor Mark Parsons, Doctor Neil Spratt, Conjoint Professor Chris Levi, Doctor Damian McLeod, Dr Peter Stanwell
Scheme Near Miss
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0900222
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice. A cluster randomised controlled trial in acute stroke care $50,000

Funding body: Victorian Department of Health

Funding body Victorian Department of Health
Project Team Laureate Professor Robert Sanson-Fisher, Conjoint Professor Chris Levi, Associate Professor Christine Paul, Conjoint Professor Cate d'Este, Professor Mark Parsons, Professor Christopher Bladin, Professor Richard Lindley, Professor John Attia
Scheme Project Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1100824
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Translational Doppler ultrasound markers of the ischaemic penumbra: A prospective observational study using CT Perfusion and angiography as comparators$40,000

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Conjoint Professor Chris Levi
Scheme Research Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G0900156
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Implementation of thrombolytic therapy in acute stroke. A cluster randomised trial$30,000

Funding body: BellBerry Limited

Funding body BellBerry Limited
Project Team Conjoint Professor Chris Levi, Professor John Attia, Associate Professor Christine Paul, Professor Mark Parsons, Professor Christopher Bladin, Professor Richard Lindley, Conjoint Professor Cate d'Este
Scheme Near Miss
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G0900221
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

A structural and functional brain imaging study of how white matter lesions in patients with minor ischaemic strike affect cognitive and motor control processes$24,600

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Associate Professor Frini Karayanidis, Professor Mark Parsons, Emeritus Professor Patricia Michie, Conjoint Professor Chris Levi, Ms Sharna Jamadar, Mr Matthew Hughes, Conjoint Associate Professor Peter Schofield, Conjoint Associate Professor Grant Bateman
Scheme Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0900150
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Minor stroke and Transient Ischaemic Attack pathways of care: a pilot of a cohort study based in general practice$23,025

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Professor Mark Parsons, Dr Daniel Lasserson, Conjoint Professor Parker Magin, Conjoint Professor Chris Levi
Scheme Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000933
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Sir Ronald Fisher GPU computing cluster $22,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Pablo Moscato, Conjoint Professor Chris Levi, Associate Professor Regina Berretta
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000054
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Sparke Helmore / NBN television triathlon award for research excellence$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi
Scheme Sparke Helmore/NBN Television Corporate Triathlon Award for Research Excellence
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000026
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20097 grants / $1,734,567

Australian stroke genetics collaborative - Genome-wide association study in ischaemic stroke$1,108,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Chris Levi, Conjoint Associate Professor Jonathan Sturm, Professor John Attia, Professor Rodney Scott, Doctor Lisa Lincz, Dr Simon Koblar, Professor Pablo Moscato
Scheme Project Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0188856
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

HMRI MRSP Infrastructure Grant (09-10) - Brain and Mental Health$327,892

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G1000661
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

China-Australia therapeutic hypothermia in stroke (CATHS) research program: identification of diagnostic molecular markers and therapeutic targets involved in re-warming related brain injury$230,275

Funding body: NSW Office for Science & Medical Research

Funding body NSW Office for Science & Medical Research
Project Team Conjoint Professor Chris Levi, Doctor Mark Baker, Doctor Neil Spratt, Emeritus Professor John Rostas
Scheme China-NSW Collaborative Research Program
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0190392
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Centre for Brain and Mental Health Research - International Visitors$25,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi
Scheme Special Project Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0190630
Type Of Funding Internal
Category INTE
UON Y

Establishing Computed Tomography Perfusion (CTP) imaging in an animal stroke model$20,000

Funding body: National Stroke Foundation

Funding body National Stroke Foundation
Project Team Doctor Damian McLeod, Doctor Neil Spratt, Professor Mike Calford, Conjoint Professor Chris Levi, Professor Mark Parsons
Scheme Research Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189942
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Towards better early imaging in stroke: Use of an experimental model to investigate CT brain perfusion$13,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Neil Spratt, Professor Mark Parsons, Doctor Damian McLeod, Conjoint Professor Chris Levi
Scheme Stroke Research Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189810
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Vascular Ischaemia Study$10,400

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Professor John Attia, Professor Rodney Scott, Doctor Michael Seldon, Doctor Lisa Lincz, Conjoint Associate Professor Jonathan Sturm
Scheme Research Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0900120
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20084 grants / $566,094

Low-dose tenecteplase vs standard-dose alteplase for acute ischaemic stroke: An imaging based safety and efficacy study$335,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Mark Parsons, Professor Stephen Davis, Professor Christopher Bladin, Dr Romesh Markus, Associate Professor Helen Dewey, Conjoint Professor Chris Levi
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0187651
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

A randomised controlled trial of mild hypothermia in acute ischaemic stroke$117,176

Funding body: National Heart Foundation of Australia

Funding body National Heart Foundation of Australia
Project Team Conjoint Professor Chris Levi, Professor Mark Parsons, Professor Christopher Bladin, Doctor Neil Spratt
Scheme Grant-In-Aid
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0187644
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Health services research: a randomised controlled trial to evaluate a model of comprehensive stroke care$75,918

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Chris Levi, Professor Michael Pollack
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188529
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

A randomised controlled trial of mild hypothermia acute ischaemic stroke$37,500

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188466
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20073 grants / $29,539

A functional MRI and tractography study of the effect of early upper limb therapy on brain plasticity after stroke$19,039

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Bill Budd, Professor Mark Parsons, Conjoint Professor Chris Levi
Scheme Project Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187254
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

A functional MRI study of upper limb therapy in acute stroke.$5,500

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Mark Parsons, Doctor Bill Budd, Conjoint Professor Chris Levi
Scheme Research Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187321
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Genetic polymorphisms in the native thrombolytic systems as risk factors for ischaemic stroke.$5,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Professor John Attia, Professor Rodney Scott, Dr Amanda Thrift
Scheme Research Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187320
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20068 grants / $2,047,653

PRC - Priority Research Centre for Gender health & Ageing$543,772

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Julie Byles, Professor Sandra Capra, Associate Professor Pauline Chiarelli, Conjoint Professor David Henry, Professor Tina Koch, Ms Chris Landorf, Conjoint Professor Chris Levi, Associate Professor Deb Loxton, Associate Professor Liz Milward, Conjoint Associate Professor Lynne Parkinson, Professor Dimity Pond, Conjoint Professor David Sibbritt, Associate Professor Anne Young
Scheme Priority Research Centre
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186949
Type Of Funding Internal
Category INTE
UON Y

PRC - Priority Research Centre for Brain & Mental Health Research (CBMHR)$524,282

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi, Professor Amanda Baker, Professor Mike Calford, Professor Trevor Day, Emeritus Professor Peter Dunkley, Professor Michael Hazelton, Professor Andrew Heathcote, Professor Brian Kelly, Conjoint Professor Vaughan Carr, Emeritus Professor Patricia Michie, Professor David Pow, Emeritus Professor John Rostas, Professor Ulli Schall, Professor Alistair Sim, Professor Mike Startup
Scheme Priority Research Centre
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186947
Type Of Funding Internal
Category INTE
UON Y

Keeping Brain Cells alive in Stroke Treatment$180,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi
Scheme Project Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186983
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

A functional MRI study of upper limb therapy in acute stroke$122,474

Funding body: National Heart Foundation of Australia

Funding body National Heart Foundation of Australia
Project Team Professor Mark Parsons, Doctor Bill Budd, Conjoint Professor Chris Levi, Doctor Isobel Hubbard
Scheme Grant-In-Aid
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186201
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Harmful or protective? Low dose COX-2 inhibitors and coronary or cerebrovascular occlusion$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor David Henry, Dr Patricia McGettigan, Conjoint Professor Chris Levi
Scheme Near Miss Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186057
Type Of Funding Internal
Category INTE
UON Y

Supplementary oxygen for acute ischaemic stroke: an imaging-based efficacy trial (SOS trial)$19,982

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Mark Parsons, Conjoint Professor Chris Levi
Scheme Pilot Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186701
Type Of Funding Internal
Category INTE
UON Y

The visual form and motion test as a measure of post-cardiac surgery cognitive impairment$16,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Ms Neva Bull, Conjoint Professor Chris Levi, Conjoint Associate Professor Mick Hunter
Scheme Project Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186099
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20053 grants / $361,583

Acute Stroke: Imaging the Ischaemic Penumbra with Perfusion CT$239,250

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Mark Parsons, Professor Stephen Davis, Professor Brian Tress, Dr Romesh Markus, Dr Stephen Read, Conjoint Professor Chris Levi
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0183962
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Genetic polymorphisms in the native thrombolytic and thrombotic systems as risk factors for ischaemic stroke$106,488

Funding body: National Heart Foundation of Australia

Funding body National Heart Foundation of Australia
Project Team Conjoint Professor Chris Levi, Professor John Attia, Professor Rodney Scott, Dr Amanda Thrift
Scheme Grant-In-Aid
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0184034
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

2005 RIBG allocation$15,845

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi
Scheme Research Infrastructure Block Grant (RIBG)
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185798
Type Of Funding Internal
Category INTE
UON Y

20041 grants / $28,000

Novel genetic and environmental risk factors in atherothrombosis: The role of variation in Cox-2, tpA and PAI-1 activity$28,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Conjoint Professor David Henry, Dr Patricia McGettigan, Professor John Attia, Professor Mark Parsons, Dr Michael Seldon, Professor Rodney Scott
Scheme Research Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183749
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20011 grants / $60,000

Influence of Glycemic Control on Outcome after Acute Ischaemic Stroke in Diabetic Patients.$60,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi
Scheme Research Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0180578
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20002 grants / $211,509

A randomised, controlled trial of 10% Dextran 40 in the prevention of stroke complicating Carotid Endarterectomy.$197,509

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Chris Levi, Professor Geoff Donnan, Dr B Chambers, Professor Christopher Bladin, Professor Stephen Davis, Dr John Wlodarczyk
Scheme Project Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0178440
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Brain Impairment after Cardiac Surgery.$14,000

Funding body: Brain Foundation (NSW Branch)

Funding body Brain Foundation (NSW Branch)
Project Team Conjoint Associate Professor Mick Hunter, Conjoint Professor Chris Levi
Scheme Research Grant
Role Investigator
Funding Start 2000
Funding Finish 2000
GNo G0180157
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

19991 grants / $20,000

10% Dextran 40 in the prevention of stroke complicating carotoid endarterectomy$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi
Scheme Research Grant
Role Lead
Funding Start 1999
Funding Finish 1999
GNo G0178614
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y
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Research Supervision

Current Supervision

Commenced Research Title / Program / Supervisor Type
2015 Genomics and Pharmacogenomics of Stroke
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2014 Individual Patient Profiling in Stroke Recovery: Application of Advanced Neuroimaging
Radiography, Faculty of Health and Medicine
Co-Supervisor
2014 International Comparison of Transient Ischaemic Attack Management and Output - Newcastle, Auckland, Oxford
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2014 Recovery from Stroke and Transient Ischemic Attack: The Role of Stress in Urban China and Australia
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2013 The Influence of Healthcare Pathways upon the Outcomes and Experiences of People with TIA or Minor Stroke: A Mulitmethod Approach
Nursing, Faculty of Health and Medicine
Co-Supervisor
2013 Economic Evaluation of Stroke Interventions in Selected Hospitals in Australia
Public Health, Faculty of Health and Medicine
Principal Supervisor
2011 Concussion in Professional Rugby League. What are the Potential Long- Term Consequences of Repetitive Concussive Blows
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2011 Whole-Brain CTP in Acute Ischemic Stroke
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2011 Fitness Training in Stroke Trial
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2011 Impediments to the Implementation of Thrombolytic Treatment in Acute Ischaemic Stroke
Behavioural Science, Faculty of Health and Medicine
Co-Supervisor
2010 Making Clots and Breaking Clots: Modelling Arterial Occlusion to Test Stroke Sonothrombolysis
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2007 Characteristics of Sex-specific Differences in Cardiovascular Adaptation in the First 2 Years of Life
Paediatrics, Faculty of Health and Medicine
Principal Supervisor

Past Supervision

Year Research Title / Program / Supervisor Type
2013 Minimising Risk Factors for Cervical Spine Manipulation
Physiotherapy, Faculty of Health and Medicine
Co-Supervisor
2013 Perfusion Imaging in Acute and Evolving Brain Ischemia
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2010 Genetic Polymorphisms of Platelet Glycoprotein and Cyclooxygenase-2 Genes and Their Influence on Risk of Ischaemic Stroke, 90 Day Post-Stroke Outcome, and Gene-Environment Interactions
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2002 Public Knowledge and Perception of Stroke in the Newcastle Urban Area
Public Health, Faculty of Health and Medicine
Co-Supervisor
2002 Prediction of Mortality in Patients with Acute Stroke
Public Health, Faculty of Health and Medicine
Principal Supervisor
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News

Strokefinder

Stroke detector

February 4, 2015

The Hunter Region NSW will become the international testing ground for a new microwave-imaging headpiece that helps ambulance and emergency teams rapidly diagnose stroke and other traumatic brain injuries.

Professor Chris Levi

Study of ‘minor strokes’ to prevent major impact

April 1, 2014

A community-based clinical trial that monitors people who have experienced a transient ischaemic attack (TIA) – colloquially known as a 'minor stroke' or 'funny turn' – is being expanded by researchers from the HMRI Stroke Group.

Professors Mark Parsons

International stroke trial

December 3, 2013

A Hunter stroke drug trial that yielded rapid treatment benefits for patients will expand nationally and internationally.

Conjoint Professor Chris Levi

Position

Conjoint Professor
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email chris.levi@newcastle.edu.au
Phone (02) 4921 3490
Fax (02) 4921 3488

Office

Room JHH
Building John Hunter Hospital
Location Other

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