Conjoint Associate Professor Bruce King

Conjoint Associate Professor

School of Medicine and Public Health

Career Summary

Biography

Research Expertise

Dr Bruce King is a Staff Specialist, Paediatric Endocrinology, at John Hunter Hospital and Conjoint Senior Lecturer at the University School of Medicine and Public Health.


Qualifications

  • Doctor of Philosophy, University of Newcastle
  • Bachelor of Medicine, Bachelor of Surgery, University of Queensland

Keywords

  • Biomolecular Chemistry
  • Medicinal Chemistry

Fields of Research

CodeDescriptionPercentage
110399Clinical Sciences not elsewhere classified30
060199Biochemistry and Cell Biology not elsewhere classified35
060499Genetics not elsewhere classified35
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (24 outputs)

YearCitationAltmetricsLink
2014Lopez PE, King BR, Goss PW, Chockalingam G, 'Bubble formation occurs in insulin pumps in response to changes in ambient temperature and atmospheric pressure but not as a result of vibration.', BMJ Open Diabetes Research & Care, 2 e000036 (2014) [C1]
DOI10.1136/bmjdrc-2014-000036
Co-authorsBruce King
2014Lopez P, Smart C, Morbey C, McElduff P, Paterson M, King BR, 'Extended insulin boluses cannot control postprandial glycemia as well as a standard bolus in children and adults using insulin pump therapy.', BMJ Open Diabetes Research & Care, 2 1-6 (2014) [C1]
DOI10.1136/bmjdrc-2014-000050
Co-authorsBruce King
2013Smart CEM, Evans M, O'Connell SM, McElduff P, Lopez PE, Jones TW, et al., 'Both Dietary Protein and Fat Increase Postprandial Glucose Excursions in Children With Type 1 Diabetes, and the Effect Is Additive', DIABETES CARE, 36 3897-3902 (2013) [C1]
DOI10.2337/dc13-1195Author URL
CitationsScopus - 8Web of Science - 7
Co-authorsBruce King
2012Smart CE, King BR, McElduff P, Collins CE, 'In children using intensive insulin therapy, a 20-g variation in carbohydrate amount significantly impacts on postprandial glycaemia', Diabetic Medicine, 29 E21-E24 (2012) [C1]
CitationsScopus - 8Web of Science - 5
Co-authorsClare Collins, Bruce King
2012Bandara DMWS, King BR, Howard NJ, Verge CF, Jack MM, Govind N, et al., 'A diabetes awareness campaign prevents diabetic ketoacidosis in children at their initial presentation with type 1 diabetes', Pediatric Diabetes, 13 647-651 (2012) [C1]
CitationsScopus - 13Web of Science - 15
Co-authorsBruce King
2011King BR, Goss PW, Paterson MA, Crock PA, Anderson DG, 'Hitting the dartboard from 40,000 feet: A better chance with your eyes open!', Diabetes Technology & Therapeutics, 13 1075-1076 (2011) [C3]
Co-authorsBruce King
2011King BR, Goss PW, Paterson MA, Crock PA, Anderson DG, 'Changes in altitude cause unintended insulin delivery from insulin pumps', Diabetes Care, 34 1932-1933 (2011) [C3]
DOI10.2337/dc11-0139
CitationsScopus - 12Web of Science - 8
Co-authorsBruce King
2010Smart CE, Ross K, Edge JA, King BR, McElduff P, Collins CE, 'Can children with Type 1 diabetes and their caregivers estimate the carbohydrate content of meals and snacks?', Diabetic Medicine, 27 348-353 (2010) [C1]
DOI10.1111/j.1464-5491.2010.02945.x
CitationsScopus - 16Web of Science - 11
Co-authorsBruce King, Clare Collins
2009Smart CE, Ross K, Edge JA, Collins CE, Colyvas KJ, King BR, 'Children and adolescents on intensive insulin therapy maintain postprandial glycaemic control without precise carbohydrate counting', Diabetic Medicine, 26 279-285 (2009) [C1]
DOI10.1111/j.1464-5491.2009.02669.x
CitationsScopus - 22Web of Science - 14
Co-authorsBruce King, Clare Collins, Kim Colyvas
2008Ryan RL, King BR, Anderson DG, Attia JR, Collins CE, Smart CE, 'Influence of and optimal insulin therapy for a low-glycemic index meal in children with type 1 diabetes receiving intensive insulin therapy', Diabetes Care, 31 1485-1490 (2008) [C1]
DOI10.2337/dc08-0331
CitationsScopus - 11Web of Science - 7
Co-authorsClare Collins, Bruce King, John Attia
2007King BR, Nicholson RC, 'Advances in understanding corticotrophin-releasing hormone gene expression', Frontiers in Bioscience, 12 581-590 (2007) [C1]
DOI10.2741/2084
CitationsScopus - 17Web of Science - 17
Co-authorsBruce King
2006Shipman KL, Robinson PJ, King BR, Smith R, Nicholson RC, 'Identification of a family of DNA-binding proteins with homology to RNA splicing factors', Biochemistry and Cell Biology-Biochimie Et Biologie Cellulaire, 84 9-19 (2006) [C1]
DOI10.1139/o05-139
CitationsScopus - 3Web of Science - 3
Co-authorsRoger Smith, Bruce King
2004Ni X, Hou Y, King BR, Tang X, Read MA, Smith R, Nicholson RC, 'Estrogen Receptor-Mediated Down-Regulation of Corticotropin-Releasing Hormone Gene Expression Is Dependant on a Cyclic Adenosine 3', 5'-Monophosphate Syncytiotrophoblast Cells', The Journal of Clinical Endocrinology & Metabolism, 89 2312-2318 (2004) [C1]
DOI10.1210/jc.2003-030948
CitationsScopus - 28Web of Science - 27
Co-authorsBruce King, Roger Smith
2004Smith CJ, Crock PA, King BR, Meldrum CJ, Scott R, 'Phenotype-Genotype Correlations in a Series of Wolfram Syndrome Families', Diabetes Care, 27 2003-2009 (2004) [C1]
DOI10.2337/diacare.27.8.2003
CitationsScopus - 42Web of Science - 35
Co-authorsRodney Scott, Bruce King
2004Nicholson RC, King BR, Smith R, 'Complex Regulatory Interactions Control CRH Gene Expression', Frontiers in Bioscience, 9 32-39 (2004) [C1]
DOI10.2741/1204
CitationsScopus - 36Web of Science - 33
Co-authorsBruce King, Roger Smith
2002Ni X, Nicholson RC, King B, Chan EC, Read M, Smith R, 'Estrogen Represses whereas the Estrogen-Antagonist ICI 182780 Stimulates Placental CRH Gene Expression', Journal of Clinical Endocrinology and Metabolism, 87(8) 3774-3778 (2002) [C1]
CitationsScopus - 38Web of Science - 33
Co-authorsBruce King, Roger Smith
2002King B, Smith R, Nicholson RC, 'Novel glucocorticoid and cAMP interactions on the CRH gene promoter', Molecular and Cellular Endocrinology, 194 19-28 (2002) [C1]
CitationsScopus - 58Web of Science - 51
Co-authorsRoger Smith, Bruce King
2001King BR, Smith R, Nicholson RC, 'The regulation of human corticotrophin-releasing hormone gene expression in the placenta (vol 22, pg 795, 2001)', PEPTIDES, 22 1939-+ (2001)
DOI10.1016/S0196-9781(01)00485-5Author URL
Co-authorsRoger Smith, Bruce King
2001King BR, Smith R, Nicholson RC, 'The regulation of human corticotrophin-releasing hormone gene expression in the placenta.', Peptides, 22 1941-1947 (2001)

Corticotrophin-releasing hormone (CRH) is a 41 amino acid neuropeptide that is expressed in the hypothalamus and the human placenta. Placental CRH production has been linked to th... [more]

Corticotrophin-releasing hormone (CRH) is a 41 amino acid neuropeptide that is expressed in the hypothalamus and the human placenta. Placental CRH production has been linked to the determination of gestational length in the human. Although encoded by a single copy gene, CRH expression in the placenta is regulated differently to the hypothalamus. Glucocorticoids stimulate CRH promoter activity in the placenta but inhibit it's activity in the hypothalamus, via mechanisms involving different regions of the CRH promoter. We discuss how various stimuli alter CRH promoter activity and why these responses are unique to the placenta.

DOI10.1016/S0196-9781(01)00486-7
CitationsScopus - 9
Co-authorsBruce King, Roger Smith
2001King BR, Smith R, Nicholson RC, 'The regulation of human corticotrophin-releasing hormone gene expression in the placenta', Peptides, 22 795-801 (2001) [C1]
CitationsScopus - 32Web of Science - 12
Co-authorsBruce King, Roger Smith
2001Nicholson RC, King BR, 'Regulation of CRH gene expression in the placenta', ENDOCRINOLOGY OF PARTURITION: BASIC SCIENCE AND CLINICAL APPLICATION, 27 246-257 (2001)
Author URL
CitationsWeb of Science - 6
Co-authorsBruce King
2001King BR, Nicholson RC, Smith R, 'Placental Corticotrophin-releasing Hormone, Local Effects and Fetomaternal Endocrinology', Stress: the international journal on the biology of stress, 4 219-233 (2001) [C3]
CitationsScopus - 10
Co-authorsRoger Smith, Bruce King
2000Cheng Y, Nicholson RC, King BR, Chan EC, Fitter JT, Smith R, 'Corticotropin-Releasing Hormone Gene Expresssion in Primary Placental Cells is Modulated by Cyclic Adenosine 3',5'-Monophosphate', The Journal of Clinical Endocrinology & Metabolism, 85 1239-1244 (2000) [C1]
CitationsScopus - 33Web of Science - 34
Co-authorsBruce King, John Fitter, Roger Smith
2000Cheng Y, Nicholson RC, King BR, Chan EC, Fitter JT, Smith R, 'Glucocorticoid stimulation of Corticiotrophin-releasing hormone gene expression requires a Cyclic Adenosine 3',5'-Monophosphate regulatory element in human primary Placental Cytotrophoblast Cells', The journal of Clinical Endocrinology And Metabolism, 85 (2000) [C1]
CitationsScopus - 62Web of Science - 56
Co-authorsBruce King, Roger Smith, John Fitter
Show 21 more journal articles

Conference (7 outputs)

YearCitationAltmetricsLink
2014Carrasco DS, Fu Y, Goodwin GC, King BR, Medioli AM, 'Performance limitations arising in closed loop control of blood glucose in type 1 diabetes', IFAC Proceedings Volumes (IFAC-PapersOnline) (2014) [E1]

This paper presents a preliminary study of performance limitations that arise in the closed-loop control of blood glucose, using an autonomous artificial pancreas. It is shown tha... [more]

This paper presents a preliminary study of performance limitations that arise in the closed-loop control of blood glucose, using an autonomous artificial pancreas. It is shown that a major source of limitations is due to model uncertainty, specifically due to the combined effect of the insulin infusion system (IIS), the continuous glucose monitor (CGM) and the human glucose regulatory system. It is argued that the uncertainty associated with each of these elements compromises the achievable closed-loop bandwidth, and, in the presence of disturbances, e.g. meal intake and exercise, the closed-loop response will necessarily be poor. A proposition to overcome this problem is given based on feedforward action.

Co-authorsBruce King, Graham Goodwin
2013O'Connell SM, Smart CE, Evans M, McElduff P, Lopez PE, Jones TW, et al., 'Both Protein and Fat Increase Postprandial Glucose Excursions in Children with Type 1 Diabetes and the Effect is Additive', IRISH JOURNAL OF MEDICAL SCIENCE (2013) [E3]
Author URL
Co-authorsBruce King
2013Lopez P, King BR, Chockalingham G, Goss P, 'CHANGES IN TEMPERATURE AND PRESSURE BUT NOT VIBRATION CAUSE BUBBLE FORMATION IN INSULIN PUMP CARTRIDGES AND TUBING', DIABETES TECHNOLOGY & THERAPEUTICS (2013) [E3]
Author URL
Co-authorsBruce King
2009Smart CE, Ross K, Edge J, Collins CE, King BR, 'Can children with Type 1 diabetes and their caregivers count carbohydrate accurately?', APEG Annual Scientific Meeting 2009. Abstracts, Coolum, QLD (2009) [E3]
Co-authorsClare Collins, Bruce King
2008Smart CE, Ross K, King BR, Edge JA, 'Can children with Type 1 diabetes and their carers count carbohydrate accurately?', 68th Scientific Session of the American Diabetes Association: Abstracts, San Francisco, CA (2008) [E3]
Co-authorsBruce King
2006King BR, Smith R, Nicholson RC, 'cAMP regulates CRH gene expression through a multi-element response unit', Endocrine Journal-Continuation of Endocrinologia Japonica, Queensland, Australia (2006) [E3]
Co-authorsBruce King, Roger Smith
2005King BR, Edwards (Ext) M, Smith R, Scheffer I, 'Doublecortin gene defects. Are they a cause of pseudopseudohypoparathyrodisim?', Hormone Research, Lyon, France (2005) [E3]
Co-authorsBruce King, Roger Smith
Show 4 more conferences
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Grants and Funding

Summary

Number of grants13
Total funding$783,161

Click on a grant title below to expand the full details for that specific grant.


20144 grants / $171,419

The prediction and prevention of hypoglycaemia using insulin suspension in a randomised controlled trial$63,118

Funding body: Juvenile Diabetes Research Foundation

Funding bodyJuvenile Diabetes Research Foundation
Project TeamConjoint Associate Professor Bruce King, Associate Professor Timothy Jones, Dr Elizabeth Davis, Dr Jan Fairchild, Professor Fergus Cameron, Professor Geoffrey Ambler
SchemeClinical Research Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400994
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

A comparison of three insulin dosage algorithms for meals of variable macronutrient composition on postprandial glucose levels in children with type 1 diabetes$55,264

Funding body: Australian Paediatric Endocrine Group

Funding bodyAustralian Paediatric Endocrine Group
Project TeamDoctor Carmel Smart, Conjoint Associate Professor Bruce King
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301296
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

What is the optimal percentage of rapid and extended bolus insulin in a combination insulin bolus?$48,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamMiss Prudence Lopez, Conjoint Associate Professor Bruce King, Doctor Carmel Smart
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1400137
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

JDRF Travel Grant Award - American Diabetes Association in June in San Francisco$5,037

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamMs Megan Paterson-Dick, Conjoint Associate Professor Bruce King, Doctor Carmel Smart, Miss Prudence Lopez
SchemeResearch Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1401497
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20132 grants / $72,795

AdDIT Study$62,795

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Associate Professor Bruce King
SchemeProject Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300204
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

What is the impact of meals of varying fat and protein content on postprandial blood glucose level in children and young people with type 1 diabetes mellitus$10,000

Funding body: Novo Nordisk Foundation

Funding bodyNovo Nordisk Foundation
Project TeamConjoint Associate Professor Bruce King, Dr Prudence Lopez, Mrs Carmel Smart
SchemeRegional Diabetes Support Scheme
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300522
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20123 grants / $313,942

The development of an algorithm for meals using a closed-loop insulin pump - Fellowship$159,999

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Associate Professor Bruce King
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200431
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

The Gastronomic Lunch of the Year Fellowship$100,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Associate Professor Bruce King, Dr Prudence Lopez, Doctor Carmel Smart, Dr Clare Morbey
SchemeResearch Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1201044
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

A double blind cross over trial in young insulin pump users comparing their glucose control when their insulin pump settings have been set from continuous glucose sensing data interpreted by a new com$53,943

Funding body: Hunter Children`s Research Foundation

Funding bodyHunter Children`s Research Foundation
Project TeamDoctor Donald Anderson, Conjoint Associate Professor Bruce King, Conjoint Associate Professor Patricia Crock, Ms Helen Phelan
SchemeResearch Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1101172
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20111 grants / $19,500

How do high protein and/or high fat meals affect postprandial glycaemic control in children and adolescents using intensive insulin therapy?$19,500

Funding body: Hunter Children`s Research Foundation

Funding bodyHunter Children`s Research Foundation
Project TeamProfessor Clare Collins, Mrs Carmel Smart, Conjoint Associate Professor Bruce King, Doctor Patrick McElduff
SchemeResearch Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1001010
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20081 grants / $20,000

In children with type 1Diabetes on intensive insulin therapy, can improving carbohydrate knowledge and targeted nutrition education strategies improve diabetes management?$20,000

Funding body: Hunter Children`s Research Foundation

Funding bodyHunter Children`s Research Foundation
Project TeamProfessor Clare Collins, Conjoint Associate Professor Bruce King
SchemeResearch Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188484
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20061 grants / $15,000

Identification of proteins that interact with the multifunctional protein, CREAP$15,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamConjoint Associate Professor Rick Nicholson, Conjoint Associate Professor Bruce King
SchemeResearch Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186557
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20001 grants / $170,505

Characterisation of Pituitary Target Autoantigens.$170,505

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Associate Professor Patricia Crock, Professor Rodney Scott, Conjoint Associate Professor Bruce King
SchemeProject Grant
RoleInvestigator
Funding Start2000
Funding Finish2000
GNoG0178451
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2013Impact of Dietary Protein on Postprandial Blood Glucose Levels in Type 1 Diabetes Mellitus
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2012Development of an Insulin Delivery Algorithm for Management of Meals for Type 1 Diabetes Mellitus in Children
Paediatrics, Faculty of Health and Medicine
Principal Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2012Optimising Nutrition Interventions to Improve Postprandial Glycaemia for Children and Adolescents Using Intensive Insulin Therapy
Nutrition & Dietetics, Faculty of Health and Medicine
Co-Supervisor
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Conjoint Associate Professor Bruce King

Position

Conjoint Associate Professor
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Emailb.king@newcastle.edu.au

Office

LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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