Conjoint Associate Professor Bruce King

Conjoint Associate Professor

School of Medicine and Public Health

Career Summary

Biography

Research Expertise

Dr Bruce King is a Staff Specialist, Paediatric Endocrinology, at John Hunter Hospital and Conjoint Senior Lecturer at the University School of Medicine and Public Health.


Qualifications

  • Doctor of Philosophy, University of Newcastle
  • Bachelor of Medicine, Bachelor of Surgery, University of Queensland

Keywords

  • Biomolecular Chemistry
  • Medicinal Chemistry

Fields of Research

Code Description Percentage
110399 Clinical Sciences not elsewhere classified 30
060199 Biochemistry and Cell Biology not elsewhere classified 35
060499 Genetics not elsewhere classified 35
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (24 outputs)

Year Citation Altmetrics Link
2014 Lopez PE, King BR, Goss PW, Chockalingam G, 'Bubble formation occurs in insulin pumps in response to changes in ambient temperature and atmospheric pressure but not as a result of vibration.', BMJ Open Diabetes Research & Care, 2 e000036 (2014) [C1]
DOI 10.1136/bmjdrc-2014-000036
Co-authors Bruce King
2014 Lopez P, Smart C, Morbey C, McElduff P, Paterson M, King BR, 'Extended insulin boluses cannot control postprandial glycemia as well as a standard bolus in children and adults using insulin pump therapy.', BMJ Open Diabetes Research & Care, 2 1-6 (2014) [C1]
DOI 10.1136/bmjdrc-2014-000050
Co-authors Bruce King
2013 Smart CEM, Evans M, O'Connell SM, McElduff P, Lopez PE, Jones TW, et al., 'Both Dietary Protein and Fat Increase Postprandial Glucose Excursions in Children With Type 1 Diabetes, and the Effect Is Additive', DIABETES CARE, 36 3897-3902 (2013) [C1]
DOI 10.2337/dc13-1195
Citations Scopus - 9Web of Science - 7
Co-authors Bruce King
2012 Smart CE, King BR, McElduff P, Collins CE, 'In children using intensive insulin therapy, a 20-g variation in carbohydrate amount significantly impacts on postprandial glycaemia', Diabetic Medicine, 29 E21-E24 (2012) [C1]
Citations Scopus - 8Web of Science - 5
Co-authors Clare Collins, Bruce King
2012 Bandara DMWS, King BR, Howard NJ, Verge CF, Jack MM, Govind N, et al., 'A diabetes awareness campaign prevents diabetic ketoacidosis in children at their initial presentation with type 1 diabetes', Pediatric Diabetes, 13 647-651 (2012) [C1]
Citations Scopus - 13Web of Science - 15
Co-authors Bruce King
2011 King BR, Goss PW, Paterson MA, Crock PA, Anderson DG, 'Hitting the dartboard from 40,000 feet: A better chance with your eyes open!', Diabetes Technology & Therapeutics, 13 1075-1076 (2011) [C3]
Co-authors Bruce King
2011 King BR, Goss PW, Paterson MA, Crock PA, Anderson DG, 'Changes in altitude cause unintended insulin delivery from insulin pumps', Diabetes Care, 34 1932-1933 (2011) [C3]
DOI 10.2337/dc11-0139
Citations Scopus - 12Web of Science - 8
Co-authors Bruce King
2010 Smart CE, Ross K, Edge JA, King BR, McElduff P, Collins CE, 'Can children with Type 1 diabetes and their caregivers estimate the carbohydrate content of meals and snacks?', Diabetic Medicine, 27 348-353 (2010) [C1]
DOI 10.1111/j.1464-5491.2010.02945.x
Citations Scopus - 16Web of Science - 11
Co-authors Bruce King, Clare Collins
2009 Smart CE, Ross K, Edge JA, Collins CE, Colyvas KJ, King BR, 'Children and adolescents on intensive insulin therapy maintain postprandial glycaemic control without precise carbohydrate counting', Diabetic Medicine, 26 279-285 (2009) [C1]
DOI 10.1111/j.1464-5491.2009.02669.x
Citations Scopus - 22Web of Science - 14
Co-authors Bruce King, Clare Collins, Kim Colyvas
2008 Ryan RL, King BR, Anderson DG, Attia JR, Collins CE, Smart CE, 'Influence of and optimal insulin therapy for a low-glycemic index meal in children with type 1 diabetes receiving intensive insulin therapy', Diabetes Care, 31 1485-1490 (2008) [C1]
DOI 10.2337/dc08-0331
Citations Scopus - 11Web of Science - 7
Co-authors Clare Collins, Bruce King, John Attia
2007 King BR, Nicholson RC, 'Advances in understanding corticotrophin-releasing hormone gene expression', Frontiers in Bioscience, 12 581-590 (2007) [C1]
DOI 10.2741/2084
Citations Scopus - 17Web of Science - 17
Co-authors Bruce King
2006 Shipman KL, Robinson PJ, King BR, Smith R, Nicholson RC, 'Identification of a family of DNA-binding proteins with homology to RNA splicing factors', Biochemistry and Cell Biology-Biochimie Et Biologie Cellulaire, 84 9-19 (2006) [C1]
DOI 10.1139/o05-139
Citations Scopus - 3Web of Science - 3
Co-authors Roger Smith, Bruce King
2004 Ni X, Hou Y, King BR, Tang X, Read MA, Smith R, Nicholson RC, 'Estrogen Receptor-Mediated Down-Regulation of Corticotropin-Releasing Hormone Gene Expression Is Dependant on a Cyclic Adenosine 3', 5'-Monophosphate Syncytiotrophoblast Cells', The Journal of Clinical Endocrinology & Metabolism, 89 2312-2318 (2004) [C1]
DOI 10.1210/jc.2003-030948
Citations Scopus - 28Web of Science - 27
Co-authors Bruce King, Roger Smith
2004 Smith CJ, Crock PA, King BR, Meldrum CJ, Scott R, 'Phenotype-Genotype Correlations in a Series of Wolfram Syndrome Families', Diabetes Care, 27 2003-2009 (2004) [C1]
DOI 10.2337/diacare.27.8.2003
Citations Scopus - 42Web of Science - 36
Co-authors Rodney Scott, Bruce King
2004 Nicholson RC, King BR, Smith R, 'Complex Regulatory Interactions Control CRH Gene Expression', Frontiers in Bioscience, 9 32-39 (2004) [C1]
DOI 10.2741/1204
Citations Scopus - 36Web of Science - 33
Co-authors Bruce King, Roger Smith
2002 Ni X, Nicholson RC, King B, Chan EC, Read M, Smith R, 'Estrogen Represses whereas the Estrogen-Antagonist ICI 182780 Stimulates Placental CRH Gene Expression', Journal of Clinical Endocrinology and Metabolism, 87(8) 3774-3778 (2002) [C1]
Citations Scopus - 38Web of Science - 33
Co-authors Bruce King, Roger Smith
2002 King B, Smith R, Nicholson RC, 'Novel glucocorticoid and cAMP interactions on the CRH gene promoter', Molecular and Cellular Endocrinology, 194 19-28 (2002) [C1]
Citations Scopus - 58Web of Science - 51
Co-authors Roger Smith, Bruce King
2001 King BR, Smith R, Nicholson RC, 'The regulation of human corticotrophin-releasing hormone gene expression in the placenta (vol 22, pg 795, 2001)', PEPTIDES, 22 1939-+ (2001)
DOI 10.1016/S0196-9781(01)00485-5
Co-authors Roger Smith, Bruce King
2001 King BR, Smith R, Nicholson RC, 'The regulation of human corticotrophin-releasing hormone gene expression in the placenta.', Peptides, 22 1941-1947 (2001)

Corticotrophin-releasing hormone (CRH) is a 41 amino acid neuropeptide that is expressed in the hypothalamus and the human placenta. Placental CRH production has been linked to th... [more]

Corticotrophin-releasing hormone (CRH) is a 41 amino acid neuropeptide that is expressed in the hypothalamus and the human placenta. Placental CRH production has been linked to the determination of gestational length in the human. Although encoded by a single copy gene, CRH expression in the placenta is regulated differently to the hypothalamus. Glucocorticoids stimulate CRH promoter activity in the placenta but inhibit it's activity in the hypothalamus, via mechanisms involving different regions of the CRH promoter. We discuss how various stimuli alter CRH promoter activity and why these responses are unique to the placenta.

DOI 10.1016/S0196-9781(01)00486-7
Citations Scopus - 9
Co-authors Bruce King, Roger Smith
2001 King BR, Smith R, Nicholson RC, 'The regulation of human corticotrophin-releasing hormone gene expression in the placenta', Peptides, 22 795-801 (2001) [C1]
Citations Scopus - 32Web of Science - 12
Co-authors Bruce King, Roger Smith
2001 Nicholson RC, King BR, 'Regulation of CRH gene expression in the placenta', ENDOCRINOLOGY OF PARTURITION: BASIC SCIENCE AND CLINICAL APPLICATION, 27 246-257 (2001)
Citations Web of Science - 6
Co-authors Bruce King
2001 King BR, Nicholson RC, Smith R, 'Placental Corticotrophin-releasing Hormone, Local Effects and Fetomaternal Endocrinology', Stress: the international journal on the biology of stress, 4 219-233 (2001) [C3]
Citations Scopus - 10
Co-authors Roger Smith, Bruce King
2000 Cheng Y, Nicholson RC, King BR, Chan EC, Fitter JT, Smith R, 'Corticotropin-Releasing Hormone Gene Expresssion in Primary Placental Cells is Modulated by Cyclic Adenosine 3',5'-Monophosphate', The Journal of Clinical Endocrinology & Metabolism, 85 1239-1244 (2000) [C1]
Citations Scopus - 33Web of Science - 34
Co-authors Bruce King, John Fitter, Roger Smith
2000 Cheng Y, Nicholson RC, King BR, Chan EC, Fitter JT, Smith R, 'Glucocorticoid stimulation of Corticiotrophin-releasing hormone gene expression requires a Cyclic Adenosine 3',5'-Monophosphate regulatory element in human primary Placental Cytotrophoblast Cells', The journal of Clinical Endocrinology And Metabolism, 85 (2000) [C1]
Citations Scopus - 62Web of Science - 56
Co-authors Bruce King, Roger Smith, John Fitter
Show 21 more journal articles

Conference (7 outputs)

Year Citation Altmetrics Link
2014 Carrasco DS, Fu Y, Goodwin GC, King BR, Medioli AM, 'Performance limitations arising in closed loop control of blood glucose in type 1 diabetes', IFAC Proceedings Volumes (IFAC-PapersOnline) (2014) [E1]

This paper presents a preliminary study of performance limitations that arise in the closed-loop control of blood glucose, using an autonomous artificial pancreas. It is shown tha... [more]

This paper presents a preliminary study of performance limitations that arise in the closed-loop control of blood glucose, using an autonomous artificial pancreas. It is shown that a major source of limitations is due to model uncertainty, specifically due to the combined effect of the insulin infusion system (IIS), the continuous glucose monitor (CGM) and the human glucose regulatory system. It is argued that the uncertainty associated with each of these elements compromises the achievable closed-loop bandwidth, and, in the presence of disturbances, e.g. meal intake and exercise, the closed-loop response will necessarily be poor. A proposition to overcome this problem is given based on feedforward action.

Co-authors Bruce King, Graham Goodwin
2013 O'Connell SM, Smart CE, Evans M, McElduff P, Lopez PE, Jones TW, et al., 'Both Protein and Fat Increase Postprandial Glucose Excursions in Children with Type 1 Diabetes and the Effect is Additive', IRISH JOURNAL OF MEDICAL SCIENCE (2013) [E3]
Co-authors Bruce King
2013 Lopez P, King BR, Chockalingham G, Goss P, 'CHANGES IN TEMPERATURE AND PRESSURE BUT NOT VIBRATION CAUSE BUBBLE FORMATION IN INSULIN PUMP CARTRIDGES AND TUBING', DIABETES TECHNOLOGY & THERAPEUTICS (2013) [E3]
Co-authors Bruce King
2009 Smart CE, Ross K, Edge J, Collins CE, King BR, 'Can children with Type 1 diabetes and their caregivers count carbohydrate accurately?', APEG Annual Scientific Meeting 2009. Abstracts, Coolum, QLD (2009) [E3]
Co-authors Clare Collins, Bruce King
2008 Smart CE, Ross K, King BR, Edge JA, 'Can children with Type 1 diabetes and their carers count carbohydrate accurately?', 68th Scientific Session of the American Diabetes Association: Abstracts, San Francisco, CA (2008) [E3]
Co-authors Bruce King
2006 King BR, Smith R, Nicholson RC, 'cAMP regulates CRH gene expression through a multi-element response unit', Endocrine Journal-Continuation of Endocrinologia Japonica, Queensland, Australia (2006) [E3]
Co-authors Bruce King, Roger Smith
2005 King BR, Edwards (Ext) M, Smith R, Scheffer I, 'Doublecortin gene defects. Are they a cause of pseudopseudohypoparathyrodisim?', Hormone Research, Lyon, France (2005) [E3]
Co-authors Bruce King, Roger Smith
Show 4 more conferences
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Grants and Funding

Summary

Number of grants 14
Total funding $933,161

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $150,000

Evaluation of an Australian artificial pancreas algorithm for announced and unannounced meals$150,000

Funding body: Diabetes Australia

Funding body Diabetes Australia
Project Team Conjoint Associate Professor Bruce King
Scheme Millennium Award
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1401382
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

20144 grants / $171,419

The prediction and prevention of hypoglycaemia using insulin suspension in a randomised controlled trial$63,118

Funding body: Juvenile Diabetes Research Foundation

Funding body Juvenile Diabetes Research Foundation
Project Team Conjoint Associate Professor Bruce King, Associate Professor Timothy Jones, Dr Elizabeth Davis, Dr Jan Fairchild, Professor Fergus Cameron, Professor Geoffrey Ambler
Scheme Clinical Research Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400994
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

A comparison of three insulin dosage algorithms for meals of variable macronutrient composition on postprandial glucose levels in children with type 1 diabetes$55,264

Funding body: Australian Paediatric Endocrine Group

Funding body Australian Paediatric Endocrine Group
Project Team Doctor Carmel Smart, Conjoint Associate Professor Bruce King
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301296
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

What is the optimal percentage of rapid and extended bolus insulin in a combination insulin bolus?$48,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Miss Prudence Lopez, Conjoint Associate Professor Bruce King, Doctor Carmel Smart
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1400137
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

JDRF Travel Grant Award - American Diabetes Association in June in San Francisco$5,037

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Ms Megan Paterson-Dick, Conjoint Associate Professor Bruce King, Doctor Carmel Smart, Miss Prudence Lopez
Scheme Research Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1401497
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20132 grants / $72,795

AdDIT Study$62,795

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Associate Professor Bruce King
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300204
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

What is the impact of meals of varying fat and protein content on postprandial blood glucose level in children and young people with type 1 diabetes mellitus$10,000

Funding body: Novo Nordisk Foundation

Funding body Novo Nordisk Foundation
Project Team Conjoint Associate Professor Bruce King, Dr Prudence Lopez, Mrs Carmel Smart
Scheme Regional Diabetes Support Scheme
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300522
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20123 grants / $313,942

The development of an algorithm for meals using a closed-loop insulin pump - Fellowship$159,999

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Associate Professor Bruce King
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200431
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

The Gastronomic Lunch of the Year Fellowship$100,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Associate Professor Bruce King, Dr Prudence Lopez, Doctor Carmel Smart, Dr Clare Morbey
Scheme Research Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1201044
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

A double blind cross over trial in young insulin pump users comparing their glucose control when their insulin pump settings have been set from continuous glucose sensing data interpreted by a new com$53,943

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Doctor Donald Anderson, Conjoint Associate Professor Bruce King, Conjoint Associate Professor Patricia Crock, Ms Helen Phelan
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1101172
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20111 grants / $19,500

How do high protein and/or high fat meals affect postprandial glycaemic control in children and adolescents using intensive insulin therapy?$19,500

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Professor Clare Collins, Mrs Carmel Smart, Conjoint Associate Professor Bruce King, Doctor Patrick McElduff
Scheme Research Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1001010
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20081 grants / $20,000

In children with type 1Diabetes on intensive insulin therapy, can improving carbohydrate knowledge and targeted nutrition education strategies improve diabetes management?$20,000

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Professor Clare Collins, Conjoint Associate Professor Bruce King
Scheme Research Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188484
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20061 grants / $15,000

Identification of proteins that interact with the multifunctional protein, CREAP$15,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Conjoint Associate Professor Rick Nicholson, Conjoint Associate Professor Bruce King
Scheme Research Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186557
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20001 grants / $170,505

Characterisation of Pituitary Target Autoantigens.$170,505

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Patricia Crock, Professor Rodney Scott, Conjoint Associate Professor Bruce King
Scheme Project Grant
Role Investigator
Funding Start 2000
Funding Finish 2000
GNo G0178451
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y
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Research Supervision

Current Supervision

Commenced Research Title / Program / Supervisor Type
2013 Impact of Dietary Protein on Postprandial Blood Glucose Levels in Type 1 Diabetes Mellitus
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2012 Development of an Insulin Delivery Algorithm for Management of Meals for Type 1 Diabetes Mellitus in Children
Paediatrics, Faculty of Health and Medicine
Principal Supervisor

Past Supervision

Year Research Title / Program / Supervisor Type
2012 Optimising Nutrition Interventions to Improve Postprandial Glycaemia for Children and Adolescents Using Intensive Insulin Therapy
Nutrition & Dietetics, Faculty of Health and Medicine
Co-Supervisor
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Conjoint Associate Professor Bruce King

Position

Conjoint Associate Professor
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email b.king@newcastle.edu.au

Office

Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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