Professor Alan Brichta

Professor Alan Brichta

Professor

School of Biomedical Sciences and Pharmacy (Anatomy)

Alan Brichta

Professor Alan Brichta's primary research interest is balance and the vestibular system.  His most recent NHMRC-funded research has focused on the efferent branch of the vestibular system – the pathway by which the brain can modulate inner ear sensitivity. 

Professor Alan Brichta 

Despite fifty years of ongoing research, the functional purpose of the efferent vestibular system still remains a mystery – most likely due to its inherently complex mechanisms of action. To combat this, Alan has developed a semi-intact model of the vestibular system, which allows for faithful, high-resolution recordings of hair cell function.  This recording technique has provided new information about the efferent vestibular system, with particular regards to the novel alpha-9 nicotinic receptor.

Alan has ongoing collaborations with vestibular experts Dr Americo Migliaccio (Neuroscience Research Australia; NeuRA), Dr Joseph Holt (University of Rochester, USA) and Dr Richard Rabbitt (University of Utah, USA), as well as HMRI neuroscientists Professor Bob Callister and Dr Doug Smith.  He is also closely affiliated with the Garnett Passe and Rodney Williams Memorial Foundation (GPRWMF), and the Neuro-Otology Society of Australia (NOTSA).  Alan is currently the Head of Discipline (Anatomy), supervises multiple PhD students, and teaches into a number of programs including Bachelor of Medicine and Bachelor of Biomedical Science.

What intrigues you most about the vestibular system?

I know it may sound a little strange but almost from the moment I learned about the vestibular system, I've been fascinated and intrigued by the subtle and mysterious way it works to provide us with a sense of balance.

The vestibular system allows us go about our daily activities, correcting almost every move we make, so that we don't fall over. And it does this with little or no fanfare or even very much recognition. The vestibular system is neither blatant nor does it intrude on our consciousness with the flamboyance of primary senses such as vision and hearing. If the vestibular system is doing its job properly it is almost imperceptible, working away with exquisite precision, speed, and accuracy. Perhaps it is precisely this 'backstage activity' that is responsible for our general lack of awareness and why we know so much less about this system in comparison to its close cousin, the hearing or auditory system. In short, the more I get to know the vestibular system the more I am in awe of the 'no nonsense' way in which it influences almost all aspects of our lives, making it the 'quiet achiever', or dare I say, the unsung hero or heroine of the central nervous system.

Alan Brichta

Professor Alan Brichta's primary research interest is balance and the vestibular system. His recent research has focused on the efferent branch of the vestibu

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Career Summary

Biography

Alan Brichta is a neurobiologist with research interests in the anatomy and physiology of peripheral and central vestibular system. In particular, his studies have focused on vestibular hair cells and their associated primary afferents and has recently developed an isolated preparation of the mouse inner ear to study these unusual cellular components. This approach allows stable, high-resolution, intracellular recordings whilst the tissue undergoes near 'natural' (mechanical), rather than artificial (electrical) stimulation. Results from these studies are helping us understand the cellular mechanisms underlying normal and abnormal function associated with the peripheral vestibular apparatus. In addition, Dr. Brichta is studying vestibular nucleus neurons in the brainstem that are the major recipients of transmitted vestibular organ output. These regions are thought to be highly modifiable and may prove to be ideal targets for rational therapeutic strategies aimed at treating balance disorders. Dr. Brichta was awarded a prestigious five year Garnett Passe and Rodney Williams Memorial Foundation Senior/Principal Research Fellowship.

Research Expertise
Vestibular electrophysiological and anatomical techniques, including whole-cell patch-clamp recordings together with intracellular labelling and immunohistochemistry. Experience with in vivo and in vitro preparations. Awarded major nationally competitive grants: Continually funded NHMRC Project Grants; Garnett Passe and Rodney Williams Memorial Foundation Senior / Principal Research Fellowship 2008 - 2013;

Teaching Expertise
Teaching expertise in anatomy, neuroanatomy, and neurosicence. Major reorganisation of core anatomy courses to B. Medicine, B. Biomed Sci, B. Health Sciences, including Medical Radiation Science, Physiotherapy, Oral Health, and B. Speech Pathology. Developed three new specialist subjects: Oral Health, Speech Pathology, and Neural Visceral Anatomy. Re-designed second semester Neuroanatomy block for Medicine. Course co-ordinator for first semester MEDI 2012 Medical Sciences. Attended U Queensland The teaching of anatomical sciences into health professions Seminar. Hosted the Universitys first US Fulbright Scholar. Organised teaching in new Anatomy facility - Medical Sciences West.

Administrative Expertise
Former member of Academic Senate and Faculty Board during a period of major change in teaching and learning at the University. Attracted significant equipment funding to the EM /X-Ray Unit by successfully applying for ARC-LEIF grant. Submission of Anatomy discipline Roadmap for Medical School Accreditation Committee. Contributed to the development of the new Bachelor of Podiatry Program. Provided Biomedical Science input with regard to course provisions and assessment of background course pre-requisites. Member of Faculty Library Committee during a difficult fiscal period that resulted in significant cuts in printed journal subscriptions. Member of NHMRC Grant Review Panel. External Ph.D. Examiner of Ph.D candidates.

Collaborations
In addition to his own studies on the vestibular system, Dr. Brichta has had a long-term collaboration with his good friend and colleague, Dr. Bob Callister. Together they have had over thirty years of collaborative efforts on sensory and motors systems.

Qualifications

  • PhD, Ohio University - USA
  • Bachelor of Science (Anatomy), University of New South Wales

Keywords

  • Anatomy
  • Electrophysiology
  • Neuroscience
  • Spinal Cord
  • Vestibular system

Fields of Research

Code Description Percentage
110903 Central Nervous System 30
110905 Peripheral Nervous System 20
110906 Sensory Systems 50

Professional Experience

UON Appointment

Title Organisation / Department
Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/07/2008 - 1/06/2013 Senior/Principal Research Fellowship

Garnett Passe and Rodney Williams Memorial Foundation

University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/07/2007 - 31/12/2014 A/Prof. University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/11/1998 - 1/12/2000 Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/07/1995 - 1/10/1998 Assistant Professor University of Chicago, Chicago, Illinois
Physiological and Pharmacological Sciences
United States

Membership

Dates Title Organisation / Department
1/01/2014 -  Membership - ARO International Committee ARO International Committee
Australia
1/01/2014 -  Membership - NHMRC Assigners Academy Committee NHMRC Committee
Australia
1/01/2011 - 31/12/2013 Membership - NHMRC Committee NHMRC (National Health & Medical Research Council)

Invitations

Participant

Year Title / Rationale
2012 A Question of Balance: The best-laid schemes o' mice an' men
Organisation: The Royal Society of Medicine, London Description: Much of what we have learned about the human body has come not from direct observations but has been inferred from animal studies. Fortunately, as we have learned from the human and other genome projects, we are almost genetically identical to chimpanzees and remarkably similar to mice. Sequencing of the mouse genome for example, completed in late 2002, estimates a gene count of 23,786 and for comparison, humans are estimated to have 23,686 genes – a hundred fewer! Therefore, it can be argued that what we learn in mice is applicable to humans. This assertion is most likely true when it comes to ancient and evolutionarily conservative sensory systems such as the peripheral vestibular system. To date, however, its residence deep within the hardest bone of the skull (making it neither easy to access nor convenient to manipulate) has hampered our study of the vestibular organs of the inner ear. To overcome this significant technical obstacle we have developed a surgically isolated inner ear of the mouse. This preparation allows us unprecedented access to the workings of the organs of balance. Indeed, using our isolated in vitro preparation and altering the volume of inner ear fluid by only a few nano-litres we have observed anomalous neuronal activity that may contribute to the symptoms of Meniere’s disease. By stripping the isolated inner ear preparation still further, (like layers in an onion) but carefully preserving the important and unique micro-architectural features of the individual organs, we have discovered a novel way in which the important motion detectors of the vestibular system (hair cells) communicate with their closely associated nerve afferent nerves. These results would have been difficult if not impossible to obtain without semi-intact preparations of vestibular organs. Despite these notable advances one must acknowledge that these results are from a very small mammal that weighs four orders of magnitude less than an adult human (7 grams vs. 70 kilograms). Therefore, are any of these findings relevant to humans? To address this fundamental issue we have begun to isolate viable inner ears from post-mortem human foetal tissue (10 to 18 weeks gestation). This means we can now apply some of the techniques we have learned using mice to in vitro human vestibular tissue. The preliminary results are promising. We are able to record activity from foetal hair cells and nerve terminals up to 8 hours after the tissue arrives in the laboratory. Our data suggest the human peripheral vestibular system is fully functional midway through the second trimester and indeed resembles a 3 week old, fully weaned, postnatal mouse. Taken together, these various approaches provide us with new insights into basic machinery of the peripheral balance organs in humans. Our ultimate goal is to have the findings from these animal and foetal models translated into targeted clinical therapeutics. For example, due to pathological increases in endolymph volume, we believe the membranous labyrinth is distended causing abnormal and confusing signals to the brain. Alleviating these volume changes by pharmacological and/or surgical intervention would eliminate distensions and accompanying vertiginous attacks. Similarly, based on our new understanding of the key role potassium plays in vestibular organ function, particularly between hair cells and primary afferents, suggests this ion is tightly regulated to ensure normal balance function. Thus a focus on restoration and maintenance of potassium in the inner ear would be a clinical requirement. In short, our continued hope is that better basic understanding leads to targeted diagnostic and therapeutic strategies for treating the debilitating effects of balance disorders.
2006 Developments in isolated inner ear preparations
Organisation: Garnett Passe and Rodney Williams Foundation Description: Inivited speaker
2002 Transduction in vestibular sense organs
Organisation: The Australian Health and Medical Research Congress Description: Inivited speaker
2001 Vestibular Influences on Movement
Organisation: International B¿r¿ny Society Description: Inivited Speaker

Speaker

Year Title / Rationale
2010 The unusual calyx terminals of the inner ear
Organisation: Barany Society Meeting
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (7 outputs)

Year Citation Altmetrics Link
2015 Lim R, Wellings TP, Brichta AM, 'Central Vestibular Signal Processing', Encyclopedia of Computational Neuroscience, Springer Verlag, Heidelberg Germany (2015)
DOI 10.1007/978-1-4614-7320-6
Co-authors Rebecca Lim
2015 Wellings TP, Brichta AM, Lim R, 'Vestibular Adaptation and Compensation', Encyclopedia of Computational Neuroscience, Springer Verlag, Heidelberg Germany (2015)
DOI 10.1007/SpringerReference_348071
Co-authors Rebecca Lim
2012 Lim R, Brichta AM, 'Vestibular system', The Mouse Nervous System, Academic Press, San Diego 661-678 (2012) [B1]
Co-authors Rebecca Lim
2001 Stuart DG, Pierce PA, Callister RJ, Brichta AM, McDonagh JC, 'Sir Charles Sherrington: Humanist, Mentor, and Movement Neuroscientist', Classics in Movement Science, Human Kinetics, U.S.A. 317-374 (2001) [B2]
Co-authors Robert Callister
2000 Goldberg J, Brichta AM, Wackym P, 'Efferent Vestibular System: Anatomy, Physiology, and Neurochemistry', Neurochemistry of the Vestibular System, CRC Press, Washington, D.C., U.S.A. 411 (2000) [B1]
1999 McDonagh J, Callister RJ, Brichta AM, Stuart D, 'A commentary on the properties of spinal interneurons vs. motoneurons in vertebrates and their firing-rate behaviour during movement', Motor Control: Today and Tomorrow, Academic Publishing House "Prof.Marin Drinov", Sofia, Bulgaria 3-29 (1999) [B1]
Co-authors Robert Callister
1985 Brichta AM, Grant G, 'Cytoarchitectural organisation of the spinal cord', The Rat Nervous System, Volume 2, Academic Press, Sydney 293-302 (1985)
Show 4 more chapters

Journal article (48 outputs)

Year Citation Altmetrics Link
2014 Tadros MA, Farrell KE, Schofield PR, Brichta AM, Graham BA, Fuglevand AJ, Callister RJ, 'Intrinsic and synaptic homeostatic plasticity in motoneurons from mice with glycine receptor mutations', Journal of Neurophysiology, 111 1487-1498 (2014) [C1]

Inhibitory synaptic inputs to hypoglossal motoneurons (HMs) are important for modulating excitability in brainstem circuits. Here we ask whether reduced inhibition, as occurs in t... [more]

Inhibitory synaptic inputs to hypoglossal motoneurons (HMs) are important for modulating excitability in brainstem circuits. Here we ask whether reduced inhibition, as occurs in three murine mutants with distinct naturally occurring mutations in the glycine receptor (GlyR), leads to intrinsic and/or synaptic homeostatic plasticity. Whole cell recordings were obtained from HMs in transverse brainstem slices from wild-type (wt), spasmodic (spd), spastic (spa), and oscillator (ot) mice (C57Bl/6, approximately postnatal day 21). Passive and action potential (AP) properties in spd and ot HMs were similar to wt. In contrast, spa HMs had lower input resistances, more depolarized resting membrane potentials, higher rheobase currents, smaller AP amplitudes, and slower afterhyperpolarization current decay times. The excitability of HMs, assessed by "gain" in injected current/firing-frequency plots, was similar in all strains whereas the incidence of rebound spiking was increased in spd. The difference between recruitment and derecruitment current (i.e., ¿I) for AP discharge during ramp current injection was more negative in spa and ot. GABAA miniature inhibitory postsynaptic current (mIPSC) amplitude was increased in spa and ot but not spd, suggesting diminished glycinergic drive leads to compensatory adjustments in the other major fast inhibitory synaptic transmitter system in these mutants. Overall, our data suggest long-term reduction in glycinergic drive to HMs results in changes in intrinsic and synaptic properties that are consistent with homeostatic plasticity in spa and ot but not in spd. We propose such plasticity is an attempt to stabilize HM output, which succeeds in spa but fails in ot. © 2014 the American Physiological Society.

DOI 10.1152/jn.00728.2013
Co-authors Brett Graham, Robert Callister
2014 Lim R, Drury HR, Tadros MA, Callister RJ, Brichta AM, Camp AJ, 'Preliminary Characterization of Voltage-Activated Whole-Cell Currents in Developing Human Vestibular Hair Cells and Calyx Afferent Terminals', Journal of the Association for Research in Otolaryngology, (2014) [C1]

We present preliminary functional data from human vestibular hair cells and primary afferent calyx terminals during fetal development. Whole-cell recordings were obtained from hai... [more]

We present preliminary functional data from human vestibular hair cells and primary afferent calyx terminals during fetal development. Whole-cell recordings were obtained from hair cells or calyx terminals in semi-intact cristae prepared from human fetuses aged between 11 and 18 weeks gestation (WG). During early fetal development (11-14 WG), hair cells expressed whole-cell conductances that were qualitatively similar but quantitatively smaller than those observed previously in mature rodent type II hair cells. As development progressed (15-18 WG), peak outward conductances increased in putative type II hair cells but did not reach amplitudes observed in adult human hair cells. Type I hair cells express a specific low-voltage activating conductance, G. A similar current was first observed at 15 WG but remained relatively small, even at 18 WG. The presence of a "collapsing" tail current indicates a maturing type I hair cell phenotype and suggests the presence of a surrounding calyx afferent terminal. We were also able to record from calyx afferent terminals in 15-18 WG cristae. In voltage clamp, these terminals exhibited fast inactivating inward as well as slower outward conductances, and in current clamp, discharged a single action potential during depolarizing steps. Together, these data suggest the major functional characteristics of type I and type II hair cells and calyx terminals are present by 18 WG. Our study also describes a new preparation for the functional investigation of key events that occur during maturation of human vestibular organs. © 2014 The Author(s).

DOI 10.1007/s10162-014-0471-y
Co-authors Robert Callister, Rebecca Lim
2013 Brichta AM, 'Dizzying Inspiration', International Innovation, 52-55 (2013)
2013 Tung VWK, Di Marco S, Lim R, Brichta AM, Camp AJ, 'An Isolated Semi-intact Preparation of the Mouse Vestibular Sensory Epithelium for Electrophysiology and High-resolution Two-photon Microscopy', Journal of Visualized Experiments, (2013) [C1]
DOI 10.3791/50471
Co-authors Rebecca Lim
2013 Hübner PP, Lim R, Brichta AM, Migliaccio AA, 'Glycine Receptor Deficiency and Its Effect on the Horizontal Vestibulo-ocular Reflex: a Study on the SPD1J Mouse', Journal of the Association for Research in Otolaryngology, 14 249-259 (2013) [C1]
DOI 10.1007/s10162-012-0368-6
Citations Scopus - 1Web of Science - 2
Co-authors Rebecca Lim
2012 Tadros MA, Harris B, Anderson WB, Brichta AM, Graham BA, Callister RJ, 'Are all spinal segments equal: Intrinsic membrane properties of superficial dorsal horn neurons in the developing and mature mouse spinal cord', Journal of Physiology, 590 2409-2425 (2012) [C1]
Citations Scopus - 6Web of Science - 6
Co-authors Robert Callister, Brett Graham
2012 De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Heterogeneous responses to antioxidants in noradrenergic neurons of the Locus coeruleus indicate differing susceptibility to free radical content', Oxidative Medicine and Cellular Longevity, 2012 820285 (2012) [C1]
Citations Scopus - 1Web of Science - 1
Co-authors Dirk Vanhelden, Rebecca Lim, Robert Callister
2011 De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Developmental changes in pacemaker currents in mouse locus coeruleus neurons', Brain Research, 1425 27-36 (2011) [C1]
Citations Scopus - 3Web of Science - 3
Co-authors Rebecca Lim, Dirk Vanhelden, Robert Callister
2011 Lim R, McPherson AE, Donne SW, Callister RJ, Brichta AM, 'Potassium accumulation between type I hair cells and calyx terminals in mouse crista', Experimental Brain Research, 210 607-621 (2011) [C1]
DOI 10.1007/s00221-011-2592-4
Citations Scopus - 17Web of Science - 19
Co-authors Scott Donne, Rebecca Lim, Robert Callister
2011 Flynn JR, Brichta AM, Galea MP, Callister RJ, Graham BA, 'A horizontal slice preparation for examining the functional connectivity of dorsal column fibres in mouse spinal cord', Journal of Neuroscience Methods, 200 113-120 (2011) [C1]
DOI 10.1016/j.jneumeth.2011.06.017
Citations Scopus - 6Web of Science - 5
Co-authors Brett Graham, Robert Callister
2010 Jobling P, Graham BA, Brichta AM, Callister RJ, 'Cervix stimulation evokes predominantly subthreshold synaptic responses in mouse thoracolumbar and lumbosacral superficial dorsal horn neurons', Journal of Sexual Medicine, 7 2068-2076 (2010) [C1]
DOI 10.1111/j.1743-6109.2010.01768.x
Citations Scopus - 4Web of Science - 4
Co-authors Phillip Jobling, Robert Callister, Brett Graham
2010 Lim R, Camp AJ, Walsh MA, Callister RJ, Brichta AM, 'In vitro whole-cell conductances recorded from developing human cristae.', J Vestib Res, 285-286 (2010)
Co-authors Robert Callister, Rebecca Lim
2010 Lim R, Stitt IM, Camp AJ, Walsh MA, Callister RJ, Brichta AM, 'Inhibitory synaptic transmission in the lateral vestibular nucleus.', J. Vestib. Res, 286-287 (2010)
Co-authors Rebecca Lim, Robert Callister
2010 Lim R, Callister RJ, Brichta AM, 'An increase in glycinergic quantal amplitude and frequency during early vestibular compensation in mouse', Journal of Neurophysiology, 103 16-24 (2010) [C1]
DOI 10.1152/jn.91223.2008
Citations Scopus - 9Web of Science - 6
Co-authors Rebecca Lim, Robert Callister
2010 De Oliveira R, Graham BA, Howlett MC, Gravina FS, Oliveira MW, Imtiaz MS, et al., 'Ketamine anesthesia helps preserve neuronal viability', Journal of Neuroscience Methods, 189 230-232 (2010) [C1]
DOI 10.1016/j.jneumeth.2010.03.029
Citations Scopus - 6Web of Science - 6
Co-authors Brett Graham, Rebecca Lim, Dirk Vanhelden, Robert Callister
2010 Camp AJ, Lim R, Anderson WB, Schofield PR, Callister RJ, Brichta AM, 'Attenuated glycine receptor function reduces excitability of mouse medial vestibular nucleus neurons', Neuroscience, 170 348-360 (2010) [C1]
DOI 10.1016/j.neuroscience.2010.06.040
Citations Scopus - 7Web of Science - 6
Co-authors Robert Callister, Rebecca Lim
2010 De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Pacemaker currents in mouse locus coeruleus neurons', Neuroscience, 170 166-177 (2010) [C1]
DOI 10.1016/j.neuroscience.2010.06.028
Citations Scopus - 9Web of Science - 8
Co-authors Robert Callister, Dirk Vanhelden
2009 Anderson WB, Graham BA, Beveridge NJ, Tooney PA, Brichta AM, Callister RJ, 'Different forms of glycine- and GABA(A)-receptor mediated inhibitory synaptic transmission in mouse superficial and deep dorsal horn neurons', Molecular Pain, 5 1-16 (2009) [C1]
DOI 10.1186/1744-8069-5-65
Citations Scopus - 8Web of Science - 7
Co-authors Paul Tooney, Robert Callister, Brett Graham
2009 Tadros MA, Graham BA, Brichta AM, Callister RJ, 'Evidence for a critical period in the development of excitability and potassium currents in mouse lumbar superficial dorsal horn neurons', Journal of Neurophysiology, 101 1800-1812 (2009) [C1]
DOI 10.1152/jn.90755.2008
Citations Scopus - 25Web of Science - 24
Co-authors Brett Graham, Robert Callister
2008 Graham BA, Brichta AM, Callister RJ, 'Recording temperature affects the excitability of mouse superficial dorsal horn neurons, in vitro', Journal of Neurophysiology, 99 2048-2059 (2008) [C1]
DOI 10.1152/jn.01176.2007
Citations Scopus - 19Web of Science - 20
Co-authors Brett Graham, Robert Callister
2007 Graham BA, Brichta AM, Callister RJ, 'Moving from an averaged to specific view of spinal cord pain processing circuits', Journal of Neurophysiology, 98 1057-1063 (2007) [C1]
DOI 10.1152/jn.00581.2007
Citations Scopus - 58Web of Science - 52
Co-authors Robert Callister, Brett Graham
2007 Graham BA, Brichta AM, Callister RJ, 'Pinch-current injection defines two discharge profiles in mouse superficial dorsal horn neurones, in vitro', Journal of Physiology, 578 787-798 (2007) [C1]
DOI 10.1113/jphysiol.2006.123349
Citations Scopus - 19Web of Science - 18
Co-authors Robert Callister, Brett Graham
2007 Graham BA, Brichta AM, Schofield PR, Callister RJ, 'Altered potassium channel function in the superficial dorsal horn of the spastic mouse', Journal of Physiology, 584 121-136 (2007) [C1]
DOI 10.1113/jphysiol.2007.138198
Citations Scopus - 19Web of Science - 16
Co-authors Robert Callister, Brett Graham
2006 Holt JC, Xue J-T, Brichta AM, Goldberg JM, 'Transmission between type II hair cells and bouton afferents in the turtle posterior crista', Journal of Neurophysiology, 95 428-452 (2006) [C1]
DOI 10.1152/jn.00447.2005
Citations Scopus - 23Web of Science - 20
2006 Camp AJ, Callister RJ, Brichta AM, 'Inhibitory synaptic transmission differs in mouse type A and B medial vestibular nucleus neurons in vitro', Journal of Neurophysiology, 95 3208-3218 (2006) [C1]
DOI 10.1152/jn.01001.2005
Citations Scopus - 31Web of Science - 29
Co-authors Robert Callister
2004 Graham BA, Brichta AM, Callister RJ, 'In vivo responses of mouse superficial dorsal horn neurones to both current injection and peripheral cutaneous stimulation', Journal of Physiology, 561.3 749-763 (2004) [C1]
DOI 10.1113/jphysiol.2004.072645
Citations Scopus - 42Web of Science - 39
Co-authors Brett Graham, Robert Callister
2004 Graham BA, Brichta AM, Callister RJ, 'An in vivo mouse spinal cord preparation for patch-clamp analysis of nociceptive processing', Journal of Neuroscience Methods, 136 221-228 (2004) [C1]
DOI 10.1016/j.jneumeth.2004.01.014
Citations Scopus - 16Web of Science - 14
Co-authors Robert Callister, Brett Graham
2002 Goldberg JM, Brichta AM, 'Functional Analysis of Whole Cell Currents From Hair Cells of the Turtle Posterior Crista', Journal of Neurophysiology, 88 3279-3292 (2002)
DOI 10.1152/jn.00771.2001
2002 Brichta AM, Aubert A, Eatock RA, Goldberg JM, 'Regional analysis of whole-cell currents from hair cells of the turtle posterior crista', Journal of Neurophysiology, 88 3259-3278 (2002) [C1]
Citations Scopus - 38
2002 Camp AJ, Lee H, Callister RJ, Brichta AM, 'Afferent responses to mechanical stimulation and drug application in mouse in-vitro labyrinth', Journal of Vestibular Research, 11 175 (2002) [C3]
Co-authors Robert Callister
2002 Brichta AM, Camp AJ, Lee H, Callister RJ, 'Intra-axonal recordings from canal afferents in the mouse in-vitro labyrinth', Journal of Vestibular Research, 11 177-178 (2002) [C3]
Co-authors Robert Callister
2001 Lee H-Y, Callister RJ, Brichta AM, 'Morphophysiology of Vestibular Afferents Recorded from an In Vitro Preparation of the Mouse Inner Ear', Abstracts of the Twenty-Fourth Annual Midwinter Research Meeting of the Association for Research in Otolaryngology, 0 124 (2001) [C3]
Co-authors Robert Callister
2001 Lee H-Y, Callister RJ, Brichta AM, 'Physiology of Labelled Vestibular Afferents Recorded from an In Vitro Preparation of the Mouse Inner Ear', Proceedings of the Australian Neuroscience Society, 12 217 (2001) [C3]
Co-authors Robert Callister
2000 Brichta AM, Goldberg J, 'Morphological Identification of Physiologically Characterized Afferents Innervating the Turtle Posterior Crista', Journal of Neurophysiology, 83 No. 3 1202-1223 (2000) [C1]
Citations Scopus - 36
2000 Brichta AM, Goldberg J, 'Responses to Efferent Activation and Excitatory Response-Intensity Relations of Turtle Posterior-Crista Afferents', Journal of Neurophysiology, 83 No. 3 1224-1242 (2000) [C1]
Citations Scopus - 40
2000 Won Y-S, Brichta AM, Baroody F, Boonlayangoor S, Naclerio R, 'Bactrim reduces the inflammatory response in a murine model of acute rhinosinusitis', Rhinology, 38 68-71 (2000) [C1]
Citations Scopus - 6
2000 Dailey SH, Wackym PA, Brichta AM, Gannon PJ, Popper P, 'Topographic distribution of nicotinic acetylcholine receptors in the cristae of a turtle', Hearing Research, 141 51-56 (2000)
DOI 10.1016/S0378-5955(99)00208-7
1999 Basile A, Brichta AM, Harris B, Morse D, Coling D, Skolnick P, 'Dizocilpine attenuates streptomycin-induced vestibulotoxicity in rats', Neuroscience Letters, 265 71-74 (1999) [C1]
1999 Callister RJ, Peterson E, Brichta AM, 'Neuromuscular strategies underlying ballistic movements', Progress in Brain Research, 123 233-243 (1999) [C1]
Citations Scopus - 2Web of Science - 2
Co-authors Robert Callister
1998 Bomer K, Brichta AM, Baroody F, Boonlayangoor S, Xiantang M, Naclerio RM, 'A Mouse Model of Acute Bacterial Rhinosinusitis', Archives of Otolaryngology¿Head & Neck Surgery, 124 1227-1232 (1998)
DOI 10.1001/archotol.124.11.1227
1998 Goldberg JM, Brichta AM, 'Evolutionary trends in the organization of the vertebrate crista ampullaris', Otolaryngology - Head and Neck Surgery, 165-171 (1998)
DOI 10.1016/S0194-5998(98)70051-8
1998 Brichta AM, Goldberg JM, 'The papilla neglecta of turtles: a detector of head rotations with unique sensory coding properties.', The Journal of Neuroscience, 18 4314-4324 (1998)
1996 BRICHTA AM, GOLDBERG JM, 'Afferent and Efferent Responses from Morphological Fiber Classes in the Turtle Posterior Crista', Annals of the New York Academy of Sciences, 781 183-195 (1996)
DOI 10.1111/j.1749-6632.1996.tb15701.x
1994 Brichta AM, Peterson EH, 'Functional architecture of vestibular primary afferents from the posterior semicircular canal of a turtle,Pseudemys (Trachemys) scripta elegans', The Journal of Comparative Neurology, 344 481-507 (1994)
DOI 10.1002/cne.903440402
1992 BRICHTA AM, PETERSON EH, 'Vestibular Afferents Innervating the Posterior Ampullae in a Turtle, Pseudemys scripta', Annals of the New York Academy of Sciences, 656 914-916 (1992)
DOI 10.1111/j.1749-6632.1992.tb25293.x
1988 Brichta AM, Acuna DL, Peterson EH, 'Planar Relations of Semicircular Canals in Awake, Resting Turtles, Pseudemys scripta', Brain, Behavior and Evolution, 32 236-245 (1988)
DOI 10.1159/000116551
1987 Brichta AM, Callister RJ, Peterson EH, 'Quantitative analysis of cervical musculature in rats: Histochemical composition and motor pool organization', J. Comp. Neurol, 255 351-368 (1987) [C1]
Citations Scopus - 33Web of Science - 43
Co-authors Robert Callister
1987 CALLISTER RJ, BRICHTA AM, PETERSON EH, 'QUANTITATIVE-ANALYSIS OF CERVICAL MUSCULATURE IN RATS - HISTOCHEMICAL COMPOSITION AND MOTOR POOL ORGANIZATION .2. DEEP DORSAL MUSCLES', JOURNAL OF COMPARATIVE NEUROLOGY, 255 369-385 (1987)
DOI 10.1002/cne.902550305
Citations Scopus - 24Web of Science - 34
Co-authors Robert Callister
Show 45 more journal articles

Conference (50 outputs)

Year Citation Altmetrics Link
2014 Lim R, Drury HR, Camp AJ, Tadros MA, Callister RJ, Brichta AM, 'Anatomical and physiological characterisation of human vestibular hair cells', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science, Buenos Aires, Argentina (2014) [E3]
Co-authors Rebecca Lim, Robert Callister
2014 Wellings TP, Graham BA, Camp AJ, Callister RJ, Brichta AM, Lim R, 'Calcium binding proteins subdivide medial vestibular nucleus neurons', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science, Buenos Aires, Argentina (2014) [E3]
DOI 10.3233/VES-140517
Co-authors Brett Graham, Robert Callister, Rebecca Lim
2014 Poppi LA, Tabatabaee H, Callister RJ, Lim R, Brichta AM, 'Cholinergic Activity of the Peripheral Efferent Vestibular System', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science, Buenos Aires, Argentina (2014) [E3]
DOI 10.3233/VES-140517
Co-authors Rebecca Lim, Robert Callister
2014 Khan SI, Hübner PP, Smith DW, Brichta AM, Migliaccio AA, 'Ageing reduces vestibulo-ocular reflex adaptation in mice J Vestib Res', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science (2014) [E3]
DOI 10.3233/VES-140517
Co-authors Douglas Smith
2013 Huebner PP, Lim R, Brichta AM, Migliaccio AA, 'Glycine Receptor Deficiency and Its Effect on the Vestibulo-Ocular Reflex: A Study on the SPD1J Mouse', 36th Association for Research in Otolaryngology, Baltimore, MD (2013) [E3]
Co-authors Rebecca Lim
2013 Poppi LA, Tabatabaee H, Callister RJ, Lim R, Brichta AM, 'From the ear to the brain, and back again ¿ the Efferent Vestibular System', 4th UWS Sensory Neuroscience Symposium, Sydney (2013) [E3]
Co-authors Rebecca Lim, Robert Callister
2013 Wellings TP, Brichta AM, Lim R, 'Revealing the functional organisation of central vestibular nuclei', Neuro-Otology Society of Australia, Melbourne (2013) [E3]
Co-authors Rebecca Lim
2013 Poppi LA, Tabatabaee H, Callister RJ, Lim R, Brichta AM, 'Efferent Vestibular System ¿ the mysterious part of the periphery', Neuro-Otology Society of Australia, Melbourne (2013) [E3]
Co-authors Rebecca Lim, Robert Callister
2013 Bigland M, Parkinson G, Brichta AM, Smith DW, 'Evidence for mitochondrial DNA deletions in vestibular hair cells of the aged rat', Proceedings of the Australian Neuroscience Society, Melbourne (2013) [E3]
Co-authors Douglas Smith
2013 Tadros MA, Fuglevand AJ, Brichta AM, Callister RJ, 'Electrophysiological properties of cranial and spinal motor neurons in mice', Proceedings of the Australian Neuroscience Society, Melbourne (2013) [E3]
Co-authors Robert Callister
2013 Drawitsch F, Rancz EA, Brichta AM, Canals SG, Margrie TW, 'Widespread representation of vestibular activity in the rodent brain.', Society for Neuroscience, San Diego, California, USA (2013) [E3]
2013 Wellings TP, Callister RJ, Graham BA, Brichta AM, Lim R, 'Sensing balance: the role of central vestibular nuclei', University of Western Sydney Medical School, University of Western Sydney (2013) [E3]
Co-authors Rebecca Lim, Brett Graham, Robert Callister
2012 Tadros MA, Lim R, Graham BA, Hughes DI, Brichta AM, Callister RJ, 'Excitability of human ventral horn neurons during early foetal development', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authors Robert Callister, Brett Graham, Rebecca Lim
2012 Lim R, Camp AJ, Tadros MA, Drury HR, Callister RJ, Brichta AM, 'Whole cell conductances of developing human hair cells', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authors Robert Callister, Rebecca Lim
2012 Stitt IM, Drury HR, Callister RJ, Brichta AM, Lim R, 'Anatomical and physiological characterization of mouse lateral vestibular nucleus neurons. 048', Association for Research in Otolaryngology, San Diego, California (2012)
Co-authors Robert Callister, Rebecca Lim
2012 Lim R, Camp AJ, Drury HR, Tadros MA, Callister RJ, Brichta AM, 'Characterisation of developing human hair cells', Association for Research in Otolaryngology, San Diego, California (2012)
Co-authors Robert Callister, Rebecca Lim
2012 Lim R, Stitt IM, Drury HR, Wellings TP, Callister RJ, Brichta AM, 'Electrophysiological characterization of mouse lateral vestibular nucleus neurons', Frontiers in Otolaryngology, Melbourne (2012)
Co-authors Rebecca Lim, Robert Callister
2012 Lim R, Callister RJ, Holt JC, Migliaccio AA, Brichta AM, 'Efferent modulation of peripheral vestibular organs', Neuro-Otology Society of Australia, Sydney (2012) [E3]
Co-authors Robert Callister, Rebecca Lim
2012 Lim R, Kindig AE, Callister RJ, Brichta AM, 'A special relationship between vestibular hair cells and afferent nerve terminals', Neuro-Otology Society of Australia, Sydney (2012) [E3]
Co-authors Rebecca Lim, Robert Callister
2012 Tadros MA, Jack R, Lim R, Graham BA, Brichta AM, Hughes DI, Callister RJ, 'Sensorimotor processing in the spinal cord of the developing human fetus', Society for Neuroscience, New Orleans, USA (2012)
Co-authors Brett Graham, Robert Callister, Rebecca Lim
2012 Rostas JAP, Skelding KA, Fleuchter L, Dickson PW, Spratt NJ, Brichta AM, 'CaMKII is differentially regulated in brain regions that exhibit differing sensitivities to ischemia and excitotoxicity', Society for Neuroscience, New Orleans, USA (2012)
2012 Lim R, Callister RJ, Brichta AM, 'The other part of the ear - a 'balanced' view', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Co-authors Robert Callister, Rebecca Lim
2011 Brichta AM, 'Understanding Signals from ¿Inner Space¿: recreating our sense of balance', Frontiers in Neuroengineering, UNSW, Sydney, Australia (2011)
2011 Tadros MA, Lim R, Graham BA, Hughes DI, Brichta AM, Callister RJ, 'Excitability of human ventral horn neurons during early foetal development', Poster Abstracts. Australian Neuroscience Society Annual Meeting, Auckland, NZ (2011) [E3]
Co-authors Rebecca Lim, Brett Graham, Robert Callister
2011 Graham BA, Sah P, Brichta AM, Callister RJ, Hughes DI, 'Neuroanatomical and neurochemical features of parvalbumin-expressing neurons in the mouse spinal dorsal horn', Posters. Australian Neuroscience Society 31st Annual Meeting, Auckland, New Zealand (2011) [E3]
Co-authors Brett Graham, Robert Callister
2011 Tynan RJ, Day TA, Brichta AM, Walker FR, 'Not Just Reuptake. Selective serotonin reuptake inhibitors attenuate LPS induced microglial pro-inflammatory cytokine production', Society of Neuroscience, Washington, D.C. (2011) [E3]
Co-authors Rohan Walker
2010 Lim R, Camp AJ, Walsh M, Callister RJ, Brichta AM, 'In-vitro whole-cell conductances recorded from developing human cristae', Journal of Vestibular Research, Reykavik, Iceland (2010) [E3]
Co-authors Rebecca Lim, Robert Callister
2010 Lim R, Stitt I, Camp AJ, Callister RJ, Brichta AM, 'Inhibitory synaptic transmission in the lateral vestibular nucleus', Journal of Vestibular Research, Reykavik, Iceland (2010) [E3]
Co-authors Robert Callister, Rebecca Lim
2010 Callister RJ, Walsh MA, Harris BM, Anderson WB, Brichta AM, Graham BA, 'Segmental and developmental differences in the excitability of mouse superficial dorsal horn neurons', 13th World Congress on Pain: Abstracts, Montreal, QC (2010) [E3]
Co-authors Brett Graham, Robert Callister
2010 Walsh MA, Farrell KE, Graham BA, Brichta AM, Callister RJ, 'Sodium current properties differ in neonate and adult superficial dorsal horn neurons', 13th World Congress on Pain: Abstracts, Montreal, QC (2010) [E3]
Co-authors Robert Callister, Brett Graham
2010 Harris BM, Graham BA, Bolton PS, Brichta AM, Callister RJ, 'Influence of acute neck muscle inflammation on the excitability of superficial dorsal horn neurons', 13th World Congress on Pain: Abstracts, Montreal, QC (2010) [E3]
Co-authors Philip Bolton, Brett Graham, Robert Callister
2010 Graham BA, Hughes DI, Lim R, Sah P, Brichta AM, Callister RJ, 'Characterization of calretinin expressing interneurons in the superficial dorsal horn of the mouse spinal cord', 13th World Congress on Pain: Abstracts, Montreal, QC (2010) [E3]
Co-authors Brett Graham, Robert Callister, Rebecca Lim
2009 De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Ion channel modulation by reactive species in mice locus coeruleus neurons', Journal of Physiological Sciences, Kyoto, Japan (2009) [E3]
Co-authors Robert Callister, Dirk Vanhelden
2009 De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Effect of antioxidants in pacemaking of mice locus coeruleus neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authors Robert Callister, Dirk Vanhelden
2009 Brichta AM, Lamont E, Lim R, Callister RJ, 'Vestibular effects of endolymphatic ionic and volume changes in an isolated preparation of a mouse labyrinth', Abstracts of the Thirty-Second Annual Midwinter Research Meeting Association for Research in Otolaryngology, Baltimore, MD (2009) [E3]
Co-authors Robert Callister, Rebecca Lim
2009 McPherson AE, Lim R, Callister RJ, Brichta AM, 'Voltage dependent currents in Type I and II hair cells and calyx terminals of primary afferents in an intact in vitro mouse vestibular crista preparation', Abstracts of the Thirty-Second Annual Midwinter Research Meeting Association for Research in Otolaryngology, Baltimore, MD (2009) [E3]
Co-authors Rebecca Lim, Robert Callister
2009 Lim R, Callister RJ, Brichta AM, 'Changes in glycinergic synaptic transmission and neuronal excitability in mouse medial vestibular nucleus neurons during early vestibular compensation', Abstracts of the Thirty-Second Annual Midwinter Research Meeting Association for Research in Otolaryngology, Baltimore, MD (2009) [E3]
Co-authors Rebecca Lim, Robert Callister
2009 Lim R, McPherson AE, Pow DV, Callister RJ, Brichta AM, 'Glutamate transport in the mouse inner ear is mediated by the excitatory amino acid transporter, EAAT5', Abstracts of the Thirty-Second Annual Midwinter Research Meeting Association for Research in Otolaryngology, Baltimore, MD (2009) [E3]
Co-authors Rebecca Lim, Robert Callister
2008 Jobling P, Graham BA, Brichta AM, Callister RJ, 'In vivo patch clamp recording of synaptic events evoked in superficial dorsal horn neurons after stimulation of the female reproductive tract in the mouse', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authors Phillip Jobling, Robert Callister, Brett Graham
2008 De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Influence of mitochondria in the interspike interval pacemaking currents of mice Locus Coeruleus neurons', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
Co-authors Dirk Vanhelden, Robert Callister
2008 Callister RJ, Brichta AM, Graham BA, 'Beyond the dorsal horn: The use of animal models to discover new sites for pain therapy', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
Co-authors Brett Graham, Robert Callister
2007 Camp AJ, Anderson WB, Callister RJ, Schofield PR, Brichta AM, 'Contribution of inhibitory synaptic transmission to the intrinsic membrane properties of Medial Vestibular Nucleus (MVN) neurons (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
Co-authors Robert Callister
2006 Anderson WB, Graham BA, Jobling P, Lim R, Brichta AM, Callister RJ, 'Glycine receptor diversity in the dorsal horn of the mouse spinal cord', Society for Neuroscience, Atlanta, GA (2006) [E3]
Co-authors Brett Graham, Robert Callister, Rebecca Lim, Phillip Jobling
2006 Jobling P, Graham BA, Brichta AM, Callister RJ, 'In vivo patch-clamp recording of subthreshold synaptic events evoked in dorsal horn neurons after stimulation of the female reproductive tract in the mouse', Society for Neuroscience, Atlanta, Georgia (2006) [E3]
Co-authors Brett Graham, Phillip Jobling, Robert Callister
2006 Walsh MA, Graham BA, Brichta AM, Callister RJ, 'Postnatal development of electrophysiological properties in mouse supeficial dorsal horn neurones', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
Co-authors Robert Callister, Brett Graham
2005 Graham BA, Brichta AM, Callister RJ, 'Effect of Temperature on the Discharge Properties of Mouse Superficial Dorsal Horn Neurons', Proceedings of the Australian Neuroscience Society, Perth (2005) [E3]
Co-authors Robert Callister, Brett Graham
2005 Camp AJ, Watson PJ, Schofield PR, Callister RJ, Brichta AM, 'Inhibitory Synaptic Transmission in Medial Vestibular Nucleus Neurons of Wildtype, Spastic, Spasmodic, and Oscillator Mice', Proceedings of the Australian Neuroscience Society, Perth (2005) [E3]
Co-authors Robert Callister
2005 Callister RJ, Graham BA, Brichta AM, 'In Vivo Responses of Mouse Spinal Neurones to Electrical and Functionally-Relevant Stimulation', Proceedings of the Australian Neuroscience Society Conference, Perth (2005) [E3]
Co-authors Brett Graham, Robert Callister
2004 Krajniak SG, Callister RJ, Imtiaz MS, Brichta AM, Van Helden DF, 'Investigation of a brain rhythm', Proceedings of the Australian Neuroscience Society, Australia (2004) [E3]
Co-authors Robert Callister, Dirk Vanhelden
1999 Brichta AM, Goldberg J, 'Ionic Currents of Isolated Hair Cells Selectively Harvested from Different Zones of the Turtle Posterior Crista', Proceedings of the Australian Neuroscience Society. Vol. 10, University of Tasmania, Hobart, Tasmania. (1999) [E2]
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Grants and Funding

Summary

Number of grants 53
Total funding $7,751,812

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $2,000

Association for Research in Otolaryngology, 21-25 February 2015$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Professor Alan Brichta
Scheme Travel Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500257
Type Of Funding Internal
Category INTE
UON Y

20144 grants / $719,454

Spinal processing of sensory signals from the gut$536,226

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Doctor Simon Keely, Doctor Brett Graham, Professor Alan Brichta, Dr David Hughes
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1300361
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Physiological and Behavioural Characterisation of Central Vestibular Function$90,614

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding body Garnett Passe and Rodney Williams Memorial Foundation
Project Team Dr Thomas Wellings, Professor Alan Brichta, Doctor Rebecca Lim
Scheme Research Scholarship
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1301066
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Physiological and Behavioural Characterisation of Central Vestibular Function$90,614

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding body Garnett Passe and Rodney Williams Memorial Foundation
Project Team Dr Thomas Wellings, Professor Alan Brichta, Doctor Rebecca Lim
Scheme Research Scholarship
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1301066
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

XXVIIIth Barany Society Meeting, Buenos Aires Argentina, 25-29 May 2014$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Professor Alan Brichta
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400597
Type Of Funding Internal
Category INTE
UON Y

20136 grants / $551,122

Development of functional connections in the human peripheral vestibular system$418,281

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Rebecca Lim, Professor Alan Brichta, Professor Robert Callister
Scheme Project Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1200254
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Two replacement OBIS lasers for Nikon Eclipse 80i Confocal microscope (488 nm and 594 nm)$27,841

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alan Brichta
Scheme Equipment Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1301305
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Functional characterisation of schizophrenia-associated neurodevelopmental dysfunction of miR-137$25,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Associate Professor Murray Cairns, Doctor Frederick Walker, Professor Alan Brichta, Doctor Natalie Beveridge
Scheme Near Miss Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300468
Type Of Funding Internal
Category INTE
UON Y

Functional characterisation of schizophrenia-associated neurodevelopmental dysfunction of miR-137$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Associate Professor Murray Cairns, Doctor Frederick Walker, Professor Alan Brichta, Doctor Natalie Beveridge
Scheme Near Miss
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300801
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

microRNA and translation dynamics of synaptic plasticity$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Associate Professor Murray Cairns, Professor Alan Brichta, Doctor Frederick Walker
Scheme Near Miss Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300463
Type Of Funding Internal
Category INTE
UON Y

20122 grants / $470,982

Development of peripheral sensory pathways in humans$469,167

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Professor Alan Brichta, Dr David Hughes, Doctor Phil Jobling
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100102
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Association for Research in Otolaryngology 35th Annual Mid Winter Meeting, San Diego, 25 - 29 February 2012$1,815

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Professor Alan Brichta
Scheme Travel Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200416
Type Of Funding Internal
Category INTE
UON Y

20112 grants / $349,208

Efferent modulation of the vestibular periphery$339,208

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alan Brichta, Professor Robert Callister, Doctor Rebecca Lim
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1000315
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

IMPLEN NanoPhotometer pearl$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Doctor Natalie Beveridge
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100030
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20105 grants / $1,079,500

Molecular and cellular characterisation of schizophrenia associated dysfunction in microRNA biogenesis$478,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Murray Cairns, Professor Rodney Scott, Associate Professor Paul Tooney, Emeritus Professor John Rostas, Professor Alan Brichta
Scheme Project Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0190196
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Laser microdissection microscopy system for cell and development biology$350,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Laureate Professor John Aitken, Associate Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Doctor Doug Smith, Associate Professor David McCurdy, Conjoint Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Doctor Brett Graham, Associate Professor Paul Tooney, Professor Roger Smith, Laureate Professor Paul Foster, Professor Trevor Day, Professor Robert Callister
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0190369
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Rick Thorne, Doctor Nikki Verrills, Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Doctor Doug Smith, Professor Gordon Burns, Emeritus Professor Leonie Ashman, Conjoint Professor Keith Jones, Doctor Charles De Bock, Doctor Chris Dayas, Doctor Brett Graham, Doctor Martin Horan, Doctor Rebecca Lim, Doctor Severine Roselli, Doctor Larisa Bobrovskaya, Doctor Kathryn Skelding, Doctor Frederick Walker, Doctor Jude Weidenhofer, Associate Professor Philip Bolton, Professor Alan Brichta, Professor Robert Callister, Professor Trevor Day, Associate Professor Phillip Dickson, Professor Manohar Garg, Doctor Phil Jobling, Associate Professor Derek Laver, Associate Professor Eugene Nalivaiko, Emeritus Professor John Rostas
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000055
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

XXVI Barany Society Meeting, Reykjavik, 15 - 21st August 2010 , $2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Professor Alan Brichta
Scheme Travel Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000134
Type Of Funding Internal
Category INTE
UON Y

20095 grants / $1,216,144

Spinal mechanisms underlying neck pain$451,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Associate Professor Philip Bolton, Professor Alan Brichta
Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0188840
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Neurometer CPT/C$28,435

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Philip Bolton, Professor Robert Callister, Professor Alan Brichta, Professor Robin Callister, Doctor Brett Graham, Doctor Phil Jobling
Scheme Equipment Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189845
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Leica VT1200S - Fully automated vibrating blade microtome$16,209

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Professor Alan Brichta, Conjoint Professor Keith Jones, Professor Jon Hirst, Doctor Brett Graham, Associate Professor Philip Bolton, Doctor Phil Jobling, Associate Professor Paul Tooney, Doctor Angela McPherson, Doctor Rebecca Lim, Doctor Ramatis De Oliveira, Mr Matthew Walsh
Scheme Equipment Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189842
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20083 grants / $1,044,069

Vestibular signalling mechanisms; from periphery to brainstem$1,000,000

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding body Garnett Passe and Rodney Williams Memorial Foundation
Project Team Professor Alan Brichta
Scheme Senior/Principal Research Fellowship
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188205
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Recovery of the balance system following injury$24,069

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Alan Brichta, Professor Robert Callister, Associate Professor Philip Bolton, Doctor Phil Jobling, Doctor Rebecca Lim
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188471
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Leica VT2100S Vibrating Microtome$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alan Brichta, Professor Robert Callister, Professor Dirk Van Helden, Associate Professor Philip Bolton, Doctor Rebecca Lim, Doctor Brett Graham, Dr Marcus Howlett, Doctor Angela McPherson, Doctor Mohammad Imtiaz, Doctor Ramatis De Oliveira, Mr Wayne Anderson, Mr Matthew Walsh
Scheme Equipment Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188540
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20072 grants / $37,678

High speed/sensitivity CCD camera$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Professor Alan Brichta, Professor Robert Callister, Doctor Brett Graham, Associate Professor Derek Laver, Associate Professor Liz Milward, Doctor John Holdsworth
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188196
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Developing a rodent model to study neck pain$7,678

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Robert Callister, Associate Professor Philip Bolton, Professor Alan Brichta, Doctor Brett Graham
Scheme Pilot Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187879
Type Of Funding Internal
Category INTE
UON Y

20064 grants / $1,011,402

Descending control of pain pathways$423,950

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Professor Trevor Day, Professor Alan Brichta
Scheme Project Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0185184
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The neural basis of vestibular compensation$311,472

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alan Brichta, Professor Robert Callister
Scheme Project Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0185195
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Cellular mechanisms underlying activity in the peripheral vestibular organs$269,980

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding body Garnett Passe and Rodney Williams Memorial Foundation
Project Team Professor Alan Brichta, Professor Robert Callister
Scheme Project Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0185817
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Endolymphatic changes in isolated inner ear$6,000

Funding body: Sydney University Medical Foundation

Funding body Sydney University Medical Foundation
Project Team
Scheme Meniere's Disease Foundation
Role Lead
Funding Start 2006
Funding Finish 2006
GNo
Type Of Funding External
Category EXTE
UON Y

20053 grants / $243,000

INVESTIGATION OF A BRAIN RHYTHM$220,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Dirk Van Helden, Professor Robert Callister, Professor Alan Brichta
Scheme Discovery Projects
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184333
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Novel spinal cord targets for pain management$13,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Robert Callister, Professor Alan Brichta
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184884
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Descending control of pain processing pathways in the spinal cord$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Robert Callister, Professor Alan Brichta, Professor Trevor Day
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184748
Type Of Funding Internal
Category INTE
UON Y

20045 grants / $336,047

High-Speed Confocal Microscope Live Cell Recording System$274,692

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Dirk Van Helden, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alan Brichta, Associate Professor J Keast, Dr J Brock, Dr S Head
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183031
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

High-speed Confocal Microscope Live Cell Recording System$30,000

Funding body: University of New South Wales

Funding body University of New South Wales
Project Team Professor Dirk Van Helden, Associate Professor J Keast, Laureate Professor John Aitken, Dr J Brock, Professor Eileen McLaughlin, Dr S Head, Professor Alan Brichta
Scheme Linkage Infrastructure Equipment & Facilities (LIEF) Partner funding
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183841
Type Of Funding Not Known
Category UNKN
UON Y

How does the balance system process signals?$14,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alan Brichta, Professor Robert Callister
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183499
Type Of Funding Internal
Category INTE
UON Y

Investigation a brain rythym$14,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden, Professor Robert Callister, Professor Alan Brichta
Scheme Project Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0184506
Type Of Funding Internal
Category INTE
UON Y

Annual Meeting of the Society for Neuroscience, 23-27 October 2004, USA$2,355

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alan Brichta
Scheme Travel Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0184863
Type Of Funding Internal
Category INTE
UON Y

20032 grants / $67,353

Transduction mechanisms in the in vitro mouse vestibular organs.$51,018

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding body Garnett Passe and Rodney Williams Memorial Foundation
Project Team Professor Alan Brichta
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182512
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Equipment Grant$16,335

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team
Scheme RIB Grant
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo
Type Of Funding Internal
Category INTE
UON Y

20022 grants / $339,500

Electron Microscope/X-Ray Unit Equipment Upgrade$337,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Conjoint Professor Christina Offler, Professor Bill Collins, Professor Erich Kisi, Professor Alan Brichta, Laureate Professor John Aitken, Emeritus Professor John Patrick
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181515
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Biennial Conference: Barany Society XXII Meeting and Satellite Meeting Seattle, Washington State, USA, 22-29 September 2002$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alan Brichta
Scheme Travel Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0182225
Type Of Funding Internal
Category INTE
UON Y

20012 grants / $24,042

Efferent modulation of hearing and the sense of balance$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Alan Brichta, Professor Robert Callister
Scheme Research Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0181165
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Investigation of the efferent vestibular system in a mammalian in vitro preparation.$4,042

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding body Garnett Passe and Rodney Williams Memorial Foundation
Project Team Professor Alan Brichta
Scheme Project Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0180499
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

20003 grants / $232,311

Cellular mechanisms underlying the sense of balance.$190,020

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alan Brichta, Professor Robert Callister
Scheme Project Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0178493
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Cellular Mechanisms Underlying the Sense of Balance.$30,291

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding body Garnett Passe and Rodney Williams Memorial Foundation
Project Team Professor Alan Brichta, Professor Robert Callister
Scheme Project Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0179041
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Cellular Mechanisms Underlying the Sense of Balance.$12,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Alan Brichta
Scheme Research Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0178720
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

19991 grants / $11,000

Cellular mechanisms underlying the sense of balance.$11,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alan Brichta
Scheme Special Project Grant
Role Lead
Funding Start 1999
Funding Finish 1999
GNo G0179151
Type Of Funding Internal
Category INTE
UON Y

19981 grants / $17,000

Cellular mechanisms underlying the sense of balance$17,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alan Brichta
Scheme New Staff Grant
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0180943
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed4
Current6

Total current UON EFTSL

Masters0.2
PhD1.9

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2015 Masters The Protein Phosphatase 2A in Alzheimer's Disease Pathogenesis
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Synaptic Properties of the Peripheral Efferent Vestibular System
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD MicroRNA Biogenesis in Neuronal Function and Schizophrenia
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Development of Occupational Noise Induced Hearing Loss: A Review of Identification and Management
Public Health, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Ageing of the Inner Ear Balance System
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Physiological and Behavioural Characterisation of Central Vestibular Function
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2011 PhD Electrophysiological Development of Superficial Dorsal Horn Neurons in Mice
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2010 PhD Pacemaking in Mouse Locus Coeruleus Neurons: Electrophysiological Properties, Role of Mitochondria and Development
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2007 PhD Inhibitory Synaptic Transmission in Mouse Medial Vestibular Nucleus Neurons
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2006 PhD Pain processing mechanisms in the superficial dorsal horn of the mouse spinal cord: in vivo and in vitro
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
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News

Keeping Newcastle balanced

Keeping Newcastle balanced: balance research in vestibular neuroscience

March 20, 2015

How do we understand the world around us?  A seemingly simple question.

Professor Alan Brichta

Position

Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Anatomy

Contact Details

Email alan.brichta@newcastle.edu.au
Phone (02) 4921 7026
Fax (02) 4921 7812
Link UoN Blogs

Office

Room MS309A
Building Medical Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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