Professor Alan Brichta

Professor Alan Brichta

Professor

School of Biomedical Sciences and Pharmacy (Anatomy)

Deciphering the Balance Code

Tucked away deep in the hardest part of the skull hides the vestibular system, the mysterious unsung hero of the senses. Professor Alan Brichta is its number one fan.

Professor Alan Brichta 

"We need the vestibular system for balance, it is specifically there to tell us, amongst other things, which way is up and which way is down," Alan asserts.

"What is fascinating to me is that most of the time we just don't think about it. We don't realise this thing is working in our favour until it goes wrong." 

The relatively recent recognition of the existence of the sense of balance, as well as the inaccessible position of the inner ear vestibular organs within the skull, means there is a lack of evidence-based research on this system in action.    

To counter this, Alan and his team have developed a semi-intact model of the vestibular system, which allows for live cells to remain functional.

"We are concentrating on the peripheral balance organs, the ones out in the inner ear, to see how they work, and how they communicate with the brain," he clarifies.

"People talk about exploring outer space, really we are flipping that idea on its head and are trying to discover inner space."

When not investigating the inner ear, Alan is Head of Discipline (Anatomy), supervisor of multiple research students, and teaching into a number of programs including the Bachelor of Medicine and the Bachelor of Biomedical Science.

TEAM VESTIBULAR

If you were a mysterious and misunderstood body part, Alan would be your first choice for advocate.

His extensive knowledge and unbridled fascination are equally apparent as he talks up the balance system. He embodies a fervent team supporter as he derides the other senses for not being nearly as important.

"The vestibular system is how you remember which direction you came from, and is responsible for you knowing where you are as you move through your environment," Alan explains.

"You can thank it for your awareness of whether you are lying down or standing up, and for knowing which way to swim to reach the surface of the water."

"Importantly, it keeps your eyes steady when your body is moving, so your vision is more steadycam than jumpy jumble. It is so finely tuned," he discloses, "that drinking alcohol can cause it to make you wobbly, and echo wobbly the next day as it works to compensate for your previous night's wobbliness."

Unlike the other senses, the vestibular organs don't report back to one specific part of the brain, instead sending and receiving communications with many sections of the brain. Which Alan believes is proof of the critical importance of balance information to normal brain function.

"I think it's the way it works so exquisitely well for the most part that really fascinates me," Alan muses.

"What is also fascinating to me, is that most of the time we just don't think about it."

"The balance system works so well and with such little fanfare, that when something goes wrong our world is thrown into complete disarray."

DEVASTATING DIZZINESS

Alan explains that malfunction within the vestibular system can have devastating affects on quality of life.

"The balance system itself will never kill you directly, but the resulting falls, especially in the aged, can lead to fatal consequences," Alan asserts.

"Breaking a leg, or worse still a pelvis, that's going to lead to all sorts of problems."

It's not just fear of injury that affects those with dizziness. Alan cites understandable anxiety over the possibility of creating a scene or damaging property whilst falling, as two scenarios which may make sufferers stay at home.

Due to the similarities between the effects of excessive alcohol and balance problems, accusations of drunkenness can cause further embarrassment.

"It's remarkable how quickly people do lose confidence," Alan reveals.

"And as a result, it's a hidden problem because we rarely, if ever, see people with balance problems, they are not generally out in the community."

"Whenever we have a public forum on balance and dizziness, however, it's amazing how many people attend because they are desperate to find a cure for themselves or their loved ones."

MINOR MODULATION AND MAJOR MYSTERY

Milder effects of vestibular interruption are relatively common and can be countered.  

"The brain is capable of a lot of plasticity, or modulation," Alan states.

"If the brain recognises that the signals aren't coming in quite as well as they used to, it might amplify or boost the incoming signal."

"But it can only do so much to compensate. People who have tried everything, from physiotherapy to medications to operations with little or no effect can have a very poor quality of life."

Despite the debilitating nature of balance problems, a lack of knowledge in this area means that optimum treatments are yet to be identified.

"The sad thing is we have no real treatment. We can give you sedatives; we can give you things that reduce your activity and maybe your anxiety," Alan says. 

"But really there is nothing at all we can do to stop that dizziness. Because we don't know how it works, we don't know what happens when it goes wrong, or what drugs could be specifically aimed at treating the problem."

"And this is why we need more studies."

MONITORING THE MACHINE IN MOTION

The balance system is almost completely inaccessible, positioned within the thickest part of the skull, rendering the study of its working actions very difficult.

"Using an animal model, we were amongst the first to look at it as a semi-intact system, that's our specialty," Alan confirms.

As a result of their use of this system, Alan and his team have been able to test existing theoretical frameworks and generate evidence regarding previously unobserved functions.

"We can't always learn about functions from studying the parts, or by using modeling," Alan explains. 

"We are at such a primitive stage of understanding that we need to study the system in action to advance our knowledge."

His most recent NHMRC-funded research has focused on the efferent branch of the vestibular system – the feedback pathway by which the brain can modulate inner ear sensitivity.

BALANCE PROSTHESIS

Ultimately, Alan is hoping that the work being completed by his team will result in a major improvement in the quality of life of people suffering from balance problems.

"By listening in on the communication between the inner ear organs and the brain, we are trying to decode the kinds of information that the brain is interested in," Alan explains.  

"And if we do that, then maybe we can replace it if it is damaged, or supplement it as we age."

Although we accept that our hearing is likely to be affected by age, Alan points out that it is less commonly understood that balance, which uses similar receptors or sensory cells, can also be impacted by aging.

"So if we could develop a system whereby you had a prosthesis or an aid, that would be a boon to anyone who has balance problems, particularly the elderly."

Alan notes that technologies such as accelerometers and gyroscopes have shrunk in size and cost to the extent that they could be easily incorporated into a non-obtrusive aid.

"It could be like a hearing aid, but for the balance system," Alan suggests.

"It might be on a set of glasses, or possibly it could be a chip close to, or attached to the skull. It would then generate electric signals that would help the brain to know the position of our head in three-dimensional space."

"It's one of our major goals. But first we have to understand how it works to be able to fix it," he admits.  

"At least in our case, because there is not that much known about it, and so few people working on it, we might just discover something really important tomorrow."

"Usually though, it's just little 'balanced' steps toward gaining more knowledge."

More about Alan's Career

Alan Brichta

Deciphering the Balance Code

Professor Alan Brichta's primary research interest is balance and the vestibular system. His recent research has focused on the efferent branch of the vestibu

Read more

Alan Brichta

Professor Alan Brichta's primary research interest is balance and the vestibular system.  His most recent NHMRC-funded research has focused on the efferent branch of the vestibular system – the pathway by which the brain can modulate inner ear sensitivity.  

Despite fifty years of ongoing research, the functional purpose of the efferent vestibular system still remains a mystery – most likely due to its inherently complex mechanisms of action. To combat this, Alan has developed a semi-intact model of the vestibular system, which allows for faithful, high-resolution recordings of hair cell function.  This recording technique has provided new information about the efferent vestibular system, with particular regards to the novel alpha-9 nicotinic receptor.

Alan has ongoing collaborations with vestibular experts Dr Americo Migliaccio (Neuroscience Research Australia; NeuRA), Dr Joseph Holt (University of Rochester, USA) and Dr Richard Rabbitt (University of Utah, USA), as well as HMRI neuroscientists Professor Bob Callister and Dr Doug Smith.  He is also closely affiliated with the Garnett Passe and Rodney Williams Memorial Foundation (GPRWMF), and the Neuro-Otology Society of Australia (NOTSA).  Alan is currently the Head of Discipline (Anatomy), supervises multiple PhD students, and teaches into a number of programs including Bachelor of Medicine and Bachelor of Biomedical Science.

What intrigues you most about the vestibular system?

I know it may sound a little strange but almost from the moment I learned about the vestibular system, I've been fascinated and intrigued by the subtle and mysterious way it works to provide us with a sense of balance.

The vestibular system allows us go about our daily activities, correcting almost every move we make, so that we don't fall over. And it does this with little or no fanfare or even very much recognition. The vestibular system is neither blatant nor does it intrude on our consciousness with the flamboyance of primary senses such as vision and hearing. If the vestibular system is doing its job properly it is almost imperceptible, working away with exquisite precision, speed, and accuracy. Perhaps it is precisely this 'backstage activity' that is responsible for our general lack of awareness and why we know so much less about this system in comparison to its close cousin, the hearing or auditory system. In short, the more I get to know the vestibular system the more I am in awe of the 'no nonsense' way in which it influences almost all aspects of our lives, making it the 'quiet achiever', or dare I say, the unsung hero or heroine of the central nervous system.

Alan Brichta

Professor Alan Brichta's primary research interest is balance and the vestibular system. His recent research has focused on the efferent branch of the vestibu

Read more

Career Summary

Biography

Alan Brichta is a neurobiologist with research interests in the anatomy and physiology of peripheral and central vestibular system. In particular, his studies have focused on vestibular hair cells and their associated primary afferents and has recently developed an isolated preparation of the mouse inner ear to study these unusual cellular components. This approach allows stable, high-resolution, intracellular recordings whilst the tissue undergoes near 'natural' (mechanical), rather than artificial (electrical) stimulation. Results from these studies are helping us understand the cellular mechanisms underlying normal and abnormal function associated with the peripheral vestibular apparatus. In addition, Dr. Brichta is studying vestibular nucleus neurons in the brainstem that are the major recipients of transmitted vestibular organ output. These regions are thought to be highly modifiable and may prove to be ideal targets for rational therapeutic strategies aimed at treating balance disorders. Dr. Brichta was awarded a prestigious five year Garnett Passe and Rodney Williams Memorial Foundation Senior/Principal Research Fellowship.

Research Expertise
Vestibular electrophysiological and anatomical techniques, including whole-cell patch-clamp recordings together with intracellular labelling and immunohistochemistry. Experience with in vivo and in vitro preparations. Awarded major nationally competitive grants: Continually funded NHMRC Project Grants; Garnett Passe and Rodney Williams Memorial Foundation Invited Speaker at the Royal College of Medicine, London, UK. 

Teaching Expertise
Head of the Anatomy and his teaching expertise is in histology, neuroanatomy, and neurosicence. Has helped with major reorganisation of core anatomy courses to Medicine, Biomed Sci, Health Sciences, including Medical Radiation Science, Physiotherapy, Oral Health, and Speech Pathology. Developed three new specialist subjects: Oral Health, Speech Pathology, and Neural Visceral Anatomy. Re-designed second semester Neuroanatomy block for Medicine. Hosted the Universitys first US Fulbright Scholar. Help organise teaching in new Anatomy facility - Medical Sciences West.

Administrative Expertise
Currently, Co-Director of the University of Newcastle Priority Research Centre for Brain and Mental Health. Is an NHMRC Assigners Academy member and is an Associate Editor for the Journal of Association for Research in Otolaryngology. Former member of University Research Committee, Academic Senate, and Faculty Board during a period of major change in teaching and learning at the University. Attracted significant equipment funding to the EM /X-Ray Unit with a successful application for nationally competitive ARC-LEIF grant. Submission of Anatomy discipline Roadmap for Australian Medical Accreditation Committee. Contributed to the development of the Bachelor of Podiatry Program. Provided Biomedical Science input with regard to course provisions and assessment of background course pre-requisites. Member of NHMRC Grant Review Panel. External Ph.D. Examiner of Higher Degree Research Students.

Collaborations
In addition to his own studies on the vestibular system, Dr. Brichta has had a long-term collaboration with his good friend and colleague, Dr. Bob Callister. Together they have had over thirty years of collaborative efforts on sensory and motors systems.

Qualifications

  • PhD, Ohio University - USA
  • Bachelor of Science (Anatomy), University of New South Wales

Keywords

  • Anatomy
  • Electrophysiology
  • Neuroscience
  • Spinal Cord
  • Vestibular system

Fields of Research

Code Description Percentage
110903 Central Nervous System 30
110905 Peripheral Nervous System 20
110906 Sensory Systems 50

Professional Experience

UON Appointment

Title Organisation / Department
Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/07/2008 - 1/06/2013 Senior/Principal Research Fellowship

Garnett Passe and Rodney Williams Memorial Foundation

University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/07/2007 - 31/12/2014 A/Prof. University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/11/1998 - 1/12/2000 Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/07/1995 - 1/10/1998 Assistant Professor University of Chicago, Chicago, Illinois
Physiological and Pharmacological Sciences
United States

Membership

Dates Title Organisation / Department
1/01/2014 -  Membership - ARO International Committee ARO International Committee
Australia
1/01/2014 -  Membership - NHMRC Assigners Academy Committee NHMRC Committee
Australia
1/01/2011 - 31/12/2013 Membership - NHMRC Committee NHMRC (National Health & Medical Research Council)

Invitations

Participant

Year Title / Rationale
2012 A Question of Balance: The best-laid schemes o' mice an' men
Organisation: The Royal Society of Medicine, London Description: Much of what we have learned about the human body has come not from direct observations but has been inferred from animal studies. Fortunately, as we have learned from the human and other genome projects, we are almost genetically identical to chimpanzees and remarkably similar to mice. Sequencing of the mouse genome for example, completed in late 2002, estimates a gene count of 23,786 and for comparison, humans are estimated to have 23,686 genes – a hundred fewer! Therefore, it can be argued that what we learn in mice is applicable to humans. This assertion is most likely true when it comes to ancient and evolutionarily conservative sensory systems such as the peripheral vestibular system. To date, however, its residence deep within the hardest bone of the skull (making it neither easy to access nor convenient to manipulate) has hampered our study of the vestibular organs of the inner ear. To overcome this significant technical obstacle we have developed a surgically isolated inner ear of the mouse. This preparation allows us unprecedented access to the workings of the organs of balance. Indeed, using our isolated in vitro preparation and altering the volume of inner ear fluid by only a few nano-litres we have observed anomalous neuronal activity that may contribute to the symptoms of Meniere’s disease. By stripping the isolated inner ear preparation still further, (like layers in an onion) but carefully preserving the important and unique micro-architectural features of the individual organs, we have discovered a novel way in which the important motion detectors of the vestibular system (hair cells) communicate with their closely associated nerve afferent nerves. These results would have been difficult if not impossible to obtain without semi-intact preparations of vestibular organs. Despite these notable advances one must acknowledge that these results are from a very small mammal that weighs four orders of magnitude less than an adult human (7 grams vs. 70 kilograms). Therefore, are any of these findings relevant to humans? To address this fundamental issue we have begun to isolate viable inner ears from post-mortem human foetal tissue (10 to 18 weeks gestation). This means we can now apply some of the techniques we have learned using mice to in vitro human vestibular tissue. The preliminary results are promising. We are able to record activity from foetal hair cells and nerve terminals up to 8 hours after the tissue arrives in the laboratory. Our data suggest the human peripheral vestibular system is fully functional midway through the second trimester and indeed resembles a 3 week old, fully weaned, postnatal mouse. Taken together, these various approaches provide us with new insights into basic machinery of the peripheral balance organs in humans. Our ultimate goal is to have the findings from these animal and foetal models translated into targeted clinical therapeutics. For example, due to pathological increases in endolymph volume, we believe the membranous labyrinth is distended causing abnormal and confusing signals to the brain. Alleviating these volume changes by pharmacological and/or surgical intervention would eliminate distensions and accompanying vertiginous attacks. Similarly, based on our new understanding of the key role potassium plays in vestibular organ function, particularly between hair cells and primary afferents, suggests this ion is tightly regulated to ensure normal balance function. Thus a focus on restoration and maintenance of potassium in the inner ear would be a clinical requirement. In short, our continued hope is that better basic understanding leads to targeted diagnostic and therapeutic strategies for treating the debilitating effects of balance disorders.
2006 Developments in isolated inner ear preparations
Organisation: Garnett Passe and Rodney Williams Foundation Description: Inivited speaker
2002 Transduction in vestibular sense organs
Organisation: The Australian Health and Medical Research Congress Description: Inivited speaker
2001 Vestibular Influences on Movement
Organisation: International B¿r¿ny Society Description: Inivited Speaker

Speaker

Year Title / Rationale
2010 The unusual calyx terminals of the inner ear
Organisation: Barany Society Meeting
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (5 outputs)

Year Citation Altmetrics Link
2012 Lim R, Brichta AM, 'Vestibular system', The Mouse Nervous System, Academic Press, San Diego 661-678 (2012) [B1]
Citations Scopus - 1
Co-authors Rebecca Lim
2001 Stuart DG, Pierce PA, Callister RJ, Brichta AM, McDonagh JC, 'Sir Charles Sherrington: Humanist, Mentor, and Movement Neuroscientist', Classics in Movement Science, Human Kinetics, U.S.A. 317-374 (2001) [B2]
Co-authors Robert Callister
2000 Goldberg J, Brichta AM, Wackym P, 'Efferent Vestibular System: Anatomy, Physiology, and Neurochemistry', Neurochemistry of the Vestibular System, CRC Press, Washington, D.C., U.S.A. 411 (2000) [B1]
1999 McDonagh J, Callister RJ, Brichta AM, Stuart D, 'A commentary on the properties of spinal interneurons vs. motoneurons in vertebrates and their firing-rate behaviour during movement', Motor Control: Today and Tomorrow, Academic Publishing House "Prof.Marin Drinov", Sofia, Bulgaria 3-29 (1999) [B1]
Co-authors Robert Callister
1985 Brichta AM, Grant G, 'Cytoarchitectural organisation of the spinal cord', The Rat Nervous System, Volume 2, Academic Press, Sydney 293-302 (1985)
Show 2 more chapters

Journal article (57 outputs)

Year Citation Altmetrics Link
2016 Tadros MA, Fuglevand AJ, Brichta AM, Callister RJ, 'Intrinsic excitability differs between murine hypoglossal and spinal motoneurons.', J Neurophysiol, 115 2672-2680 (2016)
DOI 10.1152/jn.01114.2015
Co-authors Robert Callister
2016 Lim R, Brichta AM, 'Anatomical and physiological development of the human inner ear.', Hear Res, (2016)
DOI 10.1016/j.heares.2016.02.004
Co-authors Rebecca Lim
2016 Farrell KE, Rank MM, Keely S, Brichta AM, Graham BA, Callister RJ, 'In vivo characterization of colorectal and cutaneous inputs to lumbosacral dorsal horn neurons in the mouse spinal cord', Neuroscience, 316 13-25 (2016)

© 2015 IBRO.Chronic abdominal pain is a common symptom of inflammatory bowel disease and often persists in the absence of gut inflammation. Although the mechanisms responsible fo... [more]

© 2015 IBRO.Chronic abdominal pain is a common symptom of inflammatory bowel disease and often persists in the absence of gut inflammation. Although the mechanisms responsible for ongoing pain are unknown, clinical and preclinical evidence suggests lumbosacral spinal cord dorsal horn neurons contribute to these symptoms. At present, we know little about the intrinsic and synaptic properties of this population of neurons in either normal or inflammed conditions. Therefore, we developed an in vivo preparation to make patch-clamp recordings from superficial dorsal horn (SDH) neurons receiving colonic inputs in naïve male mice. Recordings were made in the lumbosacral spinal cord (L6-S1) under isoflurane anesthesia. Noxious colorectal distension (CRD) was used to determine whether SDH neurons received inputs from mechanical stimulation/distension of the colon. Responses to hind paw/tail cutaneous stimulation and intrinsic and synaptic properties were also assessed, as well as action potential discharge properties. Approximately 11% of lumbosacral SDH neurons in the cohort of neurons sampled responded to CRD and a majority of these responses were subthreshold. Most CRD-responsive neurons (80%) also responded to cutaneous stimuli, compared with <50% of CRD-non-responsive neurons. Furthermore, CRD-responsive neurons had more hyperpolarized resting membrane potentials, larger rheobase currents, and reduced levels of excitatory drive, compared to CRD-non-responsive neurons. Our results demonstrate that CRD-responsive neurons can be distinguished from CRD-non-responsive neurons by several differences in their membrane properties and excitatory synaptic inputs. We also demonstrate that SDH neurons with colonic inputs show predominately subthreshold responses to CRD and exhibit a high degree of viscerosomatic convergence.

DOI 10.1016/j.neuroscience.2015.12.023
Co-authors Michelle Rank, Brett Graham, Simon Keely, Robert Callister
2016 Rabbitt RD, Brichta AM, Tabatabaee H, Boutros PJ, Ahn JH, Della Santina CC, et al., 'Heat pulse excitability of vestibular hair cells and afferent neurons.', J Neurophysiol, jn.00110.2016 (2016)
DOI 10.1152/jn.00110.2016
Co-authors Rebecca Lim
2015 Tadros MA, Lim R, Hughes DI, Brichta AM, Callister RJ, 'Electrical maturation of spinal neurons in the human fetus: Comparison of ventral and dorsal horn', Journal of Neurophysiology, 114 2661-2671 (2015) [C1]

© 2015 the American Physiological Society.The spinal cord is critical for modifying and relaying sensory information to, and motor commands from, higher centers in the central ne... [more]

© 2015 the American Physiological Society.The spinal cord is critical for modifying and relaying sensory information to, and motor commands from, higher centers in the central nervous system to initiate and maintain contextually relevant locomotor responses. Our understanding of how spinal sensorimotor circuits are established during in utero development is based largely on studies in rodents. In contrast, there is little functional data on the development of sensory and motor systems in humans. Here, we use patch-clamp electrophysiology to examine the development of neuronal excitability in human fetal spinal cords (10¿18 wk gestation; WG). Transverse spinal cord slices (300 µm thick) were prepared, and recordings were made, from visualized neurons in either the ventral (VH) or dorsal horn (DH) at 32°C. Action potentials (APs) could be elicited in VH neurons throughout the period examined, but only after 16 WG in DH neurons. At this age, VH neurons discharged multiple APs, whereas most DH neurons discharged single APs. In addition, at 16¿18 WG, VH neurons also displayed larger AP and after-hyperpolarization amplitudes than DH neurons. Between 10 and 18 WG, the intrinsic properties of VH neurons changed markedly, with input resistance decreasing and AP and after-hyperpolarization amplitudes increasing. These findings are consistent with the hypothesis that VH motor circuitry matures more rapidly than the DH circuits that are involved in processing tactile and nociceptive information.

DOI 10.1152/jn.00682.2015
Co-authors Rebecca Lim, Robert Callister
2015 Tadros MA, Farrell KE, Graham BA, Brichta AM, Callister RJ, 'Properties of sodium currents in neonatal and young adult mouse superficial dorsal horn neurons', Molecular Pain, 11 (2015) [C1]

© Tadros et al.; licensee BioMed Central.Background: Superficial dorsal horn (SDH) neurons process nociceptive information and their excitability is partly determined by the prop... [more]

© Tadros et al.; licensee BioMed Central.Background: Superficial dorsal horn (SDH) neurons process nociceptive information and their excitability is partly determined by the properties of voltage-gated sodium channels. Recently, we showed the excitability and action potential properties of mouse SDH neurons change markedly during early postnatal development. Here we compare sodium currents generated in neonate (P0-5) and young adult (=P21) SDH neurons. Results: Whole cell recordings were obtained from lumbar SDH neurons in transverse spinal cord slices (CsF internal, 32°C). Fast activating and inactivating TTX-sensitive inward currents were evoked by depolarization from a holding potential of 100mV. Poorly clamped currents, based on a deflection in the IV relationship at potentials between 60 and 50mV, were not accepted for analysis. Current density and decay time increased significantly between the first and third weeks of postnatal development, whereas time to peak was similar at both ages. This was accompanied by more subtle changes in activation range and steady state inactivation. Recovery from inactivation was slower and TTX-sensitivity was reduced in young adult neurons. Conclusions: Our study suggests sodium channel expression changes markedly during early postnatal development in mouse SDH neurons. The methods employed in this study can now be applied to future investigations of spinal cord sodium channel plasticity in murine pain models.

DOI 10.1186/s12990-015-0014-5
Co-authors Brett Graham, Robert Callister
2015 Tadros MA, Farrell KE, Graham BA, Brichta AM, Callister RJ, 'Properties of sodium currents in neonatal and young adult mouse superficial dorsal horn neurons.', Molecular pain, 11 17 (2015)
Co-authors Robert Callister, Brett Graham
2015 Rancz EA, Moya J, Drawitsch F, Brichta AM, Canals S, Margrie TW, 'Widespread Vestibular Activation of the Rodent Cortex', JOURNAL OF NEUROSCIENCE, 35 5926-5934 (2015) [C1]
DOI 10.1523/JNEUROSCI.1869-14.2015
Citations Scopus - 2
2014 Tadros MA, Farrell KE, Schofield PR, Brichta AM, Graham BA, Fuglevand AJ, Callister RJ, 'Intrinsic and synaptic homeostatic plasticity in motoneurons from mice with glycine receptor mutations', Journal of Neurophysiology, 111 1487-1498 (2014) [C1]

Inhibitory synaptic inputs to hypoglossal motoneurons (HMs) are important for modulating excitability in brainstem circuits. Here we ask whether reduced inhibition, as occurs in t... [more]

Inhibitory synaptic inputs to hypoglossal motoneurons (HMs) are important for modulating excitability in brainstem circuits. Here we ask whether reduced inhibition, as occurs in three murine mutants with distinct naturally occurring mutations in the glycine receptor (GlyR), leads to intrinsic and/or synaptic homeostatic plasticity. Whole cell recordings were obtained from HMs in transverse brainstem slices from wild-type (wt), spasmodic (spd), spastic (spa), and oscillator (ot) mice (C57Bl/6, approximately postnatal day 21). Passive and action potential (AP) properties in spd and ot HMs were similar to wt. In contrast, spa HMs had lower input resistances, more depolarized resting membrane potentials, higher rheobase currents, smaller AP amplitudes, and slower afterhyperpolarization current decay times. The excitability of HMs, assessed by "gain" in injected current/firing-frequency plots, was similar in all strains whereas the incidence of rebound spiking was increased in spd. The difference between recruitment and derecruitment current (i.e., ¿I) for AP discharge during ramp current injection was more negative in spa and ot. GABAA miniature inhibitory postsynaptic current (mIPSC) amplitude was increased in spa and ot but not spd, suggesting diminished glycinergic drive leads to compensatory adjustments in the other major fast inhibitory synaptic transmitter system in these mutants. Overall, our data suggest long-term reduction in glycinergic drive to HMs results in changes in intrinsic and synaptic properties that are consistent with homeostatic plasticity in spa and ot but not in spd. We propose such plasticity is an attempt to stabilize HM output, which succeeds in spa but fails in ot. © 2014 the American Physiological Society.

DOI 10.1152/jn.00728.2013
Citations Scopus - 2
Co-authors Brett Graham, Robert Callister
2014 Lim R, Drury HR, Tadros MA, Callister RJ, Brichta AM, Camp AJ, 'Preliminary Characterization of Voltage-Activated Whole-Cell Currents in Developing Human Vestibular Hair Cells and Calyx Afferent Terminals', Journal of the Association for Research in Otolaryngology, (2014) [C1]

We present preliminary functional data from human vestibular hair cells and primary afferent calyx terminals during fetal development. Whole-cell recordings were obtained from hai... [more]

We present preliminary functional data from human vestibular hair cells and primary afferent calyx terminals during fetal development. Whole-cell recordings were obtained from hair cells or calyx terminals in semi-intact cristae prepared from human fetuses aged between 11 and 18 weeks gestation (WG). During early fetal development (11-14 WG), hair cells expressed whole-cell conductances that were qualitatively similar but quantitatively smaller than those observed previously in mature rodent type II hair cells. As development progressed (15-18 WG), peak outward conductances increased in putative type II hair cells but did not reach amplitudes observed in adult human hair cells. Type I hair cells express a specific low-voltage activating conductance, G. A similar current was first observed at 15 WG but remained relatively small, even at 18 WG. The presence of a "collapsing" tail current indicates a maturing type I hair cell phenotype and suggests the presence of a surrounding calyx afferent terminal. We were also able to record from calyx afferent terminals in 15-18 WG cristae. In voltage clamp, these terminals exhibited fast inactivating inward as well as slower outward conductances, and in current clamp, discharged a single action potential during depolarizing steps. Together, these data suggest the major functional characteristics of type I and type II hair cells and calyx terminals are present by 18 WG. Our study also describes a new preparation for the functional investigation of key events that occur during maturation of human vestibular organs. © 2014 The Author(s).

DOI 10.1007/s10162-014-0471-y
Citations Scopus - 2
Co-authors Rebecca Lim, Robert Callister
2013 Brichta AM, 'Dizzying Inspiration', International Innovation, 52-55 (2013)
2013 Tung VWK, Di Marco S, Lim R, Brichta AM, Camp AJ, 'An Isolated Semi-intact Preparation of the Mouse Vestibular Sensory Epithelium for Electrophysiology and High-resolution Two-photon Microscopy', Journal of Visualized Experiments, (2013) [C1]
DOI 10.3791/50471
Citations Scopus - 2Web of Science - 1
Co-authors Rebecca Lim
2013 Hübner PP, Lim R, Brichta AM, Migliaccio AA, 'Glycine Receptor Deficiency and Its Effect on the Horizontal Vestibulo-ocular Reflex: a Study on the SPD1J Mouse', Journal of the Association for Research in Otolaryngology, 14 249-259 (2013) [C1]
DOI 10.1007/s10162-012-0368-6
Citations Scopus - 2Web of Science - 2
Co-authors Rebecca Lim
2012 Tadros MA, Harris B, Anderson WB, Brichta AM, Graham BA, Callister RJ, 'Are all spinal segments equal: Intrinsic membrane properties of superficial dorsal horn neurons in the developing and mature mouse spinal cord', Journal of Physiology, 590 2409-2425 (2012) [C1]
Citations Scopus - 8Web of Science - 6
Co-authors Robert Callister, Brett Graham
2012 De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Heterogeneous responses to antioxidants in noradrenergic neurons of the Locus coeruleus indicate differing susceptibility to free radical content', Oxidative Medicine and Cellular Longevity, 2012 820285 (2012) [C1]
Citations Scopus - 2Web of Science - 1
Co-authors Dirk Vanhelden, Rebecca Lim, Robert Callister
2011 De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Developmental changes in pacemaker currents in mouse locus coeruleus neurons', Brain Research, 1425 27-36 (2011) [C1]
Citations Scopus - 3Web of Science - 3
Co-authors Robert Callister, Rebecca Lim, Dirk Vanhelden
2011 Lim R, McPherson AE, Donne SW, Callister RJ, Brichta AM, 'Potassium accumulation between type I hair cells and calyx terminals in mouse crista', Experimental Brain Research, 210 607-621 (2011) [C1]
DOI 10.1007/s00221-011-2592-4
Citations Scopus - 19Web of Science - 20
Co-authors Robert Callister, Scott Donne, Rebecca Lim
2011 Flynn JR, Brichta AM, Galea MP, Callister RJ, Graham BA, 'A horizontal slice preparation for examining the functional connectivity of dorsal column fibres in mouse spinal cord', Journal of Neuroscience Methods, 200 113-120 (2011) [C1]
DOI 10.1016/j.jneumeth.2011.06.017
Citations Scopus - 6Web of Science - 6
Co-authors Jamie Flynn, Robert Callister, Brett Graham
2010 Jobling P, Graham BA, Brichta AM, Callister RJ, 'Cervix stimulation evokes predominantly subthreshold synaptic responses in mouse thoracolumbar and lumbosacral superficial dorsal horn neurons', Journal of Sexual Medicine, 7 2068-2076 (2010) [C1]
DOI 10.1111/j.1743-6109.2010.01768.x
Citations Scopus - 5Web of Science - 4
Co-authors Robert Callister, Brett Graham, Phillip Jobling
2010 Lim R, Camp AJ, Walsh MA, Callister RJ, Brichta AM, 'In vitro whole-cell conductances recorded from developing human cristae.', J Vestib Res, 285-286 (2010)
Co-authors Rebecca Lim, Robert Callister
2010 Lim R, Stitt IM, Camp AJ, Walsh MA, Callister RJ, Brichta AM, 'Inhibitory synaptic transmission in the lateral vestibular nucleus.', J. Vestib. Res, 286-287 (2010)
Co-authors Rebecca Lim, Robert Callister
2010 Lim R, Callister RJ, Brichta AM, 'An increase in glycinergic quantal amplitude and frequency during early vestibular compensation in mouse', Journal of Neurophysiology, 103 16-24 (2010) [C1]
DOI 10.1152/jn.91223.2008
Citations Scopus - 13Web of Science - 6
Co-authors Robert Callister, Rebecca Lim
2010 De Oliveira R, Graham BA, Howlett MC, Gravina FS, Oliveira MW, Imtiaz MS, et al., 'Ketamine anesthesia helps preserve neuronal viability', Journal of Neuroscience Methods, 189 230-232 (2010) [C1]
DOI 10.1016/j.jneumeth.2010.03.029
Citations Scopus - 6Web of Science - 6
Co-authors Rebecca Lim, Brett Graham, Robert Callister, Dirk Vanhelden
2010 Camp AJ, Lim R, Anderson WB, Schofield PR, Callister RJ, Brichta AM, 'Attenuated glycine receptor function reduces excitability of mouse medial vestibular nucleus neurons', Neuroscience, 170 348-360 (2010) [C1]
DOI 10.1016/j.neuroscience.2010.06.040
Citations Scopus - 9Web of Science - 7
Co-authors Rebecca Lim, Robert Callister
2010 De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Pacemaker currents in mouse locus coeruleus neurons', Neuroscience, 170 166-177 (2010) [C1]
DOI 10.1016/j.neuroscience.2010.06.028
Citations Scopus - 11Web of Science - 9
Co-authors Robert Callister, Dirk Vanhelden
2009 Anderson WB, Graham BA, Beveridge NJ, Tooney PA, Brichta AM, Callister RJ, 'Different forms of glycine- and GABA(A)-receptor mediated inhibitory synaptic transmission in mouse superficial and deep dorsal horn neurons', Molecular Pain, 5 1-16 (2009) [C1]
DOI 10.1186/1744-8069-5-65
Citations Scopus - 9Web of Science - 7
Co-authors Robert Callister, Brett Graham, Paul Tooney
2009 Tadros MA, Graham BA, Brichta AM, Callister RJ, 'Evidence for a critical period in the development of excitability and potassium currents in mouse lumbar superficial dorsal horn neurons', Journal of Neurophysiology, 101 1800-1812 (2009) [C1]
DOI 10.1152/jn.90755.2008
Citations Scopus - 29Web of Science - 25
Co-authors Brett Graham, Robert Callister
2008 Graham BA, Brichta AM, Callister RJ, 'Recording temperature affects the excitability of mouse superficial dorsal horn neurons, in vitro', Journal of Neurophysiology, 99 2048-2059 (2008) [C1]
DOI 10.1152/jn.01176.2007
Citations Scopus - 20Web of Science - 21
Co-authors Brett Graham, Robert Callister
2007 Graham BA, Brichta AM, Callister RJ, 'Moving from an averaged to specific view of spinal cord pain processing circuits', Journal of Neurophysiology, 98 1057-1063 (2007) [C1]
DOI 10.1152/jn.00581.2007
Citations Scopus - 73Web of Science - 57
Co-authors Brett Graham, Robert Callister
2007 Graham BA, Brichta AM, Callister RJ, 'Pinch-current injection defines two discharge profiles in mouse superficial dorsal horn neurones, in vitro', Journal of Physiology, 578 787-798 (2007) [C1]
DOI 10.1113/jphysiol.2006.123349
Citations Scopus - 20Web of Science - 18
Co-authors Brett Graham, Robert Callister
2007 Graham BA, Brichta AM, Schofield PR, Callister RJ, 'Altered potassium channel function in the superficial dorsal horn of the spastic mouse', Journal of Physiology, 584 121-136 (2007) [C1]
DOI 10.1113/jphysiol.2007.138198
Citations Scopus - 21Web of Science - 18
Co-authors Brett Graham, Robert Callister
2006 Holt JC, Xue J-T, Brichta AM, Goldberg JM, 'Transmission between type II hair cells and bouton afferents in the turtle posterior crista', Journal of Neurophysiology, 95 428-452 (2006) [C1]
DOI 10.1152/jn.00447.2005
Citations Scopus - 23Web of Science - 20
2006 Camp AJ, Callister RJ, Brichta AM, 'Inhibitory synaptic transmission differs in mouse type A and B medial vestibular nucleus neurons in vitro', Journal of Neurophysiology, 95 3208-3218 (2006) [C1]
DOI 10.1152/jn.01001.2005
Citations Scopus - 32Web of Science - 30
Co-authors Robert Callister
2005 Lee HY, Camp AJ, Callister RJ, Brichta AM, 'Vestibular primary afferent activity in an in vitro preparation of the mouse inner ear', Journal of Neuroscience Methods, 145 73-87 (2005) [C1]
DOI 10.1016/j.jneumeth.2004.11.021
Citations Scopus - 11Web of Science - 11
Co-authors Robert Callister
2004 Graham BA, Brichta AM, Callister RJ, 'In vivo responses of mouse superficial dorsal horn neurones to both current injection and peripheral cutaneous stimulation', Journal of Physiology, 561.3 749-763 (2004) [C1]
DOI 10.1113/jphysiol.2004.072645
Citations Scopus - 49Web of Science - 42
Co-authors Brett Graham, Robert Callister
2004 Graham BA, Brichta AM, Callister RJ, 'An in vivo mouse spinal cord preparation for patch-clamp analysis of nociceptive processing', Journal of Neuroscience Methods, 136 221-228 (2004) [C1]
DOI 10.1016/j.jneumeth.2004.01.014
Citations Scopus - 18Web of Science - 15
Co-authors Robert Callister, Brett Graham
2002 Goldberg JM, Brichta AM, 'Functional Analysis of Whole Cell Currents From Hair Cells of the Turtle Posterior Crista', Journal of Neurophysiology, 88 3279-3292 (2002)
DOI 10.1152/jn.00771.2001
2002 Camp AJ, Lee H, Callister RJ, Brichta AM, 'Afferent responses to mechanical stimulation and drug application in mouse in-vitro labyrinth', Journal of Vestibular Research, 11 175 (2002) [C3]
Co-authors Robert Callister
2002 Brichta AM, Camp AJ, Lee H, Callister RJ, 'Intra-axonal recordings from canal afferents in the mouse in-vitro labyrinth', Journal of Vestibular Research, 11 177-178 (2002) [C3]
Co-authors Robert Callister
2002 Brichta AM, Aubert A, Eatock RA, Goldberg JM, 'Regional analysis of whole-cell currents from hair cells of the turtle posterior crista', Journal of Neurophysiology, 88 3259-3278 (2002) [C1]
Citations Scopus - 41
2001 Lee H-Y, Callister RJ, Brichta AM, 'Morphophysiology of Vestibular Afferents Recorded from an In Vitro Preparation of the Mouse Inner Ear', Abstracts of the Twenty-Fourth Annual Midwinter Research Meeting of the Association for Research in Otolaryngology, 0 124 (2001) [C3]
Co-authors Robert Callister
2001 Lee H-Y, Callister RJ, Brichta AM, 'Physiology of Labelled Vestibular Afferents Recorded from an In Vitro Preparation of the Mouse Inner Ear', Proceedings of the Australian Neuroscience Society, 12 217 (2001) [C3]
Co-authors Robert Callister
2000 Dailey SH, Wackym PA, Brichta AM, Gannon PJ, Popper P, 'Topographic distribution of nicotinic acetylcholine receptors in the cristae of a turtle', Hearing Research, 141 51-56 (2000)
DOI 10.1016/S0378-5955(99)00208-7
2000 Brichta AM, Goldberg J, 'Morphological Identification of Physiologically Characterized Afferents Innervating the Turtle Posterior Crista', Journal of Neurophysiology, 83 No. 3 1202-1223 (2000) [C1]
Citations Scopus - 36
2000 Brichta AM, Goldberg J, 'Responses to Efferent Activation and Excitatory Response-Intensity Relations of Turtle Posterior-Crista Afferents', Journal of Neurophysiology, 83 No. 3 1224-1242 (2000) [C1]
Citations Scopus - 45
2000 Won Y-S, Brichta AM, Baroody F, Boonlayangoor S, Naclerio R, 'Bactrim reduces the inflammatory response in a murine model of acute rhinosinusitis', Rhinology, 38 68-71 (2000) [C1]
Citations Scopus - 6
1999 Basile A, Brichta AM, Harris B, Morse D, Coling D, Skolnick P, 'Dizocilpine attenuates streptomycin-induced vestibulotoxicity in rats', Neuroscience Letters, 265 71-74 (1999) [C1]
1999 Callister RJ, Peterson E, Brichta AM, 'Neuromuscular strategies underlying ballistic movements', Progress in Brain Research, 123 233-243 (1999) [C1]
Citations Scopus - 2Web of Science - 2
Co-authors Robert Callister
1998 Bomer K, Brichta AM, Baroody F, Boonlayangoor S, Xiantang M, Naclerio RM, 'A Mouse Model of Acute Bacterial Rhinosinusitis', Archives of Otolaryngology¿Head & Neck Surgery, 124 1227-1232 (1998)
DOI 10.1001/archotol.124.11.1227
1998 Goldberg JM, Brichta AM, 'Evolutionary trends in the organization of the vertebrate crista ampullaris', Otolaryngology - Head and Neck Surgery, 165-171 (1998)
DOI 10.1016/S0194-5998(98)70051-8
1998 Brichta AM, Goldberg JM, 'The papilla neglecta of turtles: a detector of head rotations with unique sensory coding properties.', The Journal of Neuroscience, 18 4314-4324 (1998)
1996 BRICHTA AM, GOLDBERG JM, 'Afferent and Efferent Responses from Morphological Fiber Classes in the Turtle Posterior Crista', Annals of the New York Academy of Sciences, 781 183-195 (1996)
DOI 10.1111/j.1749-6632.1996.tb15701.x
1994 Brichta AM, Peterson EH, 'Functional architecture of vestibular primary afferents from the posterior semicircular canal of a turtle,Pseudemys (Trachemys) scripta elegans', The Journal of Comparative Neurology, 344 481-507 (1994)
DOI 10.1002/cne.903440402
1992 BRICHTA AM, PETERSON EH, 'Vestibular Afferents Innervating the Posterior Ampullae in a Turtle, Pseudemys scripta', Annals of the New York Academy of Sciences, 656 914-916 (1992)
DOI 10.1111/j.1749-6632.1992.tb25293.x
1988 Brichta AM, Acuna DL, Peterson EH, 'Planar Relations of Semicircular Canals in Awake, Resting Turtles, Pseudemys scripta', Brain, Behavior and Evolution, 32 236-245 (1988)
DOI 10.1159/000116551
1987 Brichta AM, Callister RJ, Peterson EH, 'Quantitative analysis of cervical musculature in rats: Histochemical composition and motor pool organization', J. Comp. Neurol, 255 351-368 (1987) [C1]
Citations Scopus - 36Web of Science - 44
Co-authors Robert Callister
1987 CALLISTER RJ, BRICHTA AM, PETERSON EH, 'QUANTITATIVE-ANALYSIS OF CERVICAL MUSCULATURE IN RATS - HISTOCHEMICAL COMPOSITION AND MOTOR POOL ORGANIZATION .2. DEEP DORSAL MUSCLES', JOURNAL OF COMPARATIVE NEUROLOGY, 255 369-385 (1987)
DOI 10.1002/cne.902550305
Citations Scopus - 24Web of Science - 34
Co-authors Robert Callister
Show 54 more journal articles

Review (2 outputs)

Year Citation Altmetrics Link
2015 Lim R, Wellings TP, Brichta AM, 'Central Vestibular Signal Processing (2015) [D1]
DOI 10.1007/978-1-4614-7320-6_3-2
Co-authors Rebecca Lim
2014 Wellings TP, Brichta AM, Lim R, 'Vestibular Adaptation and Compensation (2014) [D1]
DOI 10.1007/978-1-4614-7320-6_6-2
Co-authors Rebecca Lim

Conference (52 outputs)

Year Citation Altmetrics Link
2015 Cairns M, Geaghan MP, Cairns HM, Carroll AP, Brichta AM, 'Molecular determinants of schizophrenia-associated alteration of miRNA biogenesis', JOURNAL OF NEUROCHEMISTRY (2015) [E3]
Co-authors Murray Cairns
2015 Tadros M, Lim R, Hughes D, Jobling P, Brichta A, Callister R, 'Electrical maturation of sensorimotor processing in the human foetus', JOURNAL OF NEUROCHEMISTRY (2015) [E3]
Co-authors Rebecca Lim, Robert Callister, Phillip Jobling
2014 Lim R, Drury HR, Camp AJ, Tadros MA, Callister RJ, Brichta AM, 'Anatomical and physiological characterisation of human vestibular hair cells', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science (2014) [E3]
Co-authors Rebecca Lim, Robert Callister
2014 Wellings TP, Graham BA, Camp AJ, Callister RJ, Brichta AM, Lim R, 'Calcium binding proteins subdivide medial vestibular nucleus neurons', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science (2014) [E3]
DOI 10.3233/VES-140517
Co-authors Robert Callister, Brett Graham, Rebecca Lim
2014 Poppi LA, Tabatabaee H, Callister RJ, Lim R, Brichta AM, 'Cholinergic Activity of the Peripheral Efferent Vestibular System', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science (2014) [E3]
DOI 10.3233/VES-140517
Co-authors Robert Callister, Rebecca Lim
2014 Khan SI, Hübner PP, Smith DW, Brichta AM, Migliaccio AA, 'Ageing reduces vestibulo-ocular reflex adaptation in mice J Vestib Res', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science (2014) [E3]
DOI 10.3233/VES-140517
Co-authors Douglas Smith
2013 Huebner PP, Lim R, Brichta AM, Migliaccio AA, 'Glycine Receptor Deficiency and Its Effect on the Vestibulo-Ocular Reflex: A Study on the SPD1J Mouse', 36th Association for Research in Otolaryngology (2013) [E3]
Co-authors Rebecca Lim
2013 Poppi LA, Tabatabaee H, Callister RJ, Lim R, Brichta AM, 'From the ear to the brain, and back again ¿ the Efferent Vestibular System', 4th UWS Sensory Neuroscience Symposium (2013) [E3]
Co-authors Rebecca Lim, Robert Callister
2013 Wellings TP, Brichta AM, Lim R, 'Revealing the functional organisation of central vestibular nuclei', Neuro-Otology Society of Australia (2013) [E3]
Co-authors Rebecca Lim
2013 Poppi LA, Tabatabaee H, Callister RJ, Lim R, Brichta AM, 'Efferent Vestibular System ¿ the mysterious part of the periphery', Neuro-Otology Society of Australia (2013) [E3]
Co-authors Rebecca Lim, Robert Callister
2013 Bigland M, Parkinson G, Brichta AM, Smith DW, 'Evidence for mitochondrial DNA deletions in vestibular hair cells of the aged rat', Proceedings of the Australian Neuroscience Society (2013) [E3]
Co-authors Douglas Smith
2013 Tadros MA, Fuglevand AJ, Brichta AM, Callister RJ, 'Electrophysiological properties of cranial and spinal motor neurons in mice', Proceedings of the Australian Neuroscience Society (2013) [E3]
Co-authors Robert Callister
2013 Drawitsch F, Rancz EA, Brichta AM, Canals SG, Margrie TW, 'Widespread representation of vestibular activity in the rodent brain.', Society for Neuroscience (2013) [E3]
2013 Wellings TP, Callister RJ, Graham BA, Brichta AM, Lim R, 'Sensing balance: the role of central vestibular nuclei', University of Western Sydney Medical School (2013) [E3]
Co-authors Rebecca Lim, Brett Graham, Robert Callister
2012 Tadros MA, Lim R, Graham BA, Hughes DI, Brichta AM, Callister RJ, 'Excitability of human ventral horn neurons during early foetal development', Abstracts. Australian Neuroscience Society 32nd Annual Meeting (2012) [E3]
Co-authors Robert Callister, Brett Graham, Rebecca Lim
2012 Lim R, Camp AJ, Tadros MA, Drury HR, Callister RJ, Brichta AM, 'Whole cell conductances of developing human hair cells', Abstracts. Australian Neuroscience Society 32nd Annual Meeting (2012) [E3]
Co-authors Robert Callister, Rebecca Lim
2012 Stitt IM, Drury HR, Callister RJ, Brichta AM, Lim R, 'Anatomical and physiological characterization of mouse lateral vestibular nucleus neurons. 048', Association for Research in Otolaryngology (2012)
Co-authors Robert Callister, Rebecca Lim
2012 Lim R, Camp AJ, Drury HR, Tadros MA, Callister RJ, Brichta AM, 'Characterisation of developing human hair cells', Association for Research in Otolaryngology (2012)
Co-authors Robert Callister, Rebecca Lim
2012 Lim R, Stitt IM, Drury HR, Wellings TP, Callister RJ, Brichta AM, 'Electrophysiological characterization of mouse lateral vestibular nucleus neurons', Frontiers in Otolaryngology (2012)
Co-authors Rebecca Lim, Robert Callister
2012 Lim R, Callister RJ, Holt JC, Migliaccio AA, Brichta AM, 'Efferent modulation of peripheral vestibular organs', Neuro-Otology Society of Australia (2012) [E3]
Co-authors Robert Callister, Rebecca Lim
2012 Lim R, Kindig AE, Callister RJ, Brichta AM, 'A special relationship between vestibular hair cells and afferent nerve terminals', Neuro-Otology Society of Australia (2012) [E3]
Co-authors Rebecca Lim, Robert Callister
2012 Tadros MA, Jack R, Lim R, Graham BA, Brichta AM, Hughes DI, Callister RJ, 'Sensorimotor processing in the spinal cord of the developing human fetus', Society for Neuroscience (2012)
Co-authors Brett Graham, Robert Callister, Rebecca Lim
2012 Rostas JAP, Skelding KA, Fleuchter L, Dickson PW, Spratt NJ, Brichta AM, 'CaMKII is differentially regulated in brain regions that exhibit differing sensitivities to ischemia and excitotoxicity', Society for Neuroscience (2012)
2012 Lim R, Callister RJ, Brichta AM, 'The other part of the ear - a 'balanced' view', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme (2012) [E3]
Co-authors Robert Callister, Rebecca Lim
2011 Brichta AM, 'Understanding Signals from ¿Inner Space¿: recreating our sense of balance', Frontiers in Neuroengineering (2011)
2011 Tadros MA, Lim R, Graham BA, Hughes DI, Brichta AM, Callister RJ, 'Excitability of human ventral horn neurons during early foetal development', Poster Abstracts. Australian Neuroscience Society Annual Meeting (2011) [E3]
Co-authors Robert Callister, Brett Graham, Rebecca Lim
2011 Graham BA, Sah P, Brichta AM, Callister RJ, Hughes DI, 'Neuroanatomical and neurochemical features of parvalbumin-expressing neurons in the mouse spinal dorsal horn', Posters. Australian Neuroscience Society 31st Annual Meeting (2011) [E3]
Co-authors Robert Callister, Brett Graham
2011 Tynan RJ, Day TA, Brichta AM, Walker FR, 'Not Just Reuptake. Selective serotonin reuptake inhibitors attenuate LPS induced microglial pro-inflammatory cytokine production', Society of Neuroscience (2011) [E3]
Co-authors Rohan Walker
2010 Lim R, Camp AJ, Walsh M, Callister RJ, Brichta AM, 'In-vitro whole-cell conductances recorded from developing human cristae', Journal of Vestibular Research (2010) [E3]
Co-authors Rebecca Lim, Robert Callister
2010 Lim R, Stitt I, Camp AJ, Callister RJ, Brichta AM, 'Inhibitory synaptic transmission in the lateral vestibular nucleus', Journal of Vestibular Research (2010) [E3]
Co-authors Rebecca Lim, Robert Callister
2010 Callister RJ, Walsh MA, Harris BM, Anderson WB, Brichta AM, Graham BA, 'Segmental and developmental differences in the excitability of mouse superficial dorsal horn neurons', 13th World Congress on Pain: Abstracts (2010) [E3]
Co-authors Brett Graham, Robert Callister
2010 Walsh MA, Farrell KE, Graham BA, Brichta AM, Callister RJ, 'Sodium current properties differ in neonate and adult superficial dorsal horn neurons', 13th World Congress on Pain: Abstracts (2010) [E3]
Co-authors Robert Callister, Brett Graham
2010 Harris BM, Graham BA, Bolton PS, Brichta AM, Callister RJ, 'Influence of acute neck muscle inflammation on the excitability of superficial dorsal horn neurons', 13th World Congress on Pain: Abstracts (2010) [E3]
Co-authors Philip Bolton, Brett Graham, Robert Callister
2010 Graham BA, Hughes DI, Lim R, Sah P, Brichta AM, Callister RJ, 'Characterization of calretinin expressing interneurons in the superficial dorsal horn of the mouse spinal cord', 13th World Congress on Pain: Abstracts (2010) [E3]
Co-authors Brett Graham, Rebecca Lim, Robert Callister
2009 De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Ion channel modulation by reactive species in mice locus coeruleus neurons', Journal of Physiological Sciences (2009) [E3]
Co-authors Dirk Vanhelden, Robert Callister
2009 De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Effect of antioxidants in pacemaking of mice locus coeruleus neurons', ANS 2009 Abstracts: Posters (2009) [E3]
Co-authors Dirk Vanhelden, Robert Callister
2009 Brichta AM, Lamont E, Lim R, Callister RJ, 'Vestibular effects of endolymphatic ionic and volume changes in an isolated preparation of a mouse labyrinth', Abstracts of the Thirty-Second Annual Midwinter Research Meeting Association for Research in Otolaryngology (2009) [E3]
Co-authors Rebecca Lim, Robert Callister
2009 McPherson AE, Lim R, Callister RJ, Brichta AM, 'Voltage dependent currents in Type I and II hair cells and calyx terminals of primary afferents in an intact in vitro mouse vestibular crista preparation', Abstracts of the Thirty-Second Annual Midwinter Research Meeting Association for Research in Otolaryngology (2009) [E3]
Co-authors Rebecca Lim, Robert Callister
2009 Lim R, Callister RJ, Brichta AM, 'Changes in glycinergic synaptic transmission and neuronal excitability in mouse medial vestibular nucleus neurons during early vestibular compensation', Abstracts of the Thirty-Second Annual Midwinter Research Meeting Association for Research in Otolaryngology (2009) [E3]
Co-authors Rebecca Lim, Robert Callister
2009 Lim R, McPherson AE, Pow DV, Callister RJ, Brichta AM, 'Glutamate transport in the mouse inner ear is mediated by the excitatory amino acid transporter, EAAT5', Abstracts of the Thirty-Second Annual Midwinter Research Meeting Association for Research in Otolaryngology (2009) [E3]
Co-authors Rebecca Lim, Robert Callister
2008 Jobling P, Graham BA, Brichta AM, Callister RJ, 'In vivo patch clamp recording of synaptic events evoked in superficial dorsal horn neurons after stimulation of the female reproductive tract in the mouse', Proceedings of the Australian Neuroscience Society (2008) [E3]
Co-authors Phillip Jobling, Robert Callister, Brett Graham
2008 De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Influence of mitochondria in the interspike interval pacemaking currents of mice Locus Coeruleus neurons', Proceedings of the Australian Physiological Society (2008) [E3]
Co-authors Dirk Vanhelden, Robert Callister
2008 Callister RJ, Brichta AM, Graham BA, 'Beyond the dorsal horn: The use of animal models to discover new sites for pain therapy', Australian and New Zealand Journal of Psychiatry (2008) [E3]
Co-authors Brett Graham, Robert Callister
2007 Camp AJ, Anderson WB, Callister RJ, Schofield PR, Brichta AM, 'Contribution of inhibitory synaptic transmission to the intrinsic membrane properties of Medial Vestibular Nucleus (MVN) neurons (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program (2007) [E3]
Co-authors Robert Callister
2006 Anderson WB, Graham BA, Jobling P, Lim R, Brichta AM, Callister RJ, 'Glycine receptor diversity in the dorsal horn of the mouse spinal cord', Society for Neuroscience (2006) [E3]
Co-authors Brett Graham, Rebecca Lim, Robert Callister, Phillip Jobling
2006 Jobling P, Graham BA, Brichta AM, Callister RJ, 'In vivo patch-clamp recording of subthreshold synaptic events evoked in dorsal horn neurons after stimulation of the female reproductive tract in the mouse', Society for Neuroscience (2006) [E3]
Co-authors Robert Callister, Brett Graham, Phillip Jobling
2006 Walsh MA, Graham BA, Brichta AM, Callister RJ, 'Postnatal development of electrophysiological properties in mouse supeficial dorsal horn neurones', Proceedings of the Australian Neuroscience Society (2006) [E3]
Co-authors Brett Graham, Robert Callister
2005 Graham BA, Brichta AM, Callister RJ, 'Effect of Temperature on the Discharge Properties of Mouse Superficial Dorsal Horn Neurons', Proceedings of the Australian Neuroscience Society (2005) [E3]
Co-authors Brett Graham, Robert Callister
2005 Camp AJ, Watson PJ, Schofield PR, Callister RJ, Brichta AM, 'Inhibitory Synaptic Transmission in Medial Vestibular Nucleus Neurons of Wildtype, Spastic, Spasmodic, and Oscillator Mice', Proceedings of the Australian Neuroscience Society (2005) [E3]
Co-authors Robert Callister
2005 Callister RJ, Graham BA, Brichta AM, 'In Vivo Responses of Mouse Spinal Neurones to Electrical and Functionally-Relevant Stimulation', Proceedings of the Australian Neuroscience Society Conference (2005) [E3]
Co-authors Brett Graham, Robert Callister
2004 Krajniak SG, Callister RJ, Imtiaz MS, Brichta AM, Van Helden DF, 'Investigation of a brain rhythm', Proceedings of the Australian Neuroscience Society (2004) [E3]
Co-authors Dirk Vanhelden, Robert Callister
1999 Brichta AM, Goldberg J, 'Ionic Currents of Isolated Hair Cells Selectively Harvested from Different Zones of the Turtle Posterior Crista', Proceedings of the Australian Neuroscience Society. Vol. 10 (1999) [E2]
Show 49 more conferences
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Grants and Funding

Summary

Number of grants 57
Total funding $8,576,245

Click on a grant title below to expand the full details for that specific grant.


20163 grants / $845,047

Mechanisms underlying efferent feedback in the vestibular system$491,473

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alan Brichta, Associate Professor Brett Graham, Doctor Rebecca Lim, Professor Robert Callister, Dr Chris Holt, Associate Professor Chris Dayas, Professor Richard Rabbitt
Scheme Project Grant
Role Lead
Funding Start 2016
Funding Finish 2018
GNo G1500239
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

HMRI MRSP Infrastructure (12-16) Brain and Mental Health Program – CBMHR$344,047

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Alan Brichta, Professor Brian Kelly
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2016
Funding Finish 2016
GNo G1600732
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Improving rapid decisions made under duress$9,527

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Scott Brown, Doctor Ami Eidels, Doctor Keith Nesbitt, Professor Alan Brichta
Scheme Linkage Pilot Research Grant
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo G1501472
Type Of Funding Internal
Category INTE
UON Y

20152 grants / $22,000

Dizzy and Deaf - restoring signals from the inner ear$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Rebecca Lim, Professor Alan Brichta, Professor Robert Callister, Doctor Doug Smith
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1501395
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Association for Research in Otolaryngology, 21-25 February 2015$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Professor Alan Brichta
Scheme Travel Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500257
Type Of Funding Internal
Category INTE
UON Y

20143 grants / $628,840

Spinal processing of sensory signals from the gut$536,226

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Doctor Simon Keely, Associate Professor Brett Graham, Professor Alan Brichta, Dr David Hughes
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2016
GNo G1300361
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Physiological and Behavioural Characterisation of Central Vestibular Function$90,614

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding body Garnett Passe and Rodney Williams Memorial Foundation
Project Team Dr Thomas Wellings, Professor Alan Brichta, Doctor Rebecca Lim
Scheme Research Scholarship
Role Lead
Funding Start 2014
Funding Finish 2015
GNo G1301066
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

XXVIIIth Barany Society Meeting, Buenos Aires Argentina, 25-29 May 2014$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Professor Alan Brichta
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400597
Type Of Funding Internal
Category INTE
UON Y

20136 grants / $551,122

Development of functional connections in the human peripheral vestibular system$418,281

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Rebecca Lim, Professor Alan Brichta, Professor Robert Callister
Scheme Project Grant
Role Investigator
Funding Start 2013
Funding Finish 2015
GNo G1200254
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Two replacement OBIS lasers for Nikon Eclipse 80i Confocal microscope (488 nm and 594 nm)$27,841

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alan Brichta
Scheme Equipment Grant
Role Lead
Funding Start 2013
Funding Finish 2014
GNo G1301305
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Functional characterisation of schizophrenia-associated neurodevelopmental dysfunction of miR-137$25,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Associate Professor Murray Cairns, Doctor Frederick Walker, Professor Alan Brichta, Doctor Natalie Beveridge
Scheme Near Miss Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300468
Type Of Funding Internal
Category INTE
UON Y

Functional characterisation of schizophrenia-associated neurodevelopmental dysfunction of miR-137$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Associate Professor Murray Cairns, Doctor Frederick Walker, Professor Alan Brichta, Doctor Natalie Beveridge
Scheme Near Miss
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300801
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

microRNA and translation dynamics of synaptic plasticity$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Associate Professor Murray Cairns, Professor Alan Brichta, Doctor Frederick Walker
Scheme Near Miss Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300463
Type Of Funding Internal
Category INTE
UON Y

20122 grants / $470,982

Development of peripheral sensory pathways in humans$469,167

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Professor Alan Brichta, Dr David Hughes, Doctor Phil Jobling
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2014
GNo G1100102
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Association for Research in Otolaryngology 35th Annual Mid Winter Meeting, San Diego, 25 - 29 February 2012$1,815

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Professor Alan Brichta
Scheme Travel Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200416
Type Of Funding Internal
Category INTE
UON Y

20112 grants / $349,208

Efferent modulation of the vestibular periphery$339,208

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alan Brichta, Professor Robert Callister, Doctor Rebecca Lim
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2013
GNo G1000315
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

IMPLEN NanoPhotometer pearl$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Associate Professor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Bristow, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Dr DAN Johnstone, Ms BELINDA Goldie, Doctor Natalie Beveridge
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100030
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20106 grants / $1,129,500

Molecular and cellular characterisation of schizophrenia associated dysfunction in microRNA biogenesis$478,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Murray Cairns, Professor Rodney Scott, Associate Professor Paul Tooney, Emeritus Professor John Rostas, Professor Alan Brichta
Scheme Project Grant
Role Investigator
Funding Start 2010
Funding Finish 2012
GNo G0190196
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Laser microdissection microscopy system for cell and development biology$350,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Laureate Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Doctor Doug Smith, Associate Professor David McCurdy, Emeritus Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Brett Graham, Associate Professor Paul Tooney, Laureate Professor Roger Smith, Laureate Professor Paul Foster, Professor Trevor Day, Professor Robert Callister
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0190369
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

XXVI Barany Society Meeting, Reykjavik, 15 - 21st August 2010 , $2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Professor Alan Brichta
Scheme Travel Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000134
Type Of Funding Internal
Category INTE
UON Y

20095 grants / $1,216,144

Spinal mechanisms underlying neck pain$451,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Professor Philip Bolton, Professor Alan Brichta
Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2011
GNo G0188840
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Neurometer CPT/C$28,435

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Philip Bolton, Professor Robert Callister, Professor Alan Brichta, Professor Robin Callister, Associate Professor Brett Graham, Doctor Phil Jobling
Scheme Equipment Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189845
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Leica VT1200S - Fully automated vibrating blade microtome$16,209

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Professor Alan Brichta, Conjoint Professor Keith Jones, Professor Jon Hirst, Associate Professor Brett Graham, Professor Philip Bolton, Doctor Phil Jobling, Associate Professor Paul Tooney, Doctor Angela McPherson, Doctor Rebecca Lim, Doctor Ramatis De Oliveira, Mr Matthew Walsh
Scheme Equipment Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189842
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20083 grants / $1,044,069

Vestibular signalling mechanisms; from periphery to brainstem$1,000,000

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding body Garnett Passe and Rodney Williams Memorial Foundation
Project Team Professor Alan Brichta
Scheme Senior/Principal Research Fellowship
Role Lead
Funding Start 2008
Funding Finish 2012
GNo G0188205
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Recovery of the balance system following injury$24,069

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Alan Brichta, Professor Robert Callister, Professor Philip Bolton, Doctor Phil Jobling, Doctor Rebecca Lim
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188471
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Leica VT2100S Vibrating Microtome$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alan Brichta, Professor Robert Callister, Professor Dirk Van Helden, Professor Philip Bolton, Doctor Rebecca Lim, Associate Professor Brett Graham, Dr Marcus Howlett, Doctor Angela McPherson, Doctor Mohammad Imtiaz, Doctor Ramatis De Oliveira, Mr Wayne Anderson, Mr Matthew Walsh
Scheme Equipment Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188540
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20072 grants / $37,678

High speed/sensitivity CCD camera$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Professor Alan Brichta, Professor Robert Callister, Associate Professor Brett Graham, Associate Professor Derek Laver, Associate Professor Liz Milward, Doctor John Holdsworth
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188196
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Developing a rodent model to study neck pain$7,678

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Robert Callister, Professor Philip Bolton, Professor Alan Brichta, Associate Professor Brett Graham
Scheme Pilot Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187879
Type Of Funding Internal
Category INTE
UON Y

20064 grants / $1,011,402

Descending control of pain pathways$423,950

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Professor Trevor Day, Professor Alan Brichta
Scheme Project Grant
Role Investigator
Funding Start 2006
Funding Finish 2008
GNo G0185184
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The neural basis of vestibular compensation$311,472

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alan Brichta, Professor Robert Callister
Scheme Project Grant
Role Lead
Funding Start 2006
Funding Finish 2008
GNo G0185195
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Cellular mechanisms underlying activity in the peripheral vestibular organs$269,980

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding body Garnett Passe and Rodney Williams Memorial Foundation
Project Team Professor Alan Brichta, Professor Robert Callister
Scheme Project Grant
Role Lead
Funding Start 2006
Funding Finish 2008
GNo G0185817
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Endolymphatic changes in isolated inner ear$6,000

Funding body: Sydney University Medical Foundation

Funding body Sydney University Medical Foundation
Project Team

Alan Brichta

Scheme Meniere's Disease Foundation
Role Lead
Funding Start 2006
Funding Finish 2006
GNo
Type Of Funding External
Category EXTE
UON N

20053 grants / $243,000

INVESTIGATION OF A BRAIN RHYTHM$220,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Dirk Van Helden, Professor Robert Callister, Professor Alan Brichta
Scheme Discovery Projects
Role Investigator
Funding Start 2005
Funding Finish 2007
GNo G0184333
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Novel spinal cord targets for pain management$13,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Robert Callister, Professor Alan Brichta
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184884
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Descending control of pain processing pathways in the spinal cord$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Robert Callister, Professor Alan Brichta, Professor Trevor Day
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184748
Type Of Funding Internal
Category INTE
UON Y

20045 grants / $336,047

High-Speed Confocal Microscope Live Cell Recording System$274,692

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Dirk Van Helden, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alan Brichta, Associate Professor J Keast, Dr J Brock, Dr S Head
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183031
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

High-speed Confocal Microscope Live Cell Recording System$30,000

Funding body: University of New South Wales

Funding body University of New South Wales
Project Team Professor Dirk Van Helden, Associate Professor J Keast, Laureate Professor John Aitken, Dr J Brock, Professor Eileen McLaughlin, Dr S Head, Professor Alan Brichta
Scheme Linkage Infrastructure Equipment & Facilities (LIEF) Partner Funding
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183841
Type Of Funding Not Known
Category UNKN
UON Y

How does the balance system process signals?$14,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alan Brichta, Professor Robert Callister
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183499
Type Of Funding Internal
Category INTE
UON Y

Investigation a brain rythym$14,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden, Professor Robert Callister, Professor Alan Brichta
Scheme Project Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0184506
Type Of Funding Internal
Category INTE
UON Y

Annual Meeting of the Society for Neuroscience, 23-27 October 2004, USA$2,355

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alan Brichta
Scheme Travel Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0184863
Type Of Funding Internal
Category INTE
UON Y

20032 grants / $67,353

Transduction mechanisms in the in vitro mouse vestibular organs.$51,018

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding body Garnett Passe and Rodney Williams Memorial Foundation
Project Team Professor Alan Brichta
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2003
Funding Finish 2004
GNo G0182512
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Equipment Grant$16,335

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team

Robert Callister

Scheme RIB Grant
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo
Type Of Funding Internal
Category INTE
UON N

20022 grants / $339,500

Electron Microscope/X-Ray Unit Equipment Upgrade$337,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Conjoint Professor Christina Offler, Professor Bill Collins, Professor Erich Kisi, Professor Alan Brichta, Laureate Professor John Aitken, Emeritus Professor John Patrick
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181515
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Biennial Conference: Barany Society XXII Meeting and Satellite Meeting Seattle, Washington State, USA, 22-29 September 2002$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alan Brichta
Scheme Travel Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0182225
Type Of Funding Internal
Category INTE
UON Y

20012 grants / $24,042

Efferent modulation of hearing and the sense of balance$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Alan Brichta, Professor Robert Callister
Scheme Research Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0181165
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Investigation of the efferent vestibular system in a mammalian in vitro preparation.$4,042

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding body Garnett Passe and Rodney Williams Memorial Foundation
Project Team Professor Alan Brichta
Scheme Project Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0180499
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

20003 grants / $232,311

Cellular mechanisms underlying the sense of balance.$190,020

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alan Brichta, Professor Robert Callister
Scheme Project Grant
Role Lead
Funding Start 2000
Funding Finish 2002
GNo G0178493
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Cellular Mechanisms Underlying the Sense of Balance.$30,291

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding body Garnett Passe and Rodney Williams Memorial Foundation
Project Team Professor Alan Brichta, Professor Robert Callister
Scheme Project Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0179041
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Cellular Mechanisms Underlying the Sense of Balance.$12,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Alan Brichta
Scheme Research Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0178720
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

19991 grants / $11,000

Cellular mechanisms underlying the sense of balance.$11,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alan Brichta
Scheme Special Project Grant
Role Lead
Funding Start 1999
Funding Finish 1999
GNo G0179151
Type Of Funding Internal
Category INTE
UON Y

19981 grants / $17,000

Cellular mechanisms underlying the sense of balance$17,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Alan Brichta
Scheme New Staff Grant
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0180943
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed4
Current6

Total current UON EFTSL

Masters0.2
PhD1.9

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2015 Masters The Protein Phosphatase 2A in Alzheimer's Disease Pathogenesis
M Philosophy (Medical Biochem), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Synaptic Properties of the Peripheral Efferent Vestibular System
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD MicroRNA Biogenesis in Neuronal Function and Schizophrenia
PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Development of Occupational Noise Induced Hearing Loss: A Review of Identification and Management
PhD (Environ & Occupat Hlth), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Ageing of the Inner Ear Balance System
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Physiological and Behavioural Characterisation of Central Vestibular Function
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2011 PhD Electrophysiological Development of Superficial Dorsal Horn Neurons in Mice
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2010 PhD Pacemaking in Mouse Locus Coeruleus Neurons: Electrophysiological Properties, Role of Mitochondria and Development
PhD (Human Physiology), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2007 PhD Inhibitory Synaptic Transmission in Mouse Medial Vestibular Nucleus Neurons
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2006 PhD Pain processing mechanisms in the superficial dorsal horn of the mouse spinal cord: in vivo and in vitro
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
Australia 42
United States 11
United Kingdom 3
Canada 2
Netherlands 2
More...
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News

NHMRC

NHMRC funding success 2016

November 13, 2015

Professor Alan Brichta has been awarded more than $491,000 in NHMRC Project Grant funding commencing in 2016 for his research project Mechanisms underlying efferent feedback in the vestibular system.

Keeping Newcastle balanced

Keeping Newcastle balanced: balance research in vestibular neuroscience

March 20, 2015

How do we understand the world around us?  A seemingly simple question.

Professor Alan Brichta

Position

Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Anatomy

Contact Details

Email alan.brichta@newcastle.edu.au
Phone (02) 4921 7026
Fax (02) 4921 7812
Link UoN Blogs

Office

Room MS309A
Building Medical Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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