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Career Summary

Biography

I obtained my BSc (Hons) and PhD in organic chemistry from the University of Strathclyde in Scotland. At the completion of my studies I took up a postdoctoral position at the University of Queensland in the area of reactive intermediates chemistry (spectroscopy at -261 ºC). After a 2 year stay, I changed research direction working alongside Professor Ron Quinn at Griffith University as a synthetic medicinal chemist. It was here I developed an interest in medicinal chemistry and teaching.

In December 1995 I was fortunate to secured a position as lecturer in organic chemistry at the University of Newcastle.

My team (the ones who do all the work) is responsible for >125 research publications and we have secured ~$25M in research funding since my arrival in Newcastle.

Qualifications

  • PhD, University of Strathclyde
  • Bachelor of Science (Honours), University of Strathclyde

Research

Research keywords

  • Anti-cancer agents
  • Anti-parastic agents
  • Chemical Biology
  • Clathrin Inhibitors
  • Drug Design and Discovery
  • Dynamin GTPase
  • Flow Chemistry
  • Organic Chemistry
  • Protein Phosphatase Inhibitors

Research expertise

Medicinal Chemistry;

* Inhibition of Protein Phosphatases as a therapeutic Strategy

* Inhibition of Dynamin GTPase

* Prevention of Pre-term delivery in Humans: Agonists & antagonists of Corticotrophin Releasing Hormone (CRH)

Green Chemistry;

Overarching Interest is in the application of organic chemistry strategies in the development of new therapeutic agents (Organic and Medicinal Chemistry). Additionally, given environmental and public concerns relating to Chemistry we are driven by a desire to develop Green Chemistry approaches in our organic and medicinal chemistry targets.

Emphasis is placed on solvent free reactions, atom efficiency, replacement of volatile organic solvents with environmentally friendly equivalents (ionic liquids), and evaluation of the most efficient synthetic routes to the desired end-points. My group's primary interests are in developing novel compounds with the ability to inhibit a number of signal transduction pathways.

The potential outcomes of our research include (but are not limited to) the development of new synthetic methodologies; the development of new drugs & the development of new tools for dissecting signal transduction pathways.

Fields of Research

CodeDescriptionPercentage
111599Pharmacology And Pharmaceutical Sciences Not Elsewhere Classified70
030400Medicinal And Biomolecular Chemistry30

Memberships

Editorial Board.

  • Editor - Medicinal Chemistry

Appointments

Honary Scientist
Children's Medical Research Institute (Australia)
01/01/2010

Awards

Recognition.

2005Vice Chancellors Award for Teaching Excellence, Science & IT
The University of Newcastle (Australia)
Excellence in research is typically characterised by research publications and grant success. Excellence in teaching is less tangible, thus the recognition of both my peers and students via this award is of greater significance than all the research success to date. The greatest contribution to research comes via inspirational teaching and engendering a zest for learning and questioning. The receipt of this award indicates that I have been partly successful, which in turn has been reflected by the research successes attained. Good teaching inspires students, inspiring students conduct world class research.

Collaboration

I am a teaching and research academic who believes that nurturing students and introducing to a positive research experience is one of the pillars of teaching at the University of Newcastle.

My research can be classified as either medicinal chemistry or chemical biology. I am known for the development of elegant approaches to highly focused compound libraries of biologically active compound. My team has established considerable corporate knowledge in the area of clathrin mediated endocytosis and its implications in neurological diseases, eg epilepsy. This led to the establishment of the dynamin modulators platform of which I am team leader (chemistry). This team interacts with, and supplies the only known endocytosis inhibitors to research teams worldwide (UK, USA, Germany, Denmark etc). I am also an integral component of the development of new anti-epileptic drugs alongside the National Institute of Health, National Institute of Neurological Disorders and Stroke (Bethesda USA).

I head the chemistry component of the Australian Cancer Research Foundation (supported by Ramaciotti) Centre for Kinomics (CFK), a new approach for direct profiling of cellular kinases, a multi-million dollar initiative providing a unique service to multiple research teams throughout Australia. Kinases are the cancer drug target of the 21st century. The CFK offers a unique opportunity to profile biological probes (drugs) and cellular kinases to identify new therapeutic targets, new uses for old drugs and rapid IC50 determination of individual compounds against the entire cellular kinome (cellular complement of protein kinases). The CFK at the University of Newcastle has established one of the first fully equipped flow chemistry laboratories in Australia comprising the ThalesNano H- and X-cube, the Syrris FRX and Syrris Africa work stations, and the VapourTech 4 pump -70 ºC unit. This facility is purpose built for the rapid optimisation of medicinal chemistry pathways and will significantly accelerate the initial optimisation phase of the UoN chemistry component of the multiple drug development pipelines initiated. I am also director of the University of Newcastle Priority Research Centre for Chemical Biology.

Teaching

Teaching keywords

  • Chemical Biology
  • Drug Design and Discovery
  • Organic Chemistry
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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2003McCluskey A, Keller PA, Morgan J, Garner JA, 'Synthesis, molecular modeling and biological activity of methyl and thiomethyl substituted pyrimidines as corticotropin releasing hormone type 1 antagonists', Organic and Biomolecular Chemistry, 1 3353-3361 (2003) [C1]
2011Von Kleist L, Stahlschmidt W, Bulut H, Gromova K, Puchkov D, Robertson MJ, et al., 'Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition', Cell, 146 471-484 (2011) [C1]
2010Odell L, Howan D, Gordon CP, Robertson MJ, Chau N, Mariana A, et al., 'The Pthaladyns: GTP competitive inhibitors of Dynamin I and II GTPase derived from virtual screening', Journal of Medicinal Chemistry, 53 5267-5280 (2010) [C1]
2011Gordon CP, Young KA, Hizartzidis L, Deane FM, McCluskey A, 'Investigation of the one-pot synthesis of quinolin-2-(1H)-ones and the discovery of a variation of the three-component Ugi reaction', Organic and Biomolecular Chemistry, 9 1419-1428 (2011) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (2 outputs)

YearCitationAltmetricsLink
2011Booker KM, Holdsworth CI, Bowyer MC, McCluskey A, 'Ionic liquids as porogens in the synthesis of molecularly imprinted polymers', Applications of Ionic Liquids in Science and Technology, Intech, Croatia 197-212 (2011) [B1]
2002McCluskey A, Lawrance GA, Leitch SK, Owen MP, Hamilton IC, 'Ionic liquids and metal ions: from green chemistry to ore refining', Ionic Liquids: Industrial applications to green chemistry, American Chemical Society, Washington DC, USA 199-214 (2002) [B1]

Co-authors: Geoffrey Lawrance

Journal article (158 outputs)

YearCitationAltmetricsLink
2014Gordon CP, Hizartzidis L, Tarleton M, Sakoff JA, Gilbert J, Campbell BE, et al., 'Discovery of acrylonitrile-based small molecules active against Haemonchus contortus', MEDCHEMCOMM, 5 159-164 (2014) [C1]
2014Stahlschmidt W, Robertson MJ, Robinson PJ, McCluskey A, Haucke V, 'Clathrin Terminal Domain- Ligand Interactions Regulate Sorting of Mannose 6-Phosphate Receptors Mediated by AP-1 and GGA Adaptors*', JOURNAL OF BIOLOGICAL CHEMISTRY, 289 4906-4918 (2014) [C1]
2014Cleland D, Olsson GD, Karlsson BCG, Nicholls IA, McCluskey A, 'Molecular dynamics approaches to the design and synthesis of PCB targeting molecularly imprinted polymers: interference to monomer-template interactions in imprinting of 1,2,3-trichlorobenzene', ORGANIC & BIOMOLECULAR CHEMISTRY, 12 844-853 (2014) [C1]
2014Zayas H, Holdsworth CI, Bowyer MC, McCluskey A, 'Evaluation of 4-substituted styrenes as functional monomers for the synthesis of theophylline-specific molecularly imprinted polymers.', Org Biomol Chem, 12 6994-7003 (2014) [C1]
2014Hizartzidis L, Tarleton M, Gordon CP, McCluskey A, 'Chemoselective flow hydrogenation approaches to isoindole-7-carboxylic acids and 7-oxa-bicyclio[2.2.1]heptanes', RSC Advances, 4 9709-9722 (2014) [C1]
2014Sobinoff AP, Sutherland JM, Beckett EL, Stanger SJ, Johnson R, Jarnicki AG, et al., 'Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility.', Hum Reprod, (2014)
2014Robertson MJ, Deane FM, Robinson PJ, McCluskey A, 'Synthesis of Dynole 34-2, Dynole 2-24 and Dyngo 4a for investigating dynamin GTPase.', Nat Protoc, 9 851-870 (2014)
2014MacGregor KA, Robertson MJ, Young KA, von Kleist L, Stahlschmidt W, Whiting A, et al., 'Development of 1,8-Naphthalimides as Clathrin Inhibitors', JOURNAL OF MEDICINAL CHEMISTRY, 57 131-143 (2014)
2014Al Otaibi A, Gordon CP, Gilbert J, Sakoff JA, McCluskey A, 'The influence of ionic liquids on the Knoevenagel condensation of 1H-pyrrole-2-carbaldehyde with phenyl acetonitriles-cytotoxic 3-substituted-(1H-pyrrol-2-yl)acrylonitriles', RSC Advances, 4 19806-19813 (2014)
2014Macgregor KA, Abdel-Hamid MK, Odell LR, McCluskey A, Chau N, Whiting A, Robinson PJ, 'Development of quinone analogues as dynamin GTPase inhibitors', European Journal of Medicinal Chemistry, 85 191-206 (2014)
2014Booker K, Holdsworth CI, Doherty CM, Hill AJ, Bowyer MC, McCluskey A, 'Ionic liquids as porogens for molecularly imprinted polymers: propranolol, a model study.', Org Biomol Chem, 12 7201-7210 (2014)
2014Abdel-Hamid MK, McCluskey A, 'In silico docking, molecular dynamics and binding energy insights into the bolinaquinone-clathrin terminal domain binding site.', Molecules, 19 6609-6622 (2014)
2014Dyson L, Young KA, McCluskey A, Wright AD, Sakoff JA, 'Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin', Bioorganic and Medicinal Chemistry, 22 1690-1699 (2014)
2014Stahlschmidt W, Haucke V, Robertson MJ, McCluskey A, Robinson PJ, 'Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors', Journal of Biological Chemistry, 289 4906-4918 (2014)
2014Trinh TN, McLaughlin EA, Gordon CP, McCluskey A, 'Hedgehog signalling pathway inhibitors as cancer suppressing agents', MedChemComm, 5 117-133 (2014)
2014Robertson MJ, Deane FM, Stahlschmidt W, von Kleist L, Haucke V, Robinson PJ, McCluskey A, 'Synthesis of the Pitstop family of clathrin inhibitors.', Nat Protoc, 9 1592-1606 (2014)
2013McGeachie AB, Odell LR, Quan A, Daniel JA, Chau N, Hill TA, et al., 'Pyrimidyn compounds: Dual-action small molecule pyrimidine-based dynamin inhibitors', ACS Chemical Biology, 8 1507-1518 (2013) [C1]
2013Tarleton M, Dyson L, Gilbert J, Sakoff JA, McCluskey A, 'Focused library development of 2-phenylacrylamides as broad spectrum cytotoxic agents', BIOORGANIC & MEDICINAL CHEMISTRY, 21 333-347 (2013) [C1]
2013McCluskey A, Daniel JA, Hadzic G, Chau N, Clayton EL, Mariana A, et al., ' Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis', Traffic, 14 1272-1289 (2013) [C1]
2013Smith CM, Haucke V, McCluskey A, Robinson PJ, Chircop M, 'Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells', MOLECULAR CANCER, 12 (2013) [C1]
2013Cleland D, McCluskey A, 'The use of effective fragment potentials in the design and synthesis of molecularly imprinted polymers for the group recognition of PCBs', Organic and Biomolecular Chemistry, 11 4646-4656 (2013) [C1]
2013Gordon CP, Venn-Brown B, Robertson MJ, Young KA, Chau N, Mariana A, et al., 'Development of Second-Generation Indole-Based Dynamin GTPase Inhibitors', Journal of Medicinal Chemistry, 56 46-59 (2013) [C1]
2013Zhang J, Luo S-X, McCluskey A, Lawrance GA, 'Metal-Templated Macrocycle Synthesis in an Ionic Liquid: A Comparison With Reaction in Protic Solvents', Synthesis and Reactivity in Inorganic, Metal Organic, and Nano Metal Chemistry, 43 1-5 (2013) [C1]
2013Harper CB, Popoff MR, McCluskey A, Robinson PJ, Meunier FA, 'Targeting membrane trafficking in infection prophylaxis: Dynamin inhibitors', Trends in Cell Biology, 23 90-101 (2013) [C1]
2013Deane FM, O'Sullivan EC, Maguire AR, Gilbert J, Sakoff JA, McCluskey A, McCarthy FO, 'Synthesis and evaluation of novel ellipticines as potential anti-cancer agents', Organic & Biomolecular Chemistry, 11 1334-1344 (2013) [C1]
2013Stehn JR, Haass NK, Bonello T, Desouza M, Kottyan G, Treutlein H, et al., 'A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells', CANCER RESEARCH, 73 5169-5182 (2013) [C1]
2013Brisbane C, McCluskey A, Bowyer M, Holdsworth CI, 'Molecularly imprinted films of acrylonitrile/methyl methacrylate/acrylic acid terpolymers: influence of methyl methacrylate in the binding performance of L-ephedrine imprinted films', Organic & Biomolecular Chemistry, 11 2872-2884 (2013) [C1]
2013Cleland D, McCluskey A, 'An extreme vertices mixture design approach to the optimisation of 1,2,3-trichlorobenzene specific molecularly imprinted polymers', ORGANIC & BIOMOLECULAR CHEMISTRY, 11 4672-4679 (2013) [C1]
2013Sobinoff AP, Beckett EL, Jarnicki AG, Sutherland JM, McCluskey A, Hansbro PM, McLaughlin EA, 'Scrambled and fried: Cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress', TOXICOLOGY AND APPLIED PHARMACOLOGY, 271 156-167 (2013) [C1]
2013McCluskey A, Daniel JA, Hadzic G, Ngoc C, Clayton EL, Mariana A, et al., 'Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis', TRAFFIC, 14 1272-1289 (2013)
2012Tarleton MJ, Bernhardt PV, McCluskey A, 'Crystal structures of (3R,3aR,4S,7R,7aS)-3-(Allyloxy)hexahydro-4,7-epoxyisobenzofuran-1(3H)-on e and (3S,3aR,4S,7R,7aS)-3-((E)-But-2-en-1-yloxy)hexahydro-4,7-epoxyisobenzofu ran-1(3H)-one: Confirmation of NMR predicted stereocentre geometry', Journal of Chemical Crystallography, 42 639-644 (2012) [C1]
2012Daniel JA, Malladi CS, Kettle E, McCluskey A, Robinson PJ, 'Analysis of synaptic vesicle endocytosis in synaptosomes by high-content screening', Nature Protocols, 7 1439-1455 (2012) [C1]
2012Tarleton MJ, Gilbert J, Sakoff JA, McCluskey A, 'Synthesis and anticancer activity of a series of norcantharidin analogues', European Journal of Medicinal Chemistry, 54 573-581 (2012) [C1]

Co-authors: Jennette Sakoff

2012Robertson MJ, Hadzic G, Ambrus JI, Pome DY, Hyde EDE, Whiting A, et al., 'The Rhodadyns, a new class of small molecule inhibitors of Dynamin GTPase Activity', ACS Medicinal Chemistry Letters, 3 352-356 (2012) [C1]
2012Nguyen TH, Maucort G, Sullivan RKP, Schenning M, Lavidis NA, McCluskey A, et al., 'Actin- and dynamin-dependent maturation of bulk endocytosis restores neurotransmission following synaptic depletion', PLoS One, 7 e36913 (2012) [C1]
2012Reid AT, Lord T, Stanger SJ, Roman SD, McCluskey A, Robinson PJ, et al., 'Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa', Journal of Biological Chemistry, 287 37659-37672 (2012) [C1]
2012Robinson KM, McCluskey A, Attalla MI, 'An ATR-FTIR study on the effect of molecular structural variations on the CO2 absorption characteristics of Heterocyclic Amines, Part II', Chemphyschem, 13 2331-2341 (2012) [C1]
2012Tarleton MJ, Gilbert J, Sakoff JA, McCluskey A, 'Cytotoxic 2-phenyacrylnitriles, the importance of the cyanide moiety and discovery of potent broad spectrum cytotoxic agents', European Journal of Medicinal Chemistry, 57 65-73 (2012) [C1]
2012Turner NW, Holdsworth CI, McCluskey A, Bowyer MC, 'N-2-propenyl-(5-dimethylamino)-1-naphthalene sulfonamide, a novel fluorescent monomer for the molecularly imprinted polymer-based detection of 2,4-dinitrotoluene in the gas phase', Australian Journal of Chemistry, 65 1405-1412 (2012) [C1]
2012Robinson K, McCluskey A, Attalla MI, 'The effect molecular structural variations has on the CO2 absorption characteristics of heterocyclic amines', ACS Symposium Series, 1097 1-27 (2012)
2011Tarleton MJ, Gilbert J, Robertson MJ, McCluskey A, Sakoff JA, 'Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound', MedChemComm, 2 31-37 (2011) [C1]
2011Harper CB, Martin S, Nguyen TH, Daniels SJ, Lavidis NA, Popoff MR, et al., 'Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism', Journal of Biological Chemistry, 286 35966-35976 (2011) [C1]
2011Gordon CP, Young KA, Robertson MJ, Hill TA, McCluskey A, 'An Ugi-intramolecular Diels-Alder route to highly substituted tetrahydroepoxyisoindole carboxamides', Tetrahedron, 67 554-561 (2011) [C1]
2011Campbell BE, Tarleton MJ, Gordon CP, Sakoff JA, Gilbert J, McCluskey A, Gasser RB, 'Norcantharidin analogues with nematocidal activity in Haemonchus contortus', Bioorganic and Medicinal Chemistry Letters, 21 3277-3281 (2011) [C1]
2011Macgregor KA, McCluskey A, 'Ionic liquids accelerate access to N-substituted-1,8-naphthalimides', Tetrahedron Letters, 52 767-769 (2011) [C1]
2011Robinson KM, McCluskey A, Attalla M, 'The effect molecular structural variations has on the CO2 absorption characteristics of heterocyclic amines', Energy Procedia, 4 224-231 (2011) [C1]
2011Tarleton MJ, McCluskey A, 'A flow chemistry route to 2-phenyl-3-(1H-pyrrol-2-yl)propan-1-amines', Tetrahedron Letters, 52 1583-1586 (2011) [C1]
2011Wright AD, McCluskey A, Robertson MJ, Macgregor KA, Gordon CP, Guenther J, 'Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi', Organic and Biomolecular Chemistry, 9 400-407 (2011) [C1]
2011Campbell BE, Hofmann A, McCluskey A, Gasser RB, 'Serine/threonine phosphatases in socioeconomically important parasitic nematodes - Prospects as novel drug targets?', Biotechnology Advances, 29 28-39 (2011) [C1]
2011Von Kleist L, Stahlschmidt W, Bulut H, Gromova K, Puchkov D, Robertson MJ, et al., 'Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition', Cell, 146 471-484 (2011) [C1]
2011Tarleton MJ, Young KA, Unicomb E, McCluskey SN, Robertson MJ, Gordon CP, McCluskey A, 'A flow chemistry approach to norcantharidin analogues', Letters in Drug Design and Discovery, 8 568-574 (2011) [C1]
2011Robinson KM, McCluskey A, Attalla MI, 'An FTIR spectroscopic study on the effect of molecular structural variations on the CO2 absorption characteristics of heterocyclic amines', ChemPhysChem, 12 1088-1099 (2011) [C1]
2011Gordon CP, Young KA, Hizartzidis L, Deane FM, McCluskey A, 'Investigation of the one-pot synthesis of quinolin-2-(1H)-ones and the discovery of a variation of the three-component Ugi reaction', Organic and Biomolecular Chemistry, 9 1419-1428 (2011) [C1]
2011Robertson MJ, Gordon CP, Gilbert J, McCluskey A, Sakoff JA, 'Norcantharimide analogues possessing terminal phosphate esters and their anti-cancer activity', Bioorganic & Medicinal Chemistry, 19 5734-5741 (2011) [C1]
2011Chircop M, Perera S, Mariana A, Lau H, Ma MPC, Gilbert J, et al., 'Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells', Molecular Cancer Therapeutics, 10 1553-1562 (2011) [C1]
2010Howes MT, Kirkham M, Riches J, Cortese K, Walser PJ, Simpson F, et al., 'Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells', Journal of Cell Biology, 190 675-691 (2010) [C1]
2010Hill TA, Mariana A, Gordon CP, Odell L, Robertson MJ, McGeachie AB, et al., 'Iminochromene inhibitors of Dynamins I and II GTPase activity and Endocytosis', Journal of Medicinal Chemistry, 53 4094-4102 (2010) [C1]
2010Odell L, Howan D, Gordon CP, Robertson MJ, Chau N, Mariana A, et al., 'The Pthaladyns: GTP competitive inhibitors of Dynamin I and II GTPase derived from virtual screening', Journal of Medicinal Chemistry, 53 5267-5280 (2010) [C1]
2010Chircop M, Malladi CS, Lian AT, Page SL, Zavortink M, Gordon CP, et al., 'Calcineurin activity is required for the completion of cytokinesis', Cellular and Molecular Life Sciences, 67 3725-3737 (2010) [C1]
2010Joshi S, Perera S, Gilbert J, Smith CM, Mariana A, Gordon CP, et al., 'The Dynamin inhibitors MiTMAB and OcTMAB induce Cytokinesis failure and inhibit cell proliferation in human cancer cells', Molecular Cancer Therapeutics, 9 1995-2006 (2010) [C1]
2010Bajsa J, McCluskey A, Gordon CP, Stewart SG, Hill TA, Sahu R, et al., 'The antiplasmodial activity of norcantharidin analogs', Bioorganic & Medicinal Chemistry Letters, 20 6688-6695 (2010) [C1]
2010Gordon CP, Byrne N, McCluskey A, 'A facile, protic ionic liquid route to N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides and N-substituted 3-oxoisoindoline-4-carboxylic acids', Green Chemistry, 12 1000-1006 (2010) [C1]
2010Turner NW, Holdsworth CI, Donne SW, McCluskey A, Bowyer MC, 'Microwave induced MIP synthesis: comparative analysis of thermal and microwave induced polymerisation of caffeine imprinted polymers', New Journal of Chemistry, 34 686-692 (2010) [C1]
2010Thaqi A, Scott JL, Gilbert J, Sakoff JA, McCluskey A, 'Synthesis and biological activity of Delta-5,6-norcantharimides: Importance of the 5,6-bridge', European Journal of Medicinal Chemistry, 45 1717-1723 (2010) [C1]
2009Mann JP, McCluskey A, Atkin R, 'Activity and thermal stability of lysozyme in alkylammonium formate ionic liquids: Influence of cation modification', Green Chemistry, 11 785-792 (2009) [C1]

DOI: 10.1039/b900021f

Co-authors: Rob Atkin

2009Sauer B, Gilbert J, Sakoff JA, McCluskey A, 'Synthesis of 4-substituted-3-hydroxy-5-oxo-10-oxa-4-azatricyclo[5.2.1]dec-3-yl Acetic Acid Ethyl Esters as Norcantharidin Analogues', Letters in Drug Design & Discovery, 6 1-7 (2009) [C1]
2009Holland IP, McCluskey A, Sakoff JA, Gilbert J, Chau N, Robinson PJ, et al., 'Steroids from an Australian Sponge Psammoclema sp', Journal of Natural Products, 72 102-106 (2009) [C1]
2009Odell L, Chau N, Mariana A, Graham ME, Robinson PJ, McCluskey A, 'Azido and diazarinyl analogues of bis-tyrphostin as asymmetrical inhibitors of dynamin GTPase', Chemmedchem, 4 1182-1188 (2009) [C1]
2009Whitehead JA, Zhang J, McCluskey A, Lawrance GA, 'Comparative leaching of a sulfidic gold ore in ionic liquid and aqueous acid with thiourea and halides using Fe(III) or HSO5- oxidant', Hydrometallurgy, 98 276-280 (2009) [C1]
2009Hill TA, Gordon CP, McGeachie AB, Venn-Brown B, Odell L, Chau N, et al., 'Inhibition of dynamin mediated endocytosis by the dynoles-synthesis and functional activity of a family of indoles', Journal of Medicinal Chemistry, 52 3762-3773 (2009) [C1]
2009Turner NW, Holmes NP, Brisbane CE, McGeachie AB, Bowyer MC, McCluskey A, Holdsworth CI, 'Effect of template on the formation of phase-inversed molecularly imprinted polymer thin films: An assessment', Soft Matter, 5 3663-3671 (2009) [C1]
2009Zayas HA, Bowyer MC, Gordon CP, Holdsworth CI, McCluskey A, 'Synthesis of biaryl-styrene monomers by microwave-assisted Suzuki coupling', Tetrahedron Letters, 50 5894-5895 (2009) [C1]
2009Odell LR, Skopec J, McCluskey A, 'Isolation and identification of unique marker compounds from the Tasmanian poppy Papaver somniferum N. Implications for the identification of illicit heroin of Tasmanian origin (vol 175, pg 202, 2008)', FORENSIC SCIENCE INTERNATIONAL, 183 105-106 (2009) [C3]
2008Thaqi A, McCluskey A, Scott JL, 'A mild Boc deprotection and the importance of a free carboxylate', Tetrahedron Letters, 49 6962-6964 (2008) [C1]
2008Zhang J, Lawrance GA, Chau N, Robinson PJ, McCluskey A, 'From Spanish fly to room-temperature ionic liquids (RTILs): Synthesis, thermal stability and inhibition of dynamin 1 GTPase by a novel class of RTILs', New Journal of Chemistry, 32 28-36 (2008) [C1]
2008Hill TA, Stewart SG, Gordon CP, Ackland SR, Gilbert J, Sauer B, et al., 'Norcantharidin analogues: Synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition', ChemMedChem, 3 1878-1892 (2008) [C1]
2008Odell L, Skopec J, McCluskey A, 'Isolation and identification of unique marker compounds from the Tasmanian poppy Papaver somniferum N. Implications for the identification of illicit heroin of Tasmanian origin', Forensic Science International, 175 202-208 (2008) [C1]
2008McCluskey A, Wentrup C, '2-pyridyinitrene from tetrazolo[1,5-a]pyridine and Pyrido[2,3-a][1,2,4]oxadiazol-2-one', JOURNAL OF ORGANIC CHEMISTRY, 73 6265-6267 (2008) [C1]
2007Hill TA, Stewart SG, Sauer B, Gilbert J, Ackland S, Sakoff JA, McCluskey A, 'Heterocyclic substituted cantharidin and norcantharidin analogues-synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity', Bioorganic and Medicinal Chemistry Letters, 17 3392-3397 (2007) [C1]
2007Hill TA, Stewart SG, Ackland S, Gilbert J, Sauer B, Sakoff JA, McCluskey A, 'Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation', Bioorganic and Medicinal Chemistry, 15 6126-6134 (2007) [C1]
2007Booker KM, Bowyer MC, Lennard CJ, Holdsworth CI, McCluskey A, 'Molecularly imprinted polymers and room temperature ionic liquids: Impact of template on polymer morphology', Australian Journal of Chemistry, 60 51-56 (2007) [C1]
2007Hemley CF, McCluskey A, Keller PA, 'Corticotropin releasing hormone - A GPCR drug target', Current Drug Targets, 8 105-115 (2007) [C1]
2007Qi Y, Evans I, McCluskey A, 'New impurity profiles of recent Australian imported 'ice': Methamphetamine impurity profiling and the identification of (pseudo)ephedrine and Leuckart specific marker compounds', Forensic Science International, 169 173-180 (2007) [C1]
2007Stewart SG, Hill TA, Gilbert J, Ackland S, Sakoff JA, McCluskey A, 'Synthesis and biological evaluation of norcantharidin analogues: Towards PP1 selectivity', Bioorganic and Medicinal Chemistry, 15 7301-7310 (2007) [C1]
2007McCluskey A, Holdsworth CI, Bowyer MC, 'Molecularly imprinted polymers (MIPs): sensing, an explosive new opportunity?', Organic & Biomolecular Chemistry, 5 3233-3244 (2007) [C1]
2007Quan A, McGeachie AB, Keating DJ, Van Dam EM, Rusak J, Chau N, et al., 'Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II', Molecular Pharmacology, 72 1425-1439 (2007) [C1]
2007Whitehead JA, Zhang J, Pereira N, McCluskey A, Lawrance GA, 'Application of 1-alkyl-3-methyl-imidazolium ionic liquids in the oxidative leaching of sulphidic copper, gold and silver ores', Hydrometallurgy, 88 109-120 (2007) [C1]
2007Odell L, McCluskey A, Failes TW, Tiekink ERT, 'Crystal and molecular structures of benzyl-(2-chloro-6-methylpyrimidin-4-yl)amine and benzyl-(4-chloro-6-methylpyrimidin-2-yl)amine: Confirmation of computationally predicted restricted rotation', Journal of Chemical Crystallography, 37 817-824 (2007) [C1]
2006Qi Y, Evans ID, McCluskey A, 'Australian Federal Police seizures of illicit crystalline methamphetamine (`ice') 1998-2002: Impurity analysis', Forensic Science International, 164 201-210 (2006) [C1]
2006Griffith R, Brown MN, McCluskey A, Ashman LK, 'Small molecule inhibitors of protein kinases in cancer - How to overcome resistance', Mini-Reviews in Medicinal Chemistry, 6 1101-1110 (2006) [C1]
2006Booker KM, Bowyer MC, Holdsworth CI, McCluskey A, 'Efficient preparation and improved sensitivity of molecularly imprinted polymers using room temperature ionic liquids', Chemical Communications, 1730-1732 (2006) [C1]
2006Schwarz LJ, Bowyer MC, Holdsworth CI, McCluskey A, 'Synthesis and evaluation of a molecularly imprinted polymer selective to 2,4,6-trichloroanisole', Australian Journal of Chemistry, 59 129-134 (2006) [C1]
2006Odell L, Skopec J, McCluskey A, 'A `cold synthesis' of heroin and implications in heroin signature analysis: Utility of trifluoroacetic/acetic anhydride in the acetylation of morphine', Forensic Science International, 164 221-229 (2006) [C1]
2006Keller PA, McCluskey A, Morgan J, O'Connor SMJ, 'The role of the HPA axis in psychiatric disorders and CRF antagonists as potential treatments', Archiv Der Pharmazie, 339 346-355 (2006) [C1]
2006Whitehead JA, Lawrence GA, Owen MP, McCluskey A, 'A new route to precious metal recovery and subsequent electrodeposition using ionic liquids', Proceedings - Electrochemical Society, PV 2004-24 901-910 (2006)
2005Hill TA, Sakoff JA, Robinson PJ, McCluskey A, 'Parallel solution-phase synthesis of targeted tyrphostin libraries with anticancer activity', Australian Journal of Chemistry, 58 94-103 (2005) [C1]
2005Hill TA, Odell L, Edwards JK, Graham ME, McGeachie AB, Rusak J, et al., 'Small molecule inhibitors of dynamin I GTPase activity: Development of dimeric tyrphostins', Journal of Medicinal Chemistry, 48 7781-7788 (2005) [C1]
2005Holdsworth CI, Bowyer MC, Lennard C, McCluskey A, 'Formulation of cocaine-imprinted polymers utilizing molecular modelling and NMR analysis', Australian Journal of Chemistry, 58 315-320 (2005) [C1]
2005McCluskey A, Leitch SK, Garner JA, Caden CE, Hill TA, Odell L, Stewart SG, 'BiCl3-mediated opening of epoxides, a facile route to chlorohydrins or amino alcohols: one reagent, two paths', Tetrahedron Letters, 46 8229-8232 (2005) [C1]
2005Leitch SK, Addison-Jones J, McCluskey A, 'Regioselective N- and C2-electrophilic substitution of 3-substituted indoles (short communication)', Tetrahedron Letters, 46 2915-2918 (2005) [C1]
2004Sakoff JA, McCluskey A, 'Protein Phosphatase Inhibition: Structure Based Design. Towards New Therapeutic Agents', Current Pharmaceutical Design, 10 1139-1159 (2004) [C1]
2004Garner JA, Hill TA, Odell L, Keller P, Morgan J, McCluskey A, 'Identification of Aminopyrimidine Regioisomers via Line Broadening Effects in 1H and 13C NMR Spectroscopy', Australian Journal of Chemistry, 57 1079-1083 (2004) [C1]
2004Schwarz LJ, Holdsworth CI, McCluskey A, Bowyer MC, 'Synthesis and Evaluation of a Molecularly Imprinted Polymer Selective to 2,4,6-Trichlorophenol', Australian Journal of Chemistry, 57 759-764 (2004) [C1]
2004Sakoff JA, Howitt IJ, Ackland S, McCluskey A, 'Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition', Cancer Chemotherapy and Pharmacology, 53 225-232 (2004) [C1]
2004Hart ME, Chamberlin AR, Walkom CC, Sakoff JA, McCluskey A, 'Modified norcantharidins: synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity', Bioorganic & Medicinal Chemistry Letters, 14 1969-1973 (2004) [C1]
2004Whitehead JA, Lawrance GA, McCluskey A, 'Analysis of Gold in Solutions Containing Ionic Liquids by Inductively Coupled Plasma Atomic Emission Spectometry', Australian Journal of Chemistry, 57 151-155 (2004) [C1]
2004Bowyer MC, Gordon CM, Leitch SK, McCluskey A, Ritchie C, 'Indium-Mediated Addition of 4-Bromocrotonic Acid to Aldehydes and Ketones - A Simple, High Yielding Route to Alpha-Allyl-Beta-Hydroxy Carboxylic Acids', Australian Journal of Chemistry: an international journal for chemical science, 57 135-137 (2004) [C1]
2004Hill TA, Odell L, Quan A, Abagyan R, Ferguson GN, Robinson PJ, McCluskey A, 'Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity', Bioorganic & Medicinal Chemistry Letters, 14 3275-3278 (2004) [C1]
2004Whitehead JA, Lawrance GA, McCluskey A, ''Green' leaching: recyclable and selective leaching of gold-bearing ore in an ionic liquid', Green Chemistry, 6 313-315 (2004) [C1]
2004Garner JA, Keller PA, McCluskey A, 'Corticotrophin Releasing Hormone: Chemistry and Recent Developments', Australian Journal of Chemistry, 57 393-407 (2004) [C1]
2004McCluskey A, Bowyer MC, 'Synthetic antibodies and the Australian wine industry: A Hunter Valley solution to cork taint?', Australian & New Zealand Grapegrower & Winemaker, 2004 111-115 (2004) [C3]

Co-authors: Michael Bowyer

2003Leitch SK, McCluskey A, 'A High Yielding One-Pot Synthesis of Allylic-Vinylic Alcohols: The Adducts of Tetraallylstannane and a,?-Unsaturated Carbonyl Compounds', Synlett, - 699-701 (2003) [C1]
2003Ackland S, Bowyer MC, Baldwin ML, Garner JA, Walkom CC, Sakoff JA, McCluskey A, 'Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines', Bioorganic Chemistry, 31 68-79 (2003) [C1]
2003Correa W, Edwards J, McCluskey A, McKinnon I, Scott JL, 'A thermodynamic investigation of solvent-free reactions', Green Chemistry, 5 30-33 (2003) [C1]
2003McCluskey A, Keller PA, Morgan J, Garner JA, 'Synthesis, molecular modeling and biological activity of methyl and thiomethyl substituted pyrimidines as corticotropin releasing hormone type 1 antagonists', Organic and Biomolecular Chemistry, 1 3353-3361 (2003) [C1]
2002McCluskey A, Ackland S, Gardiner E, Walkom CC, Sakoff J, 'The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design?', Anti-Cancer Drug Design, 16 291-303 (2002) [C1]
2002McCluskey A, Robinson P, Hill TA, Scott J, Edwards JK, 'Green chemistry approaches to the Knoevenagel condensation: comparison of ethanol, water and solvent free (dry grind) approaches', Tetrahedron Letters, 43 3117-3120 (2002) [C1]
2002Sakoff J, Ackland S, Baldwin ML, Atherton MA, McCluskey A, 'Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues', Investigational New Drugs, 20 1-11 (2002) [C1]
2002McCluskey A, Atherton MA, Walkom CC, Bowyer M, Sim A, Young D, Sakoff J, 'The first two cantharidin analogues displaying PP1 selectivity', Bioorganic & Medicinal Chemistry Letters, 12 391-393 (2002) [C1]
2002Judeh Z, Ching C, Bu J, McCluskey A, 'The first Bischler-Napieralski cyclization in a room temperature ionic liquid', Tetrahedron Letters, 43 5089-5091 (2002) [C1]
2002McCluskey A, Sim A, Sakoff J, 'Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies', Journal of Medicinal Chemistry, 45 1151-1175 (2002) [C1]
2002Gordon CM, Ritchie C, McCluskey A, Stark A, 'Indium- and tin-mediated allylation reactions in ionic liquids.', ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 224 U614-U614 (2002)
2001Lengyel I, Nairn AC, McCluskey A, Toth G, Penke B, Rostas JAP, 'Auto-inhibition of Ca2+/calmodulin-dependent protein kinase II by its ATP-binding domain', Journal of Neurochemistry, 76 1066-1072 (2001) [C1]

Co-authors: John Rostas

2001McCluskey A, Walkom CC, Bowyer MC, Ackland SP, Gardiner E, Sakoff JA, 'Cantharimides: A new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A', Bioorganic & Medicinal Chemistry Letters, 11 2941-2946 (2001) [C1]
2001McCluskey A, Muderawan IW, Muntari, Young DJ, 'A highly atom efficient, solvent promoted addition of tetraallylic, tetraallenic and tetrapropargylic stannanes to carbonyl compounds', Journal of Organic chemistry, 66 7811-7817 (2001) [C1]
2001McCluskey A, Young DJ, 'Organostannanes and ionic liquids: Toward green chemistry.', ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 221 U564-U564 (2001)
2001McCluskey A, Lawrance GA, Owen M, Hamilton IC, 'Ionic liquids: From green chemistry to ore refining.', ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 221 U584-U584 (2001)
2001McCluskey A, Sakoff JA, 'Small molecule inhibitors of serine/threonine protein phosphatases.', Mini reviews in medicinal chemistry, 1 43-55 (2001)

Co-authors: Jennette Sakoff

2000McCluskey A, Garner JA, Caballero S, Young D, 'Tetraallylstannane and Weinreb amides: a simple 'green' route to N-protected homoallylic alcohols and allyl ketones', Tetrahedron Letters, 41 8147-8151 (2000) [C1]
2000McCluskey A, Elfick LG, Morgan J, Garner JA, Keller P, 'Corticotropin releasing hormone: Therapeutic implications and medicinal chemistry developments', Bioorganic and Medicinal Chemistry., 8 1213-1223 (2000) [C1]
2000McCluskey A, Finn M, Bowman M, Keller PA, Smith R, '2,7-dimethylthiazolo[4,5-d] pyradazine-4-(5H)-thione: a corticotrophin releasing hormone type 1 receptor agonist', Australian journal of chemistry, 905-908 (2000) [C1]
2000McCluskey A, Atherton MA, Mudgee L, Sim A, Sakoff JA, Quinn R, 'Anhydride modified cantharidin analogues. Is ring opening important in the inhibition of protein phosphatase 2A?', European Journal of Medicinal Chemistry, 35 957-964 (2000) [C1]
2000Bowyer MC, 'Anhydride Modified Cantharidin Analogues: Synthesis, Inhibition of Protein Phosphatases 1 and 2A and Anticancer Activity', Bioorganic & Medicinal Chemistry Letters, 10 1687-1690 (2000) [C1]
2000McCluskey A, Finn M, Bowman M, Keller P, Smith R, '3,5-Dimethyl-7-hydrazinothiazolo[4,5-d]pyradazine-7-thiol: A corticotrophin releasing hormone type 1 receptor agonist', Australian Journal of Chemistry, 53 905-908 (2000) [C1]
2000Sakoff JA, McCluskey A, Sims ATR, Stewart JF, Ackland SP, 'A counter intuitive therapy for the treatment of cancer: Inhibition of protein phosphatases 1 and 2A by cantharidin (Spanish Fly) analogues.', CLINICAL CANCER RESEARCH, 6 4495S-4495S (2000)
1999McCluskey A, Garner JA, 'Garner, J, McCluskey, A, "A simple, expedient synthesis of substituted pyrimidines: Aminolysis of dichloropyrimidines in the presence of LiClO4', Heterocyclic Communications, 5 503-508 (1999) [C1]
1999Gordon CM, McCluskey A, 'Ionic liquids: a convenient solvent for environmentally friendly allylation reactions with tetraallylstannane', Chemical Communications, -- 1431-1432 (1999) [C1]
1999McCluskey A, 'The allylation of carbonyl (and acetal) compounds by tetraallylstannane', Green Chemistry, -- 167-168 (1999) [C1]
1999McCluskey A, Garner JA, Smith R, Leach S, Dang D, Bowman M, Keller P, 'Pharmacophore development for corticotrophin releasing hormone; new insights into inhibitor activity', Journal of Medicinal Chemistry, 42 2351-2357 (1999) [C1]
1999Keller PA, Bowman M, Dang KH, Garner JA, Leach SP, Smith R, McCluskey A, 'Pharmacophore development for corticotropin-releasing hormone: new insights into inhibitor activity', Journal of Medicinal Chemistry, 42, No. 13 2351-2357 (1999) [C1]
1999Garner JA, McCluskey A, 'Regiocontrolled amination of dichloropyrimidines in LiC104-Et20 solutions', Heterocyclic Communications, 5, No. 6 503-508 (1999) [C1]
1999McCluskey A, 'Water promoted organic chemistry. The allylation of carbonyl (and acetal) compounds by tetraallylstannane', Green Chemistry, 1 161-162 (1999) [C1]
1998McCluskey A, Ying L, Camp D, Moni R, Quinn R, 'Diimidazo[1,2-C;4',5'-E] Pyrimidines N6-N1 Conformationally Restricted Andenosines', Bioorganic and Medicinal Chemistry Letters, 8 695-698 (1998) [C1]
1998McCluskey A, Wayan Muderawan I, Muntari J, Young D, 'Solvent Assisted Addition of Tetraallylic, Tetraallenic and Tetraaproparagylic Stannanes to Aldehydes and Acetals', SynLett, -- 909-912 (1998) [C1]
1998McCluskey A, Dunkin I, 'Tetrachlorocyclopentadienone O-oxide, A Facile Oxygen Transfer Reagent, Further Evidence for the Disproportionation of Cycloalkoky Radicals', Bulletin of the Chemical Society of Japan, 71 1397-1400 (1998) [C1]
1997Cokley TM, Isaacs NS, McCluskey A, Young DJ, 'High pressure allylstannane addition to alpha-amino aldehydes: Syn diastereoselectivity in the absence of chelation control.', MAIN GROUP METAL CHEMISTRY, 20 581-582 (1997)
1997McCluskey A, Mayer DM, Young DJ, 'A simple one pot procedure for the generation of homoallylic alcohols from acetals and amino acetals', TETRAHEDRON LETTERS, 38 5217-5218 (1997)
1997Cokley TM, Harvey PJ, Marshall RL, McCluskey A, Young DJ, 'Solvent-mediated allylation of carbonyl compounds with allylic stannanes', JOURNAL OF ORGANIC CHEMISTRY, 62 1961-1964 (1997)
1996McCluskey A, Taylor C, Quinn RJ, Suganuma M, Fujiki H, 'Inhibition of protein phosphatase 2A by cantharidin analogues.', BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 6 1025-1028 (1996)
1996Cokley TM, Marshall RL, McCluskey A, Young DJ, 'The solvent promoted addition of tetraallyltin to aldehydes: A convenient and chemoselective allylation procedure', TETRAHEDRON LETTERS, 37 1905-1908 (1996)
1995MCCLUSKEY A, DUNKIN IR, 'SUPPRESSION OF THE WOLFF REARRANGEMENT OF AN UNSTRAINED ALPHA-CARBONYL CARBENE BY CO AND O-2 IN LOW-TEMPERATURE MATRICES', AUSTRALIAN JOURNAL OF CHEMISTRY, 48 1107-1116 (1995)
1995DUNKIN IR, MCCLUSKEY A, 'TETRACHLOROCYCLOPENTADIENONE O-OXIDE, A FACILE OXYGEN-ATOM TRANSFER REAGENT - THE OXIDATION OF CYCLOHEXENE', JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 89 157-161 (1995)
1995BLANCH RJ, MCCLUSKEY A, 'XCN (X=CL, BR AND I) - A NOVEL SOURCE OF ISOCYANOGEN', CHEMICAL PHYSICS LETTERS, 241 116-120 (1995)
1994DUNKIN IR, MCCLUSKEY A, 'CARBONYL CYANIDE O-OXIDE, THE ADDUCT OF DICYANOMETHYLENE AND DIOXYGEN IN ARGON MATRICES AT 12-K', SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 50 209-218 (1994)
1994DUNKIN IR, MCCLUSKEY A, 'A SPECTROSCOPIC STUDY OF THE REACTION OF THE CARBENE, TETRABROMOCYCLOPENTADIENYLIDENE, WITH O2 IN LOW-TEMPERATURE MATRICES', SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 50 151-160 (1994)
1993DUNKIN IR, MCCLUSKEY A, 'TETRABROMOCYCLOPENTADIENYLIDENE - GENERATION AND REACTION WITH CO IN LOW-TEMPERATURE MATRICES', SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 49 1179-1185 (1993)
1993DUNKIN IR, MCCLUSKEY A, 'TETRACHLOROCYCLOPENTADIENONE O-OXIDE, A FACILE OXYGEN-ATOM TRANSFER REAGENT - THE OXIDATION OF CYCLOHEXANE', JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 74 159-164 (1993)
1986DUNKIN IR, BELL GA, MCCLEOD FG, MCCLUSKEY A, 'AN INFRARED STUDY OF THE FORMATION AND PHOTOCHEMICAL DECOMPOSITION OF TETRACHLOROCYCLOPENTADIENONE O-OXIDE IN LOW-TEMPERATURE MATRICES', SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 42 567-574 (1986)
Show 155 more

Review (1 outputs)

YearCitationAltmetricsLink
2003Keller PA, Kirkwood KL, Morgan J, Westcott S, McCluskey A, 'The prevention of preterm labour - corticotrophin releasing hormone type 1 receptors as a target for drug design and development', Med. Chem. (2003) [D2]

Conference (20 outputs)

YearCitationAltmetricsLink
2013Sakoff JA, Gilbert J, Tarleton M, Robertson M, McCluskey A, 'New small molecules targeting breast cancer', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013) [E3]
2012Harper CB, Martin S, Nguyen TN, McCluskey A, Robinson PJ, Meunier FA, 'Role of the presynaptic plasma membrane in sorting local from retrograde vesicular trafficking pathways', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
2012Stehn JR, Haass NK, Bonello T, Desouza M, Kottyan G, Treutlein H, et al., 'Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells', Experimental Dermatology, Marburg, Germany (2012) [E3]
2011Robinson KM, McCluskey A, Attalla MI, 'The effect of molecular structural variations on the CO2 absorption characteristics of heterocyclic diamines for amine-based post combustion CO2 capture', Chemeca 2011: Engineering a Better World, Sydney (2011) [E1]
2011Stehn JR, Haass NK, Desouza M, Sequeira VB, Treutlein H, Zeng J, et al., 'Developing chemotherapeutics which disable the actin cytoskeleton of melanoma cells', Pigment Cell & Melanoma Research, Tampa, FL (2011) [E3]
2010Gunning PW, Hook J, Schevzov G, Desouza M, Creed S, McCluskey A, et al., 'Actin filaments containing tropomyosin Tm5NM1/2 perform essential functions as revealed by gene knockouts and anti-Tm drugs', The American Society for Cell Biology 50th Annual Meeting Abstracts, Phildelphia, PA (2010) [E3]
2010Stehn J, Schevzov G, Bonello T, McCluskey A, Haass N, Palmer S, et al., 'Tropomyosin Tm5NM1: A novel target for cancer therapy', EJC Supplements, Berlin, Germany (2010) [E3]
2010Bonello T, Stehn J, Schevzov G, Coombes J, McCluskey A, Haass N, et al., 'Targeting the tropomyosin isoform TM5NM1 impairs tumour survival, proliferation and migration', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Australia (2010) [E3]
2010McCluskey A, Robinson PJ, 'From dyngoes to dynasores: Selective dynamin inhibitors as novel antiepileptic agents', Australasian Society of Clinical and Experimental Pharmacology and Toxicology (ASCEPT) Annual Scientific Meeting, Melbourne, Vic (2010) [E3]
2010Chircop M, Perera S, Ma MPC, Lau H, Gilbert J, Jones NC, et al., 'Dynole 34-2 is a potent inhibitor of dynamin that induces cell death following cytokinesis failure and suppresses glioblastoma tumour growth in vivo', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Australia (2010) [E3]

Co-authors: Jennette Sakoff

2010Mariana A, Hill TA, McGeachie AB, Chau N, Daniel JA, Gorgani NN, et al., 'Towards isoform-selective dynamin inhibitors', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Australia (2010) [E3]
2010Joshi S, Gaddipatti S, Gilbert J, Smith CM, Gordon CP, Sakoff JA, et al., 'Dynamin inhibition: A new therapeutic approach for the treatment of cancer', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3]

Co-authors: Jennette Sakoff

2009Robinson PJ, McCluskey A, 'Dynamin inhibitors reduce synaptic transmission and are novel anti-epileptic drugs', Journal of Neurochemistry, Beijing, China (2009) [E3]
2008Bajsa J, Sahu R, McCluskey A, Duke SO, Tekwani BL, 'Antimalarial activity of cantharidin analogs: potential serine/threonine protein phosphatase inhibitors', Planta Medica, Oxford, MI (2008) [E3]
2008Wright A, McCluskey A, Macgregor K, Guenther J, 'Potential ecological role, chemistry and molecular modelling studies of secondary metabolites isolated from the tropical marine sponge Cymbastela hooperi', Planta Medica, Athens, Greece (2008) [E3]
2007Stehn JR, Butler T, Winlaw D, McCluskey A, Gunning P, 'Tropomyosin containing actin filaments as cancer-specific targets', AACR Meeting Abstracts Online (Abstracts of the 98th AACR Annual Meeting), Los Angeles (2007) [E3]
2007Chau N, Quan A, Hill TA, McCluskey A, Robinson PJ, 'The apparent potency of dynamin GTPase inhibitors is dependent on dynamin concentration: a new colorimetric assay (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
2007Quan A, McGeachie AB, Van Dam EM, Chau N, McCluskey A, Cousin MA, Robinson PJ, 'Mitmab is a surface-active dynamin inhibitor that blocks dynamin i or dynamin ii mediated endocytosis (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
2007McGeachie AB, Odell L, Hill TA, Quan A, Chau N, Graham ME, et al., 'Analogues of Bis-T-22 potently inhibit endocytosis (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
2002Sakoff JA, Ackland SP, Garg MB, Walkom CC, McCluskey A, 'Protein phosphatase 2A, a novel and unexplored anticancer target', EUROPEAN JOURNAL OF CANCER, FRANKFURT, GERMANY (2002)
Show 17 more

Patent (1 outputs)

YearCitationAltmetricsLink
2005McCluskey A, Robinson PJ, Hill TA, Methods and agents for inhibiting dynamic-dependent endocytosis (2005) [I2]
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Grants and Funding

Summary

Number of grants97
Total funding$17,374,460

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (5 grants)

Dual purpose contraception $658,952
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Laureate Professor John Aitken, Professor Adam McCluskey, Professor Kenneth Beagley
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$658,95220142016
GNo:G1300304

Pushing The Boundaries Of Flow Chemistry - Towards New Anti-Viral Agents$430,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Professor Volker Haucke
SchemeRole
Discovery ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$430,00020142016
GNo:G1300160

Characterisation of a new class of antimicrobial agent for multidrug-resistant infections$45,000
Funding Body: ARC (Australian Research Council)

Project Team
Dr Darren Trott, Professor Adam McCluskey, Mr Stephen Page
SchemeRole
Linkage ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$45,00020142014
GNo:G1401198

Enhancing radiation effects for the treatment of brain cancer $25,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jennette Sakoff, Dr JAYNE Gilbert, Professor Adam McCluskey
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$25,00020142014
GNo:G1301412

The role of dynamin is spermatogenesis and sperm-oocyte interactions$20,000
Funding Body: University of Newcastle

Project Team
Associate Professor Brett Nixon, Professor Eileen McLaughlin, Professor Adam McCluskey
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020142014
GNo:G1301400

2013 (10 grants)

Advanced Stopped Flow - Electron Paramagnetic Resonance Apparatus for Measurement of Short-Lived Free Radicals in Engineering, Science and Medicine$180,000
Funding Body: ARC (Australian Research Council)

Project Team
Conjoint Professor Bogdan Dlugogorski, Professor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Scott Donne
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF)Investigator
Total AmountFunding StartFunding Finish
$180,00020132013
GNo:G1200569

Advanced Stopped Flow - Electron Paramagnetic Resonance Apparatus for Measurement of Short-Lived Free Radicals in Engineering, Science and Medicine$175,000
Funding Body: University of Newcastle

Project Team
Conjoint Professor Bogdan Dlugogorski, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Scott Donne, Professor Adam McCluskey
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$175,00020132013
GNo:G1200186

Multi-Centre Screening and Development Platform for Pre-Clinical Drugs for Glioblastoma$101,612
Funding Body: Cancer Council NSW

Project Team
Professor Phillip Robinson, Ms Megan Chircop, Professor Roger Reddel, Professor Adam McCluskey, Dr Jennette Sakoff
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$101,61220132013
GNo:G1300989

Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

Central Contribution to Faculty Peer Review - FSIT$33,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
Special Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$33,00020132013
GNo:G1301330

New Drugs to Kill Superbugs$13,000
Funding Body: University of Newcastle - Faculty of Science & IT

Project Team
Professor Peter Lewis, Professor Adam McCluskey, Doctor Chris Gordon, Doctor Joey Ambrus
SchemeRole
Strategic Small GrantInvestigator
Total AmountFunding StartFunding Finish
$13,00020132013
GNo:G1401065

Dynamin - role in sperm oocyte interaction$10,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Eileen McLaughlin, Associate Professor Brett Nixon, Professor Adam McCluskey
SchemeRole
Near MissInvestigator
Total AmountFunding StartFunding Finish
$10,00020132013
GNo:G1300700

Dynamin - role in sperm oocyte interaction$10,000
Funding Body: University of Newcastle

Project Team
Professor Eileen McLaughlin, Associate Professor Brett Nixon, Professor Adam McCluskey
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020132013
GNo:G1300483

Faculty Visiting Fellowship 2013$3,529
Funding Body: University of Newcastle - Faculty of Science & IT

Project Team
Professor Adam McCluskey
SchemeRole
Visiting FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$3,52920132013
GNo:G1401142

2014 ARC/NHMRC Fellowship External Applicant Support - FSIT$3,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey, Dr Ali Eshragh
SchemeRole
Special Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$3,00020132013
GNo:G1301076

2012 (6 grants)

Mechanism Of Action Of Dynamin Ring Stabilizer Compounds Controlling The Actin Cytoskeleton $318,510
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Phillip Robinson, Professor Adam McCluskey
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$318,51020122014
GNo:G1101104

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$245,100
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Ms Megan Chircop, Professor Adam McCluskey, Professor Phillip Robinson, Doctor Jennette Sakoff
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$245,10020122014
GNo:G1101106

Bioaffinity mass spectrometry infrastructure to identify small molecules binding to therapeutic targets$125,000
Funding Body: University of Newcastle

Project Team
Professor Ronald Quinn, Associate Professor Sally-Ann Poulsen, Professor Ian Charles, Professor Adam McCluskey, Associate Professor Elizabeth Harry, Professor Johnson Mak
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$125,00020122012
GNo:G1100742

Identification of a novel target for the treatment of hormone positive breast cancer$30,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jennette Sakoff, Dr JAYNE Gilbert, Professor Adam McCluskey
SchemeRole
Breast Cancer Project GrantInvestigator
Total AmountFunding StartFunding Finish
$30,00020122012
GNo:G1200716

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$15,000
Funding Body: NSW Trade & Investment

Project Team
Professor Adam McCluskey, Doctor Jennette Sakoff
SchemeRole
TechVouchers ProgramChief Investigator
Total AmountFunding StartFunding Finish
$15,00020122012
GNo:G1200796

Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey, Professor Eileen McLaughlin, Professor Peter Lewis, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020122012
GNo:G1100986

2011 (12 grants)

Chemical principles underpinning a spermostatic-microbiostatic agent capable of preventing pregnancy and the spread of sexually transmitted disease$735,000
Funding Body: ARC (Australian Research Council)

Project Team
Laureate Professor John Aitken, Doctor Mark Baker, Professor Kenneth Beagley, Professor Adam McCluskey
SchemeRole
Discovery ProjectsInvestigator
Total AmountFunding StartFunding Finish
$735,00020112013
GNo:G1000173

Development of pthaladyn-based dynamin I-selective inhibitors for treatment of epilepsy$544,831
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey, Professor Phillip Robinson, Professor Terence O'Brien, Ms Megan Chircop, Doctor Jennette Sakoff
SchemeRole
Development GrantsChief Investigator
Total AmountFunding StartFunding Finish
$544,83120112013
GNo:G1000740

Establishment of a comprehensive regional biophysical analysis facility $500,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF)Investigator
Total AmountFunding StartFunding Finish
$500,00020112011
GNo:G1000630

Chemical Biology$444,961
Funding Body: University of Newcastle

Sulfonadyn-based dynamin I-specific inhibitors and epilepsy$403,931
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey, Professor Phillip Robinson
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$403,93120112013
GNo:G1100148

Establishment of a comprehensive regional biophysical analysis facility $230,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF) Partner fundingInvestigator
Total AmountFunding StartFunding Finish
$230,00020112011
GNo:G1100484

Characterisation of a new class of antimicrobial agent for multidrug-resistant infections$214,000
Funding Body: ARC (Australian Research Council)

Project Team
Dr Darren Trott, Professor Adam McCluskey, Mr Stephen Page
SchemeRole
Linkage ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$214,00020112014
GNo:G1100855

Characterisation of a new class of antimicrobial agent for multidrug-resistant infections$147,500
Funding Body: Neoculi Pty Ltd

Project Team
Dr Darren Trott, Professor Adam McCluskey, Mr Stephen Page
SchemeRole
Linkage Projects Partner fundingChief Investigator
Total AmountFunding StartFunding Finish
$147,50020112014
GNo:G1100918

Dynamin as a new drug target for the treatment of glioblastoma$96,000
Funding Body: Cancer Council NSW

Project Team
Professor Adam McCluskey
SchemeRole
Research ProgramChief Investigator
Total AmountFunding StartFunding Finish
$96,00020112013
GNo:G1100021

Development of clathrin inhibitors as novel endocytosis inhibitors$25,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020112011
GNo:G1001050

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge, Doctor Janet Holt, Doctor Xiao Yang
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$15,00020112011
GNo:G1100028

Restocking the Cupboard - Next generation Antibiotics$9,758
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
Linkage Pilot Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$9,75820112011
GNo:G1100043

2010 (9 grants)

Australian Cancer Research Foundation Cancer Research Grant$1,012,636
Funding Body: Australian Cancer Research Foundation

Project Team
Professor Adam McCluskey
SchemeRole
Cancer Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,012,63620102010
GNo:G1000006

Development of a humane non-surgical sterilization method for domestic animals$1,006,825
Funding Body: Found Animals Foundation Inc

Project Team
Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Adam McCluskey
SchemeRole
Michelson Grants in Reproductive BiologyInvestigator
Total AmountFunding StartFunding Finish
$1,006,82520102012
GNo:G0900113

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$500,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Associate Professor Rob Atkin, Doctor Clovia Holdsworth, Doctor Mark Baker, Doctor Nikki Verrills, Professor Gottfried Otting, Associate Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF)Chief Investigator
Total AmountFunding StartFunding Finish
$500,00020102010
GNo:G0190402

Streamlining the dynamin epilepsy drug pipeline$438,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Professor Phillip Robinson, Associate Professor Martin Larsen
SchemeRole
Discovery ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$438,00020102012
GNo:G0190040

The 2009 Ramaciotti Major Initiative Biomedical Research Award$300,000
Funding Body: Ramaciotti Foundations

Project Team
Professor Adam McCluskey
SchemeRole
Major Initiative for Biomedical Research (Defunct)Chief Investigator
Total AmountFunding StartFunding Finish
$300,00020102010
GNo:G1000005

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$280,000
Funding Body: University of Newcastle

Waters, Ultra high performance liquid chromatography system (nano-Aquity) $30,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Mark Baker, Laureate Professor John Aitken, Professor Adam McCluskey, Associate Professor Brett Nixon, Emeritus Professor John Rostas, Professor Eileen McLaughlin
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$30,00020102010
GNo:G1000051

Centre for Kinomics$25,000
Funding Body: John Morris Scientific Pty Ltd

Project Team
Professor Adam McCluskey
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020102010
GNo:G1000614

The design of novel, affinity-based technology to specifically isolate phosphotyrosine-containing pedtides$25,000
Funding Body: Hunter Children`s Research Foundation

Project Team
Doctor Mark Baker, Professor Adam McCluskey
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$25,00020102010
GNo:G0900191

2009 (6 grants)

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$495,000
Funding Body: ARC (Australian Research Council)

Development of dynamin inhibitors as novel therapies for epilepsy$306,001
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$306,00120092011
GNo:G0190116

Preclinical new chemical entities as novel anti-epileptic drugs targeting dynamin$132,924
Funding Body: Epilepsy Foundation of America

Project Team
Professor Adam McCluskey
SchemeRole
New Therapy Grants ProgramChief Investigator
Total AmountFunding StartFunding Finish
$132,92420092010
GNo:G1000613

Dynamin as a new drug target for he treatment of glioblastoma$74,457
Funding Body: James S. McDonnell Foundation

Project Team
Professor Adam McCluskey, Ms Megan Chircop
SchemeRole
Research AwardChief Investigator
Total AmountFunding StartFunding Finish
$74,45720092009
GNo:G0190466

Development of novel anti-epileptic drugs targeting vesicular endocytosis$66,200
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey
SchemeRole
Development GrantsChief Investigator
Total AmountFunding StartFunding Finish
$66,20020092009
GNo:G0190117

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$50,000
Funding Body: ARC (Australian Research Council)

2008 (5 grants)

HMRI Cancer Research Program - MRSP Infrastructure$1,031,290
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Professor Stephen Ackland, Emeritus Professor Leonie Ashman, Professor John Forbes, Conjoint Professor Jim Denham, Conjoint Professor Peter Hersey, Professor Gordon Burns, Professor Adam McCluskey, Doctor Nikki Verrills
SchemeRole
NSW MRSP Infrastructure GrantInvestigator
Total AmountFunding StartFunding Finish
$1,031,29020082009
GNo:G0188622

Integrated surface fabrication and characterisation laboratory$750,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Paul Dastoor, Professor John O'Connor, Professor Bruce King, Professor Adam McCluskey, Doctor Warwick Belcher, Professor Catherine Stampfl, Dr Jeffrey Reimers, Assoc. Prof Alexander Hamilton, Dr Adam Micolich, Doctor Chris Fell, Dr Scott Watkins, Dr Mark Bown, Dr Anton Stampfl, Dr Peter Evans
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF)Investigator
Total AmountFunding StartFunding Finish
$750,00020082008
GNo:G0187931

The discovery and validation of novel drug classes against parasites of major economic importance$670,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Professor Robin Gasser, Dr Jennette Sakoff
SchemeRole
Linkage ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$670,00020082010
GNo:G0187815

Partner contributions for Integrated surface fabrication and characterisation laboratory$320,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Paul Dastoor, Professor John O'Connor, Professor Bruce King, Professor Adam McCluskey, Doctor Warwick Belcher, Professor Catherine Stampfl, Dr Jeffrey Reimers, Assoc. Prof Alexander Hamilton, Dr Adam Micolich, Doctor Chris Fell, Dr Scott Watkins, Dr Mark Bown, Dr Anton Stampfl, Dr Peter Evans
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF) Partner fundingInvestigator
Total AmountFunding StartFunding Finish
$320,00020082008
GNo:G0189562

The discovery and validation of novel drug classes against parasites of major economic importance$270,000
Funding Body: Genetic Technologies Limited

Project Team
Professor Adam McCluskey, Professor Robin Gasser, Dr Jennette Sakoff
SchemeRole
Linkage Projects Partner fundingChief Investigator
Total AmountFunding StartFunding Finish
$270,00020082010
GNo:G0188378

2007 (4 grants)

Chemical listening devices: Novel sensors targeting the clandestine manufacture and transport of illicit drugs and explosives$378,942
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer, Doctor Clovia Holdsworth, Professor Christopher Lennard
SchemeRole
Linkage ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$378,94220072009
GNo:G0186611

Selective Detection and Removal of Organochlorine Residues via MIPs$105,000
Funding Body: Entech Industries

SchemeRole
IndustryChief Investigator
Total AmountFunding StartFunding Finish
$105,00020072007
GNo:17804791

Chemical listening devices: Novel sensors targeting the clandestine manufacture and transport of illicit drugs and explosives$105,000
Funding Body: Australian Federal Police

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer, Doctor Clovia Holdsworth, Professor Christopher Lennard
SchemeRole
Linkage Projects Partner fundingChief Investigator
Total AmountFunding StartFunding Finish
$105,00020072009
GNo:G0187330

Selective Detection and Removal of Organochlorine Residues via MIPs$105,000
Funding Body: Entech Industries Pty Ltd

Project Team
Professor Adam McCluskey, Doctor Clovia Holdsworth, Associate Professor Michael Bowyer
SchemeRole
Postgraduate Research ScholarshipChief Investigator
Total AmountFunding StartFunding Finish
$105,00020072010
GNo:G0187721

2006 (4 grants)

PRC - Priority Research Centre for Organic Electronics & OrganoBiosensors$549,282
Funding Body: University of Newcastle

Project Team
Professor Paul Dastoor, Professor Adam McCluskey, Professor Erica Wanless, Professor Scott Donne, Doctor John Holdsworth
SchemeRole
Priority Research CentreInvestigator
Total AmountFunding StartFunding Finish
$549,28220062013
GNo:G0186946

Consequences of Dynamin 2 PH Domain Dysfunction in Charcot-Marie-Tooth Neuropathy$217,500
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$217,50020062008
GNo:G0186208

Chemical Interventions in Neurological Diseases?$20,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020062006
GNo:G0186050

BIT's 4th Annual Congress of International Drug Discovery Science & Technology 25 May - 2 June 2006$2,400
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40020062006
GNo:G0186202

2005 (1 grants)

High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomicis Workstation$207,189
Funding Body: ARC (Australian Research Council)

2004 (8 grants)

Selective detection and removal of contaminants that have an adverse impact on Australian raw sugar quality$190,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer, Dr M O'Shea
SchemeRole
Linkage ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$190,00020042006
GNo:G0183626

Biacore3000-Expansion of Proteomics Facility$187,341
Funding Body: ARC (Australian Research Council)

Project Team
Professor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Emeritus Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF)Investigator
Total AmountFunding StartFunding Finish
$187,34120042004
GNo:G0183030

In-field sensors for the detection of illicit drugs$171,336
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer
SchemeRole
Linkage ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$171,33620042006
GNo:G0184254

Selective detection and removal of contaminants that have adverse impact on Australian raw sugar quality$51,000
Funding Body: Bureau of Sugar Experiment Stations

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer
SchemeRole
Linkage Projects Partner fundingChief Investigator
Total AmountFunding StartFunding Finish
$51,00020042006
GNo:G0184030

In-field sensors for the detection of illicit drugs$45,000
Funding Body: Australian Federal Police

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer
SchemeRole
Linkage Projects Partner fundingChief Investigator
Total AmountFunding StartFunding Finish
$45,00020042006
GNo:G0185067

Improving Drug Development: New Approaches to Rapid Development of Novel Lead Compounds$27,542
Funding Body: Ramaciotti Foundations

Project Team
Professor Adam McCluskey
SchemeRole
Major Equipment AwardChief Investigator
Total AmountFunding StartFunding Finish
$27,54220042004
GNo:G0183187

New drugs targeting protein kinases$17,000
Funding Body: Hunter Medical Research Institute

Project Team
Emeritus Professor Leonie Ashman, Professor Adam McCluskey
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$17,00020042004
GNo:G0183751

Radiocarbon dating of heroin samples as a tool to verify the conversion to alternative crops.$5,820
Funding Body: AINSE (Australian Institute of Nuclear Science & Engineering)

Project Team
Professor Adam McCluskey
SchemeRole
Use of Facilities OnlyChief Investigator
Total AmountFunding StartFunding Finish
$5,82020042004
GNo:G0183703

2003 (4 grants)

Implementation of a Methamphetamine Method for the Australian Federal Police$230,309
Funding Body: Australian Federal Police

Project Team
Professor Adam McCluskey
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$230,30920032005
GNo:G0184304

Dynamin inhibitors as tools for dissecting the endocytic pathways neurons$165,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$165,00020032005
GNo:G0182859

High Pressure and Fluorous Approaches to fostriecin libraries: New Therapeutic Opportunities.$50,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Assoc. Prof David Young, Doctor Jennette Sakoff
SchemeRole
Discovery ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$50,00020032003
GNo:G0182117

Implementation of a Methamphetamine Method for the Australian Federal Police$30,000
Funding Body: Australian Federal Police

Project Team
Professor Adam McCluskey
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$30,00020032003
GNo:G0184303

2002 (4 grants)

Antagonist of Corticotrophin Releasing Hormone as Therapeutic Agents for the Prevention of Premature Birth in Humans$375,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey, Dr P Keller, Professor Roger Smith, Dr A Ruhmann
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$375,00020022004
GNo:G0180905

Devevelopement and Use of Ionic Liquids in Metal Recovery from Ores, Concentrates and Mattes.$205,000
Funding Body: ARC (Australian Research Council)

Project Team
Emeritus Professor Geoffrey Lawrance, Dr I Hamilton, Professor Adam McCluskey
SchemeRole
Discovery ProjectsInvestigator
Total AmountFunding StartFunding Finish
$205,00020022004
GNo:G0181087

New targets for chemotherapy: anti-cancer drugs that target protein phosphatases$10,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey, Conjoint Professor Stephen Ackland, Doctor Jennette Sakoff
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020022002
GNo:G0181459

Development of new therapeutic agents for the treatment of epilepsy$8,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$8,00020022002
GNo:G0181460

2001 (4 grants)

Selective detection of Trichloroanisole and other flavour contaminants in wines using molecularly imprinted polymer technology.$30,268
Funding Body: Grape & Wine Research and Development Corporation

Project Team
Professor Adam McCluskey
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$30,26820012002
GNo:G0181473

Development of new drugs for the prevention of premature birth$10,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020012001
GNo:G0180062

Environmentally friendly ('Green') organic chemistry: Development of novel methodologies and reagents.$5,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$5,00020012001
GNo:G0180014

92nd American Association for Cancer Research Annual Meeting, USA 24-28 March 2001$2,400
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,40020012001
GNo:G0180691

2000 (3 grants)

Selective detection of Trichloroanisole and other flavour contaminants in wines using molecularly imprinted polymer technology.$26,950
Funding Body: Grape & Wine Research and Development Corporation

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$26,95020002000
GNo:G0180158

Synthesis of Drugs for Prevention of Pre-Term Delivery.$10,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey, Professor Roger Smith
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020002000
GNo:G0178828

Towards Green Chemistry: The Development of Environmentally Organic Synthesis.$7,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$7,00020002000
GNo:G0178827

1999 (5 grants)

Selective Inhibitors of Protein Phosphatases as Anti-cancer agents$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jennette Sakoff, Professor Adam McCluskey, Conjoint Professor Stephen Ackland
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$25,00019991999
GNo:G0178390

Selective detection of Trichloroanisole and other flavour contaminants in wines using molecularly imprinted polymer technology$20,000
Funding Body: Grape & Wine Research and Development Corporation

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00019991999
GNo:G0178612

Rapid Microscale Synthesis of Drugs for the Prevention of Pre-Term Delivery$13,500
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey, Professor Roger Smith
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$13,50019991999
GNo:G0178022

Development of a Versatile, Sensitive, Non-Isotopoic Method for Detecting Phosphorylated and Glycosylated Serines in Proteins and Peptides$10,000
Funding Body: University of Newcastle

Project Team
Emeritus Professor John Rostas, Professor Adam McCluskey
SchemeRole
Collaborative Research GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00019991999
GNo:G0178350

RMC Collab Partner.Development of a Versatile, Sensitive, Non-Isotopic Method for Detecting Phosphorylated and Glucosylated Serines in Proteins & Peptides.$10,000
Funding Body: Bio-Rad Laboratories Pty Ltd (Australia)

Project Team
Emeritus Professor John Rostas, Professor Adam McCluskey
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00019991999
GNo:G0178764

1998 (3 grants)

Low molecular weight ligands for corticotrophin releasing hormone receptors: Drugs for intervention during human pregnancy$47,664
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey, Dr P Keller, Professor Roger Smith
SchemeRole
Special Scholarship Initiative GrantsChief Investigator
Total AmountFunding StartFunding Finish
$47,66419982000
GNo:G0177742

Computer Modelling and Graphical Representation of the Three Dimensional Structure of Protein Phosphatases$9,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$9,00019981998
GNo:G0177303

XVth EFMC International Symposium on Medicinal Chemistry, Scotland 6-10 September 1998$2,500
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,50019981998
GNo:G0180347

1997 (3 grants)

Computer Asisted Design and Chemical Synthesis of Novel Therapeutic Agents Affecting Pregnancy the Duration of Human Pregnancy$16,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Roger Smith, Professor Adam McCluskey, Professor Alan Boura
SchemeRole
Small GrantInvestigator
Total AmountFunding StartFunding Finish
$16,00019971997
GNo:G0176726

Design and Synthesis of Novel Corticotropin-Releasing Hormone Receptors Agaonists/Antagonists: Development of New Therapeutic Agents$15,000
Funding Body: Ramaciotti Foundations

Project Team
Professor Adam McCluskey, Ian Leitch
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$15,00019971997
GNo:G0176500

Development Of A Novel, Photolytic Oxidising Agent For Use In Synthetic Chemistry.$7,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$7,00019971997
GNo:G0176634

1996 (1 grants)

Design & Synthesis ofNovel Protein Phosphatase 1 & Protein Phosphatase 2A Inhibitors$12,500
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
SchemeRole
New Staff GrantChief Investigator
Total AmountFunding StartFunding Finish
$12,50019961996
GNo:G0176326
Edit

Research Supervision

Number of current supervisions10
Total current UoN PhD EFTSL4.15

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20142018PhD (Chemistry)Co-SupervisorNovel Classes of Iminosugars as Glycosidase Inhibitors via a Flow Chemistry Approach
20132017PhD (Biological Sciences)Co-SupervisorGenetic Consequences of Paternal Acrylamide Exposure and Potential for Amelioration
20132017PhD (Chemistry)Principal SupervisorPathogenic Retroviruses - Developing Next Generation Antiviral Agents
20122016PhD (Biological Sciences)Principal SupervisorHedgehog Signaling Pathway Inhibitors as Cancer Suppressing Agents
20112015PhD (Chemistry)Principal SupervisorA Chemical Biology Approach to Novel Inhibitors of Clathrin
20112015PhD (Chemistry)Principal SupervisorSynthesis of Bolinaquinone Analogues as Clathrin Mediated Endocytosis
20102018PhD (Medicine)Co-SupervisorThe Characterisation and Classification of Residual Tool Marks on Bone Inflicted by Machetes and Samurai Swords (Sharp and Blunt) and the Survivability of Those Marks Following Thermal Trauma (Fire).
20102014PhD (Chemistry)Principal SupervisorApplication of Green Chemistry Approaches to the Ugi and Passerini Multicomponent Reactions
20072011PhD (Chemistry)Co-SupervisorExploring Signal Transduction Mechanisms in Molecularly Imprinted Polymers for Forensic Applications
20062010PhD (Chemistry)Sole SupervisorNovel Inhibitors of Dynamin GTPase

Past Supervision

YearProgramSupervisor TypeResearch Title
2014PhD (Chemistry)Co-SupervisorDrugs from Nature: 1. Dynamin I Inhibitors from Mexican Marine Algae; 2. Chemical Investigation of an Australian Aboriginal Traditional Remedy
2013PhD (Chemistry)Principal SupervisorSynthesis and Evaluation of Norcantharidin and Acrylonitrile Derivatives as Potential Anti-Cancer Agents
2013PhD (Chemistry)Principal SupervisorA Mechanistic Study into the Reaction Between Carbon Dioxide and Amines
2013PhD (Chemistry)Principal SupervisorDesign and Synthesis of Molecularly Imprinted Polymers for the Selective Extraction of Polychlorinated Biphenyls
2012PhD (Chemistry)Principal Supervisor1. Dynamin-l Inhibitors from Sessile Marine Invertebrates; 2. Chemotaxonomy of Cystophora spp.
2012PhD (Chemistry)Principal SupervisorDisruption of Clathrin Mediated-Endocytosis through Small Molecule Inhibition of Dynamin and Clathrin
2012PhD (Chemistry)Principal SupervisorSynthesis, Characterisation and Evaluation of Biphenyl Monomers for Molecular Imprinting Applications
2011M Philosophy (Chemistry)Principal SupervisorNovel Inhibitors of Clathrin Mediated Endocytosis
2010PhD (Chemistry)Co-SupervisorCharacterisation and Improved Performance of Molecularly Imprinted Polymers Prepared Using Room Temperature Ionic Liquids
2010PhD (Chemistry)Principal SupervisorOptimisation of Molecularly Imprinted Polymeric Films for the Detection of L-Ephedrine
2010PhD (Chemistry)Co-SupervisorTowards the Development of a Benzylpiperazine Specific Molecular Imprinted Polymer
2009PhD (Chemistry)Principal SupervisorNorcantharidin Analogues: PP1 and PP2A Inhibition and Potential Therapeutic Development
2008PhD (Chemistry)Principal SupervisorDesign and Synthesis of Molecularly Imprinted Polymers for the Selective Recognition of Small Chloro-Arene Contaminants
2008PhD (Chemistry)Co-SupervisorIonic Liquids for Synthesis and Metal Recovery
2007PhD (Chemistry)Sole SupervisorDesign and Synthesis of Novel Dynamin GTPase Inhibitors
2006PhD (Chemistry)Co-SupervisorNew Routes To Precious Metal Recovery Using Ionic Liquids
2006PhD (Chemistry)Co-SupervisorIonic Liquids for Explosive Technologies
2006PhD (Chemistry)Sole SupervisorNovel Inhibitors of Dynamin GTPase
2006PhD (Chemistry)Sole SupervisorCantharidin Analogues: Potential Therapeutic Agents
2005PhD (Chemistry)Co-SupervisorChemotaxonomy of the brown algal genus Cyclophoria
2004PhD (Chemistry)Sole SupervisorDesign and Synthesis of Potential CRHR1 Antagonists
2004PhD (Chemistry)Sole SupervisorDevelopment Towards Structurally Unprecedented Corticotropin Releasing Hormone Type-1 Receptor Antagonists
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Professor Adam McCluskey

Work Phone(02) 4921 6486
Fax(02) 4921 5472
Email
PositionProfessor
School of Environmental and Life Sciences
Faculty of Science and Information Technology
The University of Newcastle, Australia
Focus AreaChemistry
Office
C318,
Chemistry,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/adam-mccluskey