Applications are invited from motivated graduates to undertake a PhD in Magnetic Resonance spectroscopy (MRS) under the supervision of Dr Saadallah Ramadan

PhD Opportunities in Magnetic Resonance Spectroscopy

15 August 2014

Applications are invited from motivated graduates to undertake a PhD in Magnetic Resonance spectroscopy (MRS) under the supervision of Dr Saadallah Ramadan

1. Implementation of parallel imaging algorithm in Magnetic Resonance Spectroscopic Imaging (MRSI) in vivo

Magnetic resonance spectroscopy (MRS) is a technique that is capable of providing information about MR sensitive metabolites in tissue in vivo in a non-invasive manner. Knowledge of identity and amount of metabolites can be used to diagnose and monitor progress or disease/therapy in a tissue without resorting to any invasive biopsy techniques. MRSI is a technique that can cover a large volume of tissue in a short period of time. The availability of multiple-element coils in MR scanners open the opportunity for increasing the speed of data collection. The proposed project will basically look into various means for experimental time reduction with focus on parallel imaging techniques.

2. Two-dimensional Magnetic Resonance Spectroscopy using single-scan technique in vivo

Magnetic resonance spectroscopy (MRS) is a technique that is capable of providing information about MR sensitive metabolites in tissue in vivo in a non-invasive manner. Knowledge of identity and amount of metabolites can be used to diagnose and monitor progress or disease/therapy in a tissue without resorting to any invasive biopsy techniques. MRS can be performed in one-dimensional and two-dimensional modes. The two-dimensional mode usually takes 10-20 minutes of data collection; which is long from a clinical perspective. The project aims to develop and optimize a technique that can acquire data in a much shorter time.

3. Development and implementation of Echo Planar Correlated Spectroscopic Imaging in the human brain in vivo

Magnetic resonance spectroscopy (MRS) is a technique that is capable of providing information about MR sensitive metabolites in tissue in vivo in a non-invasive manner. Knowledge of identity and amount of metabolites can be used to diagnose and monitor progress or disease/therapy in a tissue without resorting to any invasive biopsy techniques. MRS can be performed in one-dimensional and two-dimensional modes. The two-dimensional mode is time consuming and time reduction is necessary for regular clinical implementation. A novel (4D) echo-planar correlated spectroscopic imaging (EPCOSI) is a spectroscopic sequence that is based on echo planar imaging and can acquire data in much shorter time. Optimization, development and suitable processing software is necessary to introduce this technology into the clinic.

4. Development of acquisition and processing package for two-dimensional spectroscopic in vivo data

Magnetic resonance spectroscopy (MRS) is a technique that is capable of providing information about MR sensitive metabolites in tissue in vivo in a non-invasive manner. Knowledge of identity and amount of metabolites can be used to diagnose and monitor progress or disease/therapy in a tissue without resorting to any invasive biopsy techniques. MRS can be performed in one-dimensional and two-dimensional modes. The two-dimensional mode has usually a large amount of information and proper analysis is required for correct extraction of all available information. ProFit is a Matlab algorithm that can process and quantify two-dimensional (2D) spectral datasets. Project will be focused on optimizing ProFit for different acquisitions protocols.

Application procedure

Contact Dr Saadallah Ramadan to discuss your eligibility, career goals and research interests.

Dr Saadallah Ramadan
E: Saadallah.Ramadan@newcastle.edu.au
T: +61 4042 0573

Applications close 1 December 2015