PhD Scholarship: Characterising novel metabolites in Asthma for their function and diagnostic potential
Friday, 17 March 2017
A PhD scholarship is available for a student to investigate metabolites in Asthma under the supervision of Dr Gerard Kaiko.
Severe asthma afflicts ~10% of patients who suffer from the disease and is characterised by persistent symptoms, frequent exacerbations requiring hospitalisation, and poor response to glucocorticosteroid therapy.
There is an urgent need to better understand the pathogenesis of severe asthma to enable the development of better therapies and diagnostic biomarkers.
We conducted the first global metabolomics analysis of the asthma airway metabolome.
This PhD project will investigate the metabolites identified as specifically enriched in the airways of severe asthma patients, specifically how these molecules function to contribute to disease severity.
This will involve modelling the impact of these metabolites using immune and epithelial cell assays in vitro as well as asthma models in vivo.
This project will also determine the potential of these metabolites as new biomarkers to better predict which patients will develop severe asthma.
This project will be based at the Hunter Medical Research Institute (HMRI) in one of Australia's leading respiratory disease research centres.
2017 ECR Higher Degree by Research Scholarship, UoN Advantage Scheme, value: $26,282 p.a., indexed in January each year. The scholarship is for a period of 3 and a half years.
Must have: Experience in a laboratory Honours Class One (or equivalent) or Masters degree (Research based) Strong work ethic. The scholarship is open to domestic and international applicants.
Interested applicants are advised to send an email expressing their interest.
Contact: Dr Gerard Kaiko