PHAR6213

Molecular Pathogenesis

Faculty of Health School of Biomedical Sciences and Pharmacy

10 Units 6000 Level Course

Available in 2013

Callaghan Campus	Trimester 1

Previously offered in 2012, 2011, 2010, 2009

Introduces students to the molecular basis of disease and drug response. As knowledge of the genetic basis of disease increases so does the opportunities for drug targeting and patient specific-treatments. This course considers the two key elements - the genetics of disease and the genetics of drug response (pharmacogenomics).

Objectives

Students should:
1. Have a fundamental understanding of the molecular basis of disease;
2. Understand the molecular determinants of drug response;
3. Understand the molecular basis of cancer therapeutics;
4. Understand the impact of biotherapy on therapeutics, pharmaceutical industry and society; and
5. Gain basic understanding of the ethical issues related to the use of biotherapy.

Content

1. Drug targets
2. Genomics
3. Proteomics
4. Pharmacogenetics
5. Pharmacogenomics
6. Monoclonal antibody therapeutics
7. Peptide-based therapeutics
8. Nucleic Acid therapeutics including anti-sense and gene-therapy
9. Cell-based therapeutics
10.SNP analysis
11.Ethical issues arising from the use of biotherapeutics

Replacing Course(s)

Replaces PHAR6017 Molecular Pathogenesis 10 Units.

Transition

N/A

Industrial Experience

Assumed Knowledge

PHAR6123 Human Genomics and Biomolecular Analysis for Pharmacy.

Modes of Delivery

Internal Mode

Teaching Methods

Problem Based Learning
Lecture
Tutorial

Assessment Items

Examination: Formal	Examination paper held at the end of trimester. May comprise True/False, multiple choice and short answer questions and calculations.
Other: (please specify)	Assessment may include Essays/written assignments as well as oral presentations on project tasks and generation of a report. Topics and dates will be advised in the course outline.
Other: (please specify)	Students must achieve a passing grade in the final examination and all other assessment items to obtain a passing or higher grade in this course. Students must demonstrate competency in the theoretical knowledge that forms part of the core competencies required of a pharmacist

Contact Hours

Lecture: for 3 hour(s) per Week for 10 weeks
Tutorial: for 2 hour(s) per Week for 10 weeks
Lecture: for 1 hour(s) per Week for 1 weeks

Compulsory Components

Requisite by Enrolment	This course is only available to students enrolled in the Master of Pharmacy program.
Compulsory Program Component	Students can only enrol in PHAR6213 Molecular Pathogenesis if they have completed PHAR6123 Human Genomics and Biomolecular Analysis for Pharmacy

Timetables