PHAR6113

Pharmacokinetics

Faculty of Health School of Biomedical Sciences and Pharmacy

10 Units 6000 Level Course

Available in 2013

Callaghan Campus	Trimester 1

Previously offered in 2012, 2011, 2010, 2009, 2008

Develops the students understanding of the processes involved in drug absorption, distribution and elimination and the way in which these processes influence the design of dosage regimens for individual patients.

Objectives

At the end of the course, students should:
1. Describe the role of pharmacodynamic and pharmacokinetic factors as determinants of drug response.
2. Calculate pharmacokinetic parameters and understand their physiological determinants.
3. Describe the role of physiologic, pathologic and pharmacological factors on a drug's pharmacokinetics.
4. Calculate dosage regimens for young and elderly patients with disease states or interacting drugs
5. Understand the biopharmaceutical factors which influence invivo performance of dosage forms and the methods of evaluation.

Content

1. General principles of drug action and receptor theory
2. Concept of primary and secondary pharmacokinetic parameters-clearance, volume of distribution and half life and their calculation
3. Pharmacokinetic processes of drug absorption, distribution and elimination and their physiological determinants-blood flow, binding and intrinsic clearance
4. Non-linear pharmacokinetics
5. Dosage adjustment in patients with disease states, the young and the elderly
6. Biopharmaceutics and Bioequivalence
7. Generic drug products and brand substitution
8. Population Pharmacokinetics
9. Introduction to clinical pharmacokinetics

Replacing Course(s)

Replacing PHAR6002 Pharmacokinetics 10 Units

Transition

Students requiring to repeat PHAR6002 Pharmacokinetics will undertake PHAR6113 Pharmacokinetics

Industrial Experience

Assumed Knowledge

Entry level requirements for Master of Pharmacy

Modes of Delivery

Internal Mode

Teaching Methods

Lecture
Tutorial
Computer Lab

Assessment Items

Examination: Class	In class examination during trimester
Essays / Written Assignments	Problem sets and tutorial worksheets.
Examination: Formal	Examination at the end of trimester. May comprise True/False, multiple choice and short answer questions and calculations.
Other: (please specify)	Students must achieve a passing grade overall to obtain a passing or higher grade in this course. Students must demonstrate competency in the theoretical knowledge that forms part of the core competencies required of a pharmacist

Contact Hours

Lecture: for 2 hour(s) per Week for 12 weeks
Computer Lab: for 2 hour(s) per Week for 10 weeks
Tutorial: for 2 hour(s) per Week for 1 weeks

Compulsory Components

Requisite by Enrolment	This course is available to students enrolled in the Master of Pharmacy program.

Timetables