Course code PHAR6113Units 10Level 6000Faculty of Health and MedicineSchool of Biomedical Sciences and Pharmacy

Develops the students understanding of the processes involved in drug absorption, distribution and elimination and the way in which these processes influence the design of dosage regimens for individual patients.

Available in 2015

Callaghan CampusTrimester 1
Previously offered in 2014
ObjectivesAt the end of the course, students should:
1. Describe the role of pharmacodynamic and pharmacokinetic factors as determinants of drug response.
2. Calculate pharmacokinetic parameters and understand their physiological determinants.
3. Describe the role of physiologic, pathologic and pharmacological factors on a drug's pharmacokinetics.
4. Calculate dosage regimens for young and elderly patients with disease states or interacting drugs
5. Understand the biopharmaceutical factors which influence invivo performance of dosage forms and the methods of evaluation.
Content1. General principles of drug action and receptor theory
2. Concept of primary and secondary pharmacokinetic parameters-clearance, volume of distribution and half life and their calculation
3. Pharmacokinetic processes of drug absorption, distribution and elimination and their physiological determinants-blood flow, binding and intrinsic clearance
4. Non-linear pharmacokinetics
5. Dosage adjustment in patients with disease states, the young and the elderly
6. Biopharmaceutics and Bioequivalence
7. Generic drug products and brand substitution
8. Population Pharmacokinetics
9. Introduction to clinical pharmacokinetics
Replacing Course(s)Replacing PHAR6002 Pharmacokinetics 10 Units
TransitionStudents requiring to repeat PHAR6002 Pharmacokinetics will undertake PHAR6113 Pharmacokinetics
Industrial Experience0
Assumed KnowledgeEntry level requirements for Master of Pharmacy
Modes of DeliveryInternal Mode
Teaching MethodsLecture
Computer Lab
Assessment Items
Examination: ClassIn class examination during trimester
Essays / Written AssignmentsProblem sets and tutorial worksheets.
Examination: FormalExamination at the end of trimester. May comprise True/False, multiple choice and short answer questions and calculations.
Other: (please specify)Students must achieve a passing grade overall to obtain a passing or higher grade in this course.

Students must demonstrate competency in the theoretical knowledge that forms part of the core competencies required of a pharmacist
Contact HoursLecture: for 2 hour(s) per Week for 12 weeks
Computer Lab: for 2 hour(s) per Week for 10 weeks
Tutorial: for 2 hour(s) per Week for 1 weeks
Compulsory Components
Requisite by EnrolmentThis course is available to students enrolled in the Master of Pharmacy program.
Timetables2015 Course Timetables for PHAR6113