Endocrinology and Injectable Dosage Formulations
|Course code PHAR3101||Units 10||Level 3000||Faculty of Health and MedicineSchool of Biomedical Sciences and Pharmacy|
Presents the pathophysiology of altered health states and their management including both pharmacological and non-pharmacological interventions. Specific conditions covered in this course include diabetes, thyroid, pituitary and adrenal conditions. The course considers aspects of pharmacy practice including a systematic review of prescription and non-prescription medications and complementary and alternate medicines, which will address the quality use of medicines in the management of these conditions.
The course builds on student's existing knowledge and understanding of the physical pharmacy principles and provides students with an understanding of how these principles are applied to the preparation of injectable dosage formulations. The stability of these drug products and factors influencing the storage and shelf life of products is included in this course. In considering the formulation of injectable dosage formulations and sterile drug products, the clinical application of aseptic technique, sterility testing, isotonicity, stability and incompatibilities of parenteral formulations will be discussed and expanded upon in this course.
Pharmacokinetic and pharmacodynamic considerations in conditions affecting the endocrine system are covered including the kinetics of parenteral drug administration.
Application of the knowledge developed in this course will be complemented by clinical skills training.
Not available in 2014
|Objectives||At the end of this course students will be able to:|
1. Describe the pathophysiology and management (pharmacological and non-pharmacological) of diabetes.
2. Describe the pathophysiology and management of thyroid, pituitary and adrenal conditions.
3. Describe the quality use of medicines' issues surrounding these therapeutic agents in the treatment of these conditions and continue to develop clinical skills and communication skills in the therapeutic management of these conditions.
4. Identify the principles of drug stability and discuss pharmacy practice issues relating to storage of injectable drug products.
5. Describe the formulation and manufacture of injectable dosage forms and sterile drug products.
6. Understand the skills required in the preparation of aseptic injectable pharmaceutical products and issues surrounding sterility testing, drug compatibility and isotonicity.
7. Use advanced pharmaceutical principles to help avoid drug interactions and incompatibilities, in particular for intravenous formulations.
8. Describe the pharmacodynamic and pharmacokinetic factors as determinants of drug response in conditions affecting the endocrine system, and of injectable formulations.
9. Develop an understanding of the pharmacology, design and delivery of medicines used in veterinary practice.
|Content||1. This course will cover the pathophysiology, therapeutic treatment and pharmacy practice issues in the management of:|
- Thyroid, adrenal and pituitary conditions.
2. The concept of minor illness and major disease will be discussed, including the use of prescription and non-prescription products, including Complementary and Alternate Medicines. Non-pharmacological approaches to the management of these conditions will also be discussed.
3. The course covers advanced concepts in formulation development and design of injectable preparations including:
- Sterile products, aseptic technique, microbial contamination, spoilage and preservation, principles of sterilisation and storage considerations.
- Advanced dispensing skills in the aseptic preparation of injectable pharmaceutical products.
- Sterilisation and sterility testing of injectable pharmaceutical products.
- Drug interactions and incompatibilities particularly for intravenous formulations.
4. The course covers all pharmacokinetic/pharmacodynamic considerations for therapeutic agents used in the management of conditions affecting the endocrine system including:
- Pharmacokinetic considerations in IV bolus dosing and IV infusion.
- Extravascular dosing and subcutaneous drug administration.
5. The principles of veterinary medicine including:
- Pharmacology of medicines used in veterinary practice.
- The design and delivery of medicines used in veterinary practice.
|Assumed Knowledge||PHAR2204 Clinical Pharmacotherapy 1|
|Modes of Delivery||Internal Mode|
Self Directed Learning
|Contact Hours||Lecture: for 3 hour(s) per Week for 10 weeks|
Tutorial: for 2 hour(s) per Week for 10 weeks
Workshop: for 3 hour(s) per Week for 1 weeks