Gastrointestinal Health and Solid Dosage Formulations

Course code PHAR2203Units 10Level 2000Faculty of Health and MedicineSchool of Biomedical Sciences and Pharmacy

Presents the pathophysiology of altered health states and their management including both pharmacological and non-pharmacological interventions. Specific conditions covered in this course include gastrointestinal and hepatobiliary conditions. The course considers aspects of pharmacy practice including a systematic review of prescription and non-prescription medications and Complementary and Alternate Medicines, which will address the quality use of medicines in the management of these conditions.

The course builds on student's existing knowledge and understanding of physical pharmacy principles and provides students with an understanding of how these principles are applied to the preparation of solid dosage formulations. The stability of these drug products and factors influencing the storage and shelf life of products is included in this course. In considering the formulation of solid dosage formulations and sterile drug products, the clinical application of tablets, capsules and implants will be discussed and expanded upon in this course.

Pharmacokinetic considerations in conditions of the gastrointestinal and hepatobiliary system are covered such as the process of absorption; bioavailability and first pass clearance; and the clearance of substances by the liver.

Application of the knowledge developed in this course will be complemented by clinical skills training.

Available in 2015

Callaghan CampusSemester 2
ObjectivesAt the end of this course students will be able to:
1. Describe the pathophysiology and management (pharmacological and non-pharmacological) of gastrointestinal and hepatobiliary conditions.
2. Describe the pathophysiology and management (pharmacological and non-pharmacological) of oral and dental conditions including principles of oral hygiene.
3. Describe the pathophysiology and principles for the treatment of infectious diseases affecting the gastrointestinal tract (gastroenteritis, giardiasis, traveller's diarrhoea, Colorado, campylobacter enteritis, salmonella enteritis, shigellosis, biliary tract infection, intra-abdominal infection, dental infections).
4. Gain an understanding of the signs, symptoms and complications of these common gastrointestinal infections; be aware of the pathogens involved, understand relevant diagnostic tests and be aware of first and second line infective therapy as well as non-pharmacological approaches to the management of these infections.
5. Describe the quality use of medicines' issues surrounding the use of therapeutic agents in the management of these conditions and continue to develop clinical skills and communication skills in the therapeutic management of these conditions.
6. Identify the principles of drug stability and discuss pharmacy practice issues relating to storage of solid oral dosage forms.
7. Describe the formulation and manufacture of solid dosage forms and sterile drug products.
8. Understand the skills required in the preparation of solid pharmaceutical products including tablets and capsules.
9. Describe the role of pharmacodynamics and pharmacokinetic factors as determinants of drug response in gastrointestinal and hepatobiliary conditions.
10. Understand the underlying principles of absorption; bioavailability and first pass clearance; and the clearance of substances by the liver including the concepts of high/low extraction and metabolism.
Content1. This course will cover the pathophysiology, therapeutic management (pharmacological and non-pharmacological) and pharmacy practice issues in the management of:
- Gastrointestinal conditions (including peptic ulcer disease, reflux, nausea and vomiting and inflammatory bowel disease).
- Hepatobiliary disorders (including cirrhosis, pancreatitis, biliary obstruction).
- Anaemia in the context of Vitamin B12 deficiency.
- Oral and dental health (including dental disorders; periodontal disease; medications used in dental procedures; and oral hygiene).
2. The pathophysiology and principles for the management of the following infectious diseases:
- Gastroenteritis, giardiasis, traveller's diarrhoea, Colorado, campylobacter enteritis, salmonella enteritis, shigellosis, biliary tract infection, intra-abdominal infection.
3. The concept of minor illness and major disease will be discussed, including the use of prescription and non-prescription products, including Complementary and Alternate Medicines. Non-pharmacological approaches to the management of these conditions will also be discussed.
4. The basic underlying principles of good nutrition and healthy eating including supplementation.
5. The course covers advanced concepts in formulation development and design of solid dosage forms including:
- Sterile products, aseptic technique, microbial contamination, spoilage and preservation, principles of sterilisation and storage considerations.
- Dispensing and compounding skills in the preparation of solid dosage forms, including tablets, capsules and implants.
- Factors influencing stability, stability testing and prediction of shelf life including kinetics of chemical decomposition in solution and in the solid state.
- Dispensing skills in the extemporaneous preparation of pharmaceutical products.
6. The course covers all pharmacokinetic considerations for therapeutic agents used in the management of gastrointestinal and hepatobiliary disorders including:
- Principles of absorption; active and passive transport mechanisms and transporter systems/proteins, p-glycoprotein.
- Bioavailability and first pass clearance; an introduction to bioequivalence.
- Clearance of substances by the liver including the concept of high/low extraction and metabolism.
- Genetic variability in pharmacokinetics and pharmacodynamics.
Replacing Course(s)NA
TransitionNA
Industrial Experience0
Assumed KnowledgePHAR1101 Introduction to Pharmacy and Formulation Sciences 1 , PHAR1201 Introduction to Pharmacy and Formulation Sciences 2
Modes of DeliveryInternal Mode
Teaching MethodsLecture
Practical
Tutorial
Assessment Items
Examination: ClassCourse Learning Objectives 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
Examination: FormalCourse Learning Objectives 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
PracticalExtemporaneous Dispensing Examinations
Course Learning Objectives 6, 7, 8

Compulsory Course Component: Students must demonstrate competency in both theoretical knowledge and practical dispensing skills which form part of the core competencies required of a pharmacist so an overall mark of at least 60% in a combination of the extemporaneous dispensing examinations is required to be deemed competent in compounding and pharmaceutical dispensing. On achieving a passing grade, a final mark will be given in the course and it will be recorded that the student has satisfied the compulsory course component. Students who fail to satisfy this compulsory course component will be offered a supplementary examination. Students who are required to complete a supplementary examination and satisfactorily pass the assessment and pass the course overall will be awarded a maximum mark of 50 for the course. Those who do not pass the supplementary examination will be awarded a zero mark and a FF grade, irrespective of their final numeric mark.
Quiz - On-lineCourse Learning Objectives 6, 7, 8
Contact HoursLecture: for 3 hour(s) per Week for 12 weeks
Tutorial: for 1 hour(s) per Week for 12 weeks
Practical: for 3 hour(s) per Week for 10 weeks
Compulsory Components
Compulsory Course ComponentThe assessment components test a student's competency in one or more of the course learning objectives since these form part of the core competencies required of a pharmacist so students must:
1. achieve an overall mark of at least 60% in a combination of the extemporaneous dispensing examinations to be deemed competent in compounding and dispensing.
Requisite by EnrolmentThis course is only available to students enrolled in the Bachelor of Pharmacy (Honours) program.
Compulsory Program ComponentPrior successful completion of PHAR1101 Introduction to Pharmacy and Formulation Sciences 1 and PHAR1201 Introduction to Pharmacy and Formulation Sciences 2.
Timetables2015 Course Timetables for PHAR2203