PHAR2203Gastrointestinal Health and Solid Dosage Formulations

Course handbook

Description

Presents the pathophysiology of altered health states and their management including both pharmacological and non-pharmacological interventions. Specific conditions covered in this course include gastrointestinal and hepatobiliary conditions. The course considers aspects of pharmacy practice including a systematic review of prescription and non-prescription medications and Complementary and Alternate Medicines, which will address the quality use of medicines in the management of these conditions. The course builds on student's existing knowledge and understanding of physical pharmacy principles and provides students with an understanding of how these principles are applied to the preparation of solid dosage formulations. The stability of these drug products and factors influencing the storage and shelf life of products is included in this course. In considering the formulation of solid dosage formulations and sterile drug products, the clinical application of tablets, capsules and implants will be discussed and expanded upon in this course. Pharmacokinetic considerations in conditions of the gastrointestinal and hepatobiliary system are covered such as the process of absorption; bioavailability and first pass clearance; and the clearance of substances by the liver. Application of the knowledge developed in this course will be complemented by clinical skills training.

Availability2024 Course Timetables

Learning outcomes

On successful completion of the course students will be able to:

1. Describe the pathophysiology and management (pharmacological and non-pharmacological) of gastrointestinal and hepatobiliary conditions.

2. Describe the pathophysiology and management (pharmacological and non-pharmacological) of oral and dental conditions including principles of oral hygiene.

3. Describe the pathophysiology and principles for the treatment of infectious diseases affecting the gastrointestinal tract (gastroenteritis, giardiasis, traveller's diarrhoea, Colorado, campylobacter enteritis, salmonella enteritis, shigellosis, biliary tract infection, intra-abdominal infection, dental infections).

4. Describe the signs, symptoms and complications of common gastrointestinal infections; be aware of the pathogens involved, understand relevant diagnostic tests and be aware of first and second line infective therapy as well as non-pharmacological approaches to the management of these infections.

5. Describe the quality use of medicines' issues surrounding the use of therapeutic agents in the management of gastrointestinal conditions and continue to develop clinical skills in the therapeutic management of these conditions.

6. Identify the principles of drug stability and discuss pharmacy practice issues relating to storage of solid oral dosage forms.

7. Describe the formulation and manufacture of solid dosage forms and sterile drug products.

8. Describe the preparation of solid pharmaceutical products including tablets and capsules.

9. Describe the role of pharmacodynamics and pharmacokinetic factors as determinants of drug response in gastrointestinal and hepatobiliary conditions.

10. Describe the process of drug metabolism by the liver including genetic variation in pharmacokinetics and pharmacodynamics.

Content

1. This course will cover the pathophysiology, therapeutic management (pharmacological and non-pharmacological) and pharmacy practice issues in the management of:

- Gastrointestinal conditions (including peptic ulcer disease, reflux, nausea and vomiting and inflammatory bowel disease).

- Hepatobiliary disorders (including cirrhosis, pancreatitis, biliary obstruction).

- Anaemia in the context of Vitamin B12 deficiency.

- Oral and dental health (including dental disorders; periodontal disease; medications used in dental procedures; and oral hygiene).

2. The pathophysiology and principles for the management of the following infectious diseases:

- Gastroenteritis, giardiasis, traveller's diarrhoea, Colorado, campylobacter enteritis, salmonella enteritis, shigellosis, biliary tract infection, intra-abdominal infection.

3. The concept of minor illness and major disease will be discussed, including the use of prescription and non-prescription products, including Complementary and Alternate Medicines. Non-pharmacological approaches to the management of these conditions will also be discussed.

4. The basic underlying principles of good nutrition and healthy eating including supplementation.

5. The course covers advanced concepts in formulation development and design of solid dosage forms including:

- Sterile products, aseptic technique, microbial contamination, spoilage and preservation, principles of sterilisation and storage considerations.

- Dispensing and compounding skills in the preparation of solid dosage forms, including tablets, capsules and implants.

- Factors influencing stability, stability testing and prediction of shelf life including kinetics of chemical decomposition in solution and in the solid state.

6. The course covers pharmacokinetic and pharmacodynamic considerations for therapeutic agents used in the management of gastrointestinal and hepatobiliary disorders including:

- Principles of absorption; active and passive transport mechanisms and transporter systems/proteins, p-glycoprotein.

- Bioavailability and first pass clearance; an introduction to bioequivalence.

- Clearance of substances by the liver including the concept of high/low extraction and metabolism.

- Genetic variability in pharmacokinetics and pharmacodynamics.

Requisite

This course is only available to students enrolled in the Bachelor of Pharmacy (Honours) [12328] program, and who have successfully completed HUBS1403 and HUBS1404.

Assumed knowledge

PHAR2103

Assessment items

Formal Examination: End of Semester Examination
Compulsory Requirement: Submit assessment item - Must submit this assessment to pass the course.

In Term Test: Weekly Quiz - Tutorial/Practical assessments
Compulsory Requirement: Submit assessment item - Must submit this assessment to pass the course.

In Term Test: Mid-Semester Examination
Compulsory Requirement: Submit assessment item - Must submit this assessment to pass the course.

Contact hours

Semester 2 - 2024 - Callaghan

Course outline

Course outline not yet available.