Human Infection and Immunity 2

Course code HUBS3602Units 10Level 3000Faculty of Health and MedicineSchool of Biomedical Sciences and Pharmacy

This course provides integrated learning between the areas of microbiology, virology and immunology that builds on the knowledge developed in HUBS2601. Students will study advanced topics in microbiology: bacterial and viral pathogenesis, molecular methods of diagnosis and characterisation, replication strategies, treatment and prevention; and Immunology: haematopoiesis, innate and adaptive (cell-mediated and humoral) responses and autoimmunity.
The course is organised as a series of modules, which include problem based tutorials, lectures and practical classes. This course prepares students for a career in laboratory-based research in the biomedical sciences, particularly in areas that focus on microbial infection, immune mediated defence against infection and immunopathological processes that affect the health of the global community.

Available in 2015

Callaghan CampusSemester 1
Previously offered in 2014
ObjectivesThe objectives of this course are to provide students with advanced knowledge and understanding of microbiology, virology and immunology.
At the end of this course students will be able to:
1. Describe the pathogenesis of microbial and viral infections and apply this knowledge to any specific infectious disease.
2. Demonstrate knowledge of the utilisation of contemporary biomedical and molecular techniques to diagnose and characterise infectious microbes and in the development of new diagnostics, prevention and treatment strategies for infectious diseases.
3. Describe at an advanced level human immunity and the development of immune responses that are important in the prevention and development of disease.
4. Demonstrate how to research topics, seek out information and solve problems in microbiology and immunology.
5. Demonstrate practical skills necessary to conduct laboratory-based investigations in microbiology and immunology.
6. Analyse, discuss and present laboratory-based data and scientific information in written and oral forms of communication.
ContentBacteriology: This is an advanced course in bacteriology that is designed to investigate the high level understanding of host: pathogen relationships, diagnosis and characterisation of infection, vaccination and chemotherapy of infection, using specific examples. At the end of this module students will have an advanced understanding of the important basic and clinical concepts of bacteriology including:
1. Investigation of a specific pathogenic bacterial infection
2. Current concepts in diagnosis and characterisation
3. Vaccination against bacteria
4. Antibiotics and resistance
5. Diagnosis, characterisation, vaccination and treatment of pneumococcal infection
6. Listeria monocytogenes
7. Research in bacteriology

Virology: The content in this module is designed to provide an overview of the replication strategies employed by different viruses and how they contribute to the mechanisms of viral pathogenesis. Students will then develop an understanding of how this knowledge can be used to develop specific control and treatment strategies against specific viruses that are important in human disease such as retroviruses, positive and negative sense RNA viruses, and small, medium and large sized DNA viruses. This module concludes by covering the antiviral responses, how viruses have adapted to overcome these responses and treatment/prevention strategies employed against viruses based on our knowledge of viral replication and pathogenesis.

Immunology: This module of the course uses the knowledge about microbiology and virology detailed above, and expands on the immunological responses to human infection. Topics include:
1. Immune System Overview
2. Bone Marrow/Haematopoiesis
3. Innate Immune Response
4. Inflammation/epithelial barrier
5. T-cell subsets: Asthma, allergy and microRNA
6. Auto-immunity
7. Immunodeficiencies
Replacing Course(s)Components of HUBS3206 Advanced Human Molecular Science (20 units)
TransitionHUBS3206 Advanced Human Molecular Science (20 units) will not be offered from 2012. Repeating students will be required to complete HUBS2209 Human Molecular Science (10 units) and HUBS3602 Human Infection and Immunity 2(10 units) from 2012 onwards.
Industrial Experience0
Assumed KnowledgeHUBS2601 Human Infection and Immunity 1 or equivalent.
Modes of DeliveryInternal Mode
Teaching MethodsProblem Based Learning
Assessment Items
Essays / Written AssignmentsCourse Learning Objectives 1,2,3,4
Examination: FormalCourse Learning Objectives 1,2,3,4,5,6
Compulsory Course Component: In order to demonstrate that a student has fulfilled course objectives relating to the understanding of the material expounded during the course students must pass both the formal examination AND continual assessment in order to be able to pass the course overall.
Laboratory ExercisesAssessment may include
Submission of student Laboratory manual and
Assessment of laboratory skills
Other: (please specify)Compulsory Course Component: Laboratory Attendance: This course has objectives (Course objective 5 & 6) and assessment that relate to laboratory skills, so it is a requirement that you achieve a satisfactory level of attendance at laboratory sessions. Students who miss a laboratory session, and have grounds for adverse circumstances, will be provided alternative arrangements to meet these objectives & complete the assessment.
Presentations - ClassOral presentations
Course Learning Objectives 1-4,6
Contact HoursLaboratory: for 5 hour(s) per Week for 4 weeks
Tutorial: for 2 hour(s) per Week for 6 weeks
Lecture: for 2 hour(s) per Week for 11 weeks
Compulsory Components
Compulsory Course ComponentIn order to demonstrate that a student has fulfilled course objectives relating to the understanding of the material expounded during the course students must
1 pass both the formal examination AND continual assessment in order to be able to pass the course overall and
2. achieve a satisfactory level of attendance at laboratory sessions.
Timetables2015 Course Timetables for HUBS3602