HUBS2601

Human Infection and Immunity 1

10 Units 2000 Level Course

Available in 2014

Callaghan Campus Semester 1

Previously offered in 2013, 2012, 2011, 2010, 2009, 2008, 2007, 2006, 2005

This course will build on the knowledge gained in the Year 1 Human Bioscience course: HUBS1404 Biomedical Science Part 2. Students will learn general principles of infection and immunity including the growth and metabolism of human microbial pathogens, mechanisms of microbial pathogenesis and infection control strategies. Students will also learn about host defence mechanisms to combat microbial infections.

Objectives The objectives of this course are to provide students with a post-introductory knowledge and understanding of microbiology, virology and immunology.
At the end of this course students will be able to:
1. Describe the basic structures and growth characteristics of bacteria and viruses.
2. Demonstrate knowledge of contemporary biomedical and molecular techniques to diagnose and characterize infectious microbes
3. Describe prevention and treatment strategies for infectious diseases.
4. Describe human immunity and the development of immune responses that are important in the prevention and development of disease.
5. Demonstrate how to research topics, seek out information and solve problems in microbiology and immunology.
6. Demonstrate practical skills necessary to conduct laboratory-based investigations in microbiology and immunology.
7. Analyse, discuss and present laboratory-based data and scientific information in written and oral forms of communication.
Content Bacteriology
1. Microbial diversity and structure
2. Bacterial nutrition, metabolism, growth and study
3. Bacterial genetics and evolution
4. Bacterial virulence factors and their regulation,
5. Pathogenicity islands secretion systems
6. Microbial pathogenicity and epidemiology
7. Mechanisms of bacterial pathogenicity

Virology
1. Understand virus structure and what makes them different to eukaryotes/prokaryotes. Brief understanding of methods of diagnosis
2. Broad understanding of the classification of different viruses that are important to human disease
3. Broad understanding of different replication strategies employed by different viruses
4. Understand how viruses alter cells to cause disease (i.e. Affect on host cells, changes in host immunity, tissue tropism, pathogenesis etc)
5. Understand how vaccines work, how they are designed and the advantages/dis-advantages of the different types of vaccines (e.g. attenuated Vs killed)
6. Understand the different targets of antiviral drugs. As well as understand how and why are these antivirals are designed to be specific to viruses
7. Comprehensive review of a number of important gastrointestinal viruses and respiratory viruses

Immunology
1. Immune System: Structure & Components
2. Innate Immunity (1): First Line of Defence
3. Innate Immunity (2): Induced Response
4. Adaptive Immunity (1): Antigen Presentation
5. Adaptive Immunity (2): T-cell/ B-cell activation & function
6. Cytokines/Chemookines & Their Receptors: Role in coordinating the immune response
7. Antibodies/Complement
8. The Immune System & Disease: Asthma & Allergy
Replacing Course(s) Replaces components of 20 unit HUBS2404 Cell and Molecular Science Part 2
Transition Not applicable
Industrial Experience 0
Assumed Knowledge HUBS1403 Biomedical Science Part 1 and HUBS1404 Human Bioscience Part 2 or equivalent
Modes of Delivery Internal Mode
Teaching Methods Problem Based Learning
Lecture
Laboratory
Tutorial
Assessment Items
Examination: Class Course Learning Objectives 1,2,3,4
Examination: Formal A formal end of semester written examination.
Course Learning Objectives 1,2,3,4

Students must pass the formal examination and the continual assessment (combined in class examination and lab reports) in order to be able to pass the course overall.
Laboratory Exercises Assessment of laboratory reports based on work conducted in a laboratory environment.
Assessment of laboratory skills demonstrated in the laboratory.
Course Learning Objectives 5,6,7

Attendance: This course has objectives (Course objectives 5, 6 & 7) and assessment that relate to laboratory skills, so it is a requirement that you achieve a satisfactory level of attendance at laboratory sessions. Students who miss a laboratory session, and have grounds for special circumstances, will be provided alternative arrangements to meet these objectives & complete the assessment.
Presentations - Tutorial Presentation of learning goals
Course Learning Objectives 5,7
Contact Hours Laboratory: for 4 hour(s) per Week for 6 weeks
Tutorial: for 1 hour(s) per Week for 12 weeks
Lecture: for 2 hour(s) per Week for 12 weeks
Compulsory Components
Requisite by Enrolment Students enrolled in the Bachelor of Biomedical Science program
Timetables 2014 Course Timetables for HUBS2601