Advanced Human Bioscience

Course code HUBS1416Units 10Level 1000Faculty of Health and MedicineSchool of Biomedical Sciences and Pharmacy

HUBS1416 provides students with a background of core concepts in pharmacology, microbiology, immunology, neurophysiology and genetics.
Integral to this course is an understanding of homeostasis, the complementarity of anatomy and physiology, and the interrelationships between body organ systems. Relevant clinical examples are introduced and discussed where possible around the National Health Priority areas of Cardiovascular Health, Diabetes, Asthma, Obesity, Cancer Control, Mental Health, Arthritis & Musculoskeletal conditions and Injury Prevention and Control.

Knowledge, comprehension and application of these core concepts is essential for understanding both physiological and pathophysiological processes in the patient which students will encounter in future studies and career.

Available in 2014

Callaghan CampusSemester 2
OurimbahSemester 2
Port Macquarie Nth Coast InstSemester 2
Previously offered in 2013, 2012, 2011, 2010, 2009, 2008, 2007, 2006, 2005
ObjectivesStudents who successfully complete this course will have demonstrated knowledge and understanding of the following:

1. To explain the general principles of pharmacology including pharmacokinetics and pharmacodynamics.
2. To describe the pharmacokinetics relevant for paediatric and geriatric patients.
3. To describe general drug interactions.
4. To explain the pharmacology of the autonomic nervous system and list the main classes of drugs that affect the autonomic nervous system including their indications, mechanism of action and adverse effects.
5. To explain the pharmacology of the central nervous system and list the main classes of drugs that affect the central nervous system including their indications, mechanism of action and adverse effects.
6. To describe the mechanism of action of some major drug classes such as analgesics and chemotherapeutics.

1. To list the types and classification of microbes of clinical relevance.
2. To describe how microbes are grown and studied.
3. To list and explain the factors involved in microbial pathogenesis (determinants of disease).
4. To describe the manifestation, diagnosis and treatment of infection/disease.
5. To describe the epidemiology of infectious disease.
6. To describe the methods for control and prevention of infection.
7. To describe the mechanism of action and adverse effects of antimicrobials.
8. To describe the common causative agents of infectious disease in man, disease manifestations and potential consequences.
9. To describe the emerging infectious diseases.

1. To describe the functional components of the lymphatic system.
2. To describe the basic components and function of the non-specific and specific immune systems.
3. To explain the roles of cytokines, complement and inflammation.
4. To explain how vaccination primes the immune system to protect us against certain pathogens.
5. To list and describe the four principal types of hypersensitivity
6. To describe autoimmune and immunodeficiency diseases.
7. To explain how stress and aging affects the immune response.

1. To revise the structural and functional characteristics of the major divisions of the nervous system.
2. To describe the structural and functional characteristics of neurones and explain the basis of neuronal signalling.
3. To describe the structure and function of the spinal cord and spinal nerves and explain the clinical significance of spinal reflexes.
4. To list the major regions of the brain and describe their broad function.
5. To describe the structure and function of the cerebral ventricles, the cerebral meninges, and describe the production and function of cerebrospinal fluid.
6. To describe the target and functional role of each of the cranial nerves.
7. To describe the structural and functional characteristics of the sensory receptors for general senses and list the modalities of function subserved by the principal sensory tracts of the spinal cord.
8. To list the neural pathways that mediate pain.
9. To understand the basic structure and function of the special senses.
10. To describe the brain and spinal cord pathways that control contractions of skeletal muscle and explain the difference between the medial and lateral motor pathways.
11. To describe the structure and functions of the sympathetic and parasympathetic divisions of the autonomic nervous system, particularly in regard to control of the heart, the blood vessels, the bladder and the bowel.

1. To describe the basis of human inheritance and genetic variation.
2. To understand pedigrees and punnett squares.
3. To describe the basis of genetic disease in man.
4. To understand procedures and issues involved in genetic testing.
5. To introduce the concept of population genetics and pharmacogenomics.
- General principles of pharmacology - drug nomenclature, interactions of drugs with target receptors, the pharmacokinetic properties of drugs, including absorption, distribution, metabolism and excretion and the pharmacodynamics of drugs
- General principles of drug interactions,drug-drug interactions and general adverse reactions
- General principles of paediatric and geriatric pharmacology - effects of aging on the pharmacodynamics,pharmacokinetics and therapeutic effects of drugs
- Pharmacology of the autonomic nervous system including the major neurotransmitters and receptors (adrenergic and cholinergic systems) and the organ systems they affect
- Pharmacology of the central nervous system including the major neurotransmitters and receptors (dopamine, glutamate, GABA and serotonin transmitters) and their effects on the brain
- Understand physiology and pharmacological treatment of psychosis, schizophrenia depression, bipolar disorder and Parkinsons disease
- An introduction to analgesics and chemotherapy drugs (including antibiotics) - indications, mechanism of action and adverse effects of each drug class will be discussed.

- Clinically important microbes and how they are classified
- How microbes and viruses are grown & studied
- Determinants of health & infectious disease, factors in microbial pathogenesis/resistance to infection
- Manifestations of infectious disease, diagnosis and treatment of infection/disease
- Epidemiology of infection
- Control & prevention of infection - disinfection, antisepsis & sterilisation
- The mechanism of action and adverse effects of antimicrobials
- Common infectious disease in man - causes, manifestations and potential consequences
- Emerging infectious disease.

- The structure and function of the lymphatic system
- Non-specific defences
- The specific immune system
- Role of cytokines, complement and inflammation
- Vaccination - priming the immune response
- Inflammation - tissue response to injury
- Hypersensitivity reactions - adverse immune responses
- Auto-immune disorders - inappropriate immune response
- Immunodeficiency conditions
- Immunology of aging -immune system changes in the elderly
- Stress and the immune response.

- Revision - the major divisions of the nervous system, structure & function of neurons, function of glia , resting membrane potential and the process of neurotransmission.
- The spinal cord, spinal nerves & spinal reflexes
- Structure and function of the brain, the ventricular system & the cranial nerves
- Structure and function of sensory receptors & somatosensory pathways
- Pain pathways
- Special senses
- Somatic motor control pathways from cerebral cortex to spinal cord
- Structure and function of the autonomic nervous system with emphasis on basic aspects of control of heart & blood vessels, bowel & bladder.

- DNA, Genes & Chromosomes - Composition and structure of the human genome, and relationship between genome structure and function
- Genetic Inheritance - Pedigree construction, basic classical genetics - Mendelian and sex-linked inheritance patterns, Calculation of risks of inheritance using Punnett squares
- Genetic Diversity - Genome replication, Genome mutation and recombination in human diversity and disease, Brief overview of non-Mendelian /complex genetics
- Genetic Diseases Overview - The genetic basis of disease, how the main types of genetic disorder arise, Chromosomal disorders and Single gene disorders
- The genetic basis of cancer
- Genetic Diseases Screening - Multifactorial disorders, Ageing-related disorders and Screening for genetic disorders - techniques, pros & cons
- Introduction to Population Genetics - Genetic risk/susceptibility factors and protective factors, and factors influencing the genetic composition of human populations
- The introduction to Pharmacogenomics.
Replacing Course(s)Not applicable
TransitionNot applicable
Industrial Experience0
Assumed KnowledgeHUBS1401 Human Bioscience or HUBS1406 Human Bioscience for Nursing & Midwifery
Modes of DeliveryFlexible Delivery / Student Centred Learning
Internal Mode
Teaching MethodsLecture
Self Directed Learning
Assessment Items
Examination: FormalEnd of semester examination
Course Learning Objectives; all

Students must achieve a passing grade in the formal written examination and must gain a passing grade overall to be able to obtain a passing or higher grade in this course.
Quiz - On-lineMinitests during semester
Course Learning Objectives; all
Contact HoursTutorial: for 2 hour(s) per Week for 12 weeks
Lecture: for 2 hour(s) per Week for 12 weeks
Self Directed Learning: for 7 hour(s) per Week for Full Term
Timetables2014 Course Timetables for HUBS1416