Analytical and Medicinal Chemistry

Course code CHEM2201Units 10Level 2000Faculty of Science and Information TechnologySchool of Environmental and Life Sciences

The first part of the course provides an introduction to the fundamental instrumental methods of chemical analysis commonly used in analytical laboratories. This section will include discussion and examples of techniques used to confirm purity (chromatography) and spectroscopic characterization of compounds (Mass spectrometry, atomic absorption spectrometry etc).
The second part of the course discusses basic separation and purification techniques including chromatography.
The third aspect of the course introduces advanced concepts and methods employed in organic chemistry, the branch of chemistry that deals with compounds of carbon, studying the functional groups of organic molecules, and their chemical reactions. The students will learn how to make organic compounds (synthesis), how to draw their structure, and how to show that we do have the compound we claim (characterisation). The main spectroscopic techniques (infrared, nuclear magnetic resonance and mass spectroscopy) for the characterisation of organic compounds are taught before the lab sessions start.
The final part of the course introduces students to medicinal chemistry, which is designed to examine chemistry at the interface between the chemical and biological sciences. The basic principles of synthetic and structural chemistry are applied to examination of the synthesis of biologically active molecules and drugs, and the structure, activity and interaction of biomolecules, including metalloproteins and natural products. Close links between the biological and chemical sciences will become apparent.
Theory is brought to practice in the laboratory using a wide range of typical examples.

This course has compulsory course components and students must:
1. participate in and submit laboratory reports for the established minimum requirements and obtain a minimum passing grade of 50%; and
2. obtain a minimum passing grade of 40% in the final, end-of-semester examination for the course.
3. have a current vaccination record, Criminal Record Check and Prohibited Employment Declaration.

In order to participate in this course, students must complete a compulsory Health and Safety requirement. Students will receive full information on this compulsory component in the course outline provided by the School of Environmental & Life Sciences.

Not available in 2014

ObjectivesOn successful completion of this course, students will:

1. Understand the range and uses of analytical methods in chemistry
2. Appreciate of the role of chemistry in quantitative analysis
3. Understand chemical methods employed for elemental and compound analysis
4. Have experienced some scientific methods employed in analytical chemistry
5. Understand the range and chemistry of carbon-based compounds
6. Understand chemical methods employed for problem solving involving organic systems
7. Have experienced some scientific methods employed in organic chemistry
8. Understand the range and chemistry of compounds of biological or medicinal relevance
9. Understand the role of the chemist in the development of drugs and pharmaceuticals
10. Understand the principal tasks for the synthesis or isolation and characterization of natural molecules, proto-drugs and drug candidate identification
11. Have experienced the scientific methods employed in natural products, bioinorganic and medicinal chemistry.
Content1. Spectrophotometry
- Electromagnetic radiation
- Atomic and molecular energy levels
- Absorption and emission of radiation, spectra
- Beer's law relationship between absorption and concentration
- Instruments for UV-visible spectrophotometry
- Choosing a spectrophotometric method
- Techniques of spectrophotometric determination
2. Electroanalytical Methods
- Electrolysis and electrodeposition
- Coulometry
- Polarography
- Electrode types
- Applications
3. Atomic Spectroscopy
- Atomic absorption spectroscopy
- Flame emission spectroscopy
- Plasma and electric discharge spectroscopy
4. Chromatography
- Principles of chromatography
- Gas chromatography
- Liquid chromatography (HPLC)
5. Introduction to structure determination and characterisation of compounds: infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, mass spectroscopy.
6. Molecular Structure: Stereochemistry
7. Substituent Group Chemistry:
- Alcohols and ethers
- Amines and thiols
- Alkyl halides
- Aldehydes and ketones
- Carboxylic acids, derivatives of carboxylic acids
- Heterocyclic compounds
8. Natural Compounds:
- The isolation of compounds from natural organisms such as bacteria, fungi, plants and the marine environment
- Applications of isolated compounds
9. Medicinal Compounds:
- The range and role of synthetic molecules in medicine
- Current approaches to the chemical synthesis of new drugs
- Current approaches to the rational design and development of new drugs.
Replacing Course(s)NA
TransitionNA
Industrial Experience0
Assumed KnowledgeCHEM1010 and CHEM1020.
Modes of DeliveryInternal Mode
Teaching MethodsLecture
Laboratory
Tutorial
Assessment Items
Examination: FormalThis is a compulsory course component. Students must obtain a minimum passing grade of 40% in the final, end-of-semester examination for the course in order to demonstrate that they have fulfilled course objectives relating to the understanding of the material expounded during lectures and/or described in assigned readings.

On achieving a passing grade, a final mark will be given in the course and it will be recorded that the student has satisfied the compulsory course component. Students who fail to satisfy the compulsory course component will be awarded a zero mark and a FF grade, irrespective of their final numeric mark. In such case, the normal avenues of appeal are open to them.
Laboratory ExercisesThis is a compulsory course component. Students must participate in 75% of the laboratory sessions and submit laboratory reports for the established minimum requirements and obtain a passing grade of at least 50% in order to demonstrate that the student has fulfilled course objectives relating to appropriate laboratory skills and professional and safety responsibilities. On achieving the passing grade, a final mark will be given in the course and it will be recorded that the student satisfied the essential criterion. Those students who fail to satisfy the compulsory course components will have the normal avenues of appeal open to them.
Make-up provisions
Students who are unable to complete the required number of laboratory exercises for reasons beyond their control will be offered the opportunity to make up at least one experiment at the discretion of the Discipline of Chemistry.
Other: (please specify)Tutorial assessments
Quiz - On-line
Contact HoursLaboratory: for 3 hour(s) per Week for 8 weeks
Tutorial: for 1 hour(s) per Week for 12 weeks
Lecture: for 3 hour(s) per Week for 12 weeks
Compulsory Components
Compulsory Course ComponentWHS-Safety Induction or Risk Assessment. In order to participate in this course, students must complete a compulsory safety induction, criminal record check, prohibited employment declaration, and hold a current First Aid Certificate.
Compulsory Course ComponentIn order to meet course objectives aligned with the students' understanding of, and ability to manipulate and apply the theoretical concepts, which form the core of the material expounded during lectures, and/or described in assigned readings, students must:
1. Participate in 75% of the laboratory sessions
2. Submit laboratory reports for the established minimum requirements and obtain a minimum passing grade of 50%; and
3. Obtain a minimum passing grade of 40% in the final, end-of-semester examination for the course.
Compulsory Program ComponentSuccessful completion of CHEM1010 and CHEM1020.