Analytical and Medicinal Chemistry
|Course code CHEM2201||Units 10||Level 2000||Faculty of Science and Information TechnologySchool of Environmental and Life Sciences|
The first part of the course provides an introduction to the fundamental instrumental methods of chemical analysis commonly used in analytical laboratories. This section will include discussion and examples of techniques used to confirm purity (chromatography) and spectroscopic characterization of compounds (Mass spectrometry, atomic absorption spectrometry etc).
The second part of the course discusses basic separation and purification techniques including chromatography.
The third aspect of the course introduces advanced concepts and methods employed in organic chemistry, the branch of chemistry that deals with compounds of carbon, studying the functional groups of organic molecules, and their chemical reactions. The students will learn how to make organic compounds (synthesis), how to draw their structure, and how to show that we do have the compound we claim (characterisation). The main spectroscopic techniques (infrared, nuclear magnetic resonance and mass spectroscopy) for the characterisation of organic compounds are taught before the lab sessions start.
The final part of the course introduces students to medicinal chemistry, which is designed to examine chemistry at the interface between the chemical and biological sciences. The basic principles of synthetic and structural chemistry are applied to examination of the synthesis of biologically active molecules and drugs, and the structure, activity and interaction of biomolecules, including metalloproteins and natural products. Close links between the biological and chemical sciences will become apparent.
Theory is brought to practice in the laboratory using a wide range of typical examples.
This course has compulsory course components and students must:
1. participate in and submit laboratory reports for the established minimum requirements and obtain a minimum passing grade of 50%; and
2. obtain a minimum passing grade of 40% in the final, end-of-semester examination for the course.
3. have a current vaccination record, Criminal Record Check and Prohibited Employment Declaration.
In order to participate in this course, students must complete a compulsory Health and Safety requirement. Students will receive full information on this compulsory component in the course outline provided by the School of Environmental & Life Sciences.
Not available in 2014
|Objectives||On successful completion of this course, students will: |
1. Understand the range and uses of analytical methods in chemistry
2. Appreciate of the role of chemistry in quantitative analysis
3. Understand chemical methods employed for elemental and compound analysis
4. Have experienced some scientific methods employed in analytical chemistry
5. Understand the range and chemistry of carbon-based compounds
6. Understand chemical methods employed for problem solving involving organic systems
7. Have experienced some scientific methods employed in organic chemistry
8. Understand the range and chemistry of compounds of biological or medicinal relevance
9. Understand the role of the chemist in the development of drugs and pharmaceuticals
10. Understand the principal tasks for the synthesis or isolation and characterization of natural molecules, proto-drugs and drug candidate identification
11. Have experienced the scientific methods employed in natural products, bioinorganic and medicinal chemistry.
- Electromagnetic radiation
- Atomic and molecular energy levels
- Absorption and emission of radiation, spectra
- Beer's law relationship between absorption and concentration
- Instruments for UV-visible spectrophotometry
- Choosing a spectrophotometric method
- Techniques of spectrophotometric determination
2. Electroanalytical Methods
- Electrolysis and electrodeposition
- Electrode types
3. Atomic Spectroscopy
- Atomic absorption spectroscopy
- Flame emission spectroscopy
- Plasma and electric discharge spectroscopy
- Principles of chromatography
- Gas chromatography
- Liquid chromatography (HPLC)
5. Introduction to structure determination and characterisation of compounds: infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, mass spectroscopy.
6. Molecular Structure: Stereochemistry
7. Substituent Group Chemistry:
- Alcohols and ethers
- Amines and thiols
- Alkyl halides
- Aldehydes and ketones
- Carboxylic acids, derivatives of carboxylic acids
- Heterocyclic compounds
8. Natural Compounds:
- The isolation of compounds from natural organisms such as bacteria, fungi, plants and the marine environment
- Applications of isolated compounds
9. Medicinal Compounds:
- The range and role of synthetic molecules in medicine
- Current approaches to the chemical synthesis of new drugs
- Current approaches to the rational design and development of new drugs.
|Assumed Knowledge||CHEM1010 and CHEM1020.|
|Modes of Delivery||Internal Mode|
|Contact Hours||Laboratory: for 3 hour(s) per Week for 8 weeks|
Tutorial: for 1 hour(s) per Week for 12 weeks
Lecture: for 3 hour(s) per Week for 12 weeks