BIOS6140
Advanced Clinical Trials & Meta-Analysis
10 Units
Not available in 2014
Previously offered in 2011, 2010, 2009, 2008, 2007, 2006, 2005, 2004
This course will provide students with advanced knowledge and skills relating to randomised clinical trials. Students will be exposed to the statistical principles, issues and methods involved in the design and analysis of randomised controlled trials (RCTs).
| Objectives | On completion students should: 1. have an advanced understanding of randomised controlled trials; 2. be able to design and analyse a wide variety of randomised control trials; |
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| Content | The first component of the course discusses methods in RCTs for determining stopping rules for interim analyses, spending functions, stochastic curtailment, analysis methods used with cross-over designs, preference outcomes, N-of-1 studies and equivalence, and non-inferiority trials. The second component discusses the statistical principles encountered in relation to aspects of regulatory/reporting guidelines, and relates to reports prepared for data safety and monitoring committees. | ||
| Replacing Course(s) | N/A | ||
| Transition | N/A | ||
| Industrial Experience | 0 | ||
| Assumed Knowledge | Mathematical Background for Biostatistics; Design of Experiments & RCTs; Probability and Distribution Theory Principles of Statistical Inference; Linear Models; *Survival Analysis * Co-requisite - may be taken concurrently. Semester availability: |
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| Modes of Delivery | Distance Learning : Paper Based | ||
| Teaching Methods | Self Directed Learning | ||
| Assessment Items |
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| Contact Hours | Self Directed Learning: for 6 hour(s) per Week for Full Term |