Survival Analysis

Course code BIOS6030Units 10Level 6000Faculty of Health and MedicineSchool of Medicine and Public Health

Aims to enable students to understand the impact of computers and the corresponding availability of data sets (often very large data sets) on the way we think about data and proceed to analyse or report on it. Explores biostatistical applications of survival analysis with an emphasis on underlying theoretical and computational issues, practical interpretation and communication of results.
This course is offered in conjunction with the Biostatistics Collaboration of Australia (BCA).

Available in 2015

Distance Education - CallaghanSemester 1
Previously offered in 2014
ObjectivesAt the end of this unit you should be able to:
1. Understand the nature of survival data, especially censoring and truncation;
2. Summarise and display survival data using nonparametric methods;
3. Analyse survival data using the Cox proportional hazards model, including: hypothesis testing; diagnostic testing; the use of stratification and time-dependent variables, where appropriate; and interpret results;
4. Analyse survival data using parametric (accelerated failure-time) models;
5. Formulate, implement and interpret multiple-event models, and select appropriate model;
6. Determine sample size for a simple survival analysis;
7. Produce appropriate displays for publication.
ContentThrough a series of case studies, students will explore the various methods for handling survival data. These begin with the Kaplan-Meier curve definition and its extension to the comparison of survival prospects of several groups of courses using the logrank test and confidence intervals for relative risks, emphasising graphical displays and assessing underlying assumptions. The connection between Mantel-Haenszel methods and survival analysis is thus emphasised. The Cox proportional hazards model is introduced as a method for handling continuous covariates. Various extensions of this model, including time-dependent covariates and multiple outcomes, are considered, as well as the censored linear regression model.
Replacing Course(s)N/A
TransitionN/A
Industrial Experience0
Assumed KnowledgeEpidemiology (EPID6420);
Mathematical Background for Biostatistics (BIOS6040);
Probability and Distribution Theory (BIOS6170);
Principles of Statistical Inference (BIOS6050);
Linear Models (BIOS6070).
Modes of DeliveryDistance Learning : Paper Based
Teaching MethodsEmail Discussion Group
Assessment Items
Essays / Written AssignmentsAssignments 90% (3 written assignments the first worth 26%, the second worth 36% and the last worth 28%), Short answer exercises 10% (two exercises worth 5% each).
Contact HoursSelf Directed Learning: for 8 hour(s) per Week for Full Term
Compulsory Components
Requisite by EnrolmentThis course is only available to students enrolled in the Graduate Diploma in Medical Statistics or Master of Medical Statistics programs.
Timetables2015 Course Timetables for BIOS6030